Global ETD Search

1	Live-Cell Imaging of Stress Signaling Dynamics in a Cell Fate Decision / 細胞運命決定におけるストレスシグナル伝達動態の生細胞イメージング Miura, Haruko 23 January 2019 (has links) 京都大学 / 0048 / 新制・課程博士 / 博士(生命科学) / 甲第21474号 / 生博第405号 / 新制\|\|生\|\|53(附属図書館) / 京都大学大学院生命科学研究科高次生命科学専攻 / (主査)教授松田道行, 教授影山龍一郎, 教授渡邊直樹 / 学位規則第4条第1項該当 / Doctor of Philosophy in Life Sciences / Kyoto University / DFAM p38 JNK DUSP1 cross-inhibition fluorescence imaging KTR cell-to-cell variability 460
2	THE MENINGIOMA ENHANCER LANDSCAPE DELINEATES PROGNOSTIC SUBGROUPS AND DRIVES DRUGGABLE DEPENDENCIES Prager, Briana C. 07 September 2020 (has links) No description available. Biomedical Research Bioinformatics Cellular Biology Oncology Meningioma epigenetics enhancers brain tumors DUSP1
3	Étude du rôle de la phosphatase DUSP1 dans la régulation de la réponse immunitaire innée autonome dans les cellules épithéliales pulmonaires lors de l'infection par le virus respiratoire syncytial et le virus Sendai Robitaille, Alexa 08 1900 (has links) No description available. DUSP1 JIP1 JNK p38 migration apoptose virus respiratoire syncytial cytokines Paramyxovirus Pneumovirus Apoptosis Respiratory Syncytial Virus
4	The influence of Toll-like receptors on murine invariant natural killer T cell activation Villanueva, Alexander Ian 21 June 2013 (has links) Invariant natural killer T (iNKT) cells are a versatile subclass of T lymphocytes which recognize glycolipid antigens. iNKT cells are capable of rapidly producing a broad array of cytokines in response to stimulation; thus, they play an important role in the early regulation of a variety of immune responses. It was hypothesized that iNKT cells express functional Toll-like receptors (TLRs) and that stimulation of TLRs by their ligands modulates iNKT cells responses. In the first objective, it was revealed that upon stimulation with anti-CD3 monoclonal antibody and interferon (IFN)-α, expression of TLRs was enhanced in iNKT cells. Furthermore, stimulation of iNKT cells with TLR ligands led to a significant increase in the expression of several cytokines. In the second objective, the mechanisms behind the modulatory effects of the TLR9 ligand (CpG-ODN) on iNKT cells were determined. Altogether, these findings suggest a direct role for TLRs in iNKT cell activation. / Ontario Graduate Scholarship immunology NKT cells innate immunity Toll-like receptors real-time PCR ELISA Western blot flow cytometry macrophage cell lines hybridoma VSV MAPK MAPK phosphatase DUSP1 CpG T cells natural killer cells gene expression

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