Thesis (Ph. D.)--Joint Doctoral Program in Educational Leadership (California State University, Fresno and University of California, Davis). / Typescript. Includes bibliographical references. Also available via the World Wide Web. (Restricted to UC campuses).

Thesis (M.S.)--Brigham Young University. Dept. of Teacher Education, 2004. / Includes bibliographical references (p. 61-63).

Thesis (M.A.)--York University, 1998. Graduate Programme in Psychology. / Typescript. Includes bibliographical references (leaves 49-51). Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL:http://wwwlib.umi.com/cr/yorku/fullcit?pMQ27383.

Thesis (Ph. D.)--University of Missouri-Columbia, 2002. / Typescript. Vita. Includes bibliographical references (leaves 163-170). Also available on the Internet.

Includes bibliographical references (p. 38-40).

Thesis (Ph. D.)--University of Missouri-Columbia, 2002. / Typescript. Vita. Includes bibliographical references (leaves 163-170). Also available on the Internet.

This study focuses on different manufacturing processes and material choices for products that are designed to help the future to be more sustainable. These products were developed in a global project that explored the field and subfields of urban mining. This thesis is a part of that project and is meant to come with valuable input to the results. In this urban mining project two products were developed. The two different products that has been developed during this project is the NIX and the UM Factory. They work together with keeping material on the construction site when space is limited in order to reduce the transportation, both for the environmental benefit and also from a cost perspective. Together they will not only keep the material on the site but also refine them so they can be used again. This thesis will look into how these two products can be manufactured and what materials is a suitable choice for the products. These two factors were also thought about during the development of the products, both how to make it as simple design that was easy to produce while still fulfilling the requirements set. Also what materials might be a suitable choice for different parts of the products is considered, in order to be reliable, easy to work with, and relatively cheap. The study also explored some methods and materials that might be worth looking into in a few years. Methods and materials that today are undeveloped or not economically viable.

This thesis consists of two topics: statistical selection and profile monitoring. Statistical selection is related to ranking and selection in simulation and profile monitoring is related to statistical process control. Ranking and selection (R&S) is to select a system with the largest or smallest performance measure among a finite number of simulated alternatives with some guarantee about correctness. Fully sequential procedures have been shown to be efficient, but their actual probabilities of correct selection tend to be higher than the nominal level, implying that they consume unnecessary observations. In the first part, we study three conservativeness sources in fully sequential indifference-zone (IZ) procedures and use experiments to quantify the impact of each source in terms of the number of observations, followed by an asymptotic analysis on the impact of the critical one. Then we propose new asymptotically valid procedures that lessen the critical conservativeness source, by mean update with or without variance update. Experimental results showed that new procedures achieved meaningful improvement on the efficiency. The second part is developing a wavelet-based distribution-free tabular CUSUM chart based on adaptive thresholding. WDFTCa is designed for rapidly detecting shifts in the mean of a high-dimensional profile whose noise components have a continuous nonsingular multivariate distribution. First computing a discrete wavelet transform of the noise vectors for randomly sampled Phase I (in-control) profiles, WDFTCa uses a matrix-regularization method to estimate the covariance matrix of the wavelet-transformed noise vectors; then those vectors are aggregated (batched) so that the nonoverlapping batch means of the wavelet-transformed noise vectors have manageable covariances. Lower and upper in-control thresholds are computed for the resulting batch means of the wavelet-transformed noise vectors using the associated marginal Cornish-Fisher expansions that have been suitably adjusted for between-component correlations. From the thresholded batch means of the wavelet-transformed noise vectors, Hotelling’s T^2-type statistics are computed to set the parameters of a CUSUM procedure. To monitor shifts in the mean profile during Phase II (regular) operation, WDFTCa computes a similar Hotelling’s T^2-type statistic from successive thresholded batch means of the wavelet-transformed noise vectors using the in-control thresholds; then WDFTCa applies the CUSUM procedure to the resulting T^2-type statistics. Experimentation with several normal and nonnormal test processes revealed that WDFTCa outperformed existing nonadaptive profile-monitoring schemes.

Agents, by definition, (1) are situated in an environment upon which their actions affect changes and (2) have some level of autonomy from the control of humans or other agents. Being situated requires that the agent have a mechanism for sensing the environment as well as actuators for changing the environment. Autonomy implies that each agent has the freedom to make their own decisions. Rational agents are those agents that decide to execute actions that are in their “best interests” according to their desires, using a model of those desires on which they make those decisions. Action selection is complicated due to uncertainty when operating in a dynamic environment or where other actors (agents) can also influence the environment. This dissertation presents an action selection framework and algorithms that are (1) rational with respect to multiple desires and (2) responsive with respect to changing desires. Agents can use the concept of commitments, and the subsequent communication of those commitments, to coordinate their actions and reduce their uncertainty. Coordination is layered on top of this framework by describing and analyzing how commitments affect the agents’ desires in their action selection models. This research uses the domain of UAV surveillance to experimentally explore the balance between under-commitment and over-commitment. Where previous approaches concentrate on the semantics of commitment, this research concentrates on the pragmatics of commitment, describing how to use utility calculations to enable an agent to decide when making a commitment is in its best interests. / text

RNA interference, or RNAi, is a cellular mechanism that describes the sequence-specific post transcriptional gene silencing observed in plants, fungi, and metazoans, facilitated by short double-stranded RNAs and microRNAs (miRNAs) with sequence complementarity to target mRNAs. Many of the regulatory mechanisms of the RNAi pathway by which these small miRNAs are first processed, from primary transcripts to precursor miRNA stemloops and then to mature miRNAs, by the multiprotein complexes Drosha and Dicer, respectively, still remain unknown. Within the miRNA biogenesis pathway, there is strong evidence pointing to the terminal loop region as an important regulatory determinant of miRNA maturation. To further elucidate the terminal loop's exerted control over miRNA processing, we propose a combined in vitro / in vivo selection experiment of a randomized pri-miRNA terminal loop library in search of an optimally processed pre-miRNA substrate. Here, we report the isolation of a premiRNA terminal loop sequence that is favorably processed by Drosha in vivo but also functions as an effective cis-inhibitor of further pre-miRNA processing by downstream Dicer. This terminal loop also demonstrated modular properties of Dicer inhibition in two different miRNAs, and should prove useful in further elucidating the mechanisms of miRNA processing in context of a newly proposed Dicer cleavage model (Gu et al. 2012). In combination, these findings may have important implications in both Drosha and Dicer's direct role in gene expression and miRNA biogenesis, the regulatory proteins that modulate their respective functions, as well as the potential development of new design rules for the more efficient processing and targeting of miRNA-based technology and RNAi therapeutics. / text