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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

3-D Conformance Analysis of Manufacturing Plans Using M-Maps, by Explicating Formal GD&T Schema from the Process Plan

January 2015 (has links)
abstract: A process plan is an instruction set for the manufacture of parts generated from detailed design drawings or CAD models. While these plans are highly detailed about machines, tools, fixtures and operation parameters; tolerances typically show up in less formal manner in such plans, if at all. It is not uncommon to see only dimensional plus/minus values on rough sketches accompanying the instructions. On the other hand, design drawings use standard GD&T (Geometrical Dimensioning and tolerancing) symbols with datums and DRFs (Datum Reference Frames) clearly specified. This is not to say that process planners do not consider tolerances; they are implied by way of choices of fixtures, tools, machines, and operations. When converting design tolerances to the manufacturing datum flow, process planners do tolerance charting, that is based on operation sequence but the resulting plans cannot be audited for conformance to design specification. In this thesis, I will present a framework for explicating the GD&T schema implied by machining process plans. The first step is to derive the DRFs from the fixturing method in each set-up. Then basic dimensions for the features to be machined in each set up are determined with respect to the extracted DRF. Using shop data for the machines and operations involved, the range of possible geometric variations are estimated for each type of tolerances (form, size, orientation, and position). The sequence of manufacturing operations determines the datum flow chain. Once we have a formal manufacturing GD&T schema, we can analyze and compare it to tolerance specifications from design using the T-map math model. Since the model is based on the manufacturing process plan, it is called resulting T-map or m-map. Then the process plan can be validated by adjusting parameters so that the m-map lies within the T-map created for the design drawing. How the m-map is created to be compared with the T-map is the focus of this research. / Dissertation/Thesis / Masters Thesis Mechanical Engineering 2015
2

Understanding Lean Manufacturing According to Axiomatic Design Principles

Reynal, Vicente A., Cochran, David S. 11 1900 (has links)
In this paper, a sequence of implementation steps will be developed through the application of axiomatic design. This sequence will provide a design methodology for lean production which connects manufacturing system design objectives to operation design parameters. / Lean Aerospace Initiative
3

Sustainability by Design: How to Promote Sustainable Tourism Behavior through Persuasive Design?

Liu, Zhaoran, M.A. 11 July 2019 (has links)
No description available.
4

Vers un nouvel outil d'étude de la reconnaissance hôte-ligand : conception de nouveaux inhibiteurs de PDE4 guidée par docking quantique, synthèse et évaluation biologique / Toward a new tool of host-ligand recognition : design of new PDE4 inhibitors guided by quantum docking, synthesis and biological evaluation

Barberot, Chantal 06 December 2013 (has links)
Dans la recherche de nouveaux traitements des maladies broncho-pulmonaires comme l'asthme et la broncho-pneumopathie chronique obstructive, les inhibiteurs de PDE4 sont des cibles intéressantes. Dans cette voie, notre laboratoire s'intéresse à la synthèse d'une nouvelle famille d'inhibiteurs à base pyridazinone. Pour cela, cette thèse couple la modélisation moléculaire (docking : développement méthodologique et application), la synthèse organique ainsi que des tests biologiques.Dans un premier temps, le développement du logiciel d'amarrage moléculaire AlgoGen a été poursuivi. AlgoGen (créé initialement à l'université de Lorraine en 2009) est un logiciel qui couple un algorithme génétique pour la recherche conformationnelle à une évaluation de l'énergie protéine-ligand à un niveau quantique semi-empirique alors que les autres logiciels existant effectuent ce calcul à un niveau classique en général. Le calcul d'une énergie à un niveau quantique est très coûteux en temps. C'est pourquoi, nous avons apporté de nombreuses modifications à ce logiciel afin d'accroître son efficacité dans la recherche conformationnelle. Ce logiciel a ensuite été utilisé sur un jeu de 22 dimères (typiques des reconnaissances moléculaires biologiques) et à huit systèmes protéine-ligand.Dans un deuxième temps, huit inhibiteurs ont été synthétisés et testés in vitro sur la cible PDE4. Pour compléter ce volet expérimental, une étude de structure-activité a été effectuée grâce au docking moléculaire (AlgoGen, Autodock, Glide) pour rationaliser les activités mesurées (IC50). Pour terminer, des pharmaco-modulations guidées par docking ont été réalisées afin de proposer de nouveaux inhibiteurs de plus grandes affinités avec la protéine PDE4D. / For the research of new treatment of bronchopulmonary diseases such as asthma and chronic obstructive pulmonary disease (COPD), the PDE4 inhibitors are an attractive target. Our laboratory is interested in a new PDE4 inhibitors family based on the pyridazinone pattern. For this purpose, this thesis couples molecular modeling (docking: methodological development and application), organic synthesis and biological tests.First, the development of the molecular docking software AlgoGen was continued. AlgoGen (initially created at university of Lorraine in 2009) is a program which couples a genetic algorithm for the conformational research and a protein-ligand energy evaluation at the quantum semi-empirical level while other software do this evaluation at a classical level. Quantum energy calculations are very time consuming. That is the reason why some modifications have been made to improve its efficiency for the conformational search. This software was then used for calculations on a set of 22 dimers (typical in biological molecular recognition) as well on 8 ligand-protein complexes.Secondly, eight inhibitors were synthesized and tested in vitro on the PDE4 target. To complete the experimental part, a structure-activity relationship study was carried out through a molecular docking to rationalize the measured activity (IC50). Finally, pharmaco-modulations guided by docking were made to propose new inhibitors with more affinity with the protein.
5

Enhancing Augmented Reality:Real-time Identification and Differentiation of Architectural Elements and Decor in Living Spaces / Förbättrad Augmented Reality: Realtidsidentifiering och Differentiering av Arkitektoniska Element och Dekor i Bostadsutrymmen

Lundberg, Filip January 2024 (has links)
This study explores how interior design can be complemented with Augmented Reality(AR), focusing on a software developed using Unity and implemented with ARKit foriOS platforms. The software intended to allow real-time visualization of walls in rooms,all the while having the capability of excluding decorations, furniture or other objectsobstructing the identified walls. This would allow the user to adjust the resulting virtualwall to their needs, whether that be changing the color or material of it. If succeeded, itcould revolutionize interior design as one could visualize the room completely furnishedwith the changes applied to the wall. Regrettably, the software did not reach thatstage. While the application succeeded in identifying walls and coloring them, it failedto exclude objects that obstructed the walls and open doors due to technical constraints.The paper also provides guidance as to how the result may be improved. Despite thechallenges mentioned, this application lays a foundational understanding of augmentedreality’s potential in interior design and serves as a stepping stone in a sparsely exploredarea.

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