Hybrid Make-To-Stock (MTS)-Make-To-Order (MTO) manufacturing is a well known policy that captures the benefits of both MTS and MTO policies. This manufacturing policy is adopted by many manufacturing firms because it allows for production based on customer specifications while keeping short response times. We study a hybrid MTS-MTO manufacturing system which consists of two processing stages and an intermediate buffer between these two stages. We propose two separate scenarios for ordering and replenishment of components from the first stage which will give more realistic guidance for practitioners. The first scenario is batching customer orders before being released to the first stage. The second scenario is batch replenishment of common components from the first stage. Most existing MTS-MTO models focus on one-for-one ordering and replenishment strategies. We enhance these models by introducing a batch ordering policy to account for economies of scale in ordering when there is an ordering cost associated with each order placed for common components. We use queueing theory to model the system behavior and use the matrix-geometric method to evaluate system performance under the new ordering policy. Afterwards, we develop an optimization model with the objective to minimize the system overall costs. The purpose of our optimization model is to find the optimal intermediate buffer size and the optimal order quantity for the system. In the second scenario, we introduce the batch replenishment policy from stage 1. This policy is suitable when stage 1 and stage 2 are physically distant and there is a shipping cost incurred when components are transferred from stage 1 to stage 2. The decision variables in this model are the intermediate buffer size and the shipping quantity. We show that the base stock policy is sub-optimal when there is an ordering cost incurred for ordering components. The savings from adopting the batch ordering policy are high and the response time for most customer orders is not affected. When there are shipping costs and shipping time between the two stages, we show that the right selection of the system decision variables can have a large impact on the total cost incurred by the system.

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Timely student completion of undergraduate nursing programs in order to produce practicing registered nurses (RNs) is of concern to students, faculty, governments, employers, and health care consumers across Canada. The shortage of health care professionals in Saskatchewan, particularly in nursing, is an immediate and growing concern. The average age of RNs in Saskatchewan is 44.9 years (CIHI, 2003). With the inevitability of retirement of many RNs, recruitment and retention of new nurses is critical to the quality of health care in this province. The looming shortage creates a further challenge for key stakeholders in academia, government, and health regions who hold a vested interest in the retention of nurses educated in Saskatchewan. Currently, little is known about the impact of barriers to timely completion of students in the Nursing Education Program of Saskatchewan (NEPS). Considering the aging nursing workforce, frequent, substantial numbers of nursing graduates are important to meet the demand for health human resources in the province of Saskatchewan (SRNA, 2004). <p>The purpose of this research was to conduct a secondary analysis of the NEPS Database including exit surveys completed by 363 graduates over a three-year period, 2002-2003; 2003-2004; 2004-2005. Group membership was determined by splitting data between graduates who had taken four academic years (September to April) or less to complete the program (timely completers) and those who took longer than four academic years (delayed completers). Objectives were to examine the differences between the two aforementioned groups in terms of the following variables: employment hours, financial burden, student loan status, dollar amount of bursaries awarded during the NEPS, primary responsibility the year prior to the NEPS, significant life changes during the NEPS, Aboriginal ancestry and core course averages. <p>Results show that 86% of females in the study group completed the NEPS in a timely manner compared with 58% of their male counterparts. There was a trend of higher employment hours per week in every year of the NEPS for delayed completers. However, this difference approached statistical significance only for students in year one, t (360) = 1.81, p < .07. Fifty percent of delayed completers had three or more significant life changes during the NEPS. Seventy-five percent of timely completers had two or fewer significant life changes. Students require various forms of support to ensure timely completion of the NEPS. It is anticipated that results of this research will inform policy decisions to facilitate timely completion of the NEPS.

Though erasure codes are widely adopted in high fault tolerance storage systems, there exists a serious small-write problem. Many algorithms are proposed to improve small-write performance in RAID systems, without considering the network bandwidth usage. However, the network bandwidth is expensive in cloud systems. In this thesis, we proposed an ECL-based (E-MBR codes, Caching and Logging-based) technique to improve the small-write performance without using extra network bandwidth. In addition, the ECL-based technique also reduces the delayed parity update and data recovery latency compared with the competing algorithm.

Tomato has been genetically modified for providing properties such as insect-resistance or delayed-ripening. Tomato seeds purchased from several bazaars and markets were screened for the presence of genetic modification by targeting NptII kanamycin resistance, Nos terminator, and 35S promoter gene regions which are the most commonly transformed gene regions in transgenic plants, and then ripening-delayed tomato seeds were tried to be identified in this study. F type truncated-PG gene and Sam-k gene were selected as the indicator of genetically modified ripening delayed tomatoes. DNAs of 25 seed samples were isolated by CTAB method and examined with several primer pairs, and the primer sets that provided consistent results were selected to conduct routine testing by PCR analysis of the samples. In screening analysis via conventional PCR, 4 samples were amplified with 35S, Nos and NptII primer sets. Among other samples, 3 of them were amplified with 35S and Nos primer sets and 2 of them were amplified only with 35S primer set. The amplification was observed with Nos, NptII and Sam-k primers in one sample and this sample was identified as 35 1 N, since the sequence result of the PCR product amplified with Sam-k primers showed high homology with the Samase gene of T3 Coliphage. F type truncated PG gene was not observed in any of the samples. Although this study demonstrates the presence of commonly used gene regions in genetically modified tomatoes, further analysis of the genetically modified ripening delayed tomato seeds via construct specificor event specific PCR techniques is needed for confirmation.

Genetically modified organisms are entering the human diet in all over the world. In order to have transparency in the foods that are being consumed, there is a need to trace the genetically modified organisms (GMOs) in the market and consequently this need brings the necessity of analytical methods that are capable of detecting, identifying and quantifying the transgenic events. These analytical methods also form the basis of the labeling regulations that are tried to be formed regarding GMOs. The main aim of this study is to develop and apply the detection methods for the two of the tomato events, delayed ripening and insect resistant. Currently the only validated detection methods are mainly for the corn, soybean, and cotton. There is no validated detection method for tomato. Tomato is one of the most consumed food products in Turkey and it is also among the controversial organisms in terms of genetic modifications and labeling, therefore the analysis of the genetic modifications in tomato is crucial. In this study, DNA-based detection is performed, with PCR being the chosen method of study. In order to detect the GMO-derived DNA, the method of analysis includes the following studies: species-specific, screening, gene-specific, construct-specific and inverse PCR. In addition, the quantification method is developed using the real-time PCR. In order to develop the procedure of identification method, the reference samples are used and the unknown varieties that are to be analyzed using this method are expected to have similarities with the authorized transgenic events.

Thesis (Ph. D.)--West Virginia University, 2001. / Title from document title page. Document formatted into pages; contains xii, 150 p. : ill. Vita. Includes abstract. Includes bibliographical references (p. 131-150).

Numerous cases of premature concrete deterioration due to alkali-silica reaction and/or delayed ettringite formation have developed within highway infrastructure in the state of Texas over the past two decades. Although experimental research and in-situ load testing on an international scale has indicated that moderate levels of deterioration are unlikely to pose a threat to structural safety, the discovery of reinforcing bar fracture in Japan due to ASR-related expansion has called into question the integrity of heavily damaged structures. A two-part experimental program was conducted at The University of Texas at Austin relating to ASR/DEF-induced reinforcing bar fracture. Work conducted under TxDOT Project 0-6491 included the fabrication and monitoring of four concrete specimens. Methods were employed to simulate a fracture of the transverse reinforcement within the time frame of the study and the applicability of various NDT monitoring techniques to detect bar fracture was evaluated. Furthermore, a number of reinforcing bar samples were tested and analyzed to investigate (1) the development of reinforcing bar cracking due to the bending operation and (2) the progression of cracks after application of an expansive opening force on bars with 90° bends. Research findings and conclusions form a preliminary assessment on the potential for reinforcing bar fracture within affected infrastructure in Texas. / text

Alkali-silica reaction (ASR) and delayed ettringite formation (DEF) are expansive reactions that can lead to the premature deterioration of concrete structures. Both have been implicated in the deterioration of numerous structures around the world, including many transportation structures in Texas. As a result of considerable research advances, ASR and DEF are now avoidable in new construction, but evaluating and managing the existing stock of structures damaged by these mechanisms remains a challenge. While the published guidance for evaluating structures is very effective at diagnosing the presence of ASR and DEF, there remain significant weaknesses with respect to the evaluation of structural safety and serviceability and nondestructive testing (NDT) is a minor component of the evaluation process. The research described in this dissertation involved a wide range of tests on plain and reinforced concrete at multiple scales. This included small cylinders and prisms, larger plain and reinforced concrete specimens in outdoor exposure, full-scale reinforced concrete beams, and core samples from the outdoor exposure specimens and full-scale reinforced concrete beams. Nondestructive test methods were applied at all scales, and the full-scale beams were also tested in four-point flexure to determine the effects of ASR and DEF on flexural strength and serviceability. Severe expansions from ASR and DEF did not reduce the strength of the full-scale beams or result in excessive deflections under live loads, despite significant decreases in the compressive strength and elastic modulus measured from core samples. Most NDT methods were found to be effective at low expansions but had difficulty correlating to larger expansions. Two promising NDT methods have been identified for future research and development, and guidance regarding existing test methods is offered. / text

Background: Chronic wounds are a significant health problem in various populations. Psychosocial stress is a lifestyle factor that has been shown to directly influence wound healing. Current findings support roles for assessment and reduction of psychosocial stress in the comprehensive management of chronic wounds, however, a gap remains between current research and current clinical practice. Purpose: To develop a novel method by which to educate nurses about the effects of psychosocial stress on wound healing while incorporating state-of-the-art technology that is sensitive to the needs of individuals with various learning styles. Objectives: To review current literature documenting the relationship between chronic psychosocial distress and delayed wound healing to identify essential content to include in educational modules for nurses. To develop three educational modules for nurses in inpatient and outpatient settings that address the relationship between chronic psychosocial distress and delayed wound healing, and the effects of stress-reduction interventions in formats that meet the needs of different learning styles. To conduct a focus group discussion with nurse-participants regarding educational module content and delivery methods in order to evaluate and improve these educational modules. Methods: A series of literature reviews were performed between June, 2010 and October, 2013, using articles identified through searches using the databases PubMed and CINAHL. Essential content regarding psychosocial stress and its impact on wound healing was identified, and was used in the development of educational modules, designed to meet the basic needs of individuals with different learning styles. A purposive sample of nurses was recruited through the use of flyers, reviewed the educational modules online, and met for a focus group to discuss their experiences with these modules. Outcomes: A novel method was developed by which to deliver educational material to nurses about psychosocial stress and delayed wound healing. Participants were motivated to learn, had self-awareness of their preferred learning styles, and responded positively to this method of education delivery; they were able to articulate the basic concepts presented in the modules. These findings may be generalizable to a larger audience and may inform the development of future education-delivery approaches in this area.