In this thesis we implement an ensemble of sequence analysis strategies aimed at identifying functional and structural protein features. The first part of this work was dedicated to two case studies of specific proteins analyzed to provide candidate functional positions for experimental validation: the protein alpha-synuclein (αsyn) and the alanine racemases protein family. In the case of αsyn, the objective was to predict its aggregation prone regions. For the alanine racemase protein family, the scope was to predict sites responsible for substrate specificity. In these two studies, computational predictions allowed systematically exploring potentially functionally relevant protein sites in an efficient manner that may not be possible to implement with traditional experimental approaches. Our strategy provided a powerful forecasting tool for the selection of candidate sites to be later verified experimentally. In the second part, we analyze the role of intrinsic disorder (ID) as a modulator of protein function in different organisms and cellular processes, which is largely unexplored. As key components of the diverse cellular pathways, disordered proteins are often involved in many diseases, including cancer and neurodegenerative diseases. Thus, there is an impeding need to unveil the general principles underlying the role of ID in proteins. We provide a multi-scale analysis of the involvement of ID in protein function starting with a large-scale analysis at genomic level of the role of ID in Arabidopsis, zooming in into the specific processes of vesicular trafficking in Human and yeast, and finally focusing on specific proteins of diverse organisms. The results of this thesis provide a better understanding of the functional roles mediated by ID in different organisms and biological processes, such as acting as flexible linkers connecting structured domains, mediating protein-protein interactions, and assisting the quick assembly of large macromolecular complexes. In addition, we present evidence of the use of ID as a mechanism to increase the complexity of protein and biological networks, and as a means to increase the adaptability of proteins in specific processes. Thus, our results contribute to elucidating the relationship between network and organismal complexity and ID, while they also provide evidence of the evolutionary advantages offered by ID.

We study three problems related to searching and sorting in multisets in the cache-oblivious model: Finding the most frequent element (the mode), duplicate elimination and finally multi-sorting. We are interested in minimizing the cache complexity (or number of cache misses) of algorithms for these problems in the context under which the cache size and block size are unknown. We start by showing the lower bounds in the comparison model. Then we present the lower bounds in the cache-aware model, which are also the lower bounds in the cache-oblivious model. We consider the input multiset of size <i>N</i> with multiplicities <i>N</i>₁,. . . , <i>N_k</i>. The lower bound for the cache complexity of determining the mode is &Omega;({<i>N</i> over <i>B</i>} log {<i>M</i> over <i>B</i>} {<i>N</i> over <i>fB</i>}) where &fnof; is the frequency of the mode and <i>M</i>, <i>B</i> are the cache size and block size respectively. Cache complexities of duplicate removal and multi-sorting have lower bounds of &Omega;({<i>N</i> over <i>B</i>} log {<i>M</i> over <i>B</i>} {<i>N</i> over <i>B</i>} - £{<i>k</i> over <i>i</i>}=1{<i>N_i</i> over <i>B</i>}log {<i>M</i> over <i>B</i>} {<i>N_i</i> over <i>B</i>}). We present two deterministic approaches to give algorithms: selection and distribution. The algorithms with these deterministic approaches differ from the lower bounds by at most an additive term of {<i>N</i> over <i>B</i>} loglog <i>M</i>. However, since loglog <i>M</i> is very small in real applications, the gap is tiny. Nevertheless, the ideas of our deterministic algorithms can be used to design cache-aware algorithms for these problems. The algorithms turn out to be simpler than the previously-known cache-aware algorithms for these problems. Another approach to design algorithms for these problems is the probabilistic approach. In contrast to the deterministic algorithms, our randomized cache-oblivious algorithms are all optimal and their cache complexities exactly match the lower bounds. All of our algorithms are within a constant factor of optimal in terms of the number of comparisons they perform.

This study aimed to explore a program development process and explain how each component of the process contributes to overall procedure for determining 1st, 2nd, and 3rd grade students&rsquo / multiple intelligences profiles. The action research was conducted through implementing the incremental components of development process namely / (1) needs assessment, (2) program design, (3) program implementation and verification, (4) summative evaluation. Purposeful sampling methods were used to select the participants of the study. On the basis of the purposeful sampling methods, the participants comprised of two elementary schools with their 1st, 2nd and 3rd grade students, teachers, parents / three branch teachers / instruments developers / experts from the fields of multiple intelligences, psychology, sociology, social pediatrics, neurology, psychiatry, and child neurology. The data collection methods were interview, observation, written document analysis, questionnaire. Descriptive and content qualitative analyses were used to analyze the data. For the validity and reliability purposes of the materials developed throughout the study, quantitative data and quantitative data analysis were conducted. The results of the needs assessment indicated that the 1st, 2nd and 3rd grade teachers had various purposes to determine their students&rsquo / multiple intelligences profile. They used various methods having both weaknesses and strengths. The most appropriate method was using multiple methods / sources. The program with its materials was developed in the program design phase. The materials were &ldquo / story inventory,&rdquo / &ldquo / film inventory,&rdquo / &ldquo / parent questionnaire,&rdquo / and &ldquo / performance assessment.&rdquo / The program including its materials had both weaknesses and strengths. Therefore, effective modifications were conducted on the program in the program implementation and verification phase. Finally, the results of the summative evaluation indicated that the study and the program reached their purposes largely.

Frequency modulated continuous wave (FM-CW) radar altimeters are used in civil and military applications. Proximity fuses, automatic cruise control systems of cars, radar altimeter of planes are examples to these applications. The goal of this thesis is to present a method for altitude determination using an FM-CW radar. For this purpose principles of radars and FM-CW systems are studied and related subjects are inspected. After this inspection, algorithms for altitude determination are evaluated. Consequently signal detection and processing methods are proposed to build an altitude determining algorithm. Also an analytical test environment for altitudes between 100 m and 4000 m is developed in computer as a result of researches. Test environment simulated the performance of altitude determining algorithm and FM-CW Radar Altimeter. The hardware is designed and implemented accordingly.

The objective of my diploma thesis was the focus of the locations near the village Božetice. The reconnaissance, adding PPBP, make out and surveying work run throught out around the watercourse Mlýnská stoka. Before focusing the area and the subsequent set up assistant points was conducted reconnaissance of the current point field, a stabilization of new assistant points for surveying mark out. For measuring and surveying method was used rayon, polygonal traverse and the method of GNSS. Elevation of points were determined tachymetry or GNSS. The mark out was used Topcon total station R 340 5616 and South GPS S-82 receiver. Location was focused in the coordinate system S-JTSK and vertical system Bpv.

Inaccuracy in landmark identification is regarded as the most important source of error in cephalometry. Better definition of landmarks should therefore contribute to better clinical decisions and research validity. This study primarily comprised of an ex vivo investigation on 50 extracted lower incisor teeth to determine whether radiopaque markers could be utilised to accurately assess lower incisor inclination. Fifty extracted lower incisor teeth were mounted onto a Perspex sheet. Radiopaque markers, manufactured from 1mm wide strips of lead film from used peri-apical radiographs, were attached to the crowns of the mounted teeth. A lateral cephalometric radiograph was taken in accordance to standard radiographic procedures (radiograph A). This showed the true inclination of the teeth. A second radiograph was taken with the roots obscured (radiograph B). Three observers traced the inclinations of the teeth on radiograph B (from incisor edge through the middle of the labio-lingual crown-root junction). The determination was done on two different occasions and the assessments compared with the true inclination. Comparative statistical analysis was applied to the readings and the results indicated that this method compared favourably with other methods to determine incisor inclination. In addition, clinical application of opaque markers to the teeth of patients demonstrated the following: it indicated exactly which tooth was being assessed, provided clear definition of the anatomical crown in the sagittal plane and served as a constant reference point for clinical, study model and cephalometric measurements. decisions and research validity. Opaque radiographic markers on teeth can contribute to more accurate cephalometric measurements in orthodontics, leading to better diagnoses, treatment planning and research validity. / Thesis (MChD (Orthodontics))--University of Pretoria, 2005. / Orthodontics / unrestricted

It is evident that, if industrial arts teachers have subscribed to a set of objectives to guide or give direction to their teaching program, they should be used. It is not sufficient to formulate the aims then lay them aside to collect dust. Rather these aims or objectives should be used effectively as a learning guide. Upon these objectives the teacher should build his whole program.

This thesis establishes priorities for recreation expenditures in Cache County, Utah. This is achieved by comparing the supply and demand of facilities for the most popular activities in order to determine \Vhere there are deficiencies. Once these priorities have been determined, the problem of where the facilities to meet these priorities should be located is discussed. Recommendations are made as to what needs to be done to specifically locate these facilities.

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The thesis provides a quantitative analysis of the Czech export with a further focus on the electrical engineering and on the electric motors and generators. The tool used for the analysis is the gravity model of the international trade, and the estimation method employed is the PPML estimator. The novelty of the research lies in a one country export analysis, and in a comparison of the export functions on three different aggregations and for two states (the Czech Republic and France). The panel data analysis of the period between 1995 and 2013 reveals that the Czech Republic was more export-driven than France, an unanticipated fact about a dissimilarity of the total and the machinery and transport equipment export functions of the Czech Republic, and a statistically nonsignificant influence of the euro on the Czech export. The one year analyses of 1995 and 2013 reveal an increasing importance of the distance and the partner's GDP on both countries' exports, and a nonimportance of the partner's EU membership and of the geographic location in the CEE on the Czech export. JEL Classification C13, C23, F10, F12, F14 Keywords determining factors of export, gravity models of trade, Czech Republic, electrical engineering Author's e-mail t.tachovska@seznam.cz Supervisor's e-mail benacekv@fsv.cuni.cz