The aim of the thesis is to describe the situation in transformation 110/22 kV in distribution area E.ON East. Next to describe the current practice in the replacement of 110/22 kV transformers and mention the possibilities of replacing the machines at the end of their lifecycle with respect to the development of the load of the individual transformer stations in the distribution area. An integral part of the thesis is also the economic evaluation of premature replacement of transformers from two different perspectives. The next point is to look at the current possibilities in the lifecycle lengthening of these devices and to suggest a method for monitoring the state of paper insulation to estimate the remaining lifetime of the transformer. The last point is the evaluation of the transition of a significant customer from a voltage level of 22 kV to a voltage level of 110 kV, including related technical and economic issues.

Speech is one of the basic forms of human communication and disruption of communication ability can negatively affect the life of man. deals with the elaboration of logopedic theory, which serves as a basis for the follow-up design and application creation in the field of speech therapy. The thesis is divided into five chapters. The first chapter deals with the history of speech therapy with an emphasis on domestic logopaedia, the logopedic intervention process in its entirety, and the differentiation of individual types of impaired communication skills. The second chapter focuses on a specific disruption of communication skills - dyslalia.The application for the treatment of dyslalia is determined by the application, which is elaborated in the third chapter. The fourth chapter contains a detailed description of the designed and created application, including an explanation of the processes running in the application when the application is being used. The last chapter of this diploma thesis contains a summary of the results of the practical testing of the application together with suggestions for improvement of the application.

High-resolution Thomson scattering system on the COMPASS tokamak provides electron temperature and density profiles in the central and edge plasma region. The spatial resolution in the edge plasma region is optimized for edge transport barrier studies. Formation of characteristic edge profiles (pedestals) is observed during high-confinement mode, i.e. the core electron temperature and density are raised up by the value of pedestal height. Both the electron and density pedestals are well-fitted by a modified hyperbolic tangent (mtanh) function, a five parameter model giving important parameters such as pedestal height and width, necessary for further analysis of the physics behind the transport barrier formation. A fitting technique of the full radial profiles of electron temperature, density and pressure during H-mode is also described. Using the fitting, electron temperature and density on top of pedestal are statistically processed to find a possible threshold for various H-mode regimes.

Title: Comparison of the results of aerobic exercise testing while kayak paddling whith crank ergometry of upper limbs. Aims: The aim of the study was to determine the relationship between the results of aerobic execise diagnostics of 6 elite kayakers (white water slalom) when paddling of flat water with crank ergometry of upper limbs. The results obtained when paddling on flat water were also compared with results obtained when paddling in the pool with counter (bachelor thesis). Based on the results we wanted to answer the question about the possible use specific forms of stress diagnosis (spiroergometry) in routine practice of training proces. Methods: We used standardized laboratory spiroergomtry stress test at crank ergometry of upper limbs and spiroergometry stress test when paddling on flat water of the same protocol. To obtain the functional values of physiological indicators in both test we used mobile spiroergometry equipment Cortex Metamax 3B and sporttester Polar. Feedback of probands were identified based on suervey with closed questions. Results: Testing kayakers reached when paddling on flat water the average functional values: heart rate (HR) 188,5 (±8,77) beats per minute, maximal oxygen uptake (VO2max.) 56 ml.kg.min-1 (±6.31); maximum ventilation (VMAX.) 127.31 l.min-1 (±15.16);...

Cystic fibrosis (CF) is genetically conditioned, autosomal recessive disease that occurs in the European population with a prevalence of about 1:2500 - 1:1800. In this disease we observe a mutation of the CTFR gene with subsequent fault in chloride channels. Such afflicted individuals usually suffer from chronic respiratory problems, pancreatic insufficiency, high concentration of chloride ions in sweat and obstructive azoospermia. Genetic testing of CFTR gene is indicated in individuals who meet the CF clinical picture and a positive sweat test (increased concentration of chlorides in the sweat). Genetic testing of the CFTR gene is usually done by using commercial kits detecting the most common mutations of the CFTR gene in the Czech Republic. If the testing results are negative, it is further performed an MLPA method that captures the larger deletions and duplications of gene, eventually a sequencing of all exons is. Despite the well-established algorithm of the testing, some patients suffering from symptoms of CF are left without genetic findings. Thanks to development of next generation sequencing, it is possible to make the diagnosis of CF more effective and uncover the variants that were not captured by previous methods.

This Master thesis focuses on the neuropsychological test called Rey-Osterrieth complex figure test and its diagnostic value in the clinical assesment of schizophrenic patients. Deficiency of cognitive functioning is a dominating feature in the clinical picture of schizophrenic patients. Attention is brought especially to the specific aspects of the ROCF performance in the clinical group of schizophrenic patients. Theoretical part is based on the realized investigative studies focused on the Rey-Osterrieth complex figure test and its value in cognitive assesment in psychodiagnostic praxis. The diagnostic method ROCF is presented in its complexity, the way of administration, assesment and interpretation are described and attention is also brought to the specific features of ROCF performance in healthy, neurological and psychiatric patients with focus on schizophrenic individuals. Empirical part of the thesis in the first section compares the ROCF performance of Czech healthy individuals and schizophrenic patients. The influence of demografic and other factors on the ROCF performance was analyzed and isolated elements of the figure and their difficultness was evaluated in both surveyed groups. Outcomes of this master thesis could contribute to the present knowledge of the diagnostic possibilities of...

This thesis focuses on the relationship between theory of mind and language skills in Czech preschoolers. The theoretical part summarizes current knowledge about theory of mind, its relationship to language skills, and some areas of development of preschool children. The empirical part describes the research of the relationship between theory of mind and language skills of Czech preschoolers. Fifty-five children in total participated in this research, twenty children in a younger group (m=42 months), and thirty-five children in an older group (m=54 months). Theory of mind has been assessed by two false-belief tasks: Sally-Ann Task, and Smarties task. Language skills were tested by Grammar reasoning test, and Understanding of grammar test from test battery of Seidlová-Málková and Smolík (2014). The older group has significantly better results in false-belief tasks then the younger group. Despite anticipated results, there was not statistically significant difference between the younger and the older groups' language skills. A moderate positive correlation was found between language skills and false-belief understanding in both groups. KEYWORDS Theory of Mind, False Belief Understanding, Language Skills, Preschoolers, Sally-Ann Task, Smarties Task

Supernumerary marker chromosomes (sSMCs) are a relatively rare cytogenetic phenomenon. Their laboratory examination is often difficult, and the clinical interpretation is even more challenging. The main reason is that most sSMC carriers have no clinical manifestations. The chromosome origin and exact range of the aberration are very important, as well as the fact that sSMCs are often found in mosaics that can strongly influence both the phenotype and the interpretation of result. Prenatal sSMC finding is one of the most challenging situations in both clinical and laboratory genetics. This work deals with the investigation process of sSMC carriers using molecular cytogenetic techniques, especially fluorescence in situ hybridization (FISH). We investigated a total of 67 families collected both prospectively and retrospectively, and we found 70 unique sSMCs in a total of 74 individuals. Six cases were familial and in three cases two sSMCs were found in one individual. According to the initial karyotype finding, the cases were divided into two groups, sSMCs supernumerary to a normal karyotype (group A) and sSMCT s supernumerary to the Turner karyotype (group B). The chromosomal origin was successfully determined in 88,6 % sSMCs. In group A the most common findings were sSMCs derived from chromosome 15,...

The diploma thesis summarizes professional theoretical findings describing the development and culture of organizations. This is the background for the theoretical framework, which focuses on presentation of the subject and on the tools used for diagnostics of an organizations. First, the thesis provides structured and clearly defined theoretical framework, which corresponds to a Diagnosis of Organizations taught at the Faculty of Humanities. The main goal of the thesis is to provide a feedback on the theoretical and practical education of this subject. For purposes of the thesis, the method of deep interview was selected, followed by analysis and presentation of selected data. The interviews were performed with six respondents, graduates of the Faculty of Humanities - master's degree program Management and Supervision in Social and Health Care Organizations. The final part of the thesis presents the results of the research. Keywords: tool Diagnosis of Organisations, organization, graduate, diagnostic, feedback, management, health and social management

This master thesis is dedicated to the importance of diagnostics of auditory memory in preschool children in means of determining school readiness. The theoretical part of this thesis contains an elaborate description of the somatic, cognitive and social development of preschool children. The second chapter concerns memory in general, categorizing auditory memory in the whole system and description of its individual modalities. It is also briefly mentioned how auditory memory is affected by the presence of specific language impairment in children. The third chapter describes school readiness. There are individual areas of focus described which affect school readiness, methods of diagnostics and how deficits in auditory memory are related to future poor reading and writing. The last chapter of the theoretical section summarizes diagnostic materials which asses auditory memory in preschool children and which are available in the Czech Republic as well as foreign countries. The research part of this thesis is mainly dedicated to the new Test of auditory memory in preschool children which was compiled with this thesis. The main goal of the research was to assess the level of auditory memory in preschool children with this new test and determine how specific language impairment, bilingual education and...