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The technique of transcranial Doppler ultrasound (TCD) was used to assess cerebral blood flow (CBF) in humans. Studies were performed at rest and during dynamic submaximal exercise. In the resting experiments, TCD was combined with the technique of dynamic end-tidal forcing to study the dynamics of the CBF response to step changes in end-tidal (i.e. arterial) PC02 and PO2 In the resting and exercise experiments, the degree of consistency was examined between three indices of CBF that can be extracted from the TCD spectrum. Finally, the ventilatory and the CBF responses to acute isocapnic hypoxia were examined to try to quantify the possible reduction in ventilation that could be attributed to changes in CBF with hypoxia. In the studies performed at rest, during either hypoxia and/or hypercapnia (Chapter 2), the three indices of CBF extracted from the TCD spectrum were all consistent. However, during submaximal exercise (Chapter 5), the indices were less consistent and results suggest that the increase in CBF with exercise that has been reported with TCD needs to be treated with caution. The dynamic studies of the CBF response to step changes in end-tidal PC02 and PO2 in humans revealed that the CBF response to hypercapnia (Chapter 3) is characterised by a significant asymmetry, with a slower on-transient than off-transient, and also by a degree of undershoot following the relief of hypercapnia. The CBF response to hypocapnia (Chapter 4) is also characterised by a significant asymmetry, with a faster on-transient than off-transient. Furthermore, there is a slow progressive adaptation throughout the hypocapnic period. These studies show that the CBF responses to hypercapnia and hypocapnia are much faster than previously been thought. Finally, the work described in Chapter 6 attempts to quantify the possible reduction in ventilation that could be attributed to changes in CBF with hypoxia to determine whether it could be of sufficient magnitude to underlie hypoxic ventilatory decline (HVD). The results suggest that, in awake humans, changes in CBF during acute isocapnic hypoxia are quantitatively insufficient to underlie HVD.

Approved for public release; distribution is unlimited / The use of the HF radar to measure and map surface currents has proliferated along the coastlines of many countries for purposes of Search and Rescue, Oil Spill Management, Oceanographic and Fishery Science studies. In the US Navy, these surface current maps are being evaluated for operational use in real-time data assimilating coastal circulation models, and direct monitoring tools in environmentally sensitive operating areas. The SeaSonde HF radar, a DF system, was considered in this study. It uses the MUSIC algorithm to recover bearings from the Doppler backscatter spectrum of the sea surface. By varying the radial and antenna patterns, the simulated backscatter spectra were passed through the SeaSonde software suite for radial pattern recovery. This unprecedented approach directly evaluated SeaSondeâ s MUSIC, and the associated uncertainties were examined against the simulated inputs of (1) fixed amplitude and phase deviations from the ideal antenna pattern, (2) measured antenna patterns and (3) decreasing SNR. It was found that using the measured antenna pattern to recover radials yielded least uncertainty, but a definitive prediction of MUSICâ s radial-recovery capability in relation to the patternâ s complex amplitude and phase structure remained illusive. The results highlighted the need to calibrate the militaryâ s DF-systems for accurate azimuth recovery. / Outstanding Thesis

Approved for public release, distribution unlimited / The flow around second-generation controlled diffusion blades in cascade at stall was examined experimentally through the use of a two-component laser-Doppler velocimeter (LDV). The experimental results were compared with computational fluid dynamics predictions in order to provide information that will allow for more exact design of advanced blades. Midspan blade surface pressure data were also collected over a range of Reynolds numbersbased on chord of 270,000 to 720,000. Pressure distribution plots verified that the blades were in the stalled condition. The LDV measurement surveys were taken at one inlet station, at three stations on the suction side of the blade, and at three stations in the wake.

Approved for public release; distribution is unlimited / The estimation of time delay and Doppler difference of a signal arriving at two physically separated sensors is investigated in this thesis. Usually, modified cross power spectrum coupled with Doppler compensation is used to detect a common, passive signal received at two separated sensors. Another successful approach uses the cross coherence to achieve this goal. This thesis modifies these two techniques to model the Doppler difference via an autoregressive (AR) technique. Analytical results are derived and experimentally verified via a computer simulation. Performance at high and low signal to noise ratios (SNRs) is examined. / http://archive.org/details/armodelingofcohe00leej / Captain, Korea Air Force

Introducción: La circular de cordón umbilical es frecuente en embarazos a término y constituye una de las mayores preocupaciones de las gestantes, siendo la ecografía el examen de diagnóstico principal. Por este motivo, el objetivo de este estudio es determinar la valoración de la ecografía Doppler Color frente a una ecografía en modo B para un mejor diagnóstico. Materiales y Métodos: Se realizó un estudio transversal en 88 gestantes a término del Hospital Daniel A. Carrión en los meses de Junio a Setiembre del 2010. Para determinar la valoración del diagnóstico por ecografía Doppler color y en modo B se utilizó la Ficha de Recolección de datos de ambas ecografías, siendo demostradas finalmente por la información recolectada de las Historias Clínicas post-parto. Resultados: La valoración del diagnóstico por ecografía Doppler color en la circular de cordón en embarazo a término presentó VPP del 100% (IC 95%, 98.39 al 1000), VPN del 100% (IC 95%, 99.12 al 100), sensibilidad del 100% (IC 95%, 98.39 a 100), especificidad 100% (IC 95%, 99.12 a 100). El índice de validez de la prueba fue del 100%. La valoración del diagnóstico por ecografía en modo B en la circular de cordón en embarazo a término presentó VPP del 100% (IC 95%, 96.88 al 100), VPN del 79.17% (IC 95%, 69.09 al 89.24), sensibilidad del 51.61% (IC 95%, 32.41 al 70.82), especificidad del 100% (IC 95%, 99.12 al 100). El índice de validez de la prueba fue del 82.95%. La prevalencia de la circular de cordón iagnosticados por ambas ecografías fue del 35.23%. Conclusión: La ecografía Doppler color es altamente sensible para detectar la presencia de circular de cordón, así lo confirma la historia clínica post parto. La capacidad que tiene la ecografía Doppler color de detectar falsos circular de cordón así como verdaderos circular de cordón es 100%. No existe diferencia significativa en la sensibilidad de cada tipo de ecografía (modo B y Doppler) cuando se relaciona la edad y la paridad con la presencia de circular de cordón.

Nous proposons une nouvelle méthode pour quantifier la vorticité intracardiaque (vortographie Doppler), basée sur l’imagerie Doppler conventionnelle. Afin de caractériser les vortex, nous utilisons un indice dénommé « Blood Vortex Signature (BVS) » (Signature Tourbillonnaire Sanguine) obtenu par l’application d’un filtre par noyau basé sur la covariance. La validation de l’indice BVS mesuré par vortographie Doppler a été réalisée à partir de champs Doppler issus de simulations et d’expériences in vitro. Des résultats préliminaires obtenus chez des sujets sains et des patients atteints de complications cardiaques sont également présentés dans ce mémoire. Des corrélations significatives ont été observées entre la vorticité estimée par vortographie Doppler et la méthode de référence (in silico: r2 = 0.98, in vitro: r2 = 0.86). Nos résultats suggèrent que la vortographie Doppler est une technique d’échographie cardiaque prometteuse pour quantifier les vortex intracardiaques. Cet outil d’évaluation pourrait être aisément appliqué en routine clinique pour détecter la présence d’une insuffisance ventriculaire et évaluer la fonction diastolique par échocardiographie Doppler. / We propose a new method for quantification of intra-cardiac vorticity (Doppler vortography) based on conventional Doppler images. To characterize the vortices, an index called “blood vortex signature” (BVS) was obtained using a specific covariance-based kernel filter. The reliability of BVS measured by Doppler vortography was assessed in mock Doppler fields issued from simulations and in vitro experimentations. Some preliminary results issued from healthy subjects and patients with heart disease were also presented in this research project. Strong correlations were obtained between the Doppler vortography-derived and ground-truth vorticities (in silico: r2 = 0.98, in vitro: r2 = 0.86, in vivo: p = 0.004). Our results demonstrated that Doppler vortography is a potentially promising echocardiographic tool for quantification of intra-ventricular vortex flow. This technique can be easily implemented for routine checks to recognize ventricular insufficiency and abnormal blood patterns at early stages of heart failure to decrease the morbidity of cardiac disease.

Powerful remote sensing techniques can covert time variability of polarization profiles of stellar spectral lines into vector magnetic fields maps of stellar surfaces. These techniques are widely applied to interpret observations but have been tested using only simplistic tests. It would be of interest to test magnetic inversion methods using polarization spectra simulated for realistic and physical models of stellar magnetic fields provided by recent 3D numerical simulations. Doppler Imaging is a method to reconstruct vector magnetic field maps of stellar surfaces from variation of polarization profiles. The work in this thesis presents numerical experiments to evaluate the performance of Magnetic Doppler Imaging (MDI) code INVERS10. The numerical experiments showed that in given high-resolution observations in four Stokes parameters, the code is capable of reconstructing magnetic field vector distributions, over the stellar surface, simultaneously and without any prior assumptions about the magnetic field geometry. Input data consists of polarization measurements in the line profiles and the reconstruction is performed by solving the regularized inverse problem. Right results were obtained by testing different type of models covering simple, complex and unusual complex magnetic field distribution. Whilst using incomplete Stokes parameter datasets containing only Stokes I and V profiles, the INVERS10 code was able to reconstruct a global stellar magnetic fields of only simple models and give accurate and reliable results. Testing the code with different inclination and azimuth angle successfully gave the lowest deviation when same values are used from the true map.