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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

A study of drug metabolism in isolated rat liver cells and in isolated rabbit kidney tubules

Melnick, Lester Roy, 1950- January 1976 (has links)
No description available.
2

The Influence of the CYP2C19 and CYP2D6 genetic polymorphisms on oxidative drug metabolism

Coller, Janet K. January 1999 (has links) (PDF)
Amendements: leaves 252-254. Copies of author's previously published articles inserted. Bibliography: leaves 226-251. The CYP2C19 and CYP2D6 genetic polymorphisms control the oxidative metabolism of many different drug classes. Populations are separated into groups of extensive metabolisers (EM), poor metabolisers (PM), and in the case of CYP2D6, ultra-rapid metabolisers (UM). In vitro studies using human liver microsomes were conducted to examine the kinetics of the oxidative metabolism of flunitrazepam, and which CYP450 enzymes mediate the oxidative metabolism of flunitrazepam, (S)-mephenytoin and proguanil.
3

Effect of immunosuppressive agents on drug metabolism in rats

Bai, Shuang 28 August 2008 (has links)
Not available / text
4

GLUCOSE METABOLISM AND TRANSFORMATION OF XENOBIOTICS IN ISOLATED RAT HEPATOCYTES

Hayes, James Scott, 1946- January 1976 (has links)
No description available.
5

Discrete sliding mode control of drug infusions

Godwin, Bryan 08 1900 (has links)
No description available.
6

Developmental and pathological changes in intestinal cytochrome P450 3A

Johnson, Trevor Nigel January 2001 (has links)
No description available.
7

The Influence of the CYP2C19 and CYP2D6 genetic polymorphisms on oxidative drug metabolism / Janet K. Coller.

Coller, Janet K. January 1999 (has links)
Amendements: leaves 252-254. / Copies of author's previously published articles inserted. / Bibliography: leaves 226-251. / vi, 254 leaves : ill. ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / The CYP2C19 and CYP2D6 genetic polymorphisms control the oxidative metabolism of many different drug classes. Populations are separated into groups of extensive metabolisers (EM), poor metabolisers (PM), and in the case of CYP2D6, ultra-rapid metabolisers (UM). In vitro studies using human liver microsomes were conducted to examine the kinetics of the oxidative metabolism of flunitrazepam, and which CYP450 enzymes mediate the oxidative metabolism of flunitrazepam, (S)-mephenytoin and proguanil. / Thesis (Ph.D.)--University of Adelaide, Dept. of Clinical and Experimental Pharmacology, 2000
8

Haloperidol metabolism in man and animals /

Wong, Belinda. January 1993 (has links)
Thesis (M. Phil.)--University of Hong Kong, 1994. / Includes bibliographical references (leaves 133-154).
9

The study of the metabolism of phenylbutazone (4-butyl-1,2 -diphenylpyrazolidine - 3,5 - dione) in rats

Alexander, Dorothy Mary 18 October 2013 (has links)
In this study the metabolism of the anti-arthritic drug, phenylbutazone, was investigated in female Wistar rats, and the results compared with those of other workers in this field. Two interrelated projects were undertaken. The first covered the pattern of excretion, isolation and characterisation of the metabolites and decomposition products of phenylbutazone in rats dosed post-orally with the drug. It was found that the major route of excretion was via the urine and over 50% of the administered dose was excreted in the first 24 hours by this route. A small percentage of the dose was excreted in the faeces. The following compounds were identified using chromatographic and autoradiographic techniques: p-Hydroxy derivative of phenylbutazone γ-Hydroxy derivative of phenylbutazone in both its molecular forms (ring lactone and straight chain hydroxyl) 4-Hydroxy derivative of phenylbutazone p-γ-Dihydroxy derivative of phenylbutazone p-4-Dihydroxy derivative of phenylbutazone Hydrolysable conjugates (possibly glucuronides) Water soluble non-hydrolysable conjugates. The second project dealt with the quantitation of the water insoluble compounds isolated in the initial work. Using a unique technique, combining inverse isotope dilution assay and spectrophotometric analysis, it was found that the major metabolite was the γ-hydroxy derivative of phenylbutazone, present in both its molecular forms. Oxyphenbutazone was a minor metabolite and the p-γ-dihydroxy derivative of phenylbutazone was present only in very low concentration. These results did not conform with those of previous workers in this field who reported the γ-hydroxy derivative of phenylbutazone, in one molecular form only, as the major metabolite and the dihydroxy derivative as the second metabolite with a higher concentration in the urine than oxyphenbutazone. This disparity could be due to the fact that these workers took no account of the presence of the two molecular forms of the γ-hydroxy derivative of phenylbutazone with their different polarities and different Rf values. The present study showed that the straight chain hydroxyl isomer was probably mistakenly identified as the p-γ-dihydroxy derivative of phenylbutazone. This theory is supported by the fact that the percentage dose recovered by the previous workers of the γ-hydroxy and p-γ-dihydroxy derivatives together equalled the percentage dose recovered in this study of the two molecular forms of the γ-hydroxy derivative. / KMBT_363 / Adobe Acrobat 9.54 Paper Capture Plug-in
10

The influence of partial hepatectomy on desmethyldiazepam formation and elimination after diazepam infusion in Chinese

Li, Nan, 李楠 January 2003 (has links)
published_or_final_version / Medicine / Doctoral / Doctor of Philosophy

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