Introdução / Objetivos: O prognóstico do adenocarcinoma ampular pode ser influenciado por fatores como estadiamento e variáveis histopatológicas, como o padrão intestinal ou pancreatobiliar. O diagnóstico do padrão histopatológico pode ser auxiliado pela expressão de citoqueratinas, CK, 7 e 20 e do gene homeobox CDX2. O objetivo do estudo foi analisar associações entre características histopatológicas e sobrevida, e entre padrão histopatológico e expressão de CK7, CK20 e CDX2. Método: Estudo de coorte retrospectivo desenvolvido no Hospital de Clínicas de Porto Alegre entre 2000 e 2011. Foram avaliados dados histopatológicos, estadiamento pTNM, padrão histopatológico e expressão imunoistoquímica e sobrevida. Resultados: A amostra constou de 65 carcinomas ampulares (n = 65). Foi observado padrão intestinal em 46, pancreatobiliar em 16 e outros em três. Sobrevida em cinco anos após duodenopancreatectomia (n = 47) foi de 27%. Associaram-se à menor sobrevida na análise univariada: dois ou mais linfonodos metastáticos, razão de linfonodos, RL, maior ou igual a 20%; estágio IIB em relação a inferiores; tumor de alto grau; invasão linfovascular. Na análise multivariada, metástase linfonodal e RL ≥ 20% influenciaram sobrevida. Conclusões: O pior prognóstico foi associado à metástase linfonodal. Não foi observada associação entre padrão histopatológico e expressão imunoistoquímica. / Background / Objectives: The prognosis of patients with ampullary adenocarcinomas can be influenced by such factors as pTNM stage and histopathological variables, such as intestinal or pancreatobiliary patterns. The characterization of these patterns can be facilitated by the expression of cytokeratins 7 (CK7) and 20 (CK20) and caudal-related homeobox gene 2 (CDX2). The aim of the present study was to analyze the association between the histopathological characteristics and the survival of patients with ampullary adenocarcinomas, as well as the association between the histopathological patterns and CK7, CK20 and CDX2 expression. Methods: This retrospective cohort study was performed at the Clinics Hospital of Porto Alegre between 2000 and 2011 and examined the histopathological data, pTNM stage, histopathological patterns, immunohistochemical expression patterns and survival of patients with ampullary adenocarcinomas. Results: The sample patient population consisted of 65 ampullary carcinomas. Of these carcinoma samples, an intestinal pattern was observed for 46, a pancreatobiliary pattern was observed for 16 and other patterns were observed 3 of the samples. The 5-year survival rate for patients following pancreaticoduodenectomy (n = 47) was 27%. From the univariate analysis, the following variables were associated with shorter survival times: the presence of 2 or more metastatic lymph nodes; positive lymph node ratio (LR) ≥ 20%; stage IIB or greater; high-grade tumors; and lymphovascular invasion. From the multivariate analysis, lymph node metastases and a LR ≥ 20% were shown to influence survival significantly. Conclusions: Lymph node metastases were associated with poor patient prognoses, although no association was found between the histopathological pattern and immunohistochemical expression.

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O controle de emissões em veículos pesados está em foco desde a década de 90, com a criação de regulamentações nacionais e internacionais que impõe limites cada vez mais rígidos para as concentrações de poluentes emitidos por estes veículos. O desenvolvimento de novas tecnologias possui papel fundamental neste processo, buscando redução nos níveis de emissões com mínimo impacto negativo no desempenho e no consumo do veículo. Para tanto, o presente trabalho visa avaliar a influência da posição dos dutos de admissão de ar de cabeçotes de motores a combustão interna, especificamente em motores de ignição por compressão (MIC) de 4 válvulas, no escoamento de ar dentro do cilindro. O escoamento do ar e o movimento de swirl são fatores importantes para a mistura e distribuição do combustível injetado, e quando otimizados para uma queima melhor distribuída, contribuem para redução nos níveis de emissões. Procura-se investigar quais direções características dos dutos são determinantes para o escoamento e para o comportamento de swirl do motor através de simulações em fluidodinâmica computacional (Computational Fluid Dynamics - CFD) utilizando o programa CD-adapco STAR-CCM+®. Os resultados de alguns dos cenários simulados são comparados a resultados de testes experimentais realizados em bancada de medição de swirl, no âmbito de outro trabalho sendo desenvolvido no mesmo grupo de projeto. / The emissions control in heavy-duty vehicles has been in focus since the 1990\'s, with the creation of national and international regulations which impose strict limits for pollutant concentrations released by these vehicles. The development of new technologies has a fundamental role in this process, aiming the reduction of emission levels with minimum impact on the performance and fuel consumption of the vehicle. Therefore, the present study aims to evaluate the influence of the position of intake ports in cylinder heads from internal combustion engines, specifically 4-valves compression-ignition (CI) engines, in the in-cylinder air flow. The air flow and swirl motion are important factors for the mixture and distribution of injected fuel, and when optimized for a better distributed combustion, contribute for the reduction of emission levels. This study investigates the characteristic directions of ports which are determinant for the air flow and swirl behaviour of the engine through Computational Fluid Dynamics (CFD) simulations using CD-adapco software STAR-CCM+®. The results from a group of simulated cases are compared to experimental test results from another project, developed on the same project group, performed in a swirl meter test rig.

Introdução: O acesso biliar ecoguiado é um método de drenagem alternativo à drenagem percutânea transhepática (DPTH) e à cirurgia em pacientes com obstrução biliar distal incurável que falharam drenagem por Colangiopancreatografia Endoscópica Retrógrada (CPRE). Nos casos em que a drenagem ecoguiada anterógrada transpapilar (ou transanastomótica) e o rendez-vous ecoguiado não podem ser realizados como primeira opção, a coledocoduodenostomia (CDT) e a hepaticogastrostomia (HPG) ainda podem ser realizadas em pacientes selecionados. Estas duas vias de drenagem não anatômicas criam uma fístula entra a via biliar e o estômago ou duodeno. Não há dados na literatura que determinem superioridade de uma ou outra técnica. Objetivo: Comparar o sucesso técnico, sucesso clínico e fatores associados entre as duas vias de drenagem em pacientes com obstrução da via biliar distal maligna incurável que não lograram sucesso na drenagem por CPRE ou rendez-vous ecoguiado. Métodos: Entre abril de 2010 e dezembro de 2013, 49 pacientes com obstrução biliar distal maligna incurável que falharam CPRE e rendez-vous ecoguiado foram randomizados para CDT ou HPG. Dados referentes ao sucesso técnico, sucesso clínico, tempo de procedimento, complicações, qualidade de vida e sobrevida foram coletados até três meses após o procedimento. Todos os procedimentos foram realizados em um centro terciário de endoscopia pelo mesmo endoscopista. Próteses biliares parcialmente recobertas (Boston Scientific, Wallflex, 10 mm, 8 cm ou 6 cm) foram utilizadas em todos os pacientes com sucesso técnico. Nos casos de HPG a punção ecoguiada foi intra-hepática no ducto hepático esquerdo. Nos casos de CDT a punção foi extra-hepática no segmento distal não obstruído do colédoco. Após a punção foi realizada colangiografia com introdução de um fio guia hidrofílico de 0,035 polegada. Dilatação com cateter e um dispositivo de needle knife foi realizada para permitir introdução do sistema de disparo da prótese biliar com 8,5 Fr. Resultados: Quarenta e nove procedimentos foram realizados (25 HPG e 24 CDT). Todos os pacientes tinham dilatação da via biliar intra e extra-hepática. A taxa de sucesso técnico foi de 96 % para HPG e de 91% para CDT (p = 0,609). A taxa de sucesso clínico foi de 91% para o grupo HPG e de 77% para o grupo CDT (p = 0,234). No grupo da HPG 5 pacientes (20%) tiveram complicações (3 sangramentos, 2 biliomas e uma bacteremia). No grupo da CDT 3 pacientes (12,5%) tiveram complicações (1 bilioma, 1 sangramento e 1 perfuração). Somente o caso da perfuração necessitou tratamento cirúrgico. As outras complicações foram tratadas clinicamente. O tempo de procedimento médio foi de 47,83 min para a HPG e de 48,88 min para a CDT (p = 0,843). Conclusão: O presente estudo não demonstrou diferença estatisticamente significante em relação ao sucesso técnico, sucesso clínico, complicações e tempo de procedimento entre os dois grupos estudados. Mais estudos são necessários para elucidar o papel de cada via de drenagem / Background: EUS-guided biliary access is an alternative for percutaneous access or surgery in patients with malignant unresectable distal biliary obstruction and failed ERCP. When rendezvous or anterograde transpapillary/transanastomotic intervention fails as primary drainage options, a Choledochoduodenostomy (CDT) or a Hepaticogastrostomy (HGT) can still be performed in selected patients. This procedure creates a new \" \" y I w one route or the other should be recommended. Aim: To compare technical and clinical success and possible associated factors between the two different drainage routes CDT and HGT in patients with distal unresectable malignant biliary obstruction that failed standard ERCP and EUS-guided rendez vouz (RV) maneuver. Methods: Between April/2010 and December/2013 49 consecutive jaundiced patients with distal unresectable malignant biliary obstruction that failed previous ERCP and EUS-guided RV maneuver were elected randomly to undergo either EUS-guided CDT or HGT. Data including indications, clinical and technical success, procedural times and complications with a three-month follow-up were prospectively collected in a database. All procedures were performed in a tertiary center by the same endoscopist. A partially covered SEMS (Boston Scientific, Wallflex, 10 mm, 8 cm or 6 cm) was used in all technically successful procedures. After puncture of left hepatic duct in case of HGT or the distal unobstructed segment of common bile duct in case of CDT a cholangiogram was obtained followed by advancement of a 0,035-inch guide wire into the biliary system. Bougies and wire-guided needle-knife were used to perform track dilation to allow passage of an 8.5 Fr stent delivery system. Results: Forty-nine cases (25 HGT and 24 CDT) were performed. All patients had intra and extra hepatic biliary dilation. Technical success rate was 96 % for HGT and 91% for CDT (p = 0.609). Clinical success rate was 91% for HPG and 77% for CDT (p = 0.234). In the HGT group five patients (20%) had complications (3 bleeding, 2 bilomas and 1 bacteremia). In the CDT group 3 patients (12.5%) had complications (1 biloma, 1 bleeding and 1 perforation). Only the perforation patient required surgery. All other complications were managed clinically. The median procedural time was 47.83 min for HGT and 48.88 min for CDT (p = 0.843). Conclusion: No significant difference was found in regards to technical or clinical success, complications and procedure time between the two drainage routes. More studies are needed to clarify situations in which the CDT or the HGT should be advocated

Les travaux présentés dans cette thèse contribuent au développement du contrôle non destructif des conduits de précontrainte extérieure dans les ouvrages d'art. Une sonde capacitive a été développée pour ausculter ces conduits. L'objectif est d'en améliorer le diagnostic.Dans un premier temps, une cellule de mesure en transmission coaxiale a été développée pour caractériser les matériaux présents dans le conduit sur la bande de fréquence 50 MHz - 1 GHz. Le ciment, les produits de la ségrégation du ciment et la cire d'injection ont été étudiés.La deuxième partie du travail exploite ces résultats dans une modélisation directe du problème global. Une étude paramétrique nous a permis de proposer une méthode d'estimation de l'épaisseur de vide à l'intérieur du conduit à partir des signaux délivrés par la sonde, qui a pu être validée sur une maquette de conduit. A partir de ces résultats sont proposées plusieurs améliorations du dispositif visant à l'obtention de signaux plus riches issus des capteurs, afin de pouvoir estimer un plus grand nombre de paramètres. / The work presented in this report contributes to the development of Non Destructive Evaluation of the external post-tensioned ducts in bridges. A capacitive probe has been developed for bridge monitoring applications. The aim of this work is to improve its diagnostic.In a first step, a coaxial transmission line was developed to characterize the materials involved in the duct over the frequency range 50 MHz - 1 GHz. The cement grout, segregation products of the cement grout and the injection wax were studied.In the second part of this work the previous results are used in the modelling of the devices. A parametrical study has shown the ability to get from the signals an estimate of the thickness of the void in the duct. This estimation method has been validated using a laboratory duct. Further, several improvements of the probes are proposed to get signals containing more information in order to get a better estimation of the target parameters.

No description available.

Diploma thesis is focused on the design and dimensioning of the central air-condition system of the offices in two-story building. The thesis consists of a theoretical part which deals with air- condition systems, and computation and design part. The computation part is comprised of calculation of quantity of ventilation air, calculation of heat losses and heat gains and psychrometric evaluation of operation during summer and winter. Design part consists of design and dimensioning of air-distriutions and air ducts and consist of design of air-conditioner and machine room. There are specification of materials and drawing documentation in the end of thesis.

The main aim of this thesis is to explore fouling of air ducts and its influence on energy consumption of HVAC systems. The first part focuses on typical parts that create the IAQ in buildings and on evaluating energy consumption of air transportation. The following section deals with the theories of fluid flow, flow regimes and pressure losses that are created as a side effect. The thesis outlines possible methods of assessing the impact of pollution with an emphasis on pressure losses and their influence on the fan power consumption. The actual experimental measurement, conducted in a selected industrial plant, is focused on an influence of cleanness of textile diffuser on HVAC device power consumption. For the further research of this process, measuring equipment with suitable measurement method is designed and constructed.

The aim of this diploma thesis is to design the air conditioning system for one floor of the offices. The thesis is divided into theoretical, computational and design part. The computational part consists in determining the amount of ventilation air, calculation of heat losses, heat gains and psychrometric calculations for summer and winter season. Based on the calculated values, air ducts, end-points and air-conditioning units are designed. The diploma thesis is supplemented with a list of materials and drawing documentation.

The modern gas turbine engine industry needs a simpler and faster method to facilitate the design of gas turbine combustors due to the enormous costs of experimental test rigging and detailed computational fluid dynamics (CFD) simulations. Therefore, in the initial design phase, a couple of preliminary designs are conducted to establish initial values for combustor performance and geometric characteristics. In these preliminary designs, various one-dimensional models using analytical and empirical formulations may be used. One of the disadvantages of existing models is that they are typically geometric dependant, i.e. they apply only to the geometry they are derived for. Therefore the need for a more versatile design tool exists. In this work, which constitutes the first step in the development of such a versatile design tool, a single equation-set network simulation model to describe both steady state compressible and incompressible isothermal flow is developed. The continuity and momentum equations are solved through a hybrid type network model analogy which makes use of the SIMPLE pressure correction methodology. The code has the capability to efficiently compute flow through elements where the loss factor K is highly flow dependant and accurately describes variable area duct flow in the case of incompressible flow. The latter includes ducts with discontinuously varying flow sectional areas. Proper treatment of flow related non-linearities, such as flow friction, is facilitated in a natural manner in the proposed methodology. The proposed network method is implemented into a Windows based simulation package with a user interface. The ability of the proposed method to accurately model both compressible and incompressible flow is demonstrated through the analyses of a number of benchmark problems. It will be shown that the proposed methodology yields similar or improved results as compared to other’s work. The proposed method is applied to a research combustor to solve for isothermal flows and flow splits. The predicted flows were in relatively close agreement with measured data as well as detailed CFD analysis. / Dissertation (MEng (Mechanical Engineering))--University of Pretoria, 2005. / Mechanical and Aeronautical Engineering / unrestricted