541 |
Oxygen tension in the fetus continuous measurement of fetal subcutaneous Po2 with a needle-electrode : an experimental and clinical investigation /Aarnoudse, Jan Gerard. January 1980 (has links)
Thesis (doctoral)--Rijksuniversiteit te Groningen.
|
542 |
Praenatal bestemmelse af lungematuriteten og forebyggelse af idiopatisk respiratory distress syndrom lecithin-sphingomyelin ratio i amnionvaesken /Verder, Henrik. January 1980 (has links)
Thesis (doctoral)--Københavns Universitet.
|
543 |
Characterisation of effector and regulatory T-cell responses to blood group antigensStephen, Jillian. January 2008 (has links)
Thesis (Ph.D.)--Aberdeen University, 2008. / Title from web page (viewed on Feb. 26, 2009). Includes bibliographical references.
|
544 |
Milking the umbilical cord at term cesarean section : effect on hemoglobin levels in the first 48 hours of life /Erickson-Owens, Debra A. January 2009 (has links)
Thesis (Ph.D.) -- University of Rhode Island, 2009. / Typescript. Includes bibliographical references (leaves 157-166).
|
545 |
The molecular mechanisms underlying 6-hydroxydopamine and ethanol-induced neurotoxicityChen, Gang, January 2005 (has links)
Thesis (Ph. D.)--West Virginia University, 2005. / Title from document title page. Document formatted into pages; contains vi, 124 p. : ill. Vita. Includes abstract. Includes bibliographical references.
|
546 |
Children exposed to cocaine a look at their home environments and maternal-child interactions /Stuber, Lynda J. January 1993 (has links)
Thesis (M.S.)--University of Wisconsin-Madison, 1993. / Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 42-47).
|
547 |
An examination of the human fibrinogen-like protein2 sequence variations and genetic expression by human endothelial cells /Jenkins, Meredith E. January 2005 (has links)
Thesis (M.S.)--Georgia State University, 2005. / Title from title screen. Roberta Attanasio, committee chair; P.C. Tai, W.C. Hooper, committee members. Electronic text (57 p. : col. ill.) : digital, PDF file. Description based on contents viewed Aug. 15, 2007. Includes bibliographical references (p. 55-57).
|
548 |
Development of nanocarriers for targeted drug delivery to the placentaCureton, Natalie January 2017 (has links)
Pregnancy complications such as fetal growth restriction (FGR) are often attributed to poor uteroplacental blood flow, but the risk of systemic side-effects hinders therapeutic intervention. We have utilised novel placental-specific homing peptides to overcome this and have conjugated these to biocompatible liposomes. Peptide-conjugated liposomes were found to selectively bind to the outer syncytiotrophoblast layer of the human placenta and to the uteroplacental vasculature and labyrinth region of the mouse placenta. The novel vasodilator SE175 was selected as a nitric oxide donor with a favourable stability and release profile, to encapsulate in peptide-conjugated liposomes in an attempt to restore impaired uteroplacental blood flow in a mouse model of FGR, the endothelial nitric oxide synthase knockout mouse. Liposomes containing SE175 or PBS were prepared by lipid film hydration and targeting peptides coupled to the liposomal surface. Vehicle control, free SE175, PBS- or SE175-containing liposomes were intravenously injected on embryonic (E) days 11.5, 13.5, 15.5 and 17.5. Animals were sacrificed at E18.5 and fetal and placental weights recorded. Targeted delivery of SE175 significantly increased fetal weight compared to vehicle control but no other treatment groups, whilst significantly decreasing placental weight, indicating improved placental efficiency. Treatment was well tolerated, having no impact on litter size or resorptions. Targeted delivery of SE175, but no other treatment group, reduced a marker of lipid peroxidation in the placenta, indicating a reduction in oxidative stress. These data suggest that selective delivery of SE175 to the uteroplacental vasculature in peptide decorated liposomes may represent a novel treatment for FGR.
|
549 |
Efeitos agudos do fumo sobre a dinâmica cardiocirculatória da unidade feto-materno-placentáriaMüller, Janine Santos January 2000 (has links)
O fumo é a droga mais comumente usada na gestação, e suas conseqüências podem se manifestar por associação com prematuridade, retardo de crescimento fetal e baixo peso do recém-nascido, entre outras complicações. O tabaco possut vários metabólitos, sendo a nicotina e o monóxido de carbono os mais estudados. A nicotina atinge o feto através da placenta e concentrase no sangue fetal, no líquido amniótico e no leite materno. O uso do tabaco pela mãe causa aumento de substâncias vasoconstritoras e diminuição de substâncias vasodilatadoras no cordão umbilical, o que pode estar relacionado com as alterações perfusionais encontradas na unidade feto-matemo-placentária de gestantes tabagistas, e que podem estar associadas às alterações crônicas causadas pelo fumo.O objetivo deste trabalho foi pesquisar as alterações hemodinâmicas agudas na circulação da unidade feto-matemo-placentária imediatamente após o ato de a mãe fumar um cigarro padronizado, contendo O,Smg de nicotina e 6mg de monóxido de carbono. A população estudada foi constituída de gestantes normais, sem fatores de risco para doenças cardíacas fetais, porém fumantes crônicas. A amostra constou de 21 gestantes, que foram submetidas a uma ultrasonografia obstétrica e à ecocardiografia fetal antes e depois da exposição da mãe ao fumo. Foram verificadas a freqüência cardíaca e a pressão arterial maternas, a freqüência cardíaca fetal e a avaliação da resistência vascular medida pela relação S/D nos vasos uterinos e fetais. Foi avaliada a função sistólica e diastólica do coração fetal, através da fração de ejeção do ventrículo esquerdo e do índice de redundância do septum primum, respectivamente. Os resultados foram analisados pelo teste de Wilcoxon para dados não paramétricas. A média de idade das pacientes foi de 22,95 anos e a idade gestacional variou de 18 a 36 semanas. A média de cigarros fumados por dia era de 9,67. Os resultados comparados antes e depois da exposição da mãe ao fumo mostraram um aumento da pressão sistólica materna (p=0,004), da pressão diastólica materna (p=0,033), da freqüência cardíaca materna (p<O,OOI) e da freqüência cardíaca fetal (p=0,044). Ocorreu diminuição da relação S/D na artéria uterina esquerda (p=0,039) e na artéria uterina direita (p=0,014), imediatamente após o ato de fumar. A relação S/D na artéria cerebral média fetal não se alterou (p=0,078). O mesmo ocorreu com o fluxo sistólico no ductus arteriosus (p=O,l54) e na artéria pulmonar (p=0,958). Não houve alteração significativa na relação S/D na artéria umbilical (p=0,554). Também não ocorreram modificações na fração de ejeção do ventrículo esquerdo (p=0,943) e no índice de redundância do septum primum (p=0,836). A exposição da mãe ao fumo altera variáveis fisiológicas maternas e fetais, sem repercussão na função cardíaca fetal. A diminuição da resistência vascular uterina observada provavelmente esteja relacionada a um padrão dose-dependente da nicotina ou de seus componentes presentes no cigarro utilizado nesta pesquisa.
|
550 |
Extracellular RNAs as potential biomarkers for placental dysfunctionLeonardo, Trevor Robert Thomas 22 January 2016 (has links)
Placental dysfunction affects approximately 1 in 10 pregnant women in both the developed and developing worlds. Most commonly, it is manifested as preeclampsia or fetal growth restriction. Over the past two decades, an increasing body of research into the developmental biology of the placenta has been amassed, which points to defects in the differentiation of the trophoblast cell lineage as a key player in the pathophysiology of placental dysfunction. A number of clinical parameters are known to be associated with an elevated risk of placental dysfunction. These include maternal risk factors (such as chronic hypertension, renal disease, and lupus), history of placental dysfunction in a prior pregnancy, abnormalities in the levels of certain proteins in the maternal blood that are commonly used to estimate the risk of fetal genetic defects, and abnormalities in uterine artery Doppler waveforms. These current methods have significant drawbacks, including low specificity and sensitivity, high cost, lack of widespread availability, and lack of validity early in pregnancy. In order to provide a more cost-effective and reliable method to detect an elevated risk for placental dysfunction early in pregnancy, we explored the potential for extracellular RNAs (exRNA) in the maternal serum to be used as biomarkers. In our study, we used next generation sequencing technologies to compare extracellular microRNA (miRNA) levels in serum samples of pregnant women of different gestational ages, nonpregnant women, and placental tissue samples. We discovered that the large majority of microRNAs that were present at higher levels in pregnant serum samples than nonpregnant serum samples and were likely of placental origin. We also found that these pregnancy-specific miRNAs were enriched for miRNAs encoded on chromosomes (Chr) 14 and 19, with changes in the relative expression of these two groups of miRNAs throughout pregnancy. Moreover, the miRNA signatures of late gestational pregnant samples correlated more closely with placental tissue samples than those of early pregnant samples, which could be related to the increasing impact of a larger placenta on the maternal serum exRNA profile. Our results demonstrate the potential utility of next generation sequencing technologies in regards to differentiating between different conditions using clinical samples.
|
Page generated in 2.5716 seconds