The conventional power factor correction circuit has a fixed output voltage. However, in some applications, a PFC circuit with a wide output voltage range is needed. A single phase power factor correction circuit with wide output voltage range is developed in this work. After a comparison of two main power stage candidates (Buck+Boost and Sepic) in terms of efficiency, complexity, cost and device rating, the buck+boost converter is employed as the variable output PFC power stage. From the loss analysis, this topology has a high efficiency from light load to heavy load. The control system of the variable output PFC circuit is analyzed and designed. Charge average current sensing scheme has been adopted to sense the input current. The problem of high input harmonic currents at low output voltage is discussed. It is found that the current loop gain and cross over frequency will change greatly when the output voltage changes. To solve this problem, an automatic gain control scheme is proposed and a detailed circuit is designed and added to the current loop. A modified input current sensing scheme is presented to overcome the problem of an insufficient phase margin of the PFC circuit near the maximum output voltage. The charge average current sensing circuit will be bypassed automatically by a logical circuit when the output voltage is higher than the peak line voltage. Instead, a resistor is used to sense the input current at that condition. Therefore, the phase delay caused by the charge average current sensing circuit is avoided. The design and analysis are based on a novel air conditioner motor system application. Some detailed design issues are discussed. The experimental results show that the variable output PFC circuit has good performance in the wide output voltage range, under both the Boost mode when the output voltage is high and the Buck+Boost mode when the output voltage is low. / Master of Science

Presently, the industry accepted method for determining the positive moment strength of gravity loaded standing seam metal roof systems is the "Base Test Method". The Base Test Method provides a means for determining the positive moment strength of a multiple span, multiple purlin line standing seam roof system using the results from a set of six single span, simply supported, two-purlin line experimental tests. A set of six base tests must be conducted for each combination of purlin profile, deck panel profile, clip type, and intermediate bracing configuration. The primary objective of this study is to investigate the possibility of eliminating some of the roof system parameters specifically, clip type, purlin flange width, and roof panel thickness. This study used the results from nine series of tests. Each series consists of 11 to 14 gravity loaded base tests. The first three series were used to examine the effects of clip type on the strength of standing seam roof system. The final six series was used to examine the effects of flange width and roof panel thickness. All nine series were constructed using Z-purlin sections with flanges facing the same direction (like orientation). Based on the results of this study, clip type, purlin flange width, and roof panel thickness all have an effect on the strength of standing seam roof systems. Although none of the roof components can be completely eliminated from the required test matrix, by using trend relationships an acceptable test protocol was developed that results in a significant reduction in the number of required base tests. / Master of Science

Improving the quality factor of the mechanical oscillations of micron scale beams in a viscous fluid, such as water, is an open challenge of direct relevance to the development of future technologies. We study the stochastic dynamics of doubly-clamped micron scale beams in a viscous fluid driven by Brownian motion. We use a thermodynamic approach to compute the equilibrium fluctuations in beam displacement that requires only deterministic calculations. From calculations of the autocorrelations and noise spectra we quantify the beam dynamics by the quality factor and resonant frequency of the fundamental flexural mode over a range of experimentally accessible geometries. We carefully study the effects of the grid resolution, domain size, linear response, and time-step for the numerical simulations. We consider beams with uniform rectangular cross-section and explore the increased quality factor and resonant frequency as a baseline geometry is varied by increasing the width, increasing the thickness, and decreasing the length. The quality factor is nearly doubled by tripling either the width or the height of the beam. Much larger improvements are found by decreasing the beam length, however this is limited by the appearance of additional modes of dissipation. Overall, the stochastic dynamics of the wider and thicker beams are well predicted by a two-dimensional approximate theory beyond what may be expected based upon the underlying assumptions, whereas the shorter beams require a more detailed analysis. / Master of Science

The ASTM C457 test has long been a standard used to obtain the air void parameters of concrete materials. These air void parameters provide valuable information that has been linked to the performance of concrete under conditions such as freezing and thawing cycles. The standard test procedure involves linearly traversing a cut and polished section of a concrete specimen while a technician observes it under a microscope. Chord lengths of material constituents that the technician observes along the linear traverse are recorded and later used to calculate air void parameters statistically. This procedure is long and tedious, which makes it susceptible to human error due to operator fatigue. This study proposes and implements a new test method for evaluating concrete air void parameters using an image analysis method. A polishing procedure along with a differential interference contrast microscope are used to obtain high contrast images of material constituents, which provide raw data for the image analysis method. Because of the high contrast that can be obtained, cement paste, air voids in the cement paste, and aggregate materials in the concrete can be distinguished from one another based on these images. An image analysis program has been written for this study which linearly traverses these images and records the chord lengths of material constituents in a similar way to the standard ASTM C457 test. The chord length data must be processed further, however, because features in the images can be truncated by the edge of the image. Correction calculations for this problem are implemented in the image analysis algorithm. Two specimens which have been previously tested using the standard ASTM C457 method by the Virginia Transportation Research Council, (VTRC), are used in this study. The air void parameters obtained using the new test are compared directly with the results obtained by VTRC for the two specimens. Statistical comparisons indicate that the results of the new test are indeed significant, showing the potential it has for practical implementation. There are drawbacks to the test including a long polishing procedure, but this process can be automated. The new test appears to have excellent potential for practical application, but it should be emphasized that the test has only been implemented using materials in two concrete specimens. Further study on a variety of other concrete materials would be required for implementation in a standard procedure. / Master of Science

Factor VIII is a protein which has therapeutic applications for the treatment of Hemophilia A. Its deficiency, either qualitative or quantitative, results in Hemophilia A, a disorder affecting approximately 1 in 10,000 males. Currently, FVIII replacement therapy uses FVIII derived from plasma or cell culture. The current cost of this therapy is in excess of $150,000 per patient per year. Thus, alternative sources that are more economical are attractive. The present work focuses upon the characterization of recombinant FVIII (rFVIII) made in the milk of transgenic pigs. Two dimensional western analysis of rFVIII obtained from pig whey showed a range of FVIII species having different isoelectric points (pI) consistent with diverse glycosylation patterns. The pI of these diverse FVIII populations were accurately predicted using theoretical calculations based upon primary protein structure as variable biantennary glycosylation patterns having 0, 1, or 2 sialic acid groups present. Kinetic limitations in the adsorption of rFVIII to anion exchange media due to the nature of the complex milk environment were observed. rFVIII was purified quantitatively using batch equilibration of whey with DEAE Sepharose. This material showed proteolytic processing that was very similar to FVIII obtained from human plasma. Based upon these results, it was postulated that a dissociation of the light (A3C1C2) and heavy (A1A2B) chain due to a lack of vWF may be responsible for the low FVIII activity. / Master of Science

An investigation into the influence of cracks in bonded specimens is conducted. Photoelastic specimens containing a bondline are subjected to a constant displacement boundary condition created by bonded end grips. Specimens containing various crack orientations are analyzed to determine stress intensity factors at the induced crack tips. Specimens containing interface and sub-interface cracks were investigated. Two global geometries were used in this investigation, square and rectangular. The constant displacement boundary condition was induced on the specimen through dead weights hung from bonded aluminum end grips. Stress intensity factors were determined using photoelastic techniques. The stress intensity factors were examined to determine trends in the results as a function of changes in geometry. The effects of the induced boundary condition, the specimen geometry, and the bondline were investigated. The results from this investigation were compared to known solutions with a similar specimen geometry. These tests exhibited influences from the bondline, the boundary conditions, and the specimen geometry. The bondline tended to decrease the stress intensity factor for specimens with small crack lengths and tended to increase the stress intensity factor for specimens containing long crack lengths. As the crack length increased so too did the stress intensity factor. A reduction in the bondline to crack distance with sub-interface crack specimens caused a reduction in the stress intensity factor. A reduction in the global height of the specimen caused a reduction in the stress intensity factor also. The results from this investigation will aid in the understanding of the influence of interface and sub-interface cracks in bonded specimens. / Master of Science

Yes / A detailed steady state FCC riser process model is simulated for the first time with different compressibility (Z) factor correlations using gPROMS software. A 4-lump kinetic model is used where gas oil cracks to form gasoline, coke and gases. The usual practice has been the assumption that the FCC riser gas phase is an ideal gas at every point under any condition (varying C/O ratio, riser diameter, operating temperature and pressure, etc.). This work found that the Z factor varies at every point across the riser height depending on riser operating pressure and temperature, diameter and C/O ratio. It also shows that the magnitude of deviation of a gas phase from ideal gas behaviour can be measured over the riser height. The Z factor correlation of Heidaryan et al. (2010a) is found to be suitable for predicting the Z factor distribution in the riser. / Petroleum Technology Development Fund, Nigeria

As wireless communication systems continue to push the limits of energy and spectral efficiency, increased demands are placed on the capabilities of the receiver. At the same time, the computational resources available for processing received signals will continue to grow. This opens the door for iterative algorithms to play an increasing role in the next generation of communication receivers. In the context of receivers, the goal of iterative probabilistic processing is to approximate maximum a posteriori (MAP) symbol-by-symbol detection of the information bits and estimation of the unknown channel or signal parameters. The sum-product algorithm is capable of efficiently approximating the marginal posterior probabilities desired for MAP detection and provides a unifying framework for the development of iterative receiver algorithms. However, in some applications the sum-product algorithm is computationally infeasible. Specifically, this is the case when both continuous and discrete parameters are present within the model. Also, the complexity of the sum-product algorithm is exponential in the number of variables connected to a particular factor node and can be prohibitive in multi-user and multi-antenna applications. In this dissertation we identify three key problems which can benefit from iterative probabilistic processing, but for which the sum-product algorithm is too complex. They are (1) joint synchronization and detection in multipath channels with emphasis on frame timing, (2) detection in co-channel interference and non-Gaussian noise, and (3) joint channel estimation and multi-signal detection. This dissertation presents the advances we have made in iterative probabilistic processing in order to tackle these problems. The motivation behind the work is to (a) compromise as little as possible on the performance that is achieved while limiting the computational complexity and (b) maintain good theoretical justification to the algorithms that are developed. / Ph. D.

The actuator power factor is defined as the ratio of the total dissipative mechanical power of a PZT actuator to the total supplied electrical power to the PZT actuator. If measured experimentally, it can be used to optimize the actuator location and configuration for complex structures. The concept of actuator power factor is based on the ability of an integrated induced strain actuator such as a PZT actuator to transfer supplied electrical energy into structural mechanical energy. For a given structure such as a beam or a plate, the location and configuration of an actuator will directly influence the authority of the actuator towards driving the structure. Therefore by maximizing the average power factor for a given frequency interval, the actuator driving authority and thus the supply power utilization can be maximized. This thesis describes an experimental technique, based on the actuator power factor, for determining the optimal PZT actuator location(s) on complex structures for actuator power factor maximization and for active structural vibrational and acoustic control. For the actuator power factor analysis, the design of a removable PZT actuator unit is described. The concept of actuator power factor is ini tial1 y evaluated for the simple case of a cantilever beam and there is good agreement between the experimental and theoretical actuator power factor results. The optimization technique is then developed for the case of a complex structure designed to resemble an aircraft panel and shows good prediction for narrow-band as well as broadband power factor maximization. / Master of Science

Several uterine-derived paracrine factors have been implicated as critical regulators of conceptus development in cattle, but it remains unclear how these factors work together to establish and maintain pregnancies. The primary objectives of this work were to establish if cooperative interactions between epidermal growth factor (EGF), fibroblast growth factor-2 (FGF2) and insulin-like growth factor-1 (IGF1) promote bovine trophoblast cell proliferation, and to decipher the intracellular signaling mechanisms employed by these growth factors to regulate cell proliferation. Pilot studies established effective concentrations for each growth factor on a bovine trophoblast cell line (CT1). The first set of studies examined how each factor worked individually or in conjunction with each other to impact CT1 proliferation. Mitotic index (percentage of EdU-positive nuclei after a 45 min challenge) was increased (P<0.05) by supplementation with 10 ng/ml EGF, 10 ng/ml FGF2, or 50 ng/ml IGF1 when compared with non-treated controls. In addition, a greater increase (P<0.05) was detected when all three factors were supplemented together. A follow-up study determined that supplementation of any two growth factors could not replicate the cooperative effect noted when all three factors were provided. A second set of studies was undertaken to examine how mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase/AKT (PI3K/AKT) signaling systems mediate the independent and cooperative effects of these paracrine factors. Both EGF and IGF1 transiently activated mitogen-activated protein kinase3/1 (MAPK3/1) in CT1 cells as determined by Western Blot analysis. By contrast, FGF2 did not affect MAPK3/1 phosphorylation status, but increased AKT phosphorylation status. Neither EGF nor IGF1 impacted AKT activity. Supplementation with a pharmacological inhibitor of MAPK3/1 (PD98059) prevented EGF-, IGF1-, and FGF2-dependent increases in CT1 cell proliferation. This inhibitor also completely abolished the increases in cell proliferation observed when all three factors were supplemented together. Supplementation with a pharmacological inhibitor of AKT (Wortmannin) reduced FGF2-stimulated CT1 proliferation, but did not impact EGF- and IGF1 effects. The AKT inhibitor partially attenuated the cooperative effects of all three factors on CT1 cell proliferation. A final study examined how the combination of EGF, FGF2, and IGF1 affect bovine embryo development. In vitro produced bovine blastocysts were cultured either with the combination of growth factors or vehicle only from day 8 to day 12 post-in vitro fertilization (IVF). The combination of EGF, FGF2, and IGF1 increased (P<0.05) the percentage of hatched blastocysts and outgrowth formation versus controls. Increased (P<0.05) diameters were detected in blastocysts treated with the combination of three growth factors on day 12 post-IVF when compared to controls. Treatment with the combination of EGF, FGF2, and also IGF1 increased (P<0.05) the change of diameter from day 8 to 12 post-IVF. In summary, these observations provide evidence that cooperative interactions of uterine-derived factors promote trophoblast proliferation and conceptus development in ways that may promote the establishment and maintenance of pregnancy in cattle. The mechanisms utilized for these activities remain unresolved, but MAPK3/1 and PI3K/AKT signaling systems appear to play integral roles in some of these processes. / Master of Science