Neste trabalho é descrito um software denominado Scanc implementado no ambiente Windows, para a identificação de formas circulares em imagens digitais do tipo BMP. Dois métodos foram implementados para esse fim: a Transformada de Hough e Template Matching. Incluídos neste software encontram-se recursos para detecção de bordas e binarização da imagem, entre outros. O software tem aplicação nas mais diversas áreas, que requeiram a identificação de formas circulares. / The present work describes a software named Scanc, developed for circular pattern identification in digital bitmap images (BMP). Scanc was developed for Microsoft Windows environment and it takes advantage of two methods: Hough Transform and Template Matching. Image tools such as border detection and binarization are also available among other resources. The software finds several applications wherever circular forms identification is requered.

We give congruences modulo powers of 2 for the Fourier coefficients of certain level 2 modular functions with poles only at 0, answering a question posed by Andersen and Jenkins. The congruences involve a modulus that depends on the binary expansion of the modular form's order of vanishing at infinity. We also demonstrate congruences for Fourier coefficients of some level 4 modular functions.

Book Summary: This book is written for early childhood educators as well as those who work with children from birth through age eight. The book focuses on helping educators make the vital connection to the arts--including music, movement, drama, and the visual arts--throughout all areas of the classroom and curriculum, and on developing creative teachers who will be able to foster an artistic environment. Observations and photos of teachers and children demonstrate practical ways the arts can be used to help children reach their potential. Educators will find many ideas for open-ended activities that are important for the development of young children, and which will encourage them to think in new ways. Discussion of professional standards and recommendations allows teachers to be cognizant of goals that are important in the early years. Thorough in its coverage, the text speaks to children with special needs and cultural diversity, leaving readers with a complete information resource regarding arts in the young child's classroom.

Vaccination with immunogenic peptides offers a safe and specific way of inducing protection against pathogens, however as of yet there are no peptide-based vaccines available. The limitations on the therapeutic use of peptides are due to their poor immunogenicity and short life span in vivo. Peptide delivery systems act to circumvent these issues. The aims of this research were to investigate the ability of virus-like particles (VLP) from Rabbit haemmorhagic disease virus (RHDV) to deliver immunogenic peptides, to characterize the immune response to these particles, and to investigate whether baculovirus could also act as a delivery system. The vaccine peptides HAT (representing a T helper cell epitope) and HAB (representing the major B cell epitope) derived from the haemagglutinin antigen of influenza virus A/PR/8/34 were used as a model to investigate the ability of these virus particles to act as delivery vehicles to the immune system. A scheme for the production and purification of RHDV VLP was established. Expression of the capsid protein from RHDV in a serum-free recombinant baculovirus system using suspension cultures of up to 200 ml, and separation by isopycnic centrifugation on cesium chloride gradients led to high yields of purified RHDV VLP. Up to 20 mg of pure VLP could be obtained from an 800 ml culture of insect cells infected with recombinant baculovirus. In vitro testing revealed that RHDV VLP carrying the peptide HAT as a genetic fusion were processed by dendritic cells (DC), and that this peptide could be presented to induce activation of T cells. However, the purified RHDV VLP alone were not able to induce significant upregulation of cell activation markers CD40, CD86, and CD80. A preliminary in vivo study revealed that when RHDV VLP carrying the HAT peptide were delivered by an intraperitoneal injection in the absence of adjuvant, the immune response to the peptide was weak, therefore the route of delivery and the use of immune adjuvants with the VLP were optimised. Five different routes of delivery and two different immune adjuvants were compared. VLP were delivered through subcutaneous, intraperitoneal, transcutaneous, intramuscular and intranasal routes. Delivery of the VLP through each of these routes resulted in potent serum antibody responses. However, the strongest antibody responses were elicited when the VLP were delivered through the intraperitoneal or intranasal routes. Of these two routes, intranasal delivery gave the best mucosal responses at the lung surface, and was therefore chosen as the route of delivery for subsequent trials. CpG DNA and the wild-type baculovirus Autographa californica nucleopolyhedrovirus (AcMNPV) were tested as adjuvants for the RHDV VLP. These two adjuvants gave similar results, both acting to enhance a T[H]1 type response against the VLP, characterized by significantly increased levels of serum IgG2a and enhanced IFN-γ production. Two approaches were then tested: using the RHDV VLP as a peptide carrier with a CpG adjuvant, and using baculovirus particles directly as self-adjuvanting carriers for vaccine peptides. HAT and HAB peptides were chemically coupled to RHDV VLP. Mice that were vaccinated with these VLP mixed with a CpG adjuvant were able to raise low levels of specific antibody in the serum against influenza, and specific IgA against influenza was detected in the lung. These results indicated that, though the immune responses raised were modest, the RHDV VLP was able to deliver the vaccine peptides to the immune system. HAT and HAB peptides were chemically coupled to baculovirus particles. When mice were immunized with the baculovirus carrying the vaccine peptides, they raised significant levels of IgG1 (p<0.001) and IgG2a (p<0.05) against influenza in the serum, when compared to peptide delivered alone. A significant level of influenza-specific IgA was also detected in the lung at 10 ng/ml in the mice that received the baculovirus coupled with peptide. Analysis of splenocyte cytokines showed that these mice also responded to restimulation with IFN-γ production at around 100 pg/ml. This research revealed that RHDV VLP are able to act as carriers for vaccine peptides, however there are some limitations to their use with the HAT and HAB model peptides. It also showed that baculovirus can be rapidly modified to carry vaccine peptides by chemical conjugation, and that these peptides can be delivered to induce specific systemic and mucosal immunity, raising both B cell and cell mediated responses. Both virus particles have potential as components for new strategies for vaccination.

<p>We study the power series ring R= K[[x₁,x₂,x₃,...]]on countably infinitely many variables, over a field K, and two particular K-subalgebras of it: the ring S, which is isomorphic to an inverse limit of the polynomial rings in finitely many variables over K, and the ring R', which is the largest graded subalgebra of R.</p><p>Of particular interest are the homogeneous, finitely generated ideals in R', among them the <i>generic ideals</i>. The definition of S as an inverse limit yields a set of <i>truncation homomorphisms</i> from S to K[x₁,...,x_n] which restrict to R'. We have that the truncation of a generic I in R' is a generic ideal in K[x₁,...,x_n]. It is shown in <b>Initial ideals of Truncated Homogeneous Ideals</b> that the initial ideal of such an ideal converge to the initial ideal of the corresponding ideal in R'. This initial ideal need no longer be finitely generated, but it is always <i>locally finitely generated</i>: this is proved in <b>Gröbner Bases in R'</b>. We show in <b>Reverse lexicographic initial ideals of generic ideals are finitely generated</b> that the initial ideal of a generic ideal in R' is finitely generated. This contrast to the lexicographic term order.</p><p> If I in R' is a homogeneous, locally finitely generated ideal, and if we write the Hilbert series of the truncated algebras K[x₁,...,x_n] module the truncation of I as q_n(t)/(1-t)ⁿ, then we show in <b>Generalized Hilbert Numerators </b>that the q_n's converge to a power series in t which we call the <i>generalized Hilbert numerator</i> of the algebra R'/I.</p><p>In <b>Gröbner bases for non-homogeneous ideals in R'</b> we show that the calculations of Gröbner bases and initial ideals in R' can be done also for some non-homogeneous ideals, namely those which have an <i>associated homogeneous ideal</i> which is locally finitely generated.</p><p>The fact that S is an inverse limit of polynomial rings, which are naturally endowed with the discrete topology, provides S with a topology which makes it into a complete Hausdorff topological ring. The ring R', with the subspace topology, is dense in R, and the latter ring is the Cauchy completion of the former. In <b>Topological properties of R'</b> we show that with respect to this topology, locally finitely generated ideals in R'are <i>closed</i>.</p>

<p>Denna uppsats behandlar frågan om kolliderande standardavtal, internationellt benämnt battle of the forms. Problematiken grundas i att två parter i en avtalsförhandling har tillsänt varandra olika standardavtal med motstridiga villkor. Tvist uppkommer sedan oftast när parterna börjat prestera eller till och med fullbordat avtalet. Frågan uppkommer då vilka villkor som skall gälla samt hur denna problematik bör lösas. Eftersom problematiken är sparsamt utredd i svensk rätt har vi valt att studera tre nationella och tre internationella rättskällor och regelverk för att söka ledning i frågan. Utifrån det vi har kommit fram till kan det påpekas att en betydande majoritet av de rättskällor och regelverk vi har undersökt har frångått att lösa problematiken med hjälp av den klassiska synen på avtal samt anbud och accept. Syftet med uppsatsen har varit att ge läsaren en helhetsbild av problematiken med kolliderande standardavtal samt visa i vilken riktning utvecklingen på området tenderar att gå. Efter att ha utrett de olika rättskällorna kan vi fastslå att the knock-out rule torde vara den lösningsmodell som domstolarna generellt föredrar att tillämpa.</p>

This thesis describes a novel "Tablet-in-a-Bottle" oral suspension formulation. Ingredients with unstable physical or chemical characteristics can be placed in a core tablet, and then dry compression coated with an outer layer which provides separation from other components. The new suspension formulation comprises fast disintegrating clavulanic acid (KCA) tablets with a powder mixture containing amoxicillin. Hardness, friability, flow properties and weight uniformity of tablets for three different formulations were investigated and were all improved in a third formulation. Stability tests under different humidities were conducted. Amoxicillin and clavulanic acid in the new formulations showed the same stabilities when compared with the marketed product Augmentin��. Preliminary pharmacokinetics and bioavailability of one new formulation were evaluated by comparing in vitro release rates and in vivo urinary excretion rates. In vitro dissolution studies were carried out according to the USP XXIII paddle method. The new formulation showed faster release rates during the first hour when stirring speed was 25 rpm. However, when 75 rpm stirring speed was applied, the dissolution profiles for the new formulation and the reference marketed product were identical. A randomized two-way crossover bioequivalence study was designed to evaluate the bioavailabilities. Cmax, Tmax and AUC[subscript o--->t] of amoxicillin were within ��20% of the reference pharmacokinetic values. However, Cmax and Tmax of clavulanate were not within ��20%. Bioeqivalence between this new suspension formulation and the marketed product (Augmentin��) were evaluated using a two one-sided t-test. There is not sufficient statistical support with this test to conclude that the two products are bioequivalent. However, this is most likely due to small sample size and high intersubject variation and statistical support for bioequivalence is expected in a larger study group. / Graduation date: 1998

Thesis (Ph. D.)--University of Texas at Austin, 2006. / Vita. Includes bibliographical references.

Thesis (Ph. D.)--Ohio State University, 2006. / Title from first page of PDF file. Includes bibliographical references (p. 105-107).

Thesis (Ph. D.)--Ohio State University, 2006. / Title from first page of PDF file. Includes bibliographical references (p. 69-71).