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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
81

Factors affecting long-term habituation in Caenorhabditis elegans

Beck, Christine Daily O’Brien 11 1900 (has links)
The objective of these experiments was to explore long-term memory in Caenorhabditis elegans. This examination of memory in a simple organism with accessible genetics and a well understood biology may permit later work to define the cellular processes that underlie long-term memory. Habituation training with a vibrational stimulus was administered on Day 1, and the retention test of a block of stimuli was given 24 h after the end of training on Day 2. Long-term retention of habituation was evident as a lower level of responding on Day 2 relative to the level of responding on Day 2 of untrained controls or the initial level of responding of worms on Day 1. In Experiments 1 and 2, a habituation training protocol that produced long-term retention of habituation was established, and the effects of stimulus number, interstimulus interval (ISI), and distribution of training on both short-term and long-term habituation were examined. In Experiment 1 (10-s ISI), there appeared to be a floor effect which resulted in a low level of responding regardless of training on Day 1; thus no evidence for long-term habituation after training at a 10-s ISI could be found. In Experiment 2 (60-s ISI), worms that received distributed and massed habituation training with 60 stimuli showed a significantly lower level of responding relative to untrained controls. The distributed habituation training appeared to be more effective at inducing long-term habituation and was used in the subsequent experiments. To characterize the effects of heat shock treatments used in the behavioral experiments that follow, the effects of heat shock on two assays, the induction of a heat shock protein gene, hsp16, and the rate of egg-laying were measured in Experiment 3. All heat shock treatments used caused the induction of hsp16. In addition, the number of eggs laid during a fixed interval after heat shock was sensitive to the heat shock treatments given in Experiments 4 through 8. In Experiments 4 through 8, the effects of heat shock on short- and long-term habituation were examined. Heat shock, which acts as a general cellular stressor, was administered at different times before, during and after training. In Experiment 4, heat shock (45 min, 32°C) was administered, ending 2 h before training on Day 1. Heat shock before training did not affect the initial level of responding on Day 1, habituation during training, short-term retention of habituation between blocks of training or long-term retention of habituation. In Experiment 5, heat shock (45 min, 32°C) was administered during the rest periods of distributed training in the 1-h interval after each training block. While heat shock during training had no significant effect on responding on Day 1, long-term habituation was blocked. In Experiment 6, the possibility that heat shock before training would prevent the disruption of long-term habituation by heat shock during training by inducing thermal tolerance was examined. This was tested by administering heat shock (45 min, 32°C) that ended 2 h before training and heat shock during training. It was found that heat shock before training did not prevent the disruption of long-term habituation by heat shock during training. In Experiment 7, the effect of heat shock that ended 2 h before the retention test on Day 2 on the retention of long-term habituation was examined. It was found that heat shock on Day 2 did not disrupt the retention of habituation. Finally, in Experiment 8, the effect of brief heat shock (15 min, 32°C) at different intervals in the rest period following the training blocks was examined in an attempt to more narrowly define a critical period for consolidation of long-term habituation. Although there was no significant effect of brief heat shock on retention of habituation, the pattern of the data suggests that there may be a period of greater vulnerability worth further investigation. In summary, heat shock given before training or before the retention test did not affect long-term habituation, while heat shock during training disrupted consolidation of long-term habituation. Taken together, these behavioral results provide the foundation for an investigation of the cellular processes underlying long-term memory in C. elegans. By exploring the dynamics of the formation of long-term habituation, intervals of time critical to the formation of long-term habituation were defined. This in turn will help to focus attention on the cellular processes whose activity during those intervals of time may be important to the consolidation of long-term memory.
82

Evaluation of caenorhabditis elegans as an acute lethality and a neurotoxicity screening model

Williams, Phillip Lindly 12 1900 (has links)
No description available.
83

Development and evaluation of toxicity tests using Caenorhabditis elegans with reproduction, mutation, lethality, and behavior as end points

Middendorf, Paul Joseph 05 1900 (has links)
No description available.
84

Threshold chemosensitivity of the nematode caenorhabditis elegans

Terrill, William Forrest 05 1900 (has links)
No description available.
85

A soil toxicity test using the nematode Caenorhabditis elegans and some applications to studying metal ion sorption processes in soils

Donkin, Steven Glenn 08 1900 (has links)
No description available.
86

Genetic, serological, and biochemical analysis of surface antigen mutants of the nematode Caenorhabditis elegans that express hidden antigens

O'Brien, Peter Joseph 05 1900 (has links)
No description available.
87

Genetic and immunological studies of surface antigens of the nematode Caenorhabditis elegans

Herman, Daniel Lee 08 1900 (has links)
No description available.
88

Identification and partial characterization of a stage-specific surface antigen in C elegans

Donkin, Steven Glenn 08 1900 (has links)
No description available.
89

Colchicine induced alterations in colony development and differentiation in Eudorina

Gottlieb, Anthony David Bruce January 1974 (has links)
No description available.
90

Study of maternal-effect genes in the nematode Caenorhabditis elegans

Bénard, Claire Y. H. January 2003 (has links)
Le role des contributions epigenetiques lors du developpement d'un zygote en un organisme adulte a ete etudie a travers la caracterisation genetique et moleculaire de deux genes a effet maternel, mau-2 et clk-2, chez le nematode C. elegans. Des mutations dans ces deux genes produisent des patrons d'heritabilite differents, ainsi que des phenotypes distincts. Les mutants mau-2 sont secourus partiellement par un effet maternel, mais sont normaux quand un allele de type sauvage est exprime chez le zygote. Le gene mau-2 participe au guidage de nombreuses migrations de cellules et axones lors du developpement. Ce gene code pour une proteine de fonction inconnue, qui a ete conservee lors de l'evolution. mau-2 fonctionne dans les cellules qui migrent pendant le developpement du systeme nerveux. D'autre part, les mutants clk-2 sont completement secourus maternellement, excepte pour leurs competences reproductrices. De plus, ils dependent strictement de la presence d'un allele de type sauvage chez la mere pour leur developpement embryonnaire. clk-2 est requis pour la regulation des rythmes du developpement et du comportement. clk-2 est un gene essentiel, dont la fonction est requise entre la fin de la maturation des oocytes et le stade embryonnaire de deux cellules. clk-2 code pour une proteine qui est similaire a Tel2p, une proteine chez la levure, et est requis pour le maintien d'une longeur normale des telomeres chez le ver. Bien que mau-2 et clk-2 fonctionne differemment pendant le developpement du ver, la base de l'effet maternel semble etre tres similaire dans les deux cas. Une quantite considerable de transcrit est accumule dans les oocytes et est probablement transferee au zygote. Le transcrit ainsi fourni au zygote permet la traduction de proteine de type sauvage en quantite suffisante pour mener la plupart des fonctions de ces deux genes lors du developpement.

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