Human fungal infections among severely immunocompromised individuals have increased dramatically over the last 30 years and that coincidence with an expanding patient numbers of bone marrow and solid organ transplantation and those receiving aggressive cytotoxic chemotherapy for neoplastic diseases or immunosuppressive drugs. In recent years, many of opportunistic fungi have emerged as serious human pathogens and causing life-threatening infections of humans such as Fusarium species. Due to lack of a highly accurate diagnostic test for tracking the pathogenic Fusarium species, fusariosis is frequently misdiagnosed as aspergillosis. Delays in identification and differentiation of Fusarium spp. from other causative agents of hyalohyphomycetes associated with high morbidity and mortality rate among immunocompromised patients. This research aimed to develop a highly specific monoclonal antibody (mAb) using hybridoma technology to produce a highly genus-specific murine mAb ED7 that could be used for tracking and early detecting circulating Fusarium species antigens from other opportunistic pathogens. At present, a very little is known about the pathogenicity and interaction of human pathogenic F. solani and cells of the innate immune system like alveolar macrophages (AMØ), the residential innate immune cells of alveoli. For this reason, F. solani was genetically transformed with GFP gene and a model of immunoassay was developed to investigate the interactions of F. solani with AMØ that would allow studying the fungal pathogenicity, visualising and quantification of the pathogen during the process of macrophage phagocytosis. In addition, this model can be used to evaluate the effect of a mAb on fungal uptake by AMØ. Habitates providing direct human exposure to infectious propargules are largely unknown, but there is growing evidence that plumbing systems are sources of human pathogenic strains in the F. solani and F. oxysporum species complexes, the most common groups infecting humans. Using mAb ED7 specific to the Fusarium species, this work demonstrates how the mAb can be used as a powerful immunodiagnostic tool for accurately tracking the Fusarium species antigens in sink drain biofilms and water system samples containing mixed populations of human opportunistic filamentous and yeasts pathogenic fungi across a University campus and a tertiary care hospital. Specificity of the ELISA was confirmed by sequencing of the internally transcribed spacer 1 (ITS1)-5.8S-ITS2 rRNA-encoding regions of culturable yeasts and moulds that were recovered using mycological culture, while translation elongation factor (TEF)-1 analysis of Fusarium isolates included FSSC 1-a, FOSC 33 and FDSC ET-gr, the most common clinical pathotypes in each group. The mAb ED7 is, therefore, suitable to be carried forward for use in diagnostic assays, such as the lateral flow device.

This article analyzes political strategies of MNC subsidiaries in emerging markets. We find that institutional pressures from public and private non-market actors in the emerging market lead to increased political activism. Furthermore, we find that these relationships become stronger, when the external pressures are joined by strong firm-internal pressures. Our findings contribute to the scarce literature on firms' political strategies in emerging markets. They also support recent criticism of institutional theory's strong focus on isomorphism as the most important legitimacy-conveying mechanism. We argue that the isomorphism-based either-or logic gives way to stronger agency of the subsidiary and to a logic of active negotiation and social construction of the subsidiary's legitimacy in the emerging market. Our findings show support for this idea as political activism is one such way how the subsidiary's legitimacy can be built and nurtured.

This study aimed to understand how Muni University Library can effectively use mobile technologies to deliver social media-based library services. Data was collected from 100 undergraduate students and 4 members of staff of the University Library on the use of mobile and social media technologies for provision of library services and resources using self-administered questionnaires and face-to-face interviews, respectively. Only 88 student questionnaires were returned while all 4 members of staff participated in the face-to-face interviews. The results show that the majority (96.6 per cent) of the students own mobile devices and social media accounts that are used for both academic and personal purposes. There is convergence in responses among students and staff that mobile and social media technologies are crucial for provision of library services and resources in the 21st Century. They suggest that these technologies be used in the Muni University Library to access subject guides, MOPAC, mobile website, library map, and e-resources, and reference services. Also, the results show that the Muni University Library is already providing services to its users through mobile technologies and social media using WhatsApp, Facebook, and Kindle Fires e-readers. However, this study identified challenges that hinder the use of mobile and social media technologies, including unreliable internet connectivity, lack of a member of staff of the library responsible for managing technologies, lack of adequate skills among users and library staff required to use social media technologies, and lack of an independent library social media strategy. Discussion of the results and recommendations are presented in this mini-dissertation. / Mini Dissertation (MIT)--University of Pretoria, 2016. / Carnegie Corporation of New York / University of Pretoria / Muni University / Information Science / MIT / Unrestricted

Library users are constantly expecting new services, which puts tremendous pressure on academic libraries to re-organise their work patterns and devise better ways of service delivery in order to remain relevant. Although there are a lot of developments taking place in terms of information and communication technology (ICT), academic libraries in Sub- Saharan Africa are at different levels of ICT deployment both between different countries and within the same countries. The aim of this study is to determine the status of ICTs in Academic libraries in Central Uganda. The descriptive study employs a survey methodology gathering both quantitative and qualitative data. Data was collected from library staff responsible for the day-to-day management and administration of ICT at 17 of the 22 academic libraries in Central Uganda using survey questionnaires and interviews over a period of twelve months. Findings indicate that there is an improvement in the status of ICTs in academic libraries in Central Uganda although they are deployed at a minimum level. Funding, power fluctuations and low bandwidth still pose a major threat to ICT adoption in academic libraries in Central Uganda. This report informs government, libraries, LIS schools, LIS professional bodies and policy makers on the future course of action regarding ICT deployment and curricula. Notably, there is need for government to support infrastructural development; engage in public-private partnerships for infrastructural developments; exempt taxation of ICT equipment and supplement funding at universities. Libraries should dedicate more funds to purchase ICT equipment; automate all library functions; develop local capacity to manage ICT projects; promote awareness about ICT services and support initiatives from local and international library associations. LIS schools should conduct a curriculum review to reposition the LIS study program to the present and future needs of the job market; monitor and advice government on policy issues affecting higher education include the need to align ICTs to national development. LIS professional bodies need to champion the cause for the standardization of LIS study programs, promote networking and knowledge sharing; articulate national e-strategies and play advisory role to government, LIS schools and libraries. / Mini Dissertation (MIT)--University of Pretoria, 2016. / Carnegie Corporation of New York / Information Science / MIT / Unrestricted

Information technologies have become relevant enablers in knowledge management (KM) initiatives in academic institutions. A previous study by Anduvare (2015) revealed that the Marist International University College, Nairobi - Kenya had not adequately adopted information technologies into KM practices entwined in teaching, learning and research. This research study, therefore, set out to explore technologies that are capable of supporting KM practices in academic institutions in order to recommend some to the MIUC. Purposive sampling was used to select the MIUC full-time academic staff members as the target population as the researcher believed that they actively use knowledge at the MIUC and hence, would be in a position to understand the extent of information technology usage in KM practices. The study employed a qualitative research design that involved the use of Google forms to conduct an online survey in order to collect data from the target population. The study achieved a 100% response rate. Content analysis was utilised to analyse the data during which data within the specified themes (collaborative and distributive learning; knowledge discovery; knowledge mapping and knowledge application) was scrutinised for meaning. The data was then interpreted, presented and discussed based on the research sub-questions set for the study. The findings of the study confirmed the existence of KM practices at the MIUC. The study, thus, recommended some information technologies that support the KM practices to the MIUC which had been established through a review of literature. / Mini Dissertation (MIT)--University of Pretoria, 2016. / Information Science / MIT / Unrestricted

General content: Current methods of estimation of cost of capital in the emerging markets are often neglecting various contradictions with the essentials of the model structure and assumptions. As the result of such imprecisions, the cost of equity is often understated (overstated). This thesis will attempt to assess current level of emerging market integration, liquidity and concentration. This will be followed by evaluation of traditional and alternative models for estimation of cost of equity. The author will address several currently available models such as Credit Rating Model, D-CAPM model, various versions of traditional CAPM models. Furthermore, she will compare and contrast their limitations taking into account the context of emerging markets. The testing of the models will be performed on country basis through the means of index data. In the last chapter, discussion of the results and possible improvements of the valuation approaches will take place.

The emerging markets have become a new growth opportunity for multinational corporations (MNCs). This could be attributed to the stagnation of growth within the developed markets and the emergence of strong economic growth within emerging markets. Yet, MNCs have varying levels of success due to overlooking of certain components lacking in emerging markets, such as infrastructure. Furthermore, the strategic planning and execution frameworks utilised by MNCs are based on assumptions that are valid for the developed markets, but not always for the emerging markets.The objective of this research was to determine if there is a link between the application of specific interrelated principles for defining and executing strategy, defined by Raina (2010), and the financial success of MNCs when entering the emerging markets.The research found that there is clear evidence that if certain of the principles are applied by MNCs when entering the emerging markets, there is evidence of greater financial success.The research concluded that the interrelated strategic principles are a valuable framework to deliver financial success for MNCs entering the emerging markets. / Dissertation (MBA)--University of Pretoria, 2012. / Gordon Institute of Business Science (GIBS) / unrestricted

The obsolescing bargaining model (OBM) is the cornerstone for studying host country-MNE relations. Recent research has extended the OBM to incorporate other institutional stakeholders who participate in the multi-level, multi-party iterative political bargaining over policy issues which characterises much of the bargaining now to reflect the widespread macroeconomic changes from globalization that impinge on the model. Furthermore, the emergence of developing countries like India and China as high growthend markets has conceivably changed the nature of bargaining therein. This study adopts a triadic perspective to bargaining in EMs. The conceptualization including local MNEs addresses the lack of understanding on bargaining in EMs by suitably incorporating the institutional context which frames the triadic interplay. It focuses on the role of co-opetition by local MNEs in affecting the balance of bargaining power between host governments and foreign MNEs. Co-opetition is a strategic response by multinationals where they simultaneously compete and cooperate for mutual gains. This research enables the study to empirically challenge the assertion that the propositions of the OBM have become too dated to explain current bargaining structures. The extant literature provides the theoretical underpinnings for the development of a priori propositions which guide the empirical enquiry through a case study of the life insurance industry in India. Based on the unique insights offered through the single industry study, the analysis suggests that certain EM conditions now present the context for re- emergence of obsolescence for foreign MNEs. Furthermore, it is the evolution of the EMs’ own local MNEs who are deeply embedded in the local business culture constituting their identity as strategic insiders, who shape the development of bargaining power. Local MNEs as strategic insiders affect the foreign MNEs’ long term business prospects in EMs based on their co-opetition through an issue- area approach. Local MNEs’ existing insidership becomes the reason for both - foreign MNEs’ collaboration with them and the perpetuation of their lack of strategic insidership. It is the basis for the uneven playing field and for the deterioration in their initial bargaining power. Thus, in line with the OBM, entry bargains themselves are seen to obsolesce following the ambivalence in bargaining objectives and the sequential behaviour that both the local MNEs and the host government adopt. Co- opetition emerges as the explanatory variable while discerning the nature of emergent bargaining between governments and foreign MNEs in EMs. The application of a triadic, co-opetition perspective to bargaining is revealing andprovides original insights. An extended framework and modified propositions aredeveloped for future research. This study provides grounds for revisiting the OBM inthe context of other similar markets and for guiding future MNE strategy in EMs.

The South African Management Development Institute (SAMDI) is a Schedule 1 department with the mandate for capacity building in the public service. One of its core programmes is the Integrated Management Development Programme, which consists of the following programmes: <ul><li> Foundation Management Development Programme (FMDP) for first level supervisors;</li> <li>Emerging Management Development Programme (EMDP) for junior managers;</li> <li>Advanced Management Development Programme (AMDP) for middle managers; and the<li> <li>Presidential Strategic Leadership Development Programme (PSLDP) for senior executives.</li></ul> All these programmes have been based on solid training needs analyses, competency frameworks and cutting edge research. However, these programmes will only have an impact on service delivery if it succeeds in transferring knowledge to delegates attending it. This study will focus specifically on the EMDP, and subsequently the research question for this project is: ”Is there an increase in the knowledge of delegates that attended the EMDP?” After the analysis of the statistics it became clear that the null-hypothesis (H0 = there is no increase in the knowledge of delegates that attended the EMDP) should be accepted, as no significant differences between the pre- and post-course results could be found. / Dissertation (M.COM (Business Management))--University of Pretoria, 2007. / Business Management / unrestricted

The annual Global Venture Capital and Private Equity Country Attractiveness index which is sponsored by IESE Business school, Ernest&Young and Emlyon Business School, benchmarks the attractiveness of 116 countires for receiving institutional private equity and venture capital allocations. The factors used in determining this ranking are based on the findings from a study conducted by Groh, Liechtenstein and Leiser, (2008). South Africa was ranked 26th above Brazils' 43rd for the 2010 year meaning that as per the indexes criteria's, South Africa should be more attractive desitnation for private equity and venture capital investments over Brazil, yet the aggregate private equity deal value in South Africa in 2010 was US$1.5 billion (2009:24), while Brazil ranked 11th with aggregate deal value of US$6.3 billion (2009:US$940 million, ranking 26th) for the same period (KPMG 2011; Ernst&Young 2011).The objective of this study was to gain understanding into factors that are contributing to the attractiveness of private equity investments into Brazil through the testing of the key drivers as documented by Groh et al. (2008), and incorporating the findings of Leeds (2003) and Klonowski (2011).Throught the use of semi-structured, in-depth expert interviews, this study supported earlier studies such as that by Klonowski (2011) who contributed growth in PE investements inflow to not just the population size of a country but the ability of the inhabitants of that country to drive or stimulate local demand through the purchasing power of the emerging middle class. In the case for Brazil, the norms that have applied in other emerging markets including South Africa in relation to investor and property protection rights, administrative burdens, corporate governance and the quality of legal enforcement do not apply, or at least not to the same extent as experienced in those markets. Lastly the Study established that private equity industry itself can impact attractiveness levels both positively and negatively. / Dissertation (MBA)--University of Pretoria, 2013. / Gordon Institute of Business Science (GIBS) / unrestricted