Product Development Processes have achieved a state of some maturity in recent years, but have focused primarily on structuring technical activities from the initiation of development to launch. We advocate major advances on three fronts; first, implementing an end-to-end process from the front end through field operations, second, integrating business considerations much better into the end-to-end process, and third, incorporating a performance improvement closed loop into the process. We call the resulting process a Product Development Business Process. Three initial applications are summarized. / Improving product development processes along three key vectors leads to greatly improved business performance. / Center for Innovation in Product Development

This article explains when a judicial process starts, involving the exercise of fundamental procedural rights under the theory that is handled. Analyzing the current Peruvian legislation allows the author to conclude what concept or theory has chosen our Procedural Code. recognizing when the process starts, it is also mentioned that judicial protection must be even before any process. / El presente artículo explica cuando inicia un proceso judicial que supone el ejercicio de derechos fundamentales procesales según la teoría que se maneje. realizando un análisis de la actual legislación peruana, le permite concluir al autor cual es la concepción o teoría que nuestro Código Procesal ha optado. reconociendo cuando se entiende iniciado el proceso, se manifiesta que la tutela jurisdiccional debe ser incluso previa a dicho inicio.

Submitted by Nadir Basilio (nadirsb@uninove.br) on 2018-04-05T18:54:34Z No. of bitstreams: 1 Felipe Lascane Neto.pdf: 1163728 bytes, checksum: a278d7e1606bb03ec2721ecc0e66e730 (MD5) / Made available in DSpace on 2018-04-05T18:54:34Z (GMT). No. of bitstreams: 1 Felipe Lascane Neto.pdf: 1163728 bytes, checksum: a278d7e1606bb03ec2721ecc0e66e730 (MD5) Previous issue date: 2018-02-26 / The dissertation aims at the examination of the decisions given by the Supremo Tribunal Federal that allowed the beginning of the prison penalty involving deprivation of liberty just after the decision of second instance instead of after the final judgment of the criminal case, according to the fifth article, item LVII, of the Brazilian Federal Constitution of 1988 -, moderating, in this form, the extension of the constitutional presumption of innocence, to the extent that as the provision textually in the norm consecrating the presumption of innocence doesn’t admit this abbreviation of the cessation of the state of innocent and consequently the arrest of person who does not have against him a finally decision. / A dissertação visa ao exame das decisões prolatadas pelo Supremo Tribunal Federal que permitiram o cumprimento da pena segregativa da liberdade a partir da decisão de 2ª instância, e não mais a partir da sentença penal transitada em julgado, conforme dispõe o artigo 5º, inciso LVII, da Constituição da República Federativa do Brasil de 1988 - CR/88 -, mitigando, dessa forma, a extensão do princípio constitucional da presunção de inocência e promovendo uma mutação inconstitucional na medida em que o disposto textualmente na norma consagradora da presunção de inocência não admite esse abreviamento da cessação do estado de inocente e, consequentemente, o encarceramento de pessoa que não tem contra si uma decisão condenatória transitada em julgado.

<p dir="ltr">The purification of most active pharmaceutical ingredients (APIs) is primarily achieved through crystallization, conducted in batch, semi-batch, or continuous modes. Recently, continuous crystallization has gained interest in the pharmaceutical industry for its potential to reduce manufacturing costs and maintenance. Crystal characteristics such as size, purity, and polymorphism significantly affect downstream processes like filtration and tableting, as well as physicochemical properties like bioavailability, flowability, and compressibility. Developing an optimal operation that meets the critical quality attributes (CQAs) of these crystal properties is essential.</p><p dir="ltr">This dissertation begins by focusing on designing an innovative integrated crystallization system to enhance control over crystalline material properties. The system expands the attainable region of crystal size distribution (CSD) by incorporating multiple Mixed-Suspension Mixed-Product Removal (MSMPR) units and integrating wet milling, classification, and a recycle loop, enhancing robustness and performance. Extensive simulations and experimental data validate the framework, demonstrating significant improvements in efficiency and quality. The framework is further generalized to optimize crystallizer networks for controlling critical quality attributes such as mean size, yield, and CSD by evaluating various network configurations to identify optimal operating parameters.</p><p dir="ltr">The final part of this work concentrates on using the framework to improve continuous production of a commercial API, Atorvastatin calcium (ASC), aiming for higher yield and lower costs. This approach establishes an attainable region to increase crystal sizes and productivity. Due to ASC’s nucleation-dominated nature, the multi-stage system could not grow the crystals sufficiently to bypass granulation, the bottleneck process in ASC manufacturing. Therefore, spherical agglomeration was proposed as an intensification process within an integrated two-stage crystallization spherical agglomeration system to control the size and morphology of ASC crystals and improve downstream processing and tableting. This method proved highly successful, leading to the development of an end-to-end continuous manufacturing process integrating reaction, crystallization, spherical agglomeration, filtration, and drying. This modular system effectively addressed challenges in integrating various unit operations into a coherent continuous process with high production rates.</p>