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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Analysis of the secondary and tertiary conformations of enkephalins and analogs by high resolution proton magnetic resonance spectroscopy

Alper, Joseph Bernard. January 1978 (has links)
Thesis (M.S.)--Wisconsin. / Includes bibliographical references (leaves 61-64).
2

SYNTHESIS AND COMPARATIVE BIOLOGICAL ACTIVITIES OF CONFORMATIONALLY RESTRICTED ENKEPHALIN ANALOGS.

Hurst, Robin. January 1984 (has links)
No description available.
3

New methodologies for thioacylation of amines and thiopeptides synthesis

Lépine, François. January 1985 (has links)
No description available.
4

New methodologies for thioacylation of amines and thiopeptides synthesis

Lépine, François. January 1985 (has links)
The synthesis of an analog of Leucine enkephalin bearing a thioamide linkage in position 3 was accomplished. Attempts to couple thiodipeptides to amines by the means of activating their free carboxyl function was showed to give substituted thiazolones which were not found suitable for the synthesis of thiopeptides. Many attempts to generate new thioacylating aminoacid derivatives are described. Three types of variously substituted thioacylbenzoxazolinones were efficiently synthesized and showed good thioacylating properties. At least one of them fulfill all the requirements for performing thiopeptide synthesis on a routine basis when applied to chiral aminoacid residues.
5

Studies on the processing of proenkephalin A by the prohormone converting enzymes PC1 and PC2

Brar, Bhawanjit Kaur January 1995 (has links)
No description available.
6

Preproenkephalin gene and mRNA : studies of structure, function, cocaine responses in an animal model, and genetic association with human opiate addiction /

LaForge, Karl Steven, January 2004 (has links)
Diss. (sammanfattning) Uppsala : Univ., 2004. / Härtill 4 uppsatser.
7

Localisation of neuropeptides in the spinal trigeminal nucleus

Priestley, John V. January 1982 (has links)
No description available.
8

Effects of endocrine manipulation on the peptide levels and the gene expression of {221}-endorphin, met-enkephalin, somatostatin, substanceP and cholecystokinin in the rat hypothalamus and pituitary

張頌恩, Cheung, Chung-yan. January 1998 (has links)
published_or_final_version / Physiology / Master / Master of Philosophy
9

Addressing the Neurochemical Problem: Sensitive and Selective Measurements of Neurotransmitters, Neuropeptides, and Synaptic Vesicles

Laude, Nicholas D. January 2015 (has links)
The neurochemical problem (1) and the directive of the neuroanalytical chemist (2) can be stated as follows: (1) The chemical space of the nervous system is populated by hundreds of neuroactive species linked through extensive biological circuits which are dynamically changing in time and space in response to myriad inputs. (2) Neurochemical analysis techniques should therefore have the appropriate temporal, spatial, and chemical resolution to study these systems, while perturbing them so minimally as to allow unfettered in vivo measurements. New tools and concepts for analytical measurements of neurotransmitters, neuropeptides, and synaptic vesicles are developed and presented in this dissertation on analytical measurements for addressing the neurochemical problem. The introduction gives a broad overview of chemical neuroscience and introduces quantitative visualization of the multidimensional resolution paradigm for analytical chemists seeking to design effective experiments. Chapters two through four detail advancements in data processing and instrument design which decrease detection limits and allow for improved spatial, temporal, chemical resolution in capillary electrophoresis measurements of neurotransmitters, metabolites, and synaptic vesicles. Chapter five discusses the development of fast-scan controlled-adsorption voltammetry which has dramatically increases the spatial and temporal resolution of basal dopamine measurement in vivo. Chapter six introduces online-preservation microdialysis as a way to overcome enzymatic degradation of endogenous opioid neuropeptides during in vivo sample collection. Because of this discovery of the secretory behavior these neuropeptides is reported in the anterior cingulate cortex (ACC), a region of the brain deeply associated with pain signaling. The advancement of peptide drugs particularly glycosylated neuropeptide analogs through new methods of mass spectrometry analysis for rapid feedback in drug development are presented in chapter 7. Chapter eight concludes this work with future directions pointing towards single-cell electrochemical and mass spectrometry measurements, shotgun-microdialysis for high-throughput screening of neurotherapeutics, preliminary data on the effect of chronic pain of endogenous opioids in the ACC, and the beginnings of in vivo neuroproteomics analysis in rodent pain models.
10

Effects of endocrine manipulation on the peptide levels and the gene expression of b-endorphin, met-enkephalin, somatostatin, substance P and cholecystokinin in the rat hypothalamus and pituitary /

Cheung, Chung-yan. January 1998 (has links)
Thesis (M. Phil.)--University of Hong Kong, 1999. / Includes bibliographical references (leaves 99-[110]).

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