Submitted by Natalie Mendes (nataliermendes@gmail.com) on 2015-10-20T00:18:33Z No. of bitstreams: 1 DISSERTA??O MESTRADO FINAL.pdf: 1403027 bytes, checksum: 4b9683a755fa4e4d4944ac1aa1d6377e (MD5) / Made available in DSpace on 2015-10-20T00:18:33Z (GMT). No. of bitstreams: 1 DISSERTA??O MESTRADO FINAL.pdf: 1403027 bytes, checksum: 4b9683a755fa4e4d4944ac1aa1d6377e (MD5) Previous issue date: 2013-03-27 / Funda??o de Amparo ? Pesquisa do Estado da Bahia - FAPEB / It is mandatory to recognize its previous wounds of mouth cancer, the alleged "potentially malignant injuries" - leukoplakia, cheilitis, erythroplakia and oral lichen planus - with the objective of avoiding its development. A transversal cut study was performed in order to estimate the prevalence of potentially malignant lesions diagnosed at the Centro de Refer?ncia de Les?es Bucais of Universidade Estadual de Feira de Santana and as a means to register the accompaniment of the patients through potential clinical outputs of these lesions informed on the patient's reports from 1996 to 2012. A descriptive analysis of all variables was carried out, followed by the X2 Test of Pearson, which was used as a way of calculating the statistic significance. As a measure of association between the mouth lesion and the studied patient's likely risk factors, the Prevalence Reason calculation was performed within a population interval of 1 standard deviation. Leukoplakia was the most prevalent injury (43,6%) and erythroplakia the least one (13,7%). A statistic significance was observed among all associations of injuries with the variables related to the patient (p<0,05), as well as the lesions and the consummation of its probable risk factors (p=0,00). In the Prevalence Reason calculation, significant results were observed, among which: the leukoplakia and the exposition solely to alcohol (RP=2,47; IP=1,72-3,55); the erythroplakia and the exposition solely to alcohol (RP=2,51; IP=1,38-4,55) and to alcohol and tobacco (RP=1,8; IP=1,23-2,64); the actinic cheilitis and the exposition to solar radiation (RP=2; IP=1,61-2,50) and the solely to tobacco (RP=2,51; IP=1,75-3,59); and the oral lichen planus and the exposition solely to tobacco (RP=2,46; IP=1,80-3,36) and to alcohol and tobacco (RP=3,04; IP=2,11-4,35). Out of the total number of patients, 4,6% of them presented a new wound, among which 52,6% of them were recurrent, half presented by oral lichen planus. Concerning the clinical output, 58,3% of all cases accompanied presented an injury permanence state and 26,9% were in the process of evolving to healing, no case of evolution to mouth cancer was detected. It is mandatory to stimulate the production of studies in such field for they will support protection, prevention, control, and the treatment of the mouth lesions here explored. / Faz-se mister o reconhecimento das les?es precursoras do c?ncer bucal, as ?les?es potencialmente malignas? - leucoplasia, eritroplasia, queilite act?nica e l?quen plano - no intento de prevenir a sua progress?o. Este estudo do tipo corte transversal objetivou estimar a preval?ncia das les?es orais potencialmente malignas diagnosticadas no Centro de Refer?ncia de Les?es Bucais da Universidade Estadual de Feira de Santana e registrar o acompanhamento dos pacientes acometidos, no que se refere aos poss?veis desfechos cl?nicos dessas les?es notificados em seus prontu?rios, no per?odo de 1996 a 2012. Foi feita uma an?lise descritiva de todas as vari?veis do estudo, seguido do uso do Teste X2 (Qui-Quadrado) de Pearson para o c?lculo da medida de signific?ncia estat?stica e como medida de associa??o entre a les?o oral e os prov?veis fatores de risco dos participantes do estudo, realizou-se o c?lculo da Raz?o de Preval?ncia utilizando-se o intervalo populacional com 1 desvio padr?o. A leucoplasia foi a les?o mais prevalente (43,6%) e a eritroplasia, a menos (13,7%). Observou-se signific?ncia estat?stica entre todas as associa??es das les?es com as vari?veis relacionadas ao paciente (p<0,05), como tamb?m entre as les?es e o consumo dos seus poss?veis fatores de risco (p=0,00). No c?lculo da Raz?o de Preval?ncia, verificaram-se resultados significantes entre: a leucoplasia e a exposi??o apenas ao ?lcool (RP=2,47; IP=1,72-3,55); a eritroplasia e a exposi??o apenas ao ?lcool (RP=2,51; IP=1,38-4,55) e ao ?lcool e tabaco (RP=1,8; IP=1,23-2,64); a queilite act?nica e a exposi??o ? radia??o solar (RP=2; IP=1,61-2,50) e a apenas ao tabaco (RP=2,51; IP=1,75-3,59); e o l?quen plano e a exposi??o apenas ao tabaco (RP=2,46; IP=1,80-3,36) e ao ?lcool e tabaco (RP=3,04; IP=2,11-4,35). Do total dos pacientes, 4,6% apresentou nova les?o, dentre as quais, 52,6% eram recidivantes, metade representada pelo l?quen plano. No tocante ao desfecho cl?nico, 58,3% dos casos acompanhados, apontaram estado de perman?ncia da les?o e 26,9%, processo de evolu??o ? cura, n?o tendo sido verificado nenhum caso de evolu??o para o c?ncer oral. Torna-se imperativo a produ??o de estudos neste ?mbito, que venham subsidiar pol?ticas de prote??o, preven??o, controle e tratamento dessas les?es orais aqui exploradas.