Thesis (M. Med. Sc.)--University of Hong Kong, 2005.

Thesis (M.Sc.)--York University, 2005. Graduate Programme in Kinesiology and Health Science. / Typescript. Includes bibliographical references (leaves 70-88). Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://gateway.proquest.com/openurl?url%5Fver=Z39.88-2004&res%5Fdat=xri:pqdiss &rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:MR11787

Thesis (M.S.)--University of Nebraska at Omaha, 2005. / Includes bibliographical references (leaves 84-89). Also available online (PDF file) by a subscription to the set or by purchasing the individual file.

Orientador: Guilherme de Camargo Ferraz / Banca: Ruthnea Aparecida Lázaro Muzzi / Banca: Aureo Evangelista Santana / Resumo: As principais alterações fisiológicas ou patológicas induzidas pelo exercício que ocorrem na musculatura esquelética ou cardíaca podem ser identificadas por meio de biomarcadores séricos. Consolidados em atletas da espécie humana e equina, são praticamente inexistentes em cães estudos sobre a dinâmica destes biomarcadores relacionados com a prática de exercício máximo e treinamento. Objetivou-se determinar a cinética dos biomarcadores séricos musculares creatina quinase (CK), aspartato aminotransferase (AST), mioglobina; e cardíacos, troponina cardíaca I (cTnI) e creatina quinase isoenzima MB (CK-MB) de cães submetidos a esforço intenso e condicionamento aeróbio. A ação da venopunção sobre os biomarcadores também foi avaliada. Foram utilizados 18 cães hígidos da raça Beagle distribuídos em três grupos: sedentário (S), não treinado (NT) e treinado (T). Os cães foram submetidos a dois testes de esforço incremental (TEI-1 e TEI-2) para obtenção da curva lactato-velocidade (CLV). Verificou-se se a CLV teve modelo exponencial. O programa de treinamento foi realizado em esteira por 8 semanas na velocidade relacionada a 70-80 % do limiar de lactato (VLL). Determinou-se a velocidade correspondente a frequência cardíaca no momento da fadiga (VFCFadiga). Os biomarcadores séricos foram quantificados nos momentos basal, antes e 1, 6, 12, 24, 48 e 72 h após os TEIs. Aplicou-se análise de variância de dois fatores para amostras repetidas no tempo seguida por teste de Tukey e correlação de ... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: The main physiological or pathological alterations induced by exercise on skeletal or cardiac musculature can be identified using serum biomarkers. While studies on the dynamics of such biomarkers are consolidated in humans and horses, they are virtually inexistent on maximum exercise and training among dogs. This study aimed to determine the kinetics of the muscle serum biomarkers creatine kinase (CK), aspartate aminotransferase (AST), and myoglobin and of cardiac biomarkers cardiac troponin I (cTnI) and creatine kinase isoenzyme MB (CK-MB) of dogs subjected to intense effort and aerobic conditioning. The effect of venipuncture on the biomarkers was also assessed. Eighteen healthy Beagle dogs were assigned to three groups: sedentary (S), untrained (U), and trained (T). The dogs were subjected to two incremental effort tests (IET-1 and IET-2) so that their lactate vs. velocity curve (LVC) could be obtained. It was verified whether LVC followed an exponential model. The eight-week training program was carried out on a treadmill with speed set to 70-80% of the velocity at lactate threshold (VLT). The velocity corresponding to the heart rate at the moment of fatigue (VHRFatigue) was determined. Serum biomarkers were quantified at the baseline, before, and 1, 6, 12, 24, 48, and 72 h after the IETs. Two-factor analysis of variance was applied for samples repeated over time followed by Tukey's test and Pearson correlation (P≤0.05). The increase (P≤0.05) in the velocyties corresponding to VLT and VHRFatigue indicated an improvement in aerobic fitness of group T. Serum activity of CK and AST increased (P≤0.05), reached maximum values after 6 h in both IETs, and returned to baseline levels after 12-24 h. As a whole, the assessment of the behavior of muscle biomarkers showed recovery of muscle tissues after the IETs. Lev ... (Complete abstract click electronic access below) / Mestre

The purpose of this study was to compare the relationship between immersion running and treadmill running through the measurement of cardiorespiratory parameters. Sixteen subjects completed two exercise protocols to exhaustion. The treadmill running protocol was initiated at 3.08 m*s-l and increased a 0.22 m*s-l every sixty seconds. The immersion running protocol utilized an immersion running Ergometer (IRE). The IRE is similar to a tethered swim machine. The initial weight was set at 1 kg and Increased a 1/2 kg every sixty seconds. Heart rate (HR), oxygen consumption (V02), ventilatory equivalent (VE/V02), and minute ventilation (VE) were determined at ventilatory threshold and at maximal effort, HR, V02, VE/V02 and VE were analyzed by MANOVA (RM). Tidal volume and frequency of breathing were collected for four subjects at ventilatory threshold and at maximal effort (no statistical analysis). Two subjects who had completed the initial exercise protocols volunteered for a follow up study of blood flow distribution testing (no statistical analysis). These subjects were injected with Tc-99 2-methyloxy isobutyl isonitrlle at ventilatory threshold during immersion and treadmill running. Imaging was performed with a Selmans Gamma Camera at the UBC Dept. of Nuclear Medicine. V02 and HR at ventilatory threshold and maximal effort were significantly lower (P < .05) during immersion running. VE/V02 was significantly greater at maximal effort during immersion. Minute ventilation was unaffected by immersion, however, there was a trend towards a smaller tidal volume and greater frequency of breathing. The blood flow distribution data varied considerably partially between subjects. The significant drop in V02 at maximum effort and at ventilation threshold during immersion running may be accounted for by changes in muscle mass recruitment, muscle fibre type recruitment, recruitment pattern and state of peripheral adaptation (muscular). A lower heart rate during immersion may be due to increases in intrathoracic blood volume. The trend towards a higher breathing frequency and lower tidal volume during immersion running may be due to the increased effort to breath caused by hydrostatic chest compression. The significant increase in VE/V02 at maximal effort during immersion running was due to the significant drop in V02. It may be concluded that immersion running causes significant changes in cardiorespiratory parameters at ventilatory threshold and at maximal effort. Research is needed to investigate the significance of the changes. / Education, Faculty of / Curriculum and Pedagogy (EDCP), Department of / Graduate

A lot of attention has been focused on reducing cholesteric problems before individuals reach middle age, but is it not possible to reduce the risk factors for CHD after middle age? This study was initiated to determine id moderate exercise had an effect on the serum lipoproteins in postmenopausal women. Plasma concentrations of glucose, triglyceride (TRIG), TC, HDL, and LDL were measured before and after a monitored regime of moderate exercise.

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