Spelling suggestions: "subject:"extracorporeal photopheresis"" "subject:"extracorporeal photophoresis""
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New approaches to improve Extracorporeal Photopheresis for the treatment of Graft-versus-Host DiseasePapert, Susanne 09 May 2016 (has links)
No description available.
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Effective Extracorporeal Photopheresis of Patients with Transplantation Induced Acute Intestinal GvHD and Bronchiolitis Obliterans SyndromeReschke, Robin, Zimmerlich, Stephanie, Döhring, Christine, Behre, Gerhard, Ziemer, Mirjana 06 December 2023 (has links)
Background: Patients with steroid-refractory intestinal acute graft-versus-host disease
(aGvHD) and bronchiolitis obliterans syndrome (BOS) represent a population with a high need for
alternative and effective treatment options. Methods: We report real-life data from 18 patients treated
with extracorporeal photopheresis (ECP). This cohort consisted of nine patients with steroid-refractory
intestinal aGvHD and nine patients with BOS. Results: We document partial or complete clinical
response and reduction of symptoms in half of the patients with intestinal acute GvHD and patients
with BOS treated ECP. Responding patients tended to stay on treatment longer. In patients with BOS,
stabilization of lung function and forced expiratory volume was observed, whereas, less abdominal
pain, less diarrhea, and a reduction of systemic corticosteroids were seen in patients with intestinal
acute GvHD. Conclusions: ECP might not only abrogate symptoms but also reduce mortality caused
by complications from high-dose steroid treatment. Taken together, ECP offers a serious treatment
avenue for patients with steroid-refractory intestinal acute GvHD and BOS.
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Immune Monitoring Assay for Extracorporeal Photopheresis Treatment Optimization After Heart TransplantationDieterlen, Maja-Theresa, Klaeske, Kristin, Bernhardt, Alexander A., Borger, Michael A., Klein, Sara, Garbade, Jens, Lehmann, Sven, Ayuk, Francis Ayuketang, Reichenspurner, Herrmann, Barten, Markus J. 24 March 2023 (has links)
Background: Extracorporeal photopheresis (ECP) induces immunological changes that
lead to a reduced risk of transplant rejection. The aim of the present study was to
determine optimum conditions for ECP treatment by analyzing a variety of toleranceinducing
immune cells to optimize the treatment.
Methods: Ten ECP treatments were applied to each of 17 heart-transplant patients from
month 3 to month 9 post-HTx. Blood samples were taken at baseline, three times during
treatment, and four months after the last ECP treatment. The abundance of subsets of
tolerance-inducing regulatory T cells (Tregs) and dendritic cells (DCs) in the samples was
determined by flow cytometry. A multivariate statistical model describing the
immunological status of rejection-free heart transplanted patients was used to visualize
the patient-specific immunological improvement induced by ECP.
Results: All BDCA+ DC subsets (BDCA1+ DCs: p < 0.01, BDCA2+ DCs: p < 0.01,
BDCA3+ DCs: p < 0.01, BDCA4+ DCs: p < 0.01) as well as total Tregs (p < 0.01) and
CD39+ Tregs (p < 0.01) increased during ECP treatment, while CD62L+ Tregs decreased
(p < 0.01). The cell surface expression level of BDCA1 (p < 0.01) and BDCA4 (p < 0.01) on
DCs as well as of CD120b (p < 0.01) on Tregs increased during the study period, while
CD62L expression on Tregs decreased significantly (p = 0.04). The cell surface expression
level of BDCA2 (p = 0.47) and BDCA3 (p = 0.22) on DCs as well as of CD39 (p = 0.14) and
CD147 (p = 0.08) on Tregs remained constant during the study period. A cluster analysis
showed that ECP treatment led to a sustained immunological improvement.
Conclusions: We developed an immune monitoring assay for ECP treatment after heart
transplantation by analyzing changes in tolerance-inducing immune cells. This assay
allowed differentiation of patients who did and did not show immunological improvement.
Based on these results, we propose classification criteria that may allow optimization of
the duration of ECP treatment.
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Retrospektive Analyse der Bedeutung mikroangiopathischer Veränderungen bei Patienten unter extrakorporaler Photopherese als Therapie einer GvHD / Retrospective analysis of microangiopathic damage in patients undergoing extracorporeal photopheresis as therapy of GVHDGerlach, Birte-Kristin 22 October 2014 (has links)
Das Auftreten manifester transplantationsassoziierter thrombotischer Mikroangiopathie sowie das Auftreten leichterer, zumeist subklinischer mikroangiopathischer Veränderungen wurde in einem Kollektiv von Patienten untersucht, die zur Behandlung einer steroidrefraktären oder abhängigen akuten oder chronischen GvHD nach allogener Stammzelltransplantation eine Therapie mit extrakorporalen Photopheresen erhielten. Subklinische mikroangiopathische Schädigung wurde durch ein auf den Messwerten von Fragmentozyten, Thrombozyten sowie der LDH-Aktivität beruhendes Bewertungsschema festgestellt.
Das Auftreten von ausgeprägten mikroangiopathischen Veränderungen (Schweregrad 2) ging mit einem erniedrigten Gesamtüberleben einher.
Die Reduktion der Steroiddosis und die Verringerung der GvHD-Manifestationen wurden als Parameter für die Wirksamkeit der ECP analysiert. Ihre Effektivität wurde bestätigt.
Trotz der nachgewiesenen Effektivität der ECP in der Kontrolle der GvHD zeigte sich eine Tendenz zur Zunahme mikroangiopathischer Veränderungen unter Therapie mit ECP, in Einzelfällen mit schwerwiegenden klinischen Konsequenzen.
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