Inflammation is a central feature of various metabolic diseases including obesity and type-II diabetes. For this study, we hypothesized postprandial metabolism following an acute, high fat (HF) meal to be impaired in mice pre-injected with an inflammatory agonist. To this end, C57BL/6J mice were injected with saline or lipopolysaccharide (LPS, 1μg/kgbw) following an overnight fast and gavaged 2hr post-injection with water or a HF meal in liquid form (5kcal; 21.4%SF, 40.8%UF, 27.1%CHO, 10.7%PRO). Blood and muscle samples taken 3hr post-gavage underwent ex vivo analysis. Overall, results demonstrated a metabolic response to a HF meal that was blocked in the presence of LPS. Metabolic flexibility, though unchanged following the HF meal alone, was reduced following the HF meal in the presence of LPS. Additionally, state-4 uncoupled mitochondrial respiration, which was increased following the HF meal, was also reduced following the HF meal in the presence of LPS. Similar near-significant trends were also observed with total palmitate oxidation. Although no independent response to a HF meal or LPS exposure was observed, a unique interaction between treatments significantly diminished ADP dependent, state-3 and maximal respiration. These effects do not appear to be dependent on the production of reactive oxygen species (ROS) since neither the HF meal nor LPS exposure resulted in increased production of ROS. In conclusion, these results demonstrate that acute activation of inflammatory pathways results in alterations in metabolic response to a HF meal in skeletal muscle from mice, although the mechanism underlying these effects is not yet understood. / Master of Science

Yes / While research on factors driving corporate investment decisions has blossomed, knowledge related to the Chief Executive Officer’s (CEO’s) market sentiment on investment decision outcomes is lacking. In this study, we extend the existing corporate finance literature by examining the underexplored issue of how CEOs’ market sentiment drives firms’ investment decisions. Capitalising on a large sample of US firms for the period 2004-2014, we uncovered some crucial observations. First, we found empirical support for our theoretical contention that market sentiment drives corporate investment decisions. Second, we established that, while financial flexibility induces managers to overinvest, the expectation of future profitability leads firms to underinvest during high sentiment periods. In addition, we uncovered that the 2007/08 financial crisis significantly impacted firm behaviour and realigned managerial decision-making. Thus, the sentiment-investment relationship is more pronounced during the crisis and the post-crisis periods. Our results are robust after accounting for the possibility of endogeneity and using alternative measures of both CEOs’ market sentiment and firm investment.

Modern storage systems are designed to manage data without considering the dynamicity of user or resource requirements. This design approach does not consider the complexities of the dynamically changing runtime application behaviors as well as the unique features of underlying resources. To this end, this dissertation studies how resource and functional partitioning strategies can improve efficiency and flexibility of object stores. This dissertation presents a series of practical and efficient techniques, algorithms, and optimizations to realize efficient and flexible object stores. The experimental evaluation demonstrates the effectiveness of our design choices and strategies to make object stores flexible and resource-aware. / Ph. D. / Modern storage systems are designed to manage data without considering the dynamicity of user or resource requirements. This design approach does not consider the complexities of the dynamically changing runtime application behaviors as well as the unique features of underlying resources. To this end, this dissertation studies how resource and functional partitioning strategies can improve efficiency and flexibility of object stores. This dissertation presents a series of practical and efficient techniques, algorithms, and optimizations to realize efficient and flexible object stores. The experimental evaluation demonstrates the effectiveness of our design choices and strategies to make object stores flexible and resource-aware.

This thesis is about service provider flexibility and how provider flexibility facilitates customer value creation in contexts where customer processes and activities change. Provider flexibility is delineated as a mechanism of value creation and defined as the ability of the service provider to respond to changes or to bring about changes that support its customers’ value creation. Although provider flexibility has been implied as a relevant factor in value creation, previous studies focusing on some kind of provider flexibility would benefit from a deeper understanding of the strategic role that service provider flexibility plays in value creation. The purpose of this study is to provide a framework that explicates the strategic role of provider flexibility in value creation. The role of provider flexibility in the adjustment of the provider’s processes and activities and the development of opportunities based on insights from customer interactions are thus emphasized. Moreover, while these insights from customer interactions can offer valuable development opportunities for the service provider, these opportunities yield returns only with the transfer of the insights back to the service provider’s organization. The research process evolves along five research articles that develop the understanding of the strategic role of provider flexibility in value creation. The study builds on the empirical data from five service organizations of large industrial firms. The empirical insights from the articles are expanded and their conclusions further developed by iteratively and abductively substantiating the research model. The discussion explicates how exercising provider flexibility—in the form of organizational flexibility in the provider sphere, interaction flexibility in the joint sphere, and flexibility in use in the customer sphere—contributes to value creation. Moreover, findings show that the provider and the customer are entwined in a service system surrounding their service relationship. Provider flexibility in this aspect functions not merely as a mechanism of value creation, but also as a carrier of knowledge and information about the customer. Having this dynamics in mind, the provider continues to use provider flexibility to reinvent itself and constantly evolve the organization. This thesis contributes to the literature by providing a framework that explicates the strategic role of provider flexibility in value creation. More specifically, the contributions are: 1) an increased understanding of how provider flexibility in value creation is exercised, placing provider flexibility at the core of the encompassing process of value creation, and thus explicating the manner in which the encompassing process of value creation can unfold; and 2) an increased understanding of the strategic role of the work of part-time marketers by delineating the process of provider flexibility in value creation where different aspects of provider flexibility in value creation are linked. / <p>At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 2: Manuscript. Paper 3: Accepted. Paper 4: Manuscript.</p>

The purpose of the study was to quantify the relative contribution of low back flexibility and hamstring flexibility in the sit and reach test item of the AAHPERD Health Related Fitness Test in order to examine the validity of the sit and reach test. Subjects were 100 female students, 13 to 15 years of age in physical education classes. Hamstring flexibility was measured using the Leighton flexometer. Spinal mobility was measured using a tape measure. The sit and reach test was performed according to instructions given in the AAHPERD Test Manual. Data were analyzed using correlation, linear regression, and multiple regression. Conclusions of the investigation were (1) hamstring flexibility is moderately related to the sit and reach test, (2) low back flexibility has a very small relationship to the sit and reach test, and (3) the sit and reach test is an inadequate measure of low back and hamstring flexibility.

The purpose of this study was to examine the criterion-related validity of the sit and reach test as a measure of hamstring and low back flexibility in adult males and females. Subjects were 52 males and 52 females, 20 to 45 years of age. Hamstring flexibility was measured using a goniometer. Spinal flexibility was measured using a tape measure and an inclinometer. The sit and reach test was performed according to the AAHPERD Health Related Fitness Test Manual. Data were analyzed using correlations and appropriate descriptive statistics. Conclusions of the investigation were: 1) in adult males 20 to 45, the sit and reach test is a valid measure of hamstring flexibility but has questionable validity as a measure of low back flexibility, 2) in adult females 20 to 45, the sit and reach test is a moderately valid measure of hamstring flexibility and is not a valid measure of low back flexibility.

Ce travail est une contribution à la compréhension des capacités adaptatives des personnes âgées déprimées et non déprimées. Pour répondre à cet objectif nous avons utilisé une méthode expérimentale et une observation clinique : une étude de cas suivie longitudinalement pendant 6 ans. La relation dépression - flexibilité cognitive est évaluée au moyen d'épreuves de shifting et de fluence auprès de deux groupes de personnes âgées non démentes, déprimées et non déprimées, résidant en maisons de retraite.L'analyse quantitative et qualitative met en évidence un affaiblissement de la flexibilité cognitive qui se traduit par une corrélation négative entre les scores de dépression et ceux obtenus aux épreuves de flexibilité réactive et spontanée. Nous établissons une analogie entre les comportements adaptatifs au quotidien et les données quantitatives, et nous proposons un schéma théorique expliquant le comportement adaptatif des personnes âgées. Notre étude de cas permet une meilleure compréhension de la relation dépression-flexibilité cognitive notamment l'amélioration des capacités adaptatives suite à la baisse du niveau de dépression. / This thesis is a contribution to the understanding of adaptive capacity of depressed and non-depressed aging adults. To achieve this goal we have used an experimental method and a clinical observation: a six-year longitudinal case study. The relationship between depression and cognitive flexibility is assessed by means of shifting and fluency tasks applied to two groups of non-dement depressed and non-depressed elderly who reside in nursing institutions.The quantitative and qualitative analysis shows a decrease in cognitive flexibility which highlights a negative correlation between depression and flexibility scores. We establish an analogy between daily adaptive behaviours and quantitative data, and we propose a theoretical mechanism that explains the adaptive behaviour of the elderly. Our case study offers a deeper understanding of the relationship between depression and cognitive flexibility, particularly the improvements of adaptive capacities due to a decrease of depression.

Temporary Work Agencies (TWAs) are an example of a trend towards flexibility in the labour market. By hiring staff from TWAs organisations can keep their staff numbers down. This however, refers to the client companies´ use or temps, and omits the intermediary, the TWA, which also needs various flexibility strategies in its activities. The main purpose of this thesis is to study the organising of TWAs supply of manpower to different clients companies, and how managers and temps experience their terms of employment, working conditions and relationships with regular employees at the client companies. Two qualitative case studies were conducted. In study one, interviews have been carried out with managers and temps in a TWA and a client company in Jämtland. In the second study, managers and temps in an international TWA in Sweden were interviewed. The results show that both managers and temps work under complex conditions and demands on flexibility. The managers shall, by flexible prioritising, satisfy demands from the TWA on profitability, demands from client companies´ for an adaptable workforce and temps need of employment and community. The results also indicate that temps have to balance between a position as stranger and outsider, and handle insecurity of the assignments duration and spatial location. They have to be able to manoeuvre between the power inequalities, stigmatisation and exclusion they encounter in working conditions and social interactions in client companies. To handle such situations the ideal temp and manager have to be able to vary between distance and nearness in spatiality and indifference and involvement in social relations.

Affärssystem har blivit allt vanligare i organisationer och framhålls av systemleverantörer som ett verktyg för att öka organisationers flexibilitet. Forskning tyder dock på att affärssystem både kan öka och minska flexibiliteten för organisationer. Få empiriska studier har genomförts vad gäller affärssystems påverkan på organisationers flexibilitet och forskningen är splittrad vad gäller affärssystems påverkan på flexibiliteten för organisationer. Syftet med denna uppsats är att illustrera och förklara hur ett affärssystem påverkar flexibilitet i en organisation. För att besvara syftet skapas en analysmodell som syntetiserar tidigare forskning om flexibilitet med en organisatorisk förändringsmodell. En fallstudie utförs genom att anställda intervjuas på Posten Norden AB där affärssystemet SAP används. Uppsatsens undersökning, analys och slutsatser indikerar på att: (1) det arbetsflöde Postens affärssystem tillhandahåller är oflexibelt, (2) affärssystemet möjliggör flexibilitet i kommunikationen (3) affärssystemet hämmar flexibiliteten för vissa arbetsuppgifter på Posten, och (4) affärssystem har en komplex påverkan på flexibilitet i organisationer.

Syfte: Syftet med den här uppsatsen är att öka förståelsen för hur organisationer kan arbeta med flexibla arbetsformer. Vi vill belysa vilka konsekvenser som kan uppstå med flexibla arbetsformer och hur de påverkar organisationer. Vi önskar även att fylla gapet vi uppmärksammat i forskningen kring flexibla arbetsformer ur ett organisatoriskt perspektiv.      Metod: Uppsatsen är en kvalitativ studie med en induktiv ansats som behandlar fenomenet flexibla arbetsformer ur ett organisatoriskt perspektiv. Datainsamlingen för studien har skett genom sju kvalitativa intervjuer på Kalmar kommun.   Slutsats: Slutsatsen av studien har visat att organisationer arbetar med flexibla arbetsformer utifrån olika förutsättningar delvis i form av; tekniska förutsättningar, ständig förändring av arbetsmarknaden, konkurrens samt de anställdas förutsättningar. Genomförandet av studien har det även bidragit till att vi har kunnat identifiera både positiva och negativa konsekvenser som kan uppstå för organisationer som använder sig av flexibla arbetsformer. En positiv konsekvens som vi har kommit fram till är att organisationen blir en attraktiv arbetsgivare. En negativ konsekvens är att anställda kan ha en svårighet att balansera privatliv och arbetsliv, vilket i sin tur påverkar organisationen i form av sjukfrånvaro och produktionsbortfall.