Thesis (M.S.)--Oregon Graduate Center, 1983.

El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado. / The electronic structure, band structure and optical properties of compounds GaAs(1−x)Mx (M = Fe,Cu), for x=0.25, 0.75, and 1 are discussed via Full-potential linearized augmented plane wave calculations. An increase in absorption in the visible spectrum is observed for all compounds, which, however, is associated with an increasingly metallic character as the metal concentration increases, to the point that compound GaFe is an indirect degenerate semiconductor. The addition of Fe and Cu to the compound decreases its stability, as demonstrated by the formation enthalpies, which become progressively more positive as the content in As is decreased. The calculations were performed using both the PBE and PBEsol exchange correlation potentials and the TB-mBJ method was used to verify the band structure obtained. / Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica / Revisón por pares

Pagrindinis šio magistro baigiamojo darbo tikslas buvo apžvelgti kai kurių algoritmų ir jų kombinacijų pritaikymą daugiamačiams sekų šablonams analizuoti ir įgyvendinti algoritmą, gebantį tai atlikti. Buvo aprašyta FP-Tree medžio struktūra, kuri yra skirta kompaktiškai saugoti kritiniams (pvz., dažnai pasikartojantiems) duomenims, pateiktas FP-Growth algoritmas, galintis analizuoti tokią duomenų struktūrą ir rezultate pateikiantis visų dažnų elementų šablonų aibę. Pristatyta modifikuotų FP-Growth ir PrefixSpan algoritmų kombinacija – MD-PS-FPG algoritmas, pateikti kai kurių atliktų testavimų rezultatai, tolimesnių darbų pagrindiniai tikslai ir pan. / The main goal of this master final work was to present some of the algorithms and their combinations for the multidimensional sequence pattern mining and implement an algorithm, that is capable of doing that. FP-Tree, that is used to store critical (for example, often repeated) data, was described. FP-Growth algorithm, that can analyze FP-Tree structure and give frequent pattern set as a result, was presented. MD-PS-FPG algorithm – a combination of modified FP-Growth and PrefixSpan algorithms – was introduced. The results of some tests, further work objectives and other things were also presented.

Le suivi des flux calciques dans le cerveau de l’animal en mouvement nécessite de nouvellessondes. Nous utilisons la bioluminescence observée chez la méduse Aequorea victoria etimpliquant la protéine aequorine. Une fusion entre l’aequorine et la protéine fluorescente GFP(GA) permet d’obtenir un senseur calcique bioluminescent dont la stabilité et les propriétésspectrales sont adéquates pour de nombreuses applications. L’émission de bioluminescencepermet de suivre la propagation de l’information nerveuse de cellule en cellule, en temps réeldans des réseaux de neurones.Nous avons tout d’abord montré au moyen de construction de lignées transgéniques murinesque la protéine chimère GA peut être exprimée dans des microdomaines cellulaires pouranalyser l’activité neuronale. Nos résultats montrent pour la première fois qu’il est possibled’enregistrer in vivo et de manière non invasive dans l’animal en mouvement deschangements dans la concentration de calcium mitochondrial. Nous avons ensuite réalisé unciblage post synaptique du senseur par fusion à la protéine PSD95. Ce ciblage permet dedétecter l'entrée de calcium au niveau du récepteur NMDA.Parallèlement, nous avons cherché à améliorer les propriétés du senseur GA pour détécterl’activité calcique dans l’animal in toto. Nous identifié un nouvel analogue de lacoelenterazine conduisant à un décalage du spectre de bioluminescence de l’aequorine vers lerouge. Et par ailleurs, nous avons testé l’activité de l’aequorine en fusion avec diversesprotéines fluorescentes. Nous disposons avec ce travail de nouveaux senseurs bioluminescentspour le suivi de l’activité cérébrales dans des études comportementales. / Monitoring calcium fluxes in the brain of freely moving animals requires the development ofnew probes. We use the bioluminescence of the protein aequorin observed in the jellyfishAequorea victoria. A fusion between aequorin and GFP fluorescent protein (GA) provides abioluminescent calcium sensor whose stability and spectral properties are adequate for manyapplications. The emission of bioluminescence is suitable to track in real-time the propagationof nervous impulses from cell to cell in neural networks.We first showed by transgenic murine lines construction that the chimeric protein GA can beexpressed in cell microdomains to analyze neuronal activity. Our results show for the firsttime it is possible to record in vivo and non-invasively in the moving animal, changes in theconcentration of mitochondrial calcium. We then performed a post synaptic targeting of thesensor by fusion with the protein PSD95. This permits to detect the entry of calcium next tothe NMDA receptor.Meanwhile, we tried to improve the properties of the GA sensor to detect calcium activity inthe animal in toto and mor specifically through the skull. We identified a new analogue ofcoelenterazine leading to a shift in the spectrum of aequorin bioluminescence to red. We thentested the activity of aequorin fused with different fluorescent proteins. This leads to newbioluminescent sensors for monitoring the brain activity in behavioral studies.

International Telemetering Conference Proceedings / October 25-28, 1999 / Riviera Hotel and Convention Center, Las Vegas, Nevada / The CCSDS SCPS FP file transfer performance is compared with that of TCP/IP FTP in a simulated satellite channel environment. The comparison is made as a function of channel bit error rate and forward/return data rates. From these simulations, we see that both protocols work well when the channel error rate is low (below 10^-6) and the SCPS FP generally performs better when the error rate is higher. We also noticed a strong effect on the SCPS FP throughput as a function of forward transmission rate when running unbalanced channel tests.

DNA Microarrays are one of the latest breakthroughs in experimental molecular biology and have opened the possibility of creating datasets of molecular information to represent many systems of biological or clinical interest. Clustering techniques have been proven to be helpful to understand gene function, gene regulation, cellular processes, and subtypes of cells. Investigations show that more often than not, several genes contribute to a disease, which motivates researchers to identify a subset of genes whose expression levels are similar under a subset of conditions. Most of the subspace clustering models define similarity among different objects by distances over either all or only a subset of the dimensions. However, strong correlations may still exist among a set of objects, even if they are far apart from each other as measured by the distance functions. Many techniques, such as pCluster and zCluster, have been proposed to find subspace clusters with the coherence expression of a subset of genes on a subset of conditions. However, both of them contain the time-consuming steps, which are constructing gene-pair MDSs and distributing the gene information in each node of a prefix tree. Therefore, in this thesis, we propose a Large Itemset-Based Clustering (LISC) algorithm to improve the disadvantages of the pCluster and zCluster algorithms. First, we avoid to construct the gene-pair MDSs. We only construct the condition-pair MDSs to reduce the processing time. Second, we transform the task of mining the possible maximal gene sets into the mining problem of the large itemsets from the condition-pair MDSs. We make use of the concept of the large itemset which is used in mining association rules, where a large itemset is represented as a set of items appearing in a sufficient number of transactions. Since we are only interested in the subspace cluster with gene sets as large as possible, it is desirable to pay attention to those gene sets which have reasonably large support from the condition-pair MDSs. In other words, we want to find the large itemsets from the condition-pair MDSs; therefore, we obtain the gene set with respect to enough condition-pairs. In this step, we efficiently use the revised version of FP-tree structure, which has been shown to be one of the most efficient data structures for mining large itemsets, to find the large itemsets of gene sets from the condition-pair MDSs. Thus, we can avoid the complex distributing operation and reduce the search space dramatically by using the FP-tree structure. Finally, we develop an algorithm to construct the final clusters from the gene set and the condition--pair after searching the FP-tree. Since we are interested in the clusters which are large enough and not belong to any other clusters, we alternately combine or extend the gene sets and the condition sets to construct the interesting subspace clusters as large as possible. From our simulation results, we show that our proposed algorithm needs shorter processing time than those previous proposed algorithms, since they need to construct gene-pair MDSs.

Les nouvelles applications sur Internet nécessitent des garanties de qualité de service (QoS) de la part du réseau. Nous nous intéressons à deux paramètres de QoS : le temps de réponse et la gigue de bout-en-bout. Nous proposons un ordonnancement, noté FP/DP, à base de priorités fixes (FP), départageant les paquets ex aequo selon leurs priorités dynamiques (DP). La priorité fixe d'un flux reflète son degré d'importance et sa priorité dynamique est un paramètre temporel. FP/FIFO et FP/EDF sont deux exemples d'ordonnancement FP/DP. Nous déterminons des bornes déterministes sur les paramètres de QoS considérés, en utilisant l'approche par trajectoire. En monoprocesseur, nous améliorons les résultats existants et prouvons que FP/EDF domine FP/FIFO sous certaines conditions. En distribué, nous apportons de nouveaux résultats et montrons que l'approche par trajectoire est beaucoup moins pessimiste que l'approche holistique. Nos résultats sont appliqués dans une architecture DiffServ/MPLS.

Le glaucome est défini par une dégénérescence du nerf optique dont le principal facteur de risque est l’hypertension oculaire due à des altérations du tissu trabéculaire. Les traitements incluent des agonistes du récepteur FP, les agonistes du récepteur EP2 pouvant également avoir des effets bénéfiques.Au cours de cette thèse, un modèle de cellules trabéculaires primaires humaines a été défini et les effets du latanoprost, un agoniste FP, et du butaprost, un agoniste EP2, ont été étudiés, d'une part, sur la survie des cellules trabéculaires, et d’autre part, sur la transition myofibroblastique. Il a été montré que l’activation du récepteur EP2 permet de protéger les cellules trabéculaires d’un stress du réticulum endoplasmique par une diminution de l’accumulation de p53 qui résulte en l’inhibition de l’expression de Puma. Enfin, le butaprost entraîne l’augmentation de l’expression de Bcl-2 et la phosphorylation de Bad qui participent à l’inhibition de l’apoptose.D’autre part, le latanoprost induit une contraction des cellules trabéculaires tandis que le butaprost inhibe la contraction induite par le TGF-B2. En revanche, les deux agonistes inhibent la déposition du collagène.En conclusion, indépendamment de leur effet hypotenseur connu, le latanoprost favoriserait l’acquisition par les cellules trabéculaires d’un phénotype contractile et l’activation du récepteur EP2 pourrait limiter le développement de la dysfonction trabéculaire en protégeant de la mort cellulaire et en favorisant une relaxation. Ces résultats suggèrent que la stimulation du récepteur EP2 pourrait limiter le développement du glaucome et serait plus favorable que les agonistes du récepteur FP. / Glaucoma is defined as an optic neuropathy whose main risk factor is ocular hypertension due to alterations of the trabecular meshwork (TM). The first-line therapies for glaucoma are agonists of the FP receptor. Agonists of the EP2 receptor could also present beneficial effects.During the thesis project, a model of primary human TM cells has been defined and the effects of latanoprost, an FP agonist, and butaprost, an EP2 agonist, have been studied on, firstly, the survival of TM cells and, secondly, on the myofibroblast transition.We have shown that activation of the EP2 receptor protects TM cells from an endoplasmic reticulum stress by a decreased accumulation of p53 which results in the inhibition of Puma transcription. Finally, butaprost mediates an increased expression of Bcl-2 and an elevation of Bad phosphorylation which contribute to protection against TM cell death.Moreover, latanoprost induces TM cell contraction while butaprost inhibits TGF-B2-dependent contraction. On the other hand, both agonists inhibit collagen.In conclusion, independently of their hypotensive effects, latanoprost would favor the acquisition by TM cells of a contractile phenotype while stimulation of EP2 receptor could limit TM dysfunction by protecting against TM cell death and relaxing the tissue. These results suggest that activation of EP2 receptor could slow down or inhibit the course of glaucoma progression and would be more favorable than the FP agonists currently used.

Frequent-pattern mining from databases has been widely studied and frequently observed. Unfortunately, these algorithms are not suitable for data stream processing. In frequent-pattern mining from data streams, it is important to manage sets of items and also their history. There are several reasons for this; it is not just the history of frequent items, but also the history of potentially frequent sets that can become frequent later. This requires more memory and computational power. This thesis describes two algorithms: Lossy Counting and FP-stream. An effective implementation of these algorithms in C# is an integral part of this thesis. In addition, the two algorithms have been compared.

Syfte: Sambandet mellan Corporate Social Responsibility (CSR) och Financial Performance (FP) är väl studerat liksom sambandet mellan FP och ägarkoncentration, dock är resultaten motstridiga. Få studier har tagit alla dessa dimensioner med FP, ägarkoncentration och CSR i beaktning. Denna studie syftar därmed till att förklara hur ägarkoncentrationen i europeiska företag påverkar sambandet mellan CSR och FP. Metod: Denna studie antar ett deduktivt tillvägagångssätt inom den positivistiska forskningstraditionen. Studien är baserad på 169 börsnoterade bolag från Europa sett över åren 2009–2017. Materialet har samlats in via databasen Thomson Reuters Datastream och har sedan analyserats i IBM SPSS (Statistical Package for Social Sciences). Resultat och slutsats: Studiens resultat återspeglar att företag i Europa agerar på en marknad med en hög ägarkoncentration där de lägger mycket resurser på CSR vilket förbättrar deras FP. Slutsatsen som kan dras är dock att ju högre ägarkoncentrationen är desto större risk är det att det positiva sambandet mellan CSR och FP försvagas. Examensarbetets bidrag: Denna studie lämnar ett unikt bidrag då det är den enda studien som undersöker ägarkoncentrationens påverkan på CSR och FP över flera olika länder och branscher. Det ökade intresset kring CSR och den lagstiftning som finns sedan 2014 kan skapa agentproblem som förvärras när ägarkoncentrationen är hög. Denna studie ämnar ge praktiska bidrag till företag och organisationer i Europa, genom att uppmärksamma denna agentproblematik som försvårar arbetet med CSR och i värsta fall kan orsaka en försämrad FP. Förslag till fortsatt forskning: Studien lämnar som förslag till kommande studier att använda ett annat mått på ägarkoncentration för att se om det kan ha en annan inverkan på resultaten av studien. Ett annat förslag är att mäta alla dimensioner av CSR separat för att tydliggöra om någon variabel inom CSR påverkar FP mer än någon annan. Som ett sista förslag kan studiens kombinerade FP-mått användas parallellt med lönsamhetsmåttet Tobins Q för att verifiera resultatet. / Aim: The relationship between Corporate Social Responsibility (CSR) and Financial Performance (FP) has been studied by many scientists, as well as the relationship between FP and ownership concentration but the results have been conflicting. Few studies have been done regarding all these dimensions on which influence ownership concentration has on CSR and FP, therefore this study aims to explain how the ownership concentration in European public companies affect the relationship between CSR and FP. Method: This study has a deductive approach within the positivist research tradition. The study is based on 169 listed companies from Europe over the years 2009-2017. The data has been collected through the database Thomson Reuters Datastream and analyzed through IBM SPSS (Statistical Package for Social Sciences). Result & Conclusions: The result of this study reflect that companies in Europe act in a market with a high ownership concentration where they spend a lot of resources on CSR, which improves their FP. This can be deduced from the conclusion; a higher ownership concentration weakens the positive relationship between CSR and FP. Contribution of the thesis: This study provides a unique contribution as it is the only study that investigates the impact of ownership concentration on CSR and FP across several countries and industries. The increased interest in CSR and the legislation that exists since 2014 can create agent problems that get worse when the owner concentration is high. This study intends to provide practical contributions to companies and organizations in Europe, where they observe this agent problem that complicates the work of CSR and, in the worst-case scenario, may cause a deterioration in the FP. Suggestions for future research: Further studies may use a different dimension of ownership concentration to see if it can have a different impact on the results of the study. Another proposal is to measure all dimensions of CSR separately to clarify whether any variable within CSR affects FP more than anyone else. As a final proposal, the study's combined FP measure can be used in parallel with the profitability measure Tobins Q to verify the result.