Thesis (MBA (Business Management))--University of Stellenbosch, 2008. / ENGLISH SUMMARY: During the period of change in South Africa in the year of the first democratic elections, 1994, the first King Report on Corporate Governance appeared. For the first time in South Africa, companies had a good reference for corporate practice and conduct. A second King report, commonly referred to as King II, appeared in March 2002 and expanded on the earlier Code to produce, what was considered at the time to be, a world-class code of corporate governance. In addition to the acceptance and incorporation of King II into corporate governance practice, the JSE included compliance with the King Code as part of its listing requirements. The code itself is not an enforceable set of rules, but rather guidelines to assist companies in implementing principles of good governance. In similar vein, the JSE has given companies the flexibility to justify non-compliance. This underscores the socalled comply or explain philosophy to which corporate governance in South Africa subscribes. Studies have found the level of corporate governance in South Africa to be high, especially for an emerging market. Compliance with corporate governance principles and transparency go hand in hand. In a comply or explain regime, where the regulation is considered to be done by the market, disclosure of compliance is especially important. The goal of this research project was to conduct a survey of the top listed South African companies to ascertain what the level of disclosure of corporate governance was, with specific reference to the recommendations contained in the King Code. For the purposes of this study, the top companies were defined as the FTSE/JSE Top 40 Index companies. The supposition was that most companies, having been confronted with the King Code for almost six years, would be compliant to a large degree and will disclose their compliance. This was expected to be more evident amongst top companies who have the resources and influence to effect changes sooner and take the lead on high profile issues. The study confirmed the supposition that companies, at least in the sample, were highly compliant. There were however some areas where improvements can be made to be more in line with global best practices. / AFRIKAANSE OPSOMMING: Gedurende die periode van vernuwing in Suid-Afrika en die jaar van die eerste demokratiese verkiesing, 1994, het die eerste King verslag op korporatiewe bestuur verskyn. Vir die eerste keer het maatskappye in Suid-Afrika ‘n goeie verwysing gehad in die bepaling van hul korporatiewe bestuurspraktyke en gedrag. ‘n Tweede King verslag, alombekend as King II, het in Maart 2002 verskyn en op die eerste verslag uitgebou om ‘n kode te voorskyn te bring wat ten tyde van publisering as wêreldklas bestempel is. Bo en behalwe die aanvaarding en toepassing van King II in die korporatiewe bestuurspraktyk, het die JSE ook nakoming van die Kode as deel van die noterings vereistes ingesluit. Die King Kode opsigself is nie ‘n afdwingbare stel reëls nie, maar eerder riglyne wat maatskappy bystaan in die implementering van beginsels van goeie bestuur. In ‘n soortgelyke manier gee die JSE ook aan maatskappye die buigsaamheid om gevalle van nie-nakoming te regverdig en verdedig. Dit onderskryf die sogenaamde voldoen of verduidelik filosofie wat korporatiewe bestuur in Suid Afrika aan gehoor gee. Studies het gevind dat die vlak van korporatiewe bestuursgedrag in Suid-Afrika hoog is, veral vir ‘n ontluikende mark. Nakoming met korporatiewe bestuurgedragskodes en deursigtigheid gaan hand aan hand. In ‘n voldoen of verduidelik regime, waar die mark geag word om te reguleer, is openbaarmaking van korporatiewe bestuursgedrag van kardinale belang. Die doel van hierdie navorsingsprojek was om ‘n peiling te maak van die voorste Suid-Afrikaanse maatskappye om te bepaal wat die vlak van openbaarmaking in terme van korporatiewe bestuursgedrag was, met spesifieke verwysing na die King Kode. Vir die doeleindes van die studie is die voorste maatskappye gedefiniëer as die FTSE/JSE Top 40 Indeks. Die veronderstelling was dat meeste maatskappye, gegewe die feit dat die Kode al ses jaar in omgang is, tot ‘n groot mate aan die Kode sal voldoen en inligting rakende die voldoening openbaar maak. Dit is ook verwag dat dit veral die geval onder die voorste maatskappye sou wees aangesien hulle oor die hulpbronne en invloed beskik om veranderinge vroeër teweeg te bring en leierskap te neem met hoë profiel kwesssies. Die studie het die veronderstelling korrek bewys dat maatskappye, ten minste in die geval van die ingeslote groep, ‘n hoë vlak van voldoening en openbaarmaking ten toon stel. Daar is egter nogtans areas waar verbeterings gedoen kan word om meer in lyn met internasionale beste praktyke te kom.

Abstract in Zulu, English and Afrikaans / This study examined the consequences of Principal-Agent and Corporate Governance interactions within South Africa’s FTSE/JSE Top40 listed companies from 2008 to 2016. The study’s objectives were to examine the prevalence of Principal-Agent and Corporate Governance problems, to ascertain potential costs of these problems, to establish their socio-economic consequences, and evaluate the effectiveness of the governance codes. The study is anchored in Principal-Agent theory. Mixed methods methodology was employed, specifically Concurrent and Exploratory Sequential Mixed Methods design logics. The main findings include that, 23.91% of sample companies experienced Principal-Agent and Corporate Governance problems- significantly exceeding the study’s expectations that negligible governance problems exist and reveals the pervasiveness of these problems; executive compensation plays a bigger role in exacerbating Principal-Agent and Corporate Governance problems than expected and often considered in governance mechanisms; multi-billion rands potential costs are ascribed to Principal-Agent and Corporate Governance problems incurred by principals; unjustifiable salary inequalities resulting in other inequalities that build social mistrust; and there is limited conviction that current governance codes are effective. This study’s contributions include; proposing an executive remuneration model that considers governance of the company in determining executive compensation; formulating a governance index calculated based on King III and King IV recommendations to standardise the measurement of the quality of governance in companies; the salary Gini was used to establish compensation gaps and red-flag potential Principal-Agent problems and flaws in governance systems; and used value at risk procedures to quantify potential Principal-Agent and Corporate Governance costs. The main theoretical implications of the study’s findings are; agency theory needs extension to capture socio-economic costs and not only focus on the principal; remuneration models should consider the executive’s company governance and social and economic egalitarianism; flexibility of ‘comply or explain’ should subordinate socio-economic consequences, suggesting a hybrid approach which makes certain governance code provisions compulsory; and finally, behavioural finance theories should be used in governance research for better insights. / Lolu cwaningo lwacubungula futhi lwahlolisisa imiphumela yokuxhumana phakathi kwesimo seNhloko ne-Ejenti, i-Principal-Agent, (lapho umuntu eqoka omunye ukuba athathe izinqumo kanye/noma izinyathelo egameni lakhe) nokuPhathwa nokuLawulwa Kwenkampani, ezinkampanini ezingama-40 ebezikleliswe phezulu ohlwini lwe-FTSE/JSE eNingizimu Afrika kusukela ngowezi-2008 kuya kowezi-2016. Izinhloso zalolu cwaningo kwabe kuwukubheka ukuthi zivamise kangakanani futhi zisabalele kangakanani izinkinga eziphathelene neNhloko ne-Ejenti kanye nokuPhathwa Nokulawulwa Kwenkampani ukuze kutholakale ukuthi zingakanani izindleko ezibangelwa yilezi zinkinga, nokuthola umthelela walokhu kwinhlalomnotho, kanye nokuhlola ukuthi zisebenza kahle kangakanani izinkambiso zokuphathwa nokulawulwa kwezinkampani. Lolu cwaningo lwakhelwe phezu kwethiyori yeNhloko ne-Ejenti. Kwasetshenziswa izindlela zocwaningo ezixubile, ikakhulukazi izindlela ezixubile zokuhlola kusetshenziswa izinyathelo ezenziwa kanyekanye noma ngesikhathi esisodwa kanye nezinyathelo ezilandelanayo. Okusemqoka okwatholakala ocwaningweni kubandakanya nokuthi izinkampani okwenziwa kuzona ucwaningo ezingama-23.91% zahlangabezana nezinkinga eziphathelene neNhloko ne-Ejenti kanye nokuPhathwa Nokulawulwa Kwenkampani – okuyinani elingaphezulu kakhulu kwalokho obekulindelekile ocwaningweni, ngoba phela kwakulindeleke ukuthi zibe yingcosana kakhulu izinkinga ezikhona eziphathelene nalokhu, kepha-ke ucwaningo lwaveza ukuthi lezi zinkinga zixhaphakile impela; imiholo yabaphathi abakhulu bezinkampani idlala indima enkulu ekubhebhethekiseni izinkinga eziphathelene neNhloko ne-Ejenti kanye nokuPhathwa Nokulawulwa Kwenkampani kunalokho obekulindelekile futhi esikhathini esiningi lokhu akuyona neze into evamise ukubhekisiswa uma kwenziwa izinqubo zokuphatha nokulawula; zibalelwa kwizigidigidi zamarandi izindleko ezingena kuzona izinhloko zezinkampani okucatshangwa ukuthi zibangelwa yizinkinga eziphathelene neNhloko ne-Ejenti kanye nokuPhathwa Nokulawulwa Kwenkampani; ukungalingani ngokwemiholo, ngaphandle kwesizathu esizwakalayo salokhu, okuyinto eholela kokunye futhi ukungalingani, okudala ukungathembani emphakathini; futhi kuncane kakhulu ukuqiniseka nokukholelwa ekutheni zisebenza kahle izinkambiso zokuphatha nokulawula ezikhona njengamanje. Igalelo lalolu cwaningo libandakanya isiphakamiso semodeli yemiholo yabaphathi abakhulu ebhekisisa nodaba lokuphathwa nokulawulwa kwenkampani ngenkathi kucutshungulwa udaba lwemiholo yabaphathi abakhulu; ukuhlanganiswa kwenkomba yokuphathwa nokulawulwa kwenkampani ebalwa ngokususela kwizincomo ze-King III kanye ne-King IV zokusetshenziswa kwesikali esifanayo sokukala ikhwalithi yokuphathwa nokulawulwa kwezinkampani; isikali semiholo se-Gini sasetshenziswa ukuhlonza amagebe akhona phakathi kwemiholo kanye nokuxwayisa ngezinkinga ezingahle zivele eziphathelene neNhloko ne-Ejenti kanye nokuPhathwa Nokulawulwa Kwenkampani kanye namaphutha nobuthakathaka obukhona ezinhlelweni zokuphatha nokulawula; futhi kwasetshenziswa izinqubo zezikali zobungozi bokulahlekelwa kwenkampani ukubala inani lezindleko okungenzeka kungenwe kuzona ngenxa yezinkinga eziphathelene neNhloko ne-Ejenti kanye nokuPhathwa Nokulawulwa Kwenkampani. Imibonongqangi evele kulokho okutholakale ocwaningweni yilena elandelayo; ithiyori echaza ubudlelwano phakathi kwenhloko ne-ejenti kumele yelulwe ukuze ifake phakathi nezindleko eziphathelene nenhlalomnotho futhi lokhu kungagcini nje kuphela kwinhloko; amamodeli omholo kumele abhekisise nendlela ephethwe ngayo inkampani ngabaphathi abakhulu kanye nemfundiso yokulingana kwabantu bonke ngokwenhlalo nangokomnotho; ukuguquguquka ‘kokuthobela umthetho noma ukuchaza’ (‘comply or explain’) kumele kube ngaphansi uma kuqhathaniswa nemiphumela yenhlalomnotho, ukuze kuqhanyukwe nendlela exubile ephoqelela ukusetshenziswa kwezinkambiso zokuphatha nokulawula ezithile; kanti futhi, okokugcina, ocwaningweni lokuphatha nokulawula kumele kusetshenziswe amathiyori aphathelene nesimo somqondo sabaphathi ngenkathi bethatha izinqumo nezinyathelo eziphathelene nokuphathwa nokusetshenziswa kwezimali ukuze kuqondakale kangcono konke okuphathelene nalokhu. / Hierdie studie het van 2008 tot 2016 die gevolge van die wisselwerking tussen hoofagent- en korporatiewe regering in Suid-Afrikaanse FTSE/JSE Top 40- genoteerde maatskappye bestudeer. Die oogmerke was om die voorkoms van probleme met hoofagent- en korporatiewe regering te ondersoek; die moontlike koste en die sosio-ekonomiese gevolge daarvan te bepaal; en die doeltreffendheid van die regeerkodes te evalueer. Hierdie studie berus op die hoofagentteorie. Gemengde metodes is as metodologie gebruik, in die besonder gelyklopende en verkennende, opeenvolgende metodes. Die belangrikste bevindings is dat 23,91% van steekproefmaatskappye probleme met hoofagent- en korporatiewe regering ondervind. Dit is beduidend hoër as die persentasie wat verwag is, en ʼn aanduiding van hoe diepgaande hierdie probleme is. Die vergoeding van uitvoerende beamptes is ʼn groter oorsaak van die probleme met hoofagent- en korporatiewe regering as wat verwag is en waarvoor in regeermeganismes voorsiening gemaak word. Die potensiële koste, wat miljarde rande beloop, word gewyt aan die probleme met hoofagent- en korporatiewe regering wat prinsipale hulle op die hals haal. Onregverdigbare salarisverskille lei tot ongelykheid wat sosiale wantroue wek. Hierbenewens is daar bedenkinge oor die doeltreffendheid van die huidige regeerkodes. Die bydrae van hierdie studie behels ʼn vergoedingsmodel vir uitvoerende beamptes wat korporatiewe regering in ag neem. Hierdie studie formuleer ʼn regeerindeks wat op King III- en King IV-aanbevelings berus, en die meting van die gehalte van korporatiewe regering standaardiseer. Verskille in vergoeding, potensiële rooivlag-hoofagentprobleme en gebreke in regeerstelsels is met behulp van die salaris-gini bepaal. Waarde-op-risikoprosedures is gebruik om die potensiële koste van hoofagent- en korporatiewe regering te kwantifiseer. Die belangrikste teoretiese implikasie van die bevindings is dat die agentskapsteorie uitgebrei moet word sodat die sosio-ekonomiese koste vasgestel word, en daar nie alleen op die hoofsom gekonsentreer word nie. Afgesien hiervan moet vergoedingsmodelle rekening hou met ʼn uitvoerende beampte se korporatiewe regering en met maatskaplike en ekonomiese egalitarisme. Voorts moet die sosio-ekonomiese gevolge ondergeskik wees aan die buigsaamheid van “voldoen of verduidelik”. Dit impliseer ʼn hibridiese benadering wat die bepalings van sekere regeerkodes verpligtend maak. Ten slotte behoort finansieringsgedragteorieë in regeernavorsing aangewend te word om groter insig te verkry. / Business Management / D. Phil. (Management Studies (Finance))

The Mycobacterium genus contains major human pathogens, like Mycobacterium tuberculosis and Mycobacterium leprae, which are the causative agents of Tuberculosis and Leprosy, respectively. They have evolved as successful human pathogens by adapting to the adverse conditions prevailing inside the host, which include host immune activation, nutrient depletion, hypoxia, and so on. During such adaptation for the survival and establishment of persistent infection inside the host, the pathogen, like M. tuberculosis, regulates its cell division. It is known that M. tuberculosis enters a state of non-replicating persistence (NRP) inside the host, to establish latent infection, which helps the survival of the pathogen under adverse host conditions such as hypoxia and nutrient depletion. The pathogen can reactivate itself, to come out of the NRP state, and establish active infection at a later stage, when conditions are suitable for its proliferation. The altered physiological state of the latent bacterium makes it tolerant to drugs, which are only effective against proliferating tubercle bacilli. In view of this unique behavioural physiology of tubercle bacilli, it is important to study the process of cell division and how it is regulated in the NRP and actively growing states. The work reported in the thesis is an attempt to understand these aspects of mycobacterial cell division. iii Chapter 1. Introduction: This chapter gives a detailed introduction to bacterial cell division and its regulation in various organisms, like Escherichia coli, Bacillus subtilis, Caulobacter crescentus, and others. In the background of this information, the major studies on mycobacterial cell division and its regulation are presented. Chapter 2. Materials and Methods: This chapter describes in detail all the materials and methods used in the experiments, which are presented in the four data chapters, 3-6. Chapter 3. Ultrastructural Study of the Formation of Septal Partition and Constriction in Mycobacteria and Delineation of its Unique Features: Mycobacteria have triple-layered complex cell wall, playing an important role in its survival under adverse conditions in the host. It is not known how these layers in the mother cell participate during cell division. Therefore, the ultrastructural changes in the different envelope layers of Mycobacterium tuberculosis, Mycobacterium smegmatis, and Mycobacterium xenopi, during the process of septation and septal constriction, were studied, using Transmission and Scanning Electron Microscopy. The unique aspects of mycobacterial septation and constriction were identified and were compared with those of E. coli and Bacillus subtilis septation. Further, based on all these observations, models were proposed for septation in M. tuberculosis and M. smegmatis. Chapter 4. Identification of Asymmetric Septation and Division in Mycobacteria and Its Role in Generating Cell Size Heterogeneity: Bacterial populations are known to harbour phenotypic heterogeneity that helps survival under stress conditions, as this heterogeneity comprises subpopulations that have differential susceptibility to stress conditions. The iv heterogeneity has been known to lead to the requirement for prolonged drug treatment for the elimination of the tolerant subpopulation. Hence, it is important to study the different mechanisms, which operate to generate population heterogeneity. Therefore, in this chapter, studies were carried out to find out whether asymmetric septation and division occur in mycobacteria to generate cell size heterogeneity. Subpopulations of mycobacterial mid-log phase cells of M. tuberculosis, M. smegmatis, and M. xenopi were found to undergo asymmetric division to generate cell size heterogeneity. The asymmetric division and the ultrastructure and growth features of the products of the division were studied. Chapter 5. Study of Mycobacterial Cell Division Using Growth-Synchronised Cells: In this chapter, different stages of cell septation and constriction were studied using growth-synchronised M. smegmatis cells. Phenethyl alcohol (PEA), which has been found to reversibly arrest mycobacterial cells, was used for growth synchronisation. The growth-synchronised mycobacterial cells, which were released from PEA block, were studied at different stages of septation and septal constriction, at the ultrastructural and molecular levels. Chapter 6. Identification of the Stage of Cell Division Arrest in NRP Mycobacteria: The exact stage at which the NRP tubercle bacilli are arrested in cell division is currently unknown. In Wayne’s in vitro model for hypoxia-responsive tubercle bacilli, gradual depletion of oxygen leads to hypoxic stress, inducing the bacilli to enter non-replicating persistence (NRP) state. Using this model, the stage of cell division arrest in M. tuberculosis was characterised at the ultrastructural and molecular levels. Hypoxia-stressed M. smegmatis was used as an experimental system for contrast. The thesis concludes with salient findings, a bibliography, and the list of publications.