This diploma thesis focuses on the topic of feasibility studies. The first-theoretical part defines basic concepts such as market analysis, financial analysis or efficiency and risk assessment. The aim of the practical part of the work is to develop a feasibility study, evaluation of economic viability and thus the feasibility of the project. An integral part is the evaluation of welding methods of the steel frame of the motorcycle and its subsequent implementation.

The aim of my work is to analyse the market with the residential estates in Brno and its surroundings. To check all the factors and impacts that influence outside and inside of the neighbourhood of the residential housing living and their mutual connections. To describe the strong and weak points, future threats, the facilities in residential areas and to establish the main advantages. To evaluate the feasibility in present conditions on the base of my anlysis and to suggest a suitable solution for the residential dwelling improvement.

Noninvasive brain-computer interfaces (BCIs) use scalp-recorded electrical activity from the brain to control an application. Over the past 20 years, research demonstrating that BCIs can provide communication and control to individuals with severe motor impairment has increased almost exponentially. Although considerable effort has been dedicated to offline analysis for improving signal detection and translation, far less effort has been made to conduct online studies with target populations. Thus, there remains a great need for both long-term and translational BCI studies that include individuals with disabilities in their own homes. Completing these studies is the only sure means to answer questions about BCI utility and reliability. Here we suggest an algorithm for candidate selection for electroencephalographic (EEG)-based BCI home studies. This algorithm takes into account BCI end-users and their environment and should assist in study design and substantially improve subject retention rates, thereby improving the overall efficacy of BCI home studies. It is the result of a workshop at the Fifth International BCI Meeting that allowed us to leverage the expertise of multiple research laboratories and people from multiple backgrounds in BCI research.

The presence of pollutants known as emerging contaminants in water and wastewater is a topic of growing interest. Emerging contaminants, which include endocrine disrupting chemicals (EDCs) and pharmaceutical and personal care products (PPCPs), are compounds that remain relatively unknown, although their adverse effects have been proven. Emerging contaminants are not satisfactorily removed by traditional treatment methods; therefore, there is a need for innovative techniques. Advanced oxidation processes (AOPs) have been recognized as successful removal methods for these problematic pollutants. However, technical success is not the only factor that must be considered. Process engineering, environmental, and economic and social parameters were considered. A holistic analysis was completed using a ranking system to determine the performance of several AOPs (ozonation, UV, photocatalysis, the Fenton reaction, and integrated processes). Ultimately, H2O2/O3 presented the highest average ranking (3.45), with the other processes showing similar performance, with the exception of TiO2 photocatalysis (2.11).

Pilot studies, a subset of feasibility studies, are essential in determining the feasibility of a larger study. This is especially true when targeting populations that are difficult to recruit, such as people with HIV. Designing high quality pilot studies can help limit waste by informing researchers how to proceed. We conducted a meta-epidemiological review of pilot studies in the HIV literature published until November 25, 2020 using Medline, Embase and Cochrane Controlled Register of Trials (CENTRAL). We extracted bibliometric information, including the region and income of the country where the study was conducted, study design, using the pilot label, source of funding, nature of intervention, whether feasibility was the primary objective, progression criteria, protocol registration and sample size estimation. We used descriptive analysis to evaluate how pilot studies are designed and conducted, the outcomes assessed and how are they defined. Our search retrieved 10,597 studies, of which 248 were included in our final review. The number of pilot studies has increased with time, with 25, 55, and 44 HIV studies published in 2018, 2019, and 2020, respectively. We found that 128 studies (70.39%) used the pilot or feasibility labels in their title, however 20.31% used these titles interchangeably. 5 studies in this review included progression criteria, all of which were published in 2020. Sample size estimation was only found in 59 studies (23.9%). Pilot studies in the HIV literature are mislabeled. Sample size estimations are seldom included, and progression criteria are used. Formal guidance on the design and reporting of pilot studies in the HIV literature is necessary. / Thesis / Master of Science (MSc) / Pilot studies are important in evaluating whether planned larger studies can be conducted. They are particularly useful in the field of HIV where participants may be hard to identify and recruit. However, there are few instructions on how pilot studies in HIV should be designed. We searched the literature to see the current state of HIV pilot studies, including how they are designed, and their findings reported. We found that pilot studies are becoming more popular in the HIV field. However, there were gaps in how these studies are designed and reported. Studies were often mislabeled as pilots when they were not, the pilot study criteria were applied inconsistently and the outcomes that were evaluated were often poorly defined and their information poorly presented. Pilot studies in HIV can be reported better.

The current energy context is characterized by the absolute necessity to reduce carbon emissions in order to tackle climate change and avoid its bleakest consequences. Furthermore, the overall energy supply system presents plentiful inefficiencies that lead to outrageous waste of energy.                 Spain's energy outlook is also marked by its astonishingly high energy dependence, which has contributed to its secular deficit in the trade balance.                 District heating systems permit to cover the heat demand from the residential, service and some components of the industrial sector utilizing excess heat that otherwise would be wasted, thus, reducing the total primary energy demand. In addition, they ease the development of renewables and enable a a reduction of greenhouse emissions and other hazardous gases.                 Despite its their advantages towards the fulfilment of climate change goals and the improvement of the country's economic situation,  they they only represent an insignificant contribution to Spain's heat demand. The main target of this dissertation has been to determine the economic feasibility of regarding the development of a district heating system in the Spanish city of Gijón.                 The city of Gijón counts on several parameters that allow the development of a centralized supply, such as several sources of excess heat and a high population density with little urban sprawl. However, other circumstances such as the low specific heat demands endanger the success of these systems.                 The first step towards the determination of the economic feasibility has been to assess the heat demands of the different subsectors that comprise the building stock. Particular care has been taken in order to attain the most realistic figures to supplement lack of official statistics with other sources. Furthermore, the final results have been compared to other independent evaluations, allowing to determine its accuracy.                 Following the calculation of heat demands, the attention is focussed on the estimation of the costs of the different elements that entail the construction and operation of a district heating system; the construction and maintenance of the distribution network, the heat supply, and the interface between the distribution network and the customer's systems, the substations. The assessment of these expenses has endeavoured to be rather conservative.                 The estimation of the specific cost of heat for the district heating system and its contrast with current forms of heat supply has allowed drawing the conclusion that the new network would be economically competitive despite the conservative assumptions taken. In addition, the system would practically eliminate the emissions of carbon dioxide and nitrogen oxides from the building stock.                 Finally, the viability of the system to changes in certain key parameters has been evaluated. Overall, the system's economic performance is not jeopardized by different configurations and solely two factors, the cost of capital and the connection rate could put at risk the success of the undertaking.

FAKULTA TĚLESNÉ VÝCHOVY A SPORTU UNIVERZITY KARLOVY V PRAZE DIPLOMOVÁ PRÁCE NA TÉMA Technickoekonomická studie sportovně - regeneračního centra VEDOUCÍ PRÁCE: ZPRACOVAL: Doc. Ing. Eva Čáslavová, Csc. Matěj Kaplan Prohlašuji, že jsem diplomovou práci vypracoval samostatně a použil pouze uvedené zdroje. _______________________ Matěj Kaplan Děkuji paní Doc. Ing. Čáslavové, Csc. za praktické a teoretické rady vztahující se k diplomové práci. Abstrakt Diplomová práce na téma Technickoekonomická studie sportovně - regeneračního centra navrhuje investiční projekt ve formě technickoekonomické studie pro zřízení a provoz sportovně - regeneračních služeb v Roztokách u Prahy. Obsah technickoekonomické studie tvoří marketingová strategie, geografická strategie, lidské zdroje, materiálové vstupy a energie, organizace a řízení, finanční plán a analýza a analýza rizik. Klíčová slova: Technickoekonomická studie, finanční analýza, rizikovost projektu. Abstract The thesis on subject of Feasibility study of sport&regeneration centre is showing the investment project in form of feasibility study for development and running of the sport&regeneration facilities in Roztoky u Prahy. The feasibility study is made of marketing strategy, geographical strategy, human resources, costs of material and energy bills, organisation and...

This diploma paper deals with rural tourism and its potential in the region of Prešov, Slovakia. This region is not very industrially developed however it is rich in natural and cultural-historical rarities. The paper also studies interest of potential visitors- families with children to spend their holiday in a countryside. Feasibility study offers a general view over the rural tourism establishment, its marketing, human ressource management, analysis of its finance and its impact on the environment.

La logistique urbaine, considérée comme la dernière étape de la supply chain, recouvre toute prestation concourant à une gestion optimisée des flux de marchandises en milieu urbain. Le transport de marchandises a des effets négatifs importants dans les zones urbaines en termes de congestion, d'émissions nocives et de consommation d'espace. Pour atténuer ces effets, une collaboration entre les différents acteurs de la logistique urbaine a souvent été initiée dans de nombreuses villes. La collaboration dans les projets de logistique urbaine est difficile, elle nécessite de réunir de nombreuse parties prenantes dont les intérêts sont souvent divergents. Ces dernières années, la mutualisation logistique est apparue comme une stratégie qui mène à une collaboration systématique entre acteurs. Cependant, elle a peu été étudiée dans le contexte urbain L’objectif de cette thèse est de proposer une réflexion sur la conception d’une logistique urbaine innovante grâce à la mutualisation. Pour cela, nous avons effectué un état de l’art systématique afin d’identifier les différents champs de la logistique urbaine. Selon les résultats de cette revue de la littérature, nous avons constaté une absence d'analyse sur les aspects opérationnels de la mutualisation. Afin de remédier à ce manque, nous avons proposé un cadre général qui aide à identifier toutes les mesures nécessaires en vue d'une mutualisation efficace. Nous avons développé un nouveau concept, appelé « typologie des flux » permettant d’analyser différentes possibilités de mutualisation en logistique urbaine et ensuite d’identifier les contraintes potentielles liées à la mutualisation. Nous avons quantifié les effets de ces contraintes sur l'efficacité de la mutualisation utilisant un cas réel issu de la littérature. Enfin, nous avons mobilisé notre typologie des flux et les résultats de notre analyses expérimentales afin de classifier les facteurs clés permettant d’aborder la viabilité de la mutualisation à long terme. / City logistics, considered as the last step of supply chain management, aims to optimally plan, manage and control the freight movements within a logistical network in urban areas. Freight transportation causes significant negative impacts on the quality of living in urban areas in terms of congestion, emissions and space consumption. Collaboration has been introduced to alleviate these negative impacts; however, collaboration in city logistics projects is challenging, since additional efforts of planning and control of collaboration are significant. In recent years, pooling has emerged as a collaborative strategy that leads towards systematic collaboration between stakeholders involved while they are well-informed about the processes and have direct influence on decision making.The aim of this thesis is to study possible forms of pooling in the context of city logistics in order to analyse conditions for an efficient pooling implementation. To this end, we have conducted a comprehensive literature review on city logistics in order to analyse and classify its different aspects. Surveying the literature also conducted to identify a lack of systematic analysis on pooling in city logistics. In order to overcome this research gap, we have proposed a general stepwise framework that aids to identify all necessary steps toward an efficient pooling implementation. Furthermore, we have introduced a novel concept, called ‘typology of flow’, to analyse different possibilities of logistics pooling at a first step and to identify potential constraints before pooling implementation at a second step. We have quantified the impacts of these constraints on the efficiency of pooling using a real case raised from the literature. At the end, we have used our proposed framework, novel concept of typology of flow and results obtained from our experimental analysis in order to classify important factors for city logistics pooling viability in long term.

Background. Depression and anxiety are common and debilitating disorders, and at least one third of patients do not respond to available interventions. Morita Therapy, a Japanese psychological therapy which contrasts with established Western approaches, is currently untested in the UK and may represent a potentially effective alternative approach. Aim. To optimise and investigate the feasibility and acceptability of Morita Therapy as a treatment for depression and anxiety in the UK. Design. Three studies were undertaken in line with the MRC framework (2008) for complex interventions. Study One: scoping and systematic review to describe the extent, range and nature of Morita Therapy research activity reported in English. Study Two: intervention optimisation study, integrating literature synthesis with qualitative research, to develop the UK Morita Therapy outpatient protocol. Study Three: mixed methods feasibility study encompassing a pilot randomised controlled trial (RCT) and embedded qualitative interviews to prepare for a fully-powered RCT of Morita Therapy versus treatment as usual (TAU). Results. Study One: 66 papers meeting the inclusion criteria highlighted heterogeneity in the implementation of Morita Therapy, and an absence of both UK-based research and relevant unbiased RCTs. Study Two: a potentially deliverable and acceptable therapy protocol and tailored therapist training programme were developed for a UK population. Study Three: 68 participants were recruited and 94% retained at four month follow-up; 70.6% of Morita Therapy participants adhered to the minimum treatment dose, and 66.7% achieved remission in depressive symptoms (compared to 30.0% in TAU). Qualitative and mixed methods findings indicated that Morita Therapy was broadly acceptable to therapists and participants, and highlighted potential moderators of acceptability, treatment adherence and outcomes. Conclusions. Patients in the UK can accept the premise of Morita Therapy and find the approach beneficial. It is feasible to conduct a large-scale UK-based trial of Morita Therapy with minor modifications to the pilot trial protocols.