Thesis (Ph. D.)--University of Washington, 1986. / Vita. Bibliography: leaves [129]-138.

Sibutramine is a serotonin-noradrenaline reuptake inhibitor (SNRI) which has been shown to be a safe and effective weight-loss drug. The purpose of this study was to examine whether sibutramine has an effect on macronutrient selection in both female and male rats in addition to total food intake. Wistar rats of both sexes were divided into three groups and each group was offered a different set of three diets, each set included a carbohydrate-rich diet, a protein-rich diet and a fat-rich diet. Sibutramine (10mg/kg) was shown to consistently decrease carbohydrate and fat intake at all data points regardless of gender and diets. The effect of sibutramine on protein intake was diet and gender-specific. All doses of sibutramine decreased total food intake regardless of gender and diet group beginning at 6-h post-administration. In conclusion, sibutramine affected macronutrient selection and emphasis on dietary recommendations should be considered during therapy.

A food preference questionnaire, utilizing the Food Action Rating Scale (FACT), was developed from entrees used in congregate meal sites throughout the United States and its territories. The list of entrees was reduced to 43 choices. The FACT questionnaire was distributed to all of the participants at the Healthy Lunch Sites served by Area 6 program in East Central Indiana. There were 357 people, age 60 or older, that completed the questionnaire. Their responses were compared by age and gender. Differences in preferences of entrees were noted depending on age and gender. The five most liked entrees of the total group are Country Steak / Brown Gravy, Cubed Steak, Salmon Patties, Chicken and Noodles, and Pork Roast. The five most disliked entrees are Cheese Enchilada / mild or spicy, Turkey Divan, French Dip Sandwich, Boiled Cod, and Bean Burrito / mild or spicy. Their responses were tabulated using factor analysis. A total of eleven clusters of entrees factored together. This provided groups of entrees that received similar scores. For example, some of the groupings were turkey entrees, chopped meat and sauce, barbecued meats, fish entrees. These results can be used by menu planners to assist in writing menus. By locating an entree on one of these tables that is well liked by the group being served, the other foods listed on that particular table can be served alternately during the remainder of the menu cycle to provide a high food acceptance. / Department of Family and Consumer Sciences

The effect of melatonin, a hormone that triggers biological rhythms, was examined in relation to food intake and macronutrient selection. Wistar rats (n = 48) of both sexes were divided into 3 groups and offered a simultaneous choice of 2 diets: a carbohydrate-rich diet and a protein-rich diet, with a different type of carbohydrate and protein in each of the groups. Increased short- (4h post-injection) and long-term (12h post-injection) nocturnal total food intake was found following intraperitoneal administration of melatonin (10 000 and 15 000 pg/ml blood) at dark onset. Melatonin increased short-term carbohydrate-rich diet intake similarly across sensory contrasting diets (dextrin/cornstarch, cornstarch, and sucrose/cornstarch) and genders. However, melatonin caused an inconsistent increase in protein-rich diet intake across the various diets (casein, soy isolate, and egg protein) and genders. In conclusion, melatonin favors carbohydrate intake at the beginning of the activity period, and may act as a time indicator that provides a night signal.

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Call number: LD2668 .T4 1979 H68 / Master of Science

Call number: LD2668 .T4 1955 C33 / Master of Science

Photocopy of typescript. / Digitized by Kansas Correctional Industries

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