Granular materials are composed of solid, discrete particles and exhibit mechanical properties that range from fluid to solid behavior. Some of the complexity exhibited by granular systems arises due to the long-range order that develops due to particle-particle contact. Inter-particle forces in granular materials often form a distributive network of filamentary force-accommodating chains (i.e. force chains), such that a fraction of the total number of particles accommodates the majority of the forces in the system. The force chain network inherent to a system composed of granular materials controls the macroscopic behavior of the granular material. Force transmission by these filamentary chains is focused (or localized) to the grain scale at boundaries such as the granular flow substrate. Recent laboratory experiments have shown that force chains transmit extreme localized forces to the substrates of free surface granular flows. In this work we combine analog and numeric experimental approaches to investigate the forces at the bed of a simplified granular flow. A photoelastic experimental approach is used to resolve discrete forces in the granular flows. We also conduct discrete element method (DEM) simulations, using input parameters derived from measureable physical material properties of experimental and natural materials, which successfully reproduce the analog experimental results. This work suggests that force chain activity may play an unexpected and important role in the bed physics of dense granular flows through substrate modification by erosion and entrainment, and that DEM numerical methods effectively treat force chain processes in simulated granular flows.

Thesis (Ph.D.)--University of Western Sydney, 2008. / A thesis submitted to the University of Western Sydney, College of Health and Science, School of Biomedical and Health Sciences in fulfilment of the requirements for the degree of Doctor of Philosophy. Includes bibliographical references.

Proefschrift--Utrecht. / Errata slip inserted. "Stellingen" : [3] p. inserted. Bibliography: p. [74]-75.

Thesis (M.S.)--University of Michigan, 1990.

Proefschrift--Utrecht. / Errata slip inserted. "Stellingen" : [3] p. inserted. Bibliography: p. [74]-75.

No description available.

No description available.

Operant response rate can be viewed as bouts, periods of alternating engagement and disengagement with ongoing schedules of reinforcement. Relatively few studies have examined the role of force and effort on engagement bouts. Moreover, those examining effort have used switch closure devices to define the response. Switch closures tend to overestimate the effect of effort because increasing the force requirement excludes low-force responses that previously activated the switch. In the present study, we examined the effects of effort using a force transducer, which allows us to record criterion responses that meet the force requirement and subcriterion responses that do not. The current study was conducted using four male Sprague Dawley rats. Each rat was run through a series of four conditions, each with a different combination of variable interval schedules (VI 30s, VI 120s) and force requirements (5.6g, 32g). Log survivor analyses of bout structure showed that increased force requirements decreased the rate of bout initiations. Additionally, when log-survivor functions were computed using only criterion responses, shifts in the function were less extreme than when all measured responses were used; the latter finding suggests exclusion of "subcriterion" responses in prior work has overestimated the effects of force on bout structure

by Au Yeung Po See. / Title also in Chinese. / Thesis (M.A.Ed.)--Chinese University of Hong Kong, 1989. / Bibliography: p. 61-72.

Cell adhesion plays an important role in inflammation and immunological responses. Adhesion molecules (e.g., selectins and integrins) are key modulators in mediating these cellular responses, such as leukocyte trafficking under shear stress. In this thesis, we use a bio-membrane force probe (BFP) to study force regulation on kinetics and conformations of selectin and LFA-1 integrin. A new BFP was built up, and a new assay, using thermal fluctuation of the BFP, was developed and used to monitoring selectins and their ligands association and dissociations. The new BFP was also used to investigate the force and force history dependence of selectin-ligand interactions. We found tri-phasic transition of force-dependent off-rates and force-history dependence of selectin/ligaind interactions. The BFP was also used to characterize force-dependent lifetimes of the LFA-1-ICAM-1 interaction. We found that LFA-1/ICAM-1 bonds behaved as catch bond and that LFA-1-ICAM-1's catch bonds were abolished blocking the downward movement of αA domain α7 helix. Finally, the BFP was applied to dynamically probe the global conformational changes of LFA-1 and to characterize force-regulated transitions among different conformational states on a living cell. We observed dynamic transitions of LFA-1 between extended and bent conformations on living cells. The observed average distance change of LFA-1's extensions was about 18nm, while that of the bending was only about 14nm. We also found that forces could facilitate extension but they slow down the bending of LFA-1. The observed transition time of extension was less than 0.1s, while that of contraction was longer than 0.2s. Our observations here are the first in-situ evidence to demonstrate how integrins dynamically transit different conformations and how force regulates these transitions.