ITC/USA 2006 Conference Proceedings / The Forty-Second Annual International Telemetering Conference and Technical Exhibition / October 23-26, 2006 / Town and Country Resort & Convention Center, San Diego, California / In most current PCM based telemetry systems, an instrumentation engineer manually creates the sampling format. This time consuming and tedious process typically involves manually placing each measurement into the format at the proper sampling rate. The telemetry industry is now moving towards Ethernet-based systems comprised of multiple autonomous data acquisition units, which share a single global time source. The architecture of these network systems greatly simplifies the task of implementing an automatic format generator. Automatic format generation eliminates much of the effort required to create a sampling format because the instrumentation engineer only has to specify the desired sampling rate for each measurement. The system handles the task of organizing the format to comply with the specified sampling rates. This paper examines the issues involved in designing an automatic format generator for a network data acquisition system.

ITC/USA 2009 Conference Proceedings / The Forty-Fifth Annual International Telemetering Conference and Technical Exhibition / October 26-29, 2009 / Riviera Hotel & Convention Center, Las Vegas, Nevada / Configuring a modern, high-performance data acquisition system is typically a very timeconsuming and complex process. Any enhancement to the data acquisition setup software that can reduce the amount of time needed to configure the system is extremely useful. Automatic format generation is one of the most useful enhancements to a data acquisition setup application. By using Automatic Format Generation, an instrumentation engineer can significantly reduce the amount of time that is spent configuring the system while simultaneously gaining much greater flexibility in creating sampling formats. This paper discusses several techniques that can be used to generate sampling formats automatically while making highly efficient use of the system's bandwidth. This allows the user to obtain most of the benefits of a hand-tuned, manually created format without spending excessive time creating it. One of the primary techniques that this paper discusses is an enhancement to the commonly used power-of-two rule, for selecting sampling rates. This allows the system to create formats that use a wider variety of rates. The system is also able to handle groups of related measurements that must follow each other sequentially in the sampling format. This paper will also cover a packet based formatting scheme that organizes measurements based on common sampling rates. Each packet contains a set of measurements that are sampled at a particular rate. A key benefit of using an automatic format generation system with this format is the optimization of sampling rates that are used to achieve the best possible match for each measurement's desired sampling rate.

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Antibody engineering is an innovative field of research that has generated a wide range of novel antibody-based formats that both exploit and improve natural antibody properties. Novel format antibodies have the potential to offer significant advantages over natural antibodies when used as biopharmaceuticals, however these non-natural structures often pose a great challenge to the host cell used for their manufacture. Protein expression is a highly regulated process, and quality control mechanisms at each stage can result in a block, or "bottleneck" in expression. This can impact product yield, cost of goods and entry into the clinical pipeline. The molecular determinants that govern novel-format expression in host cells are poorly defined, however there is growing evidence that limited variations in both nucleotide and amino acid sequence can have a severe impact on antibody expression. Therefore this Thesis aims to investigate the consequences of sequence variation on the expression of a novel antibody format (mAbdAb) in mammalian host cells in order to determine the molecular mechanisms that govern their expression. A diverse panel of mAbdAbs with sequence variations limited to the dAb domain were generated through phage display and cloning technologies. It was determined that amino acid variations located within the CDRs of the dAb results in a range of expression titres in both transient HEK and stable CHO expression platforms. In vitro translation of mAbdAb heavy chain proteins in rabbit reticulocyte lysates (RRL) showed no difference in expression between sequence variants, therefore cell-free translation was suggested as a potential expression platform. Examination of each stage of expression in stable CHO cells revealed that the amount of mRNA was not limiting to expression and distinct expression profiles were observed at the protein level. The majority of mAbdAb constructs showed little evidence of intracellular heavy chain polypeptide which was not altered through chemical inhibition of proteolytic degradation pathways, indicating that degradation was not responsible for poor expression. This led to the hypothesis that low titres were related to how the CHO cell utilises the heavy chain message.

The multistage testing (MST) has drawn increasing attention as a balanced format of adaptive testing that takes advantages of both fully-adaptive computerized adaptive testing (CAT) and paper-and-pencil (P\&P) tests. Most previous studies on MST have focused on purely dichotomous or polytomous item formats although the mixture of two item types (i.e., mixed-format) provides desirable psychometric properties by combining the strength of both item types. Given the dearth of studies investigating the characteristics of mixed-format MST, the current study conducted a simulation to identify important design factors impacting the measurement precision of mixed-format MST. The study considered several factors-namely, total points (40 and 60), MST structures (1-2-2 and 1-3-3), the proportion of polytomous items (10%, 30%, 50% and 70%), and the routing module design (purely dichotomous and a mixture of dichotomous and polytomous items) resulting in 32 total conditions. A total of 100 replications were performed, and 1,000 normally distributed examinees were generated in each replication. The performance of MST was evaluated in terms of the precision of ability estimation across the wide range of the scale. The study found that the longer test produced greater measurement precision while the 1-3-3 structure performed better than 1-2-2 structure. In addition, a larger proportion of polytomous items resulted in lower measurement precision through the reduced test information during the test construction. The interaction between the large proportion of polytomous items and the purely dichotomous routing module design was identified. Overall, the two factors of test length and the MST structure impacted the ability estimation, whereas the impact of the proportion of polytomous items and routing module design mirrored the item pool characteristic. / text

ITC/USA 2012 Conference Proceedings / The Forty-Eighth Annual International Telemetering Conference and Technical Exhibition / October 22-25, 2012 / Town and Country Resort & Convention Center, San Diego, California / In telemetric network systems, data extraction is often an after-thought. The data description frequently changes throughout the program so that last minute modifications of the data extraction approach are often required. This paper presents an alternative approach in which automation of measurement extraction is supported. The central key is a formal declarative language that can be used to configure instrumentation devices as well as measurement extraction devices. The Metadata Description Language (MDL) defined by the integrated Network Enhanced Telemetry (iNET) program, augmented with a generalized measurement extraction approach, addresses this issue. This paper describes the TmNS Data Extractor Tool, as well as lessons learned from commercial systems, the iNET program and TMATS.

This research aims at exploring the existence of a relationship between the use of multimedia in teaching and instructional design guidelines (IDG). An ontology of types of media and teaching methods was developed. Semi-structured interviews have been conducted with 20 instructors. Qualitative and quantitative methodologies were employed. While these are results from a pilot study with a small sample, the analyses suggests a relationship between the use of media in teaching and IDG that is influenced by years of teaching experience and field of study (i.e., Social Sciences). The instructors’ self-assessment of IDG and media usage was not reliable and further validation of a self-assessment instrument is needed. This pilot study demonstrates the feasibility of the methodology which can be used in future research with more participants. / Graduate

Zugl.: Zürich, Univ., Diss., 2009.

This thesis deals with conversion of text documents from the format of so called formatting objects (XSL FO) to OpenDocument format (ODF). This conversion can be useful e. g. for distribution, printing or additional modification of a document in a text editor which supports ODF (e. g. OpenOffice). The thesis starts with description of both formats and it mentions basic elements that the formats offer for defining a text document. A comparison of both formats and description of possibilities of converting documents from XSL FO to ODF follows right after. The proved-by-practise and widely available XSLT transformation is chosen for the conversion implementation. It is illustrated on a sample application which enables to launch the conversion from an internet browser, from OpenOffice or from a command line.

ITC/USA 2006 Conference Proceedings / The Forty-Second Annual International Telemetering Conference and Technical Exhibition / October 23-26, 2006 / Town and Country Resort & Convention Center, San Diego, California / This paper presents the description of the updated Data Display Markup Language (DDML), a neutral format for data display configurations. The development of DDML is motivated by the fact that in joint service program systems, there is a critical need for common data displays to support distributed T&E missions, irrespective of the test location, data acquisition system, and display system. DDML enables standard data displays to be specified for any given system under test, irrespective of the display vendor or system in which they will be implemented. The version 3.0 of DDML represents a more mature language than the version 1.0 presented at the 2003 ITC. The updated version has been validated for completeness and robustness by developing translators between DDML and numerous vendor formats. The DDML schema has been presented to the Range Commander’s Council (RCC) Data Multiplex Committee for consideration for inclusion in the IRIG 106 standard. The DDML model will be described in terms of both the XML schema and the UML model, and various examples of DDML models will be presented. The intent of this paper is to solicit specific input from the community on this potential RCC standard.