The dissertation thesis entitled Luminescence nanoparticles for bioanalytical applications deals with the use of optical nanomaterials in life sciences. An overview of the commonly used luminescent nanoprobes is provided together with their advantages over commonly used organic dyes or fluorescence proteins. Next, surface modifications and biofunctionalization of nanoparticles with targeting moieties are discussed. Molecularly imprinted polymers are introduced as an alternative surface modification enabling biorecognition. Finally, theoretical part is concluded with recent examples of the luminescent nanoparticles in bioanalytical and imaging applications. The scientific results of the Ph.D. candidate are presented in the form of 2 review articles and 3 research articles in the peer reviewed journals.

Proefschrift Rijksuniversiteit Groningen. / Auteursnaam op omslag: Daan Thorn Leeson. Datum laatste controle: 22-12-1997. Lit.opg. - Met samenvatting in het Nederlands.

Title: Analysis of J/Psi + photon production in proton-proton collisions on ATLAS at LHC Author: Bc. Zuzana Vidláková Department: Institute of particle and nuclear physics Supervisor: prom. fyz. Václav Vrba, CSc. (Academy of Sciences of the Czech Republic) Abstract: The subject of this thesis is physics connected to quarkonia and their studies at the ATLAS detector situated at LHC in CERN, Geneva. In this thesis, following topics are cov- ered: ATLAS detector, history of physics connected to quarkonia, production mechanisms of quarkonia, software used at CERN for data analysis and cross-section measurement of J/Psi + photon continuum. The analysis was done on behalf of the B-physics working group at ATLAS. Keywords: CERN, LHC, ATLAS, B-fyzika, quarkonia

While dual-frequency GPS receivers have been used in space for more than two decades, the size, power, and cost of this technology is an important driver for future space missions. The growing availability of launch opportunities for very small satellites known as nanosatellites and CubeSats raises the possibility of more affordable access to space measurements if the observation quality is sufficient to support the user's needs. This thesis presents the initial development and testing of the Fast, Orbital, TEC, Observables, and Navigation (FOTON) receiver: a small, reconfigurable, dual-frequency, space-based GPS receiver. Originally developed as a science-grade software receiver for monitoring ionospheric scintillation and total electron content (TEC), this receiver was designed to provide high-quality GPS signal observations. The original receiver hardware was miniaturized and the software has been adapted for low earth orbit (LEO) operations. FOTON now fits within a 0.5U CubeSat form factor (8.3 x 9.6 x 3.8 cm), weighs 326 g, and consumes 4.5 W of instantaneous power, which can be reduced to <1 W orbit average power with on-off duty cycling. The receiver has been designed with commercial parts to keep manufacturing costs low. Significant testing of FOTON has been performed with live signals and with signals generated by a Spirent GPS signal simulator. Initial terrestrial tests demonstrate behavioral consistency with the original heritage high-performance receiver. Several LEO simulations are presented, demonstrating FOTON's single-frequency and dual-frequency-enhanced positioning down to 0.5 m and 1.5 m, respectively, which can be improved using Kalman filter based POD. FOTON's potential for GPS radio occultation observation is also demonstrated. In addition, its acquisition and reacquisition performance is presented; on average, FOTON's time to first fix is approximately 45 seconds. Finally, navigation in geostationary orbit (GEO), a challenging application for space-based GPS receivers, is demonstrated. Extensive testing demonstrates that FOTON is a robust, versatile, high-precision dual-frequency space receiver. Its low cost, size, weight, and power requirements are key enablers for future small-satellite missions. / text

The smartphone has changed the act of photography by enabling users to whenever and wherever take a photo. Most people are nowadays walking around with thousands of pictures in their phone- pictures that they almost never look at. Photos are keys to our memories, our identity, which is why they are important. Nevertheless, the amount has made it an overwhelming task so sort them and photos are getting lost in the mass. The photos instead get stored away on cloud servers, which is limitless. There they both become forgotten but can also potentially cause unnecessary CO2 emissions, since it takes a lot of electricity to run the datacenters where they are stored. How could we through a new way of handling and interacting with our digital photos increase their emotional value in a way that at the same time makes us aware of our digital consumption? To tackle this problem a survey and series of interviews was conducted. Both with potential users, as well as experts within psychology, technology, photo and sustainability in regarding to digitalization. The most significant finding was that the high number of photos is partially caused by the fact that today photos are taken for many different reasons. Some are taken to be kept as a memory while some are only valuable in the moment, such as a photo of a shopping list.  The end result of this project is called Pixels and is an alternative to how the ordinary camera and photo album in a phone could function. The concept lets the user together with A.I, already when the photo is taken, separate different types of photos from each other. The user is given the possibility to save and curate important memories, increasing their emotional value, as well as ease the process of getting rid of unnecessary photos causing stress and avoidable CO2 emissions. / Smartphonen har förändrat hur vi fotograferar genom att möjliggöra att när och vart som helst ta ett foto. Detta har lett till att de flesta människor idag går omkring med tusentals bilder i sin telefon - bilder som de nästan aldrig kollar på. Foton är representationer och nycklar till våra minnen, vår identitet, vilket gör dem ovärderliga. Dock har mängden bilder gjort det till en näst intill överväldigande uppgift att hantera dem. För att få plats med alla bilder laddas de istället upp till molntjänster där de potentiellt orsakar onödigt koldioxidutsläpp, då energiåtgången är hög för att driva datacentren där de är lagrade. Hur kan vi genom ett nytt sätt att hantera och interagera med våra digitala foton öka deras känslomässiga värde på ett sätt som samtidigt gör oss medvetna om vår digitala konsumtion? För att få insikt i detta problem genomfördes en enkät samt en serie intervjuer. Både med potentiella användare såväl som experter inom psykologi, teknik, foto och hållbarhet i relation till digitalisering. En viktig upptäckt var att det stora antalet foton delvis orsakas av att foton idag tas av många olika skäl. Några för att behålla som ett minne medan andra bara är värdefulla under en kort period, till exempel ett foto av en inköpslista. Slutresultatet av detta projekt kallas Pixels och är ett alternativt förslag på hur den ordinarie kameran samt albumet i en telefon skulle kunna fungera. Konceptet möjliggör för användaren att tillsammans med A.I, redan vid tillfället då fotot tas, skilja olika typer av foton från varandra. Användaren ges möjligheten att spara och kurera viktiga minnen, för att öka dess emotionella värde, samt förenkla processen av att ta bort överflödiga foton som orsakar stress och onödigt CO2-utsläpp.

Orientador: Reinaldo Quagliato Junior / Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas / Made available in DSpace on 2018-08-05T16:01:57Z (GMT). No. of bitstreams: 1 Piai_DairBicudo_D.pdf: 403156 bytes, checksum: 6d8b15778706dd7389c478ef4fa4aa0b (MD5) Previous issue date: 2005 / Resumo: A cintilografia pulmonar é o método mais usado na avaliação regional da função pulmonar em candidatos a resseção pulmonar que tenham função respiratória limítrofe. Esse método processa aquisições planares e fornece imagens bidimensionais dos pulmões e considera todos os segmentos dos lobos pulmonares como tendo o mesmo volume e função, não considerando a sobreposição espacial de áreas com diferentes funções. A cintilografia pulmonar com cortes tomográficos por outro lado, fornece imagens tomográficas dos pulmões, podendo ser um método mais acurado para a avaliação regional da função pulmonar. Nesse estudo prospectivo, o volume expiratório forçado no primeiro segundo previsto para o período pós-operatório (VEF1ppo) foi estimado em 26 pacientes com câncer de pulmão usando-se espirometria, cintilografia pulmonar de perfusão com aquisições planares (CPAP) e cintilografia pulmonar de perfusão com cortes tomográficos (CPCT). Os valores de VEF1ppo estimados por ambos métodos (CPAP e CPCT) foram comparados com os valores de volume expiratório forçado no primeiro segundo (VEF1) medidos após a operação de ressecção pulmonar (média: 48 ± 44 dias; intervalo: 15 a 180 dias; mediana: 32 dias). O coeficiente de correlação linear de Pearson foi 0.8840 (valor de p <0.0001) para o VEF1ppo estimado por CPAP, e 0.8791 (valor de p < 0,0001) para o VEF1ppo estimado por CPCT. O coeficiente de correlação linear nas lobectomias foi maior do que o coeficinte de correlação linear nas pneumonectomias em ambos métodos. Concluiu-se que ambos métodos apresentam boa correlação com a função pulmonar pós-operatória real, não demonstrando superioridade do CPCT sobre o CPAP, e que ambos métodos são mais efetivos na estimativa do VEF1ppo em lobectomias do que em pneumonectomias / Abstract: Perfusion scintigraphy is the commonest method used for the regional assessment of pulmonary function in candidates for pulmonary resection with borderline respiratory function. This method provides two-dimensional images, and it considers all the segments of the pulmonary lobes as having the same volume and function, without considering the spatial overlapping of pulmonary areas with different function. As SPECT provides tomographic imaging, it could be a more precise method for regional assessment. In this prospective study, the postoperative predicted FEV1 (FEV1ppo) was assessed in 26 patients with lung cancer using spirometric procedures, quantitative lung perfusion scan with planar acquisition (PA) and quantitative lung perfusion scan with tomographic imaging (SPECT). The estimated FEV1ppo values of both methods were compared with FEV1 value measured after surgery (mean: 48 ± 44 days, range: 15-180 days, median: 32 days). The Pearson¿s linear correlation coefficient was 0.8840 (p-value <0.0001) for FEV1ppo estimated by PA, and 0.8791 (p-value < 0,0001) for FEV1ppo estimated by SPECT. The linear correlation coefficient for lobectomy was greater than the coefficient for pneumonectomy in both methods. We concluded that both methods showed good correlation for real postoperative pulmonary function without demonstrating SPECT superiority over PA, and both methods were more effective for estimating FEV1ppo in lobectomies than in pneumonectomies / Doutorado / Clinica Medica / Doutor em Clínica Médica

Orientador: Sylvia Maria Ciasca / Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas / Made available in DSpace on 2018-08-11T14:33:13Z (GMT). No. of bitstreams: 1 Guimaraes_InesElcione_D.pdf: 4272361 bytes, checksum: 61a706cfbc3b1f7cff0820fbeb662e9a (MD5) Previous issue date: 2008 / Resumo: A doença cerebrovascular (DCV) na infância é considerada rara e interfere drasticamente na evolução da criança. Este estudo teve como objetivo relacionar as achados neuropsicológicos em crianças com DCV isquêmica ou hemorrágica, com variáveis que interferem na doença como: recorrência, etiologia, idade de instalação do quadro. Participaram do estudo 32 crianças com história de acidente vascular cerebral (AVC) isquêmico ou hemorrágico, de ambos os sexos na faixa etária de 6 a 16 anos, que foram submetidos à avaliação neuropsicológica, intelectual, viso-motor, desempenho escolar, exame de imagem funcional, entre outros. A amostra foi selecionada a partir do banco de dados do Grupo de Estudos em DCV na Infância e Adolescência do HC da UNICAMP. Participaram ainda outras 25 crianças que compuseram o grupo controle. O grupo isquêmico com 68,75% da amostra e o hemorrágico com 31,25%, não se diferiram quanto ao sexo, recorrência, crise convulsiva e idade de instalação do AVC. Constatou que 87% evoluíram com seqüela motora e 34,3% com rebaixamento intelectual. O desempenho intelectual foi mais prejudicado frente às seguintes situações: anemia falciforme, idade precoce de instalação do quadro, recorrência, evolução com crise convulsiva, dois hemisférios acometidos, lesão cortico-subcortical e seqüela motora. Verificou-se que 18,7% das crianças do grupo experimental não conseguiram responder à bateria de instrumentos, sugerindo que a lesão em regiões corticais e subcorticais em idade precoce produziram severos prejuízos cognitivos. Palavras chaves: doença cerebrovascular ¿ quociente intelectual - infância ¿ exame de imagem funcional, recorrência / Abstract: The cerebrovascular disease (CVD) during the childhood is rare and interferes drastically in the development of child. The aim of this study is to relate the neuropsychological findings in children with ischemic or hemorrhagic CVD, to variables that interfere in the disease, for example: recurrence, etiology, the age of the installation. Thirty-two children with prior history of ischemic or hemorrhagic stroke, of both sexes in the age group from 6 to 16 years, were subdued to an neuropsychological, intellectual, visual-motor, school performance, cerebral blood flow evaluation; among others, the sample was selected from the Group of Studies in CVD in childhood and adolescence database of the HC of UNICAMP. Twenty-five children also the hemorrhagic with 31,25%, there was no difference in relation of sex, recurrence, seizures and the age of installation of the CVA. It was noticed that 87% grew with motor sequelae and 34,3% with an intellectual reduction. The intellectual performance was more damaged facing these situations: sickle cell disease, premature age of the installation, recurrence, evolution of convulsive crisis, two hemispheres attacked, cortical-subcortical lesion and motor sequelae. It was checked, 18,7% of the children in the experimental group couldn¿t respond to the battery of instruments, suggesting that the lesion in the cortical an subcortical areas in early age produced severe cognitive damages. Key-words: disease cerebrovascular ¿ intelligence quotient ¿ childhood ¿ SPECT ¿ recurrence / Doutorado / Ciencias Biomedicas / Doutor em Ciências Médicas

The aim of this diploma thesis is the design of linear accelerator for oncology treatment. The design focuses on the improvement of the aesthethical side of the accelator, but also comes up with inventional solutions how to improve the radiation treatment of oncology patients to higher the chances of successful treatment of cancer.

The purpose with this study was to examine whether gender moderate the associationbetween body satisfaction and posting photos of exercise and training on Instagram. We usedan online survey to collect our participants that we posted in a local social network site forstudents in a swedish medium sized city (n = 239). The results of the moderated regressionanalysis showed that gender affect the association between body satisfaction and postingphotos of exercise and training on Instagram. As we hypothesized, men who rated high inbody satisfaction posted more photos of exercise and training on Instagram. Women’s postingof exercise and training on Instagram was not affected by their levels of body satisfaction. / Syftet med denna studie var att undersöka om kön modererar associationen mellankroppstillfredsställelse och att publicera foton av motion och träning på Instagram. Vi utfördeen webbaserad enkätundersökning som vi publicerade på en webbplats för studenter i ensvensk mellanstor stad (n = 239). Resultatet av moderation regressionsanalysen visade attkön påverkade associationen mellan kroppstillfredsställelse och att publicera foton av motionoch träning på Instagram. Enligt vår hypotes så visade resultatet att män med hög nivå avkroppstillfredsställelse publicerade mer foton av motion och träning på Instagram. Kvinnorspublicerande av motion- och träningsfoton på Instagram påverkades inte av deras nivå avkroppstillfredsställelse.

This diploma thesis deals with evaluation of toxicity and bioaccumulation of photon-upconversion nanoparticles (UCNPs) in model plant maize (Zea mays). Lanthanide-doped UCNPs with different composition and size were tested in three different concentrations in this work. The exposure took place for 168 hours. Toxicity was assessed based on four macroscopic toxicological endpoints (mortality, the length of belowground part of the plants, the length of aboveground part of the plants and whole plants length). Spatial distribution of elements yttrium, ytterbium, erbium and gadolinium in model plants was determined using laser induced breakdown spectroscopy with spatial resolution of 100 m and 26 m. Distribution of UCNPs in plants was further studied with photon-upconversion microscanning with spatial resolution of 40 m. Stability of UCNPs during and after the plant exposure was also discussed in this thesis.