Depression is a serious mental health concern affecting nearly 20% of the population (Kessler, 2002). A hallmark feature of depression is a prolonged period (i.e., 2 weeks or more) of sad mood. Because of this, recent conceptualizations have described Major Depressive Disorder as a dysfunction of emotion regulation (e.g., Kring & Bachorowski, 1999). However, the nature of this emotion regulation dysfunction in MDD is not well understood. The current study examined whether experimentally manipulating emotion regulation during a stressful task would help depressed individuals more effectively regulate subjective and physiological emotional responses. Although theorists have speculated that depression may potentiate certain emotional states, few empirical studies have been completed. One study found that depressed individuals reacted with significantly greater anger in response to a distressing and frustrating task than non-depressed individuals (Ellis, Fischer & Beevers, 2010). That study suggested that emotion regulation difficulties may contribute to the potentiation of some negative emotions, such as anger, among depressed individuals. Altering the emotion regulation strategies typically used by depressed individuals could therefore attenuate emotional reactivity to stressful experiences. Gross (1998) posits that emotion regulation can occur at two distinct points--either manipulating the input or the output of the emotional process. He refers to these as antecedent-focused (e.g., reappraisal of cognitions) or response-focused (e.g., acceptance of experience) emotion regulation. This theoretical framework provides a model through which to examine strategies to reduce distress and anger in depression. Specifically, the current dissertation examined the differential effects of manipulating an emotional response before generated (reappraisal; antecedent-focused) and after elicited (acceptance; response-focused). Depressed and non-depressed individuals were randomized to an emotion regulation strategy: reappraisal, acceptance or no strategy. They then completed a standardized, distressing task previously shown to potentiate anger (Ellis et al., 2010) and affect physiological responding (Matthews & Stoney, 1988). Subjective (i.e., anger, anxiety) and physiological (i.e., heart rate, galvanic skin response, respiration) emotional responses were collected to determine whether manipulating emotion regulation attenuates emotional reactivity to the distressing task. Results indicated that depressed individuals responded with greater anger, had lower galvanic skin conductance response, and persisted for shorter duration on the task than non-depressed individuals. Results also indicated that instructions to accept emotions increased anger during the task compared to reappraisal or no strategy. However, depression status and emotion regulation strategy did not interact, suggesting the effect of emotion regulation strategy did not differ across depression groups. Further, there were no differences between strategies for task persistence or skin conductance. Results suggest that acceptance is not an effective strategy for the acute reduction of anger. Results also emphasize the importance of anger potentiation and distress intolerance and highlight the need for continued work that identifies more effective strategies for emotion dysregulation in depression. / text

Summary: This diploma thesis deals with the relation between autoimmune processes at biological level (through proven neurological autoimmune disease - multiple sclerosis) and possible autoaggressive processes at the mental level. It is divided into several points. The first one introduces human immunity in general. The first part is followed by immune system description, including autoimmunity and the principle of diseases of this system. Thereafter, psychological aggression is described, in which the division into aggression and auto- aggression fits. This is followed by chapters on projective psychodiagnostics taking into account the detection of various forms of aggression. Then, the thesis focuses on the study of possible auto-aggressive manifestations in patients suffering from the most widespread neurological autoimmune disease, multiple sclerosis. The second half of the thesis describes the author's research on this topic.

本研究主要是想了解青少年的挫折經驗與挫折容忍度之間的關係,並探討建設性思考與社會支持在其間所扮演的角色. 以臺北市及臺灣省701位國中生生為對象,採問卷調查的方式了解受試在挫折經驗、建設性思考、社會支持及挫折容忍度變項上的狀況.研究結果發現,挫折經驗與挫折容忍度之間成顯著的負相關.而當受試有較建設性的思考方式或有較高的社會支持及對社會支持有較高的滿意度時,其挫折容忍度亦較佳.至於建設性思考是否在挫折經驗和挫折容忍度之間扮演調節變項的部份,本研究只發現學業挫折經驗與積極正向性的思考之間有顯著的交互作用,而人際挫折經驗則與自我侷限性思考有顯著的交互作用;但是在社會支持部份,本研究並無發現其與學業或人際挫折經驗之間有明顯的交互作用.各變項所顯現的性別上的差異則相當符合一般人對男女的刻板印象;受試中,以國三學生的壓力最大,可能亦是輔導最可著力的ㄧ群. 上述的研究結果除可提供作為未來探究有關挫折經驗與挫折容忍度關係時的參考之外,亦可對學校教育及親職教育提供下列幾點建議:1.變化教材或教學方式,以減少學生的挫折經驗;2.提供老師建設性思考的課程,使師生在教學互動中培養建設性的思考,得以提昇挫折容忍度;3.對男女生的挫折經驗所提供的輔導方向應有所不同;4.培養師長、家長都能成為孩子遇到挫折時的社會支持來源;5.針對不同年級的學生提供預防教育課程,改變其對挫折的容忍度. / This research mainly intends to understand the relations between frustration experience and frustration tolerance of teenagers, and discuss the roles the constructive thinking and social support play in these issues.Based on questionnaire survey of 701 senior high school students, four variables-frustration experience, frustration tolerance, social support andconstructive thinking are investigated. The research results show that an obvious negative relation exists between frustration experience and frustration tolerance. Those who have more constructive thinking or receive more social support and accepted by the society have better performance on frustration tolerance. As to the question whether the constructive thinking play the role of a moderator variable between frustration experience and frustration tolerance, this research only found that obvious interactions exist between study frustration experience and positive thinking, as well as between human relation frustration experience and self-restrained thinking. However, the research did not find any obvious interaction between study/human relation frustration experience and social support. The different performance on different variables owing to sex difference complies with the stereotype. The research results also show that the graduating senior high school students suffer the highest pressure and could be the group that the assistance could really do something for.The research results mentioned above could provide useful information for further investigation on the relations of frustration experience and frustration tolerance. They also provide some advice for normal education andparents education: 1. Changing the teaching material or teaching methods in order to reduce the student's frustration experience. 2. Providing training courses with constructive thinking for teachers.It will build up constructive thinking as well as strengthen frustration tolerance both for teachers and students by way of teaching and studying - mutual responses. 3. The assistance provided for male or female students in order to conquer their frustration experience should be different. 4. Cultivating both parents and teachers the ability and willing of providing supports. Whenever teenagers face frustration, parents and teachers can become the source of social support.5. For students of different grades providing suitable preventive education courses in order to enhance their frustration tolerance.

Solicitud de embargo por publicación en revista indexada. / El propósito del presente estudio fue adaptar y validar la Escala de Tolerancia a la Frustración (Oliva et al., 2011) para su uso en población adolescente peruana. El muestreo fue intencional y se evaluó a 436 adolescentes quechuahablantes de Cusco y Apurímac, entre los 12 y 17 años de edad de ambos sexos. Se analizó la estructura factorial de la escala y su confiabilidad. Para esto, se aplicó el Análisis Factorial Exploratorio (AFE) y el Análisis Factorial Confirmatorio (AFC), donde se dividió la muestra estadística de manera aleatoria en 206 y 230 participantes respectivamente. Los resultados evidencian que el AFE revela la unidimensionalidad de la escala con autovalores mayores a los generados por el azar y que explica el 44.5% de la varianza total. Asimismo, las cargas factoriales fueron mayores a 0.40 y el AFC corroboró esta estructura. El modelo evidenció satisfactorios y mejores índices de ajuste (CFI = 1.000; RMSEA = .000; SRMR = .049). El coeficiente de consistencia interna fue adecuado (ω = .67). Se concluye que, la traducción al quechua de la escala cuenta con evidencias preliminares para ser considerada una medida precisa, válida e invariante para evaluar la tolerancia a la frustración en adolescentes quechuahablantes peruanos. / The purpose of the present study was to adapt and validate the Frustration Tolerance Scale (Oliva et al., 2011) for its use in the Peruvian adolescent population. The sampling was intentional and 436 Quechua-speaking adolescents from Cusco and Apurímac, between 12 and 17 years of age of both sexes, were evaluated. The factorial structure of the scale and its reliability were analyzed. For this, the Exploratory Factor Analysis (EFA) and the Confirmatory Factor Analysis (CFA) were applied, where the statistical sample was randomly divided into 206 and 230 participants respectively. The results show that the EFA reveals the unidimensionality of the scale with eigenvalues ​​greater than those generated by chance and that it explains 44.5% of the total variance. Likewise, factor loadings were greater than 0.40 and the AFC corroborated this structure. The model showed satisfactory and better fit indices (CFI = 1,000; RMSEA = .000; SRMR = .049). The internal consistency coefficient was adequate (ω = .67). It is concluded that the Quechua translation of the scale has preliminary evidence to be considered a precise, valid and invariant measure to evaluate tolerance to frustration in Quechua-speaking Peruvian adolescents. / Tesis