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This thesis is about the experience of older people who travel through an airport. The research reported took place at the interface of population ageing, tourism travel and airport management. Although air transport is influenced by population ageing, older people’s experiences within this specific environment are largely untold. This is surprising, as flying is the preferred form of travel for much of international tourism and airports represent key infrastructure for the provision of dependable services. Thus, there are gaps in knowledge on older travellers at an airport and the airport’s role in this part of leisure travel. In particular, a holistic examination of older travellers’ experiences within the airport environment is missing. This research uses different approaches to the experience concept to explore the expectations, needs and demands of older travellers. It investigates the airport experience of older travellers, in light of the changing roles of airports in society. In the form of a qualitative single-case study, it examines the situation of the older leisure traveller at Frankfurt Airport in Germany. Data was collected through 66 interviews with older leisure travellers, frontline employees and managers, complemented by 50 observations. This provides a comprehensive perspective of the older travellers’ airport experience and represents a novel approach. The thesis makes several contributions to experience, travel and tourism literature. On the demand side, the findings allow for a better understanding of the experience of the older passengers. The effect of ageing on an airport’s customer base is investigated. It is discussed whether this group needs special treatment within the regular passenger process. On the supply side, the emerging role of the airport as part of the overall holiday journey is explored. Furthermore, the findings show how airport management deals with this particular passenger group.

archives@tulane.edu / 1 / Pravin Pathak

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<p> It is shown that under suitable conditions a g-function determines a continuous function. Relationships between these are examined. In particular, under sufficiently strong conditions, both induce the same homomorphism of Cech homology groups. A realisation theorem giving conditions under which a homomorphism of Cech homology groups is induced by a continuous function is proved.</p> / Thesis / Doctor of Philosophy (PhD)

G protein-coupled receptors (GPCRs) activate heterotrimeric G proteins (Gαβγ), which together form one of the most important signaling axes found in the cell. Because GPCRs are very common targets for therapeutic drugs, the mechanisms underlying their regulation are of high biomedical importance. Downstream of GPCR activation, there are many cytoplasmic proteins that regulate the activity of G proteins, providing an opportunity for therapeutic intervention. The neuronal protein GINIP binds directly to Gαi and is believed to play a role in modulating GPCR-mediated neurotransmission, an exquisitely-balanced process whereby dysregulation leads to neurological disorders including chronic pain and epilepsy. However, the molecular and structural determinants of GINIP underlying and required for proper regulation of G protein signaling downstream of GPCRs are unclear. In the studies presented here, we dissect the molecular and structural basis by which GINIP regulates G proteins after receptor activation and contributes to the fine-tuning of neurotransmitter responses in the nervous system. First, we revealed a new paradigm of G protein regulation by GINIP whereby it biases GPCR responses favoring Gβγ-mediated signaling to the detriment of Gα-mediated signaling. Second, we demonstrated that GINIP uses specific residues in the first loop of the PHD domain to physically engage Gαi by adopting a binding mode similar to that of G protein effectors like adenylyl cyclase, which is in turn required for the subsequent modulation of G protein signaling. Together, these insights advance our understanding of how GPCR signaling is fine-tuned by GINIP to set the tone of neurotransmission. Characterizing this layer of G protein regulation after receptor activation is crucial for developing novel therapeutic approaches to target diseases that arise from dysregulated GPCR signaling.

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My thesis aims to create a place of worship for the people of the neighborhood of Plataforma, located in Salvador Bahia, Brazil. Candomble was introduced to Brazil during times of slavery and is the root of Afro-Brazilian culture. In the chaotic world of favelas (Portuguese for slums) the religion of Candomble brings people together and gives order to the community. The neighborhood's current temple also functions as the local priest's home. As an area of low socioeconomic status, Plataforma has been neglected, and so has its temple. My design seeks to honor the importance of religion in this area of Brazil by using sacred architecture to create a structure that is culturally and religiously sensitive. Construction of the temple mimics the natural architecture of the favelas, and the materials used for the site can be found in the area. My hope for this project is to work in collaboration with the non-profit organization Axis Mundi, to raise the funds and support necessary to build this temple for the community of Plataforma. / Master of Architecture

Orientador: Silvia Rodrigues Machado / Resumo: Fibras gelatinosas são células especializadas de esclerênquima que possuem uma camada interna altamente modificada de aparência gelatinosa e translúcida, denominada camada-G. Diversas funções são atribuídas as fibras gelatinosas sendo a principal e mais conhecida a sua relação com o lenho de tração. Porém, outras funções de cunho fisiológico e adaptativo, tais como armazenamento de água e manutenção da orientação foliar foram descritas para as fibras gelatinosas. As fibras gelatinosas são reportadas em diversas famílias de angiospermas nos mais diversos ambientes, com isso outras funções podem ser associadas a ocorrência das fibras gelatinosas nos mais diferentes ambientes. O objetivo desse estudo foi analisar as fibras gelatinosas em representantes de Eriosema (DC.) Desv. um gênero de leguminosa comumente encontrado em Cerrado, visando a acessar variações na distribuição e organização das fibras gelatinosas no eixo vegetativo aéreo e subterrâneo, caracterizar a estrutura básica e a histoquímica das paredes celulares. O estudo foi conduzido com 19 táxons coletados em diferentes áreas de Cerrado, sendo amostrados a folha, caule aéreo e órgão subterrâneo. O material foi processado de acordo com técnicas usuais em anatomia e histoquímica vegetal. Uma espécie foi considerada como modelo e foram utilizados os anticorpos LM5 e LM10 marcadores para galactanos e xilanos, respectivamente, nas paredes das fibras gelatinosas. As fibras gelatinosas ocorreram por todo o corpo vegetativo d... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: Gelatinous fibers (G-fibers) are specialized sclerenchyma cells that have a highly modified, translucent, gelatinous appearance inner layer called the G-layer. Several functions are attributed to the G-fibers being the main and best known its relation with the tension wood. However, other physiological and adaptive functions, such as water storage and maintenance of leaf orientation, have been described for G-fibers. G-fibers are reported in several angiosperm families in the most diverse environments, so other functions may be associated with the occurrence of G-fibers in the most different environments. The purpose of this study was to analyze the G-fibers in representatives of Eriosema (DC.) Desv. a genus of legumes commonly found in Cerrado, aiming to access variations in the distribution and organization of G-fibers in the aerial and underground vegetative axis, to characterize the basic structure and histochemistry of cell walls. The study was conducted with 19 taxa collected in different areas of Cerrado, being sampled the leaf, aerial stem and underground organ. The material was processed according to usual techniques in plant anatomy and histochemistry. LM5 and LM10 antibodies that mark galactans and xylans, respectively, were used on the G-fibers walls. G-fibers occurred throughout the vegetative body of the studied Eriosema taxa, being extraxylary in regions with primary growth and xylary in regions with secondary growth. As for the organization, in the leaf the G-... (Complete abstract click electronic access below) / Doutor