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Genetically modified (GM) crops developed for insect control express cry genes from the bacterium Bacillus thuringiensis (Bt). These genes produce target specific insecticidal proteins that protect the plant against insect pest attacks throughout the growing season. The largest threat to the continued success of these insecticidal GM crops is the potential development of target pest resistance. Models and theories suggested several possible strategies to delay the development of resistance. Of these strategies the high-dose/refuge strategy was selected as the optimal insect resistance management (IRM) option and is currently implemented throughout the world. The high-dose/refuge strategy comprises planting Bt maize plants that produce high doses of the toxin and non-Bt plants (refugia) in close proximity to one another. The theory behind this strategy is that the high dose of toxin kills nearly all the individuals of the target pest while the refuge area sustains susceptible pest individuals that survive on the crop and mate with survivors on the Bt crop. Recent reports of resistance development to Bt crops has raised questions about the refuge concept. In the cases where resistance has developed it was largely ascribed to non- compliance to the prescribed refuge requirements or non-functionality of the refuge approach. The Bt crops used throughout the world were developed in North America against the insect pests that occur there. Since there are differences in the lifecycles and behaviour of insect species targeted by Bt crops the refuge areas also needs to be specified for different target pests. For example, the currently used IRM strategies do not differentiate between polyphagous and monophagous pests and also do not take into account differences that exist in biology and behaviour of different pest species. These IRM strategies have also been developed mainly with large scale commercial farming systems in mind and do not take into account farming systems in developing countries. Current IRM strategies need to be revised and adapted for use by small-scale African farmers. / Thesis (MSc (Environmental Sciences))--North-West University, Potchefstroom Campus, 2012.

Genetically modified (GM) crops developed for insect control express cry genes from the bacterium Bacillus thuringiensis (Bt). These genes produce target specific insecticidal proteins that protect the plant against insect pest attacks throughout the growing season. The largest threat to the continued success of these insecticidal GM crops is the potential development of target pest resistance. Models and theories suggested several possible strategies to delay the development of resistance. Of these strategies the high-dose/refuge strategy was selected as the optimal insect resistance management (IRM) option and is currently implemented throughout the world. The high-dose/refuge strategy comprises planting Bt maize plants that produce high doses of the toxin and non-Bt plants (refugia) in close proximity to one another. The theory behind this strategy is that the high dose of toxin kills nearly all the individuals of the target pest while the refuge area sustains susceptible pest individuals that survive on the crop and mate with survivors on the Bt crop. Recent reports of resistance development to Bt crops has raised questions about the refuge concept. In the cases where resistance has developed it was largely ascribed to non- compliance to the prescribed refuge requirements or non-functionality of the refuge approach. The Bt crops used throughout the world were developed in North America against the insect pests that occur there. Since there are differences in the lifecycles and behaviour of insect species targeted by Bt crops the refuge areas also needs to be specified for different target pests. For example, the currently used IRM strategies do not differentiate between polyphagous and monophagous pests and also do not take into account differences that exist in biology and behaviour of different pest species. These IRM strategies have also been developed mainly with large scale commercial farming systems in mind and do not take into account farming systems in developing countries. Current IRM strategies need to be revised and adapted for use by small-scale African farmers. / Thesis (MSc (Environmental Sciences))--North-West University, Potchefstroom Campus, 2012.

This thesis provides a sociological exploration of the politics of new agricultural technologies in the United Kingdom. It addresses some of the key issues involved in these politics, as well as how they are discussed and fought over. Conceptually it addresses these questions by focussing on issues of risk, science and governance. In doing so, this thesis situates the politics of GM crops and foods in relation to wider normative concerns about the cultural values, relationships and institutions shaping agriculture, and British society more generally. Empirically, this thesis applies a qualitative methodology, primarily relying on data generated from a series of in-depth interviews. Through these interviews active participants in the debate were able to express a variety of opinions about the risks and benefits of agricultural biotechnology. The interview data is further supplemented by some documentary evidence, particularly as relates to several government led initiatives addressing agricultural debates in terms of contestations over risk and knowledge. Key chapters in this thesis look at the way in which the debate over GM crops and foods has been shaped by perceptions of the role and values of the life-industry, science and the Government in developing and regulating biotechnology. Finally, this thesis also addresses how society, and practices of governance in particular, are able to accommodate these political issues in managing risk and regulating technological change.

Genetically modified insect-resistant (Bt) cotton is widely cultivated in Pakistan, although the Pakistani Government has yet to approve its commercial cultivation. This thesis is the first in-depth, systematic and critical examination of its commercialisation through the informal sector, and explains the conundrum of around 6.4 million acres of ‘illegal’ cultivation of a GM crop. / Most popular Bt varieties under cultivation in Pakistan contain Monsanto’s genetic modification event (called MON 531), widely believed to be under patent protection in Pakistan. Not wanting to infringe Monsanto’s intellectual property rights (IPR), the Pakistani Government has refused biosafety approval to these varieties. Consequently, the Pakistani breeders of these high-yielding Bt varieties commercialised them in the informal sector. This research decriminalises seed provision in the informal sector and shows that rather than being discrete categories, the formal/informal sectors are locations across which breeders and varieties travel. / For its part, Monsanto is not willing to enter the Pakistani seed market, considering it too disorderly in which to operate. It seeks to operate in the ‘high-differential’ end of the market, therefore requiring active engagement of the Government to keep the farmer from dropping out. Alternatively, Monsanto proposes that the Government licenses MON 531 on payment of an annual technology fee for use by Pakistani farmers and breeders. This technology fee is compared with Monsanto’s cost of development of Bt products, and Pakistan’s budgetary allocation for agriculture. On both counts, the technology fee demanded by Monsanto is excessive. / An examination of Pakistan’s patent law and the patents granted to Monsanto reveals that neither MON 531 nor biotechnological products/processes required for its insertion in local cotton varieties are patented in Pakistan. Thus Pakistan presents a unique case where the Government has consistently honoured patents that it never issued. It is argued that Monsanto’s non-existent IPR has been honoured due to the particular social relations between Monsanto and Pakistani farmers and breeders. Since MON 531 is a commodity objectifying the labour of a particular social group, a patent thereupon becomes a means to operationalise the social relations between this social group and those who consume this commodity. / An alternate route for commercialisation is through the hybrid seed. Monsanto is willing to enter the Pakistani seed market if its technology can be carried in hybrid seeds. But the use of hybrid seed is economically unfeasible in cotton production, and there are significant problems with hybrid seed production in large quantities for the Pakistani market. Yet Monsanto and other companies prefer the hybrid route to technology commercialisation because of an important latent function that hybrids perform – they stop the farmer from saving seed. / It is argued that IPR and the use of hybrid seed are key social and technical strategies for accumulation by dispossession. They represent the commodification of seed, which is a pre-requisite for the process of accumulation. At the same time, these appear to be the only available strategies within existing social relations for improving cotton germplasm and for providing quality Bt seed to the Pakistani farmer.

Genetically modified insect-resistant (Bt) cotton is widely cultivated in Pakistan, although the Pakistani Government has yet to approve its commercial cultivation. This thesis is the first in-depth, systematic and critical examination of its commercialisation through the informal sector, and explains the conundrum of around 6.4 million acres of ‘illegal’ cultivation of a GM crop. / Most popular Bt varieties under cultivation in Pakistan contain Monsanto’s genetic modification event (called MON 531), widely believed to be under patent protection in Pakistan. Not wanting to infringe Monsanto’s intellectual property rights (IPR), the Pakistani Government has refused biosafety approval to these varieties. Consequently, the Pakistani breeders of these high-yielding Bt varieties commercialised them in the informal sector. This research decriminalises seed provision in the informal sector and shows that rather than being discrete categories, the formal/informal sectors are locations across which breeders and varieties travel. / For its part, Monsanto is not willing to enter the Pakistani seed market, considering it too disorderly in which to operate. It seeks to operate in the ‘high-differential’ end of the market, therefore requiring active engagement of the Government to keep the farmer from dropping out. Alternatively, Monsanto proposes that the Government licenses MON 531 on payment of an annual technology fee for use by Pakistani farmers and breeders. This technology fee is compared with Monsanto’s cost of development of Bt products, and Pakistan’s budgetary allocation for agriculture. On both counts, the technology fee demanded by Monsanto is excessive. / An examination of Pakistan’s patent law and the patents granted to Monsanto reveals that neither MON 531 nor biotechnological products/processes required for its insertion in local cotton varieties are patented in Pakistan. Thus Pakistan presents a unique case where the Government has consistently honoured patents that it never issued. It is argued that Monsanto’s non-existent IPR has been honoured due to the particular social relations between Monsanto and Pakistani farmers and breeders. Since MON 531 is a commodity objectifying the labour of a particular social group, a patent thereupon becomes a means to operationalise the social relations between this social group and those who consume this commodity. / An alternate route for commercialisation is through the hybrid seed. Monsanto is willing to enter the Pakistani seed market if its technology can be carried in hybrid seeds. But the use of hybrid seed is economically unfeasible in cotton production, and there are significant problems with hybrid seed production in large quantities for the Pakistani market. Yet Monsanto and other companies prefer the hybrid route to technology commercialisation because of an important latent function that hybrids perform – they stop the farmer from saving seed. / It is argued that IPR and the use of hybrid seed are key social and technical strategies for accumulation by dispossession. They represent the commodification of seed, which is a pre-requisite for the process of accumulation. At the same time, these appear to be the only available strategies within existing social relations for improving cotton germplasm and for providing quality Bt seed to the Pakistani farmer.

The demand for plant and other production is increasing with the growth of human population when the territory where plants can be grown is continually decreasing. The present agricultural production of food, industrial materials and drugs of plant origin is not enough for people, as for the effort to achieve higher environmental comfort, especially in developed countries. We are trying to find a simpler, cleaner and cheaper ways of crop production. The genetic modification is one of the modern ways how to achieve this goal. Students get a lot of information about this topic from various sources, but mainly just from the internet and television. It is recommended that students should be able to compare information received from the media with school knowledge as for avoiding opinion pressure and manipulations.

Bumble bees (bombus spp.) are significant pollinators of many plants, and are particularly attracted to mass-flowering crops such as Oilseed Rape (Brassica Napus), which they cross-pollinate. B. napus is both wind and insect-pollinated, and whilst it has been found that wind is its most significant pollen vector, the influence of bumble bee pollination could be non-trivial when bee densities are large. Therefore, the assessment of pollinator-mediated cross-pollination events could be important when considering containment strategies of genetically modified (GM) crops, such as GM varieties of B. napus, but requires a landscape-scale understanding of pollinator movements, which is currently unknown for bumble bees. I developed an in silico model, entitled HARVEST, which simulates the foraging and consequential inter-patch movements of bumble bees. The model is based on principles from Reinforcement Learning and Individual Based Modelling, and uses a Linear Operator Learning Rule to guide agent learning. The model incoproates one or more agents, or bees, that learn by ‘trial-and-error’, with a gradual preference shown for patch choice actions that provide increased rewards. To validate the model, I verified its ability to replicate certain iconic patterns of bee-mediated gene flow, and assessed its accuracy in predicting the flower visits and inter-patch movement frequencies of real bees in a small-scale system. The model successfully replicated the iconic patterns, but failed to accurately predict outputs from the real system. It did, however, qualitatively replicate the high levels of inter-patch traffic found in the real small-scale system, and its quantitative discrepancies could likely be explained by inaccurate parameterisations. I also found that HARVEST bees are extremely efficient foragers, which agrees with evidence of powerful learning capabilities and risk-aversion in real bumble bees. When applying the model to the landscape-scale, HARVEST predicts that overall levels of bee-mediated gene flow are extremely low. Nonetheless, I identified an effective containment strategy in which a ‘shield’ comprised of sacrificed crops is placed between GM and conventional crop populations. This strategy could be useful for scenarios in which the tolerance for GM seed set is exceptionally low.

面對未來全球人口成長、可耕地減少等現象，生物技術在農業上的應用日益增加。其中，基因改造技術等基因層次相關的平臺應用技術更是提升農作物價值的關鍵—透過跨物種功能應用，大幅提升育種效率。自1996年基改作物商業化種植開始至今，美國都是全球最大種植國家，也是基改作物研發先驅國家。生技農業政策以及和基因改造作物有關法規之制訂使基改作物在美國蓬勃發展，尤其是專利保護對於種子產業之影響尤為深遠。專利權所提供的完善保護使大量資本進入種子產業，投入資源將農業生物技術應用於種子培育上，此舉也促成Monsanto等跨國農業生技公司之興起，主導全球基因改造作物之市場。 Monsanto將研發重心放在基改種子之研發，其在生技種子相關營業比重遠高於同業，同時，其投入特殊性狀之基改種子研發之回收遠高於其他公司之相同營業項目之投資報酬率。Monsanto積極藉由併購取得基因、基因轉殖技術以及種子種源。掌握關鍵基因、基因轉殖技術以及大量且優良種源使含有Monsanto轉殖基因作物在市場上佔有極大的比例。在美國，超過一半以上之主要作物種植面積為基因改造作物，尤其是基因改造大豆，佔大豆總種植面積之比例高達94%。市面上絕大多數基改大豆係Monsanto的抗嘉磷塞（RounupReady，RR1Y）基改大豆種子。藉由智慧財產保護策略，Monsanto並進一步限制RR1Y及其他基改作物之使用方式。 惟RR1Y專利將在2014年到期，農民可在2014年時留種種植基改大豆種子而不用每年購買種子，或購買學名（generic）抗嘉磷塞轉基因大豆種子。在美國所種植之大豆約有四成會外銷，而外銷國家基改作物規範法規是出口與否之關鍵。若未取得歐盟、中國等主要外銷國家基改作物主管機關之批准，呈交包括基因之轉殖植物對環境衝擊之風險評估、包含該基因之轉殖植物所製成食品之安全性評估等基改作物資訊，則抗嘉磷塞基因大豆無法進入該國糧食市場。然而，在目前美國農業生技基改作物相關規範下，學名基改種子廠必須在專利種子專利到期後，才能進行實驗及田間試驗，呈交相關資料以符合基改作物主管機關之要求。透過建立學名基改作物快速獲得核准查驗登記之程序，允許學名廠依賴專利基改作物原廠之實驗及田間試驗資料以建立其學名基改作物之安全性與性狀表現有效性，同時，允許學名基改作物在原基改作物開發廠專利期滿前即可開始進行試驗，可以使學名抗嘉磷塞大豆種子以及其他學名基改種子能在原專利基改作物種子專利到期後順利進入市場，促使基改作物種子價格競爭，並對於專利基改作物研發公司進行適度之補償，以促進產業發展。 / The development of new technologies in plant breeding has led to improvements in the efficiency scientists produce improved plant varieties. Genetic modification is among the developments that support plant breeding. The introduction of genetically modified crops has revolutionized the agriculture industry. With patent protection available on GM traits, varieties and other aspects of seed production, private R&D investments in the seed industry have increased tremendously. Monsanto has been the leading company in investing agricultural biotechnology and has obtained a dominant position in the GM traits found in soybeans, cotton, corn and other commercialized crops. Currently, over 90 percent of soybeans planted in the United States were herbicide-resistant, with Monsanto’s Roundup Ready being the dominant soybeans planted. In 2014, however, the agriculture industry will be facing the expiration of a patent for Roundup Ready soybeans. Despiate the fact that the patent expiration date is approaching, the agricultural biotech industry has no guideline in place to tell its players exactly how to transition seamlessly from patent monopolies to generic competition. The transition problem is espectially significant for soybeans exported to oversea markets as more than 40 percent of the soybeans grown in the U.S. are exported. In order for those soybeans to be accepted in the grain channel, regulatory approvals are required in countries that import soybeans. Obtaining data, which includes scitific data on the trait being developed, for regulatory approvals can take years to complete. If a generic trait is to reach market immediately after the original trait go off patent, the data generation process should begin before patent expiration. A Hatch-Waxman type patent infringement defense for activities necessary to obtain regulatory approvals for biotech traits can ensure that seed companies have sufficient time to obtain registrations for a generic Roundup Ready trait or other generic traits. Current legislation should be modified to adequately oversee the transition to the generic use of genetically modified crops and, in the mean time, ensure the availability of generic modified crops.