Thesis (M.S.)--University of Michigan, 1973.

Thesis (M.S.P.H.)--University of Michigan, 1941.

Indiana University-Purdue University Indianapolis (IUPUI) / Introduction: Bacteremia involving oral bacteria and the systemic inflammatory responses are mechanisms that could causally link oral and systemic diseases. Objective: To use an experimental gingivitis model (EGM) in 2 clinical studies to 1) examine the systemic inflammatory responses to dental plaque, and assess racial differences in these responses; 2) determine whether dental plaque accumulation causes bacteremia and subsequent systemic responses following toothbrushing. Additionally, a laboratory study was conducted to examine the interaction between circulating human neutrophils and Fusobacterium nucleatum. Methods: For both clinical studies, healthy adults, aged 18-31 years, were recruited. In the first study, black and white, males and females participated in a 21-day EGM; in the second study, white adults participated in a 7-day EGM. In both studies, subjects visited the clinic weekly for: 1) measurement of the plaque index (PI) and gingival index (GI); 2) collection of peripheral blood samples to evaluate systemic markers of inflammation. In the second study, to analyze bacteremic episodes during the experimental phase, peripheral blood samples were collected at baseline and at 0.5, 5, and 30 minutes post-toothbrushing. In the laboratory study, interactions between F. nucleatum and circulating neutrophils were examined using a luminol-enhanced chemiluminescence assay. Results: During the experimental phases of both clinical studies, PI and GI increased (p<0.05) with a correlation between PI and GI ≥0.79. In the first study, dental plaque accumulation resulted in a systemic response that manifested as changes (p<0.05) in the level of inflammatory markers, hematologic factors, markers of lipid metabolism, and markers of metabolic change. This systemic response differed between individuals of different gender and race. In the second study, bacteremic episodes and changes in hematologic factors were observed post-toothbrushing during the experimental phase. Activation of neutrophils with F. nucleatum, in the laboratory study, increased the levels of neutrophil chemiluminescence (p<0.05). Conclusions: Overall, the findings of these investigations may shed light on the mechanistic pathways by which oral infection may impose risk for systemic diseases and provide some evidence to support a possible causal association between oral and systemic diseases. The clinical significance of this in systemic inflammatory diseases requires further investigation.

Determina la influencia de la edad en la prevalencia y severidad de la inflamación gingival durante la gestación. Participan 60 mujeres grávidas durante el tercer trimestre de gestación divididas en tres niveles etáreos: jóvenes (15-19), en edad fértil ideal (20-35) y añosas (35 a más); las cuales serán seleccionadas a partir de un control de placa bacteriana. Asimismo se considera 30 mujeres no gestantes como grupo control divididas en los mismo niveles etáreos. Se descarta la presencia de enfermedades sistémicas y otras condiciones que influencien en la exactitud de los resultados. La condición gingival se evaluará usando el índice de Loe y Silness.

Master of Dental Surgery / In setting out this thesis, an attempt has been made to give a detailed investigation of the gingival changes which may take place in pregnancy and with particular reference to pregnancy gingivitis or, as it is referred to in this thesis: gingivitis gravidarum. Gingivitis gravidarum is that gingivitis which occurs in the pregnant state and is attributable to, or aggravated by the gravid state. A clinical survey has been carried out and a detailed study of all available literature made. As a result of this study, comparisons are drawn between Australian born and immigrant groups. There are many unsolved problems concerning the condition, and although this investigation does not cover any new ground in the light of world research, it is, to the best of my knowledge, the first time that a survey as comprehensive as this has been made in this country.

published_or_final_version / abstract / Dentistry / Master / Master of Dental Surgery

Master of Dental Surgery / In setting out this thesis, an attempt has been made to give a detailed investigation of the gingival changes which may take place in pregnancy and with particular reference to pregnancy gingivitis or, as it is referred to in this thesis: gingivitis gravidarum. Gingivitis gravidarum is that gingivitis which occurs in the pregnant state and is attributable to, or aggravated by the gravid state. A clinical survey has been carried out and a detailed study of all available literature made. As a result of this study, comparisons are drawn between Australian born and immigrant groups. There are many unsolved problems concerning the condition, and although this investigation does not cover any new ground in the light of world research, it is, to the best of my knowledge, the first time that a survey as comprehensive as this has been made in this country.

Diss. (sammanfattning) Göteborg : Göteborgs universitet, 2009. / Härtill 5 uppsatser.

Thesis (doctoral)--Malmo University, Sweden, 2005. / Added t.p. with thesis statement inserted. Includes bibliographical references.

Thesis (doctoral)--University of Göteborg, 1993. / Added t.p. with thesis statement inserted. Includes bibliographical references.