Global ETD Search

31	Cardiovascular Dysfunction in COVID-19: Association Between Endothelial Cell Injury and Lactate Yang, Kun, Holt, Matthew, Fan, Min, Lam, Victor, Yang, Yong, Ha, Tuanzhu, Williams, David L., Li, Chuanfu, Wang, Xiaohui 01 January 2022 (has links) Coronavirus disease 2019 (COVID-19), an infectious respiratory disease propagated by a new virus known as Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has resulted in global healthcare crises. Emerging evidence from patients with COVID-19 suggests that endothelial cell damage plays a central role in COVID-19 pathogenesis and could be a major contributor to the severity and mortality of COVID-19. Like other infectious diseases, the pathogenesis of COVID-19 is closely associated with metabolic processes. Lactate, a potential biomarker in COVID-19, has recently been shown to mediate endothelial barrier dysfunction. In this review, we provide an overview of cardiovascular injuries and metabolic alterations caused by SARS-CoV-2 infection. We also propose that lactate plays a potential role in COVID-19-driven endothelial cell injury. COVID-19 (complications) humans HMGB1 (high mobility group box 1) aerobic glycolytic metabolism cardiovascular dysfunction endothelial cells (metabolism) lactate thrombosis vascular permeability SARS-CoV-2 endothelium lactic acid (metabolism) vascular diseases (pathology) Surgery
32	Multifonctionnalité de l'aldolase glycolytique : mécanisme catalytique et interaction avec un peptide de la protéine du syndrome Wiskott-Aldrich St-Jean, Miguel January 2008 (has links) Thèse numérisée par la Division de la gestion de documents et des archives de l'Université de Montréal. Aldolase glycolytique Glycolytic aldolase Mécanisme catalytique Catalytic mechanism Clivage du substrat Substrate cleavage Condensation aldolique Aldol condensation Transfert de proton stéréospécifique Stereospecific proton transfer Interaction protéine-protéine Protein-protein interaction Protéine du syndrome Wiskott-Aldrich Wiskott-Aldrich syndrome protein Dynamique de l'actine Actin dynamics Cristallographie Crystallography Macromolecular X-ray diffraction
33	Multifonctionnalité de l'aldolase glycolytique : mécanisme catalytique et interaction avec un peptide de la protéine du syndrome Wiskott-Aldrich St-Jean, Miguel January 2008 (has links) Thèse numérisée par la Division de la gestion de documents et des archives de l'Université de Montréal Aldolase glycolytique Glycolytic aldolase Mécanisme catalytique Catalytic mechanism Clivage du substrat Substrate cleavage Condensation aldolique Aldol condensation Transfert de proton stéréospécifique Stereospecific proton transfer Interaction protéine-protéine Protein-protein interaction Protéine du syndrome Wiskott-Aldrich Wiskott-Aldrich syndrome protein Dynamique de l'actine Actin dynamics Cristallographie Crystallography Macromolecular X-ray diffraction

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