Thesis (M.A.)--Indiana University, 2008. / Title from screen (viewed on June 3, 2009). Department of English, Indiana University-Purdue University Indianapolis (IUPUI). Advisor(s): Ulla Connor, William V. Rozycki, Thomas A. Upton. Includes vita. Includes bibliographical references (leaves 95-99).

Indiana University-Purdue University Indianapolis (IUPUI) / The subject of this case study is an international postdoc, a principal investigator of a large medical research laboratory. The study’s objective: examine the systematic process of writing a grant proposal in L2 English from start to finish. Obtaining original computer files exempt from being saved-over became a significant obstacle in examining the systematic process. Ethnographic data reveal pedagogical implications for L2 instruction in grasping the big picture, summarizing to fit word limitations, understanding the application process, familiarity of the grant genre of a specific discipline, and the skills to network with peers. This study opens the door to further studies that might provide a better window of understanding in the systematic writing process of an international postdoctoral’s grant proposal.

abstract: This project presents a mixed methods analysis of proposal editing in sponsored research administration at U.S.-based universities. As sponsored research funding has become increasingly competitive, universities have sought to support their faculty and research infrastructure by offering proposal editing services as a component of the proposal development process. However, the relative newness of proposal and research development as fields, combined with prior studies that show a general lack of research into proposal editing and faculty perceptions of proposal development resources, mean that these areas can benefit from additional focused research. This study aimed to answer two primary research questions: How do universities approach and offer proposal editing as a component of the proposal development process, and what are faculty reactions to editing services as a resource during that same process? The study consisted of two components: a survey of 32 faculty members' perceptions of editing services as an element of their proposal development, and interviews with ten research administrators and editors to discuss how editing services function within the proposal preparation process. Despite a small sample size and disciplinary homogeneity, the survey results showed that demand for institutionally provided editing services varies by research field and activity level, but that faculty showed noticeable interest in at least having the option of an editor reviewing their proposals prior to submission. Interview participants agreed that faculty who are new or early in their careers, along with faculty who speak English as a second language, are especially interested in receiving editing services. Editors themselves provide various levels of edit, dependent on their own backgrounds, editing timelines, and faculty receptiveness to the edits. When provided, edits focus on compliance and grammar, but deeper edits help academic styles of writing transition into more persuasive grant writing styles to strategically position the proposal. As proposal editing services become more widespread as a way of supporting faculty and increasingly proposal quality and success, universities should implement editing services according to faculty demand and needs. Careful implementation can ensure that editing services fully support faculty while making a meaningful impact on a university's research development strategies and goals. / Dissertation/Thesis / Masters Thesis Technical Communication 2019

Sexual harassment in Cairo's public spaces is a symptom of infringement upon women’s rights in Egypt. Which is ingrained in the socioeconomic context, cultural, and traditional norms of the society. This grant proposal and background research proposes the construction of an extensive anti-sexual harassment infrastructure base in Egypt. The infrastructure platform is built on an evidence-based strategy and guided by recognized best practices. The platform is geared towards alleviating the symptoms of sexual harassment in Cairo's public spaces by constructing the urgently required, but currently missing, national mechanisms which are necessary to prevent, report, prosecute, and provide survivor services for victims of sexual harassment. In addition to the immediate perceived causes and effects of sexual harassment in Egypt there is also deep-rooted ecological factors that must be considered. These ecological factors, on an individual level, both biological and personal, include the fact that approximately 97% of Egyptian girls witness female gentile mutilation (FGM) in a publicized fashion between the ages 4 & 10. The practice of FGM, may have indoctrinated little boys and little girls, from an early age, that it is socially acceptable to inflict physical and psychological pain and suffering upon the female. FGM carried out at this age, as opposed to male circumcision, which is carried out during early infancy, allows for the neurological trauma that is generated leaves a lasting imprint. On a family level, 49% of adolescent rural girls marry before the age of 16. Marriage at this age is internationally recognized as sexual abuse, yet is common practice in rural Egypt. This practice sets a negative precedence for accommodating women's voices, this precedence may last a lifetime. On a community level, based on the most recent statistically significant surveys, approximately 70% of youth, both male and female, believe women are subordinate to men. This dictates that male must exercise control of resources and decision-making. And, that a girl must do what her brother says, even if he is younger. On a society level, 86% of surveyed male respondents indicated they would do “nothing” to try and stop sexual harassment if they witnessed it happening to a stranger in public. And finally, even from the moment they are born, the large majority of women in Egypt, because of religious dictates, inherit only half of what a male sibling would. Ceteris paribus, women in Egypt, just by virtue of being female, based on inheritance, are only able to afford a living standard, for themselves and their family that is only half as high as that of their male siblings living standard, unless of course their male sibling is benevolent enough to bestow upon them his own wealth. All these factors invariable, where they apply, undermine women's status in society and negatively impact attitudes of protecting women from harm and violence, in all its forms, which includes sexual harassment in public spaces.

With tightening university budgets, never before has the activity level of research grant proposal writing been more intense. With increased proposal numbers, including for the National Science Foundation's (NSF) prestigious CAREER award, has also come increased competition and decreased funding rates. This dissertation has searched for successful and unsuccessful characteristics from funded and unfunded CAREER proposals. The research focused on a study of two key subjects: 1) a corpus of 20 texts that included 12 funded proposals and 8 unfunded proposals from across NSF programs, and 2) an ethnographic analysis comprised from interviews with 14 NSF program officers (PO) from varying programs. Coding elements with the texts to uncover topical chains of content, rhetorical, and document design strategies revealed sound rhetorical moves and rhetorical mistakes. The study also illustrated evidence of adherence to or neglect of NSF-mandated writing/formatting conventions as connected to the likelihood of receiving funding. Moreover, the study revealed conventions that have developed for the genre that are not prescribed by NSF but that, nevertheless, seem to be expected. Through genre field analysis, the study's interviews with program officers (PO) revealed a system of genre-agents and player-agents that interact together in a highly rhetorical and social system. This system, comprised of locales in which a multitude of play scenarios can be enacted to exert influence, operates within fairly exact rules of play. Such rules may be published by NSF or simply be "understood," yet principal investigators (PI) are held accountable for them regardless. The ethnography created from interviews with POs revealed multiple genre field elements (e.g., genre- and player-agents, transformative locales, play scenarios, penalty conditions) as well as common mistakes and best practices. A complete mapping of the CAREER award proposal preparation, submission, and review process resulted from the study, which mapping has offered insightful strategies to expand PI (and other agents') influence on the funding process. The dissertation concluded by offering investigators a step-by-step process to identify and map the elements of the proposal genre field in which they operate.

Cancer cells are most clearly characterized by their abnormal and uncontrolled cell growth. One of the most notable theories that explains the vast proliferative capacity of tumorigenic cells is the Warburg effect, a significant shift in metabolism wherein cancer cells preferentially fuel cell division using aerobic glycolysis instead of aerobic respiration. This upregulation of glycolytic fermentation in aerobic environments is highly unusual - glycolysis is typically utilized in anaerobic conditions, but nonetheless dominates cancer metabolic activity in spite of the presence of oxygen. Since the discovery the Warburg effect in the 1920s, researchers have struggled to identify whether aerobic glycolysis is a cause or consequence of carcinogenesis. Interestingly, a new theory recently emerged that challenges this widely-accepted metabolic paradigm for cancer. Known as the reverse Warburg effect, this new mechanism shows that in carcinomas such as breast cancer, the Warburg effect occurs not in cancer cells, but rather in tumor-adjacent stromal fibroblasts. These cancer-associated fibroblasts (CAFs) in the greater tumor microenvironment produce lactate - a high-energy metabolite formed as a byproduct of aerobic glycolysis - to fuel aerobic respiration and rapid tumorigenesis in neighboring cancer cells. This emerging theory emphasizes the pivotal role of the tumor microenvironment in determining whether cancer cells undergo aerobic glycolysis or aerobic respiration. Central to this lactate-linked metabolic intersection are two critical enzymes that regulate a cell's metabolic commitment - lactate dehydrogenase (LDH) and pyruvate dehydrogenase complex (PDHc). In order to clarify the mechanisms through which CAFs induce tumorigenesis in breast cancer, we plan to carry out two specific aims: (1) evaluate the enzymatic activity of LDH and PDHc, and (2) compare LDH and PDHc enzyme content. Using co-culture techniques to study the breast cancer tumor microenvironment in vitro, we will compare the enzymatic activity and enzyme content of both MCF7 breast cancer cells and CAFs to identify whether the reverse Warburg effect occurs due to post-translational enzyme activation or increased enzyme synthesis.

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