Humans' incredible capacity to model the complexity of the physical world is possible because they cast this complexity as the composition of simpler entities and rules to process them. Extensive work in cognitive science indeed shows that human perception and reasoning ability is structured around objects. Motivated by this observation, a growing number of recent work focused on entity-centric approaches to learning representation and their potential to facilitate downstream tasks. In the first contribution, we show how an entity-centric approach to learning a transition model allows us to extract meaningful visual entities and to learn transition rules that achieve better compositional generalization. In the second contribution, we show how an entity-centric approach to generating graphs allows us to design a model for conditional graph generation that permits direct optimisation of the graph properties. We investigate the performance of our model in a prototype-based molecular graph generation task. In this task, called lead optimization in drug discovery, we wish to adjust a few physico-chemical properties of a molecule that has proven efficient in vitro in order to make a drug out of it. / L'incroyable capacité des humains à modéliser la complexité du monde physique est rendue possible par la décomposition qu'ils en font en un ensemble d'entités et de règles simples. De nombreux travaux en sciences cognitives montre que la perception humaine et sa capacité à raisonner est essentiellement centrée sur la notion d'objet. Motivés par cette observation, de récents travaux se sont intéressés aux différentes approches d'apprentissage de représentations centrées sur des entités et comment ces représentations peuvent être utilisées pour résoudre plus facilement des tâches sous-jacentes. Dans la première contribution on montre comment une architecture centrée sur la notion d'entité va permettre d'extraire des entités visuelles interpretables et d'apprendre un modèle du monde plus robuste aux différentes configurations d'objets. Dans la deuxième contribution on s’intéresse à un modèle de génération de graphes dont l'architecture est également centrée sur la notion d'entités et comment cette architecture rend plus facile l'apprentissage d'une génération conditionelle à certaines propriétés du graphe. On s’intéresse plus particulièrement aux applications en découverte de médicaments. Dans cette tâche, on souhaite optimiser certaines propriétés physico-chmiques du graphe d'une molécule qui a été efficace in-vitro et dont on veut faire un médicament.

A (self-) adaptive system is a system that can dynamically adapt its behavior or structure during execution to "adapt" to changes to its environment or the system itself. From a security standpoint, there has been some research pertaining to (self-) adaptive systems in general but not enough care has been shown towards the adaptation itself. Security of systems can be reasoned about using threat models to discover security issues in the system. Essentially that entails abstracting away details not relevant to the security of the system in order to focus on the important aspects related to security. Threat models often enable us to reason about the security of a system quantitatively using security metrics. The structural adaptation process of a (self-) adaptive system occurs based on a reconfiguration plan, a set of steps to follow from the initial state (configuration) to the final state. Usually, the reconfiguration plan consists of multiple strategies for the structural adaptation process and each strategy consists of several steps steps with each step representing a specific configuration of the (self-) adaptive system. Different reconfiguration strategies have different security levels as each strategy consists of a different sequence configuration with different security levels. To the best of our knowledge, there exist no approaches which aim to guide the reconfiguration process in order to select the most secure available reconfiguration strategy, and the explicit security of the issues associated with the structural reconfiguration process itself has not been studied. In this work, based on an in-depth literature survey, we aim to propose several metrics to measure the security of configurations, reconfiguration strategies and reconfiguration plans based on graph-based threat models. Additionally, we have implemented a prototype to demonstrate our approach and automate the process. Finally, we have evaluated our approach based on a case study of our making. The preliminary results tend to expose certain security issues during the structural adaptation process and exhibit the effectiveness of our proposed metrics.