The objective of this work was to evaluate the efficacy of an induced normothermia protocol by comparing patient mortality and outcomes in patients treated at Boston Medical Center (BMC) before and after the implementation of the protocol. The controls (regular fever management) and the cases (induced normothermia) were demographically similar, except there were more whites (p = 0.01) in the control group and more of the patients in the control group were transferred to BMC from outside hospitals (p = 0.006), although there was not a higher incidence of death among patients who were transferred from outside hospitals (p = 0.55). The patients in the case group were kept normothermic throughout the first 7 days of their hospital stay more effectively than those in the control group (p = 0.0001). Average intracranial pressure (ICP) and cerebral perfusion pressure (CPP) were not different between the two groups, although mean arterial pressure (MAP) was (p = 0.84; p = 0.08; p = 0.02, respectively). Mortality was lower in the case group by hospital discharge (p = 0.007) and patients in the case group were more likely to achieve a positive functional outcome (p = 0.03). In light of these findings, there is a need for high-quality prospective trials to assess the efficacy of induced normothermia compared to regular fever management.

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Bakgrund: 46-77% av alla patienter drabbas av en mild hypotermi någon gång i det perioperativa förloppet. En av punkterna på WHOs checklista för säker kirurgi är hypotermi och huruvida patienten lider risk att drabbas av hypotermi och vilka åtgärder som ska tas för att förhindra det. Det finns flertalet komplikationer patienten kan drabbas av vid intraoperativ hypotermi och operationssjuksköterskan arbetar för att förhindra det. Motiv: Det finns mycket forskning om vad som händer med patienten vid oplanerad intraoperativ hypotermi och hur det bör förebyggas. Men det finns inte lika mycket forskning om operationssjuksköterskors erfarenhet i området. Motivet var därför att medvetande göra hur operationssjuksköterskan arbetar med intraoperativ hypotermi. Syfte: Syftet med studien är att beskriva operationssjuksköterskors erfarenheter av oplanerad intraoperativ hypotermi hos vuxna patienter, konsekvenser av det samt sätt att förebygga detta.  Metod: Studien var en empirisk kvalitativ studie där åtta specialistsjuksköterskor inom operationssjukvård från en operationsavdelning i södra Sverige blev intervjuade. Innehållsanalysen till studien var inspirerad av Graneheim och Lundmans innehållsanalys. Resultat: Resultatet i studien baseras på tre kategorier med åtta underkategorier. Kategorierna presenteras som Samarbete mellan yrkeskategorier nödvändigt, Konsekvenser av hypotermi, Hypotermi och omvårdnadsåtgärder Konklusion: Operationsteamets erfarenheter och de utsatta normerna på avdelningen styr det förebyggande arbetet mot intraoperativ hypotermi. Mycket av ansvaret verkar ligga på anestesisjuksköterskorna. Samarbete mellan dem olika personalkategorierna i teamet är viktigt. Operationssjuksköterskor upplever oro och stress för att inte tillräckligt förebygga hypotermi och orsaka patienten onödigt lidande. / Background: 46-77% of all patients experience a mild hypothermia at some point in the perioperative course. One of the items on the WHO's checklist for safe surgery is hypothermia and whether the patient is at risk of developing hypothermia and what measures should be taken to prevent it. There are several complications the patient may experience with intraoperative hypothermia and the theater nurse works to prevent it. Motive: There is a lot of research on what happens to the patient in unplanned intraoperative hypothermia and how it could be prevented. But there is not as much research on the surgical nurse's experience in the area. The motive was therefore to disclose how the surgical nurse works with intraoperative hypothermia. Aim: The aim of the study is to describe theater nurse’s experience of unplanned intraoperative hypothermia in adult patients, consequences of it and ways to prevent it Methods: The study was an empirical qualitative interview study in which eight theater nurses from a surgical department in southern Sweden. The analysis was performed using qualitative content analysis inspired by Graneheim and Lundman Result: The results of the study are based on three categories with eight subcategories. The categories are presented as Teamwork necessary, Consequences of hypothermia, Hypothermia and Nursing measures    Conclusion: Surgical team’s experience and the norms in the department guide the preventive work against intraoperative hypothermia. Much of the responsibility seems to lie on the anesthesia nurses. Teamwork between the different team professions is important. Theater nurses experience some anxiety and stress that their preventive measures are not sufficient and contributes to unnecessary patient suffering.

Bakgrund: Alla patienter som opereras i generell anestesi löper risk för perioperativ hypotermi. Obehandlad hypotermi kan leda till fysiologiska komplikationer och orsaka lidande för patienten och utgör en risk för patientens säkerhet samt ökade vårdkostnader. Enligt den teoretiska modellen Perioperative Patient Focused Model ansvarar operationssjuksköterskan för säker vård och behöver förebygga och behandla perioperativ hypotermi. Det finns olika metoder för att förhindra hypotermi, det saknas dock tillräcklig kunskap om dessa bland vårdpersonal och därför finns ett behov av att sammanställa och utvärdera den aktuella evidensen av perioperativ hypotermiprevention. Syfte: Sammanställa olika metoder och deras effektivitet för förebyggande av perioperativ hypotermi hos vuxna patienter i generell anestesi. Metod: Deskriptiv litteraturstudie med systematisk ansats baserad på 22 kvantitativa randomiserade kontrollstudier analyserade med hjälp av narrativ syntes. Resultat: Aktiva metoder för hypotermiprevention är effektivare än passiva metoder, där varmluftstäcke var den effektivaste metoden. Andra effektiva metoder, speciellt när överkroppen inte kan täckas intraoperativt, är värmemadrass samt värmda infusionsvätskor. Samtidigt pekar resultatet på att flera olika metoder bör användas tillsammans, varav minst en aktiv metod, och alla patienter oavsett ingrepp har nytta av att få preoperativ uppvärmning. Slutsats: Även om det är svårt att helt förhindra perioperativ hypotermi hos alla patienter är det möjligt att förebygga och begränsa dess omfattning genom att kombinera olika befintliga metoder baserat på operationssjuksköterskans perioperativa bedömning av patienten. / Background: All patients who undergo surgery under general anesthesia are at risk of perioperative hypothermia. Untreated hypothermia can lead to physiological complications and cause suffering for the patient, thereby posing a risk to the patient's safety, as well as increased healthcare costs. According to the Perioperative Patient Focus Model the operating room (OR) nurse must provide safe care and thereby prevent and treat perioperative hypothermia. There are various methods to prevent hypothermia, however, there is a lack of sufficient knowledge about these among healthcare personnel and therefore there is a need to compile and evaluate the current evidence of perioperative hypothermia prevention. Aim: To compile different methods and their effectiveness for the prevention of perioperative hypothermia in adult patients under general anesthesia.  Method: Descriptive literature study with a systematic approach based on 22 quantitative randomized control trials analyzed using narrative synthesis. Results: Active methods of hypothermia prevention are more effective than passive methods, forced air blanket being the most effective method. Other effective methods, especially when the upper body cannot be covered intraoperatively, are heating mattresses and warmed infusion fluids. At the same time, the results indicate that several different methods should be used together, of which at least one active method, and all patients, regardless of surgery intervention, benefit from preoperative warming. Conclusion: Although it is difficult to completely prevent perioperative hypothermia in all patients, it is possible to prevent and limit the extent by combining different existing methods based on the operating nurse's perioperative assessment of the patient.

OBJECTIVES The aim of this study was to test the hypothesis that hypothermia and early reperfusion are synergistic for limiting infarct size when an acutely occluded coronary is associated with cardiac arrest. BACKGROUND Cohort studies have shown that 1 in 4 post-cardiac arrest patients without ST-segment elevation has an acutely occluded coronary artery. However, many interventional cardiologists remain unconvinced that immediate coronary angiography is needed in these patients. METHODS Thirty-two swine (mean weight 35 +/- 5 kg) were randomly assigned to 1 of the following 4 treatment groups: group A, hypothermia and reperfusion; group B, hypothermia and no reperfusion; group C, no hypothermia and reperfusion; and group D, no hypothermia and no reperfusion. The left anterior descending coronary artery was occluded with an intracoronary balloon, and ventricular fibrillation was electrically induced. Cardiopulmonary resuscitation was begun after 4 min of cardiac arrest. Defibrillation was attempted after 2 min of cardiopulmonary resuscitation. Resuscitated animals randomized to hypothermia were rapidly cooled to 34 degrees C, whereas those randomized to reperfusion had such after 45 min of left anterior descending coronary artery occlusion. RESULTS At 4 h, myocardial infarct size was calculated. Group A had the smallest infarct size at 16.1 +/- 19.6% (p < 0.05). Group C had an intermediate infarct size at 29.5 +/- 20.2%, whereas groups B and D had the largest infarct sizes at 41.5 +/- 15.5% and 41.1 +/- 15.0%, respectively. CONCLUSIONS Acute coronary occlusion is often associated with cardiac arrest, so treatment of resuscitated patients should include early coronary angiography for potential emergent reperfusion, while providing hypothermia for both brain and myocardial protection. Providing only early hypothermia, while delaying coronary angiography, is not optimal. (J Am Coll Cardiol Intv 2016; 9: 2403-12)

The myocardium is known to release CPK, LDH1 , and GOT in response to ischemia as a result of myocardial infarction. This study was designed to induce the release of cardiac enzymes without adversely effecting the myocardium by perfusion hypothermia, thereby suggesting that these enzymes are not as specific in the diagnosis of myocardial infarction as once thought. Hypothermia was by in vivo perfusion of the left anterior descending coronary artery. Enzyme activity was measured from sera samples spectrophotometrically and electrophoretically. Significant CPK and LDH1 increases were observed in animals perfused between 25 and 19 C. These results indicate that, while heart function remained unchanged, an alteration occurred in the membrane integrity of the myocardial cells.

A hipotermia ainda é um problema que responde por uma proporção de complicações no período pós-operatório que podem ser preveníveis. Apesar da melhora nas técnicas anestésico-cirúrgicas, estima-se que ocorre em mais de 70% dos pacientes no período perioperatório, sendo uma preocupação para a equipe de saúde. Frente a isso, melhorias no treinamento dos profissionais de enfermagem com relação à hipotermia se faz necessário. Os objetivos do estudo foram: Avaliar a influência de intervenções educativas sobre o conhecimento da hipotermia dos Auxiliares de Enfermagem e da assistência de enfermagem no período intraoperatório, identificar a diferença do conhecimento sobre hipotermia do Auxiliar de Enfermagem, após a intervenção educativa e comparar a assistência de enfermagem prestada ao paciente cirúrgico, antes e após a intervenção educativa. Para tanto, realizou-se uma pesquisa com abordagem metodológica quantitativa, quase experimental, com um grupo de comparação antes e depois. Participaram do estudo 35 auxiliares de enfermagem. Para a coleta de dados, elaborou-se um questionário e um roteiro de observação da assistência direta ao paciente que foram validados pela técnica Delphi. Do total dos profissionais, 91% eram do sexo feminino, 65,7% tinham se formado em instituição privada; 45,7% pertenciam à faixa etária de 20 a 30 anos, 48,6% com tempo de formação entre 1 a 5 anos e 91,4% com tempo de atuação no Centro Cirúrgico entre 1 a 5 anos. O teste t mostrou diferença estatisticamente significante em relação ao conhecimento (p=0,00) e observação direta (p=0,00) após a intervenção educativa; entretanto, o teste de análise de variância para medidas repetidas não mostrou diferença significativa do conhecimento e na assistência direta ao paciente, após a intervenção educativa quando relacionado às variáveis sociodemográficas estudadas. Pelo teste t, todos os itens do questionário referente ao conhecimento sobre hipotermia e ao roteiro de assistência direta ao paciente mostraram diferença significativa, após a intervenção educativa. Concluiu-se que, apesar das limitações deste estudo, se pôde inferir que a intervenção educativa foi efetiva, visto que a diferença nas médias do conhecimento e na assistência direta aumentaram após a intervenção, uma vez que os conceitos sobre hipotermia foram ancorados, ampliados e modificados na estrutura cognitiva dos profissionais de enfermagem, conforme a teoria de aprendizagem significativa de David Ausubel. / Hypothermia is still a problem that responds for a percentage of the complications in the post operatory period that can be preventable. Despite the improvement in the anesthesia surgery techniques, it is estimated that it happens in more than 70% of the patients in the peri operatory period, being a worrying for the health team. Because of this, improvements in the nursery professionals training in relation to hypothermia are necessary. The goals of this study were: to evaluate the influence of the educational interventions over the hypothermia knowledge of the Nursery Assistants and the nursery assistance in the intra-operatory period, to identify the difference of knowledge over hypothermia of the Nursery Assistance, after the educational intervening and compare the nursery assistance given to the surgical patient, before and after the educational intervening. For such, a research was held with a quantitative methodological approach, nearly experimental, with a comparison group before and after. 35 nursery assistants participated on the study. For the data survey, a questionnaire was elaborated and a script for observation of the direct assistance to the patient which was validated by the Delphi Technique. From the total of the professionals, 91% were female, 65.7% were graduated from a private institution, 45.7% were between 20 and 30 years of age, 48.6% have been graduated for 1 to five years and 91.4% have been acting in the Surgical Center for 1 to 5 years. The t test shows statistical meaningful difference of knowledge (p=0.00) and of direct observance (p=0.00) after the educational intervening as for the socio-demographical variants studied. By the t test, all the items in the questionnaire referring to the knowledge in hypothermia and to the script in the direct assistance to the patient showed meaningful difference, after the educational intervening. It was concluded that, in spite of the limitations of this study, it is possible to infer that the educational intervening was effective, given that the difference in the averages of knowledge and in the direct assistance increased after the intervening, once the concepts on hypothermia were anchored, broadened and modified in the cognitive structure of the nursery professionals, according to the meaningful learning theory from David Ausubel.

A isquemia cerebral causada pela parada cardíaca leva ao desapareciemnto neuronal. studamos os mecanismos de morte celular envolvidos na isquemia in vitro em linhagem de neuroblastoma.O insulto isquêmicao foi reproduzido cultivando as células sem fatores de crescimento, sem glicose e em embiente hipóxico produzido por um sistema de anaerobiose. Os resultados sugerem que a privação de oxigênio, glicose e fatores de cresciemtno do meio de cultura reproduzem o fenômeno semelhante a isquemia. INvestigamos ainda a participação de processo apoptótico e sua modulação térmica. Observams que a hipotermia produz neuroproteção, enquanto a hipertermia agrava o processo de morte celular por apoptose. / Cardiac arrest causes cerebral ischemia and neuronal disappearance. We investigate celular death mechanisms elucidated by a model of ischemia in neuroblastoma cell line. The ischemic insult was reproduced by deprivation of growth factors and glucose in a hypoxic environment produced by an anaerobiosis system. Our results validate the experimental model and revel the participation of an apoptotic process in the celular loss induced by ischemia. We also demonstrated that hypothermia can be used as a neuroprotector agent whereas hyperthermia aggavates celular damage.