Thesis (S.M.)--Harvard-MIT Division of Health Sciences and Technology; and, (M.B.A.)--Massachusetts Institute of Technology, Sloan School of Management, 2006. / Includes bibliographical references (leaves 47-48). / For a growing number of indications, combination therapies are becoming increasingly common due in part to their superior efficacy, as compared to monotherapies. In fact, in the case of infectious diseases such as AIDS and tuberculosis, combination therapies are now the standard of care. With the emergence of drug-device combinations, genetic testing, and individualized medicine, this trend towards combination therapies is likely to continue to grow. In this context the pricing of combination therapies is a critical component that needs to be understood by medical practitioners, payors and policy makers. There are three factors to consider in the pricing of combination therapies: the characteristics and structure of the market in which the combined product is sold, the absence or presence of market exclusivity, and the prices of the components of the combined product, when sold individually. When one or more of the components of the combined product has market exclusivity, additional factors such as exclusionary bundling, tying, and double marginalization may come into play. / (cont.) In this thesis I discuss combination therapies, describe the factors that can affect the pricing of combination therapies, and then attempt to identify the relationships among component pricing, market forces, market exclusivity and the pricing of combination therapies. To illustrate these relationships empirically, I will analyze data from a sample of unified combined drugs, a subset of combination therapies. The results of this analysis are consistent with a hypothesis that, for combination drugs with a patented ingredient, the elimination of double marginalization by efficient transfer pricing and economic and exclusionary bundling, lowers the price of the unified combination drug relative to the price of its constituents. / b y Sundar Subramaniam. / M.B.A. / S.M.

Thesis (S.M.)--Harvard-MIT Division of Health Sciences and Technology; and, (M.B.A.)--Massachusetts Institute of Technology, Sloan School of Management, 2007. / Vita. / Includes bibliographical references (leaf 28). / Venture capital investment performance data and performance attribution are not typically published. Venture investors articulate (and sell to LPs) conflicting strategies; the popular business literature and culture is rife with rapidly changing beliefs about the relative attractiveness of healthcare venture subsectors, particularly therapeutics and devices. To examine these issues in a more rigorous format I developed a dataset of healthcare venture deals, scored each deal with a new metric ("jb-score"), and assigned each portfolio company to appropriate subsectors. This dataset was then used to examine subsector performance, persistence, and fund strategy attribution (pure vs. mixed healthcare strategies.) Specifically, I found that the performance characteristics of device and therapeutic (aka biotech or drug) investments are similar: both subsectors evidence similar jb-scores and firms who invest heavily in these subsectors show similar levels of persistent overperformance with devices showing somewhat higher persistence. Firms that focus on one subsector do not perform as well as firms that follow a more balanced strategy. Finally, I examine the validity of the jb-score and offer some suggestions for future improvements. / by Jeffrey S. Behrens. / M.B.A. / S.M.

Thesis (Ph. D.)--University of Oregon, 2001. / Typescript. Includes vita and abstract. Includes bibliographical references (leaves 446-456). Also available for download via the World Wide Web; free to University of Oregon users.

Thesis (M.A.)--University of Wisconsin--Madison, 1969. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (Ph. D.)--Harvard University, 2004. / Includes bibliographical references.

abstract: There have been multiple attempts of coupling neural networks with external memory components for sequence learning problems. Such architectures have demonstrated success in algorithmic, sequence transduction, question-answering and reinforcement learning tasks. Most notable of these attempts is the Neural Turing Machine (NTM), which is an implementation of the Turing Machine with a neural network controller that interacts with a continuous memory. Although the architecture is Turing complete and hence, universally computational, it has seen limited success with complex real-world tasks. In this thesis, I introduce an extension of the Neural Turing Machine, the Neural Harvard Machine, that implements a fully differentiable Harvard Machine framework with a feed-forward neural network controller. Unlike the NTM, it has two different memories - a read-only program memory and a read-write data memory. A sufficiently complex task is divided into smaller, simpler sub-tasks and the program memory stores parameters of pre-trained networks trained on these sub-tasks. The controller reads inputs from an input-tape, uses the data memory to store valuable signals and writes correct symbols to an output tape. The output symbols are a function of the outputs of each sub-network and the state of the data memory. Hence, the controller learns to load the weights of the appropriate program network to generate output symbols. A wide range of experiments demonstrate that the Harvard Machine framework learns faster and performs better than the NTM and RNNs like LSTM, as the complexity of tasks increases. / Dissertation/Thesis / Masters Thesis Computer Science 2020

The purpose of this research paper is to analyze a historical, theological subject concerning the rationale for the transition from a Puritanical view of God at Harvard in the early seventeenth century to a Utilitarian perspective in the first part of the nineteenth century. The Puritans had a profound effect on Harvard, bringing with them severe discipline and an authoritarian view of God. As a result, many of the first Harvard students left the college never to return,[1] and the school had significant difficulties in maintaining an enrollment in its early years. Puritanism viewed students as being essentially depraved and only allowed to live by the grace of God. The Cambridge community portrayed the Lord as being an almost heartless, judgmental father, whose main concern was the discipline of the wayward children. This perspective led to regular beatings, cruelty, and a lack of concern for scholarship that encouraged the pursuit of multiple points of view. However with the coming of Romanticism and Unitarianism to Massachusetts in the early part of the nineteenth century, there was an emerging, change in the nature of truth with respect to God. The people envisioned the Lord, as a kindly parent, who was primarily concerned with the happiness of the individual and the community. With this perspective came a drastically different view of theology, wherein all points of view had to be examined and understood. The rigidity of Puritanism gave way to the more liberal Unitarianism, and God became part of a joyous experience of living. This paper examines the change that occurred at Harvard with respect to the University’s view of God and its impact on the academic curricula. It considers the reasons for the charge and the view of the students, faculty, and administration. It a analyzes how changes within a community can have a profound influence on changes within a college, and it provides a basis for academic freedom that is the basis for academic freedom—a concept that was alien to the Puritans. The key question is whether it has been successful in shaping the development of academia or whether it has caused more chaos than success? [1] George M. Marsden. The Soul of the American University (Oxford: Oxford, 1994) 33-5.

The purpose of the study was to ascertain the effects of induced fatigue on performance of the balance, lengthwise test, the leg raise test, the vertical space te4st, and the separate feet test.

Se presentó la importancia del desarrollo de competencias por medio de metodologías participativas de aprendizaje, especialmente en la educación virtual. Dentro de este contexto, se mostró la información, recursos y materiales pedagógicos que ofrece la plataforma HBP, en particular los casos de estudio. Se explicó como HBP puede ser una herramienta aliada de los docentes para conectar la academia con el mundo real y que no estén disociados. Así los alumnos tienen un rol clave en su formación y aprenden a aplicar los conocimientos que adquieren de forma práctica, tal y como deberán hacerlo luego en su propio su ejercicio profesional. El ponente concluyó absolviendo las consultas de los participantes.

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering; and, Harvard-MIT Division of Health Sciences and Technology, 1998. / Includes bibliographical references (leaves 149-154). / by Li Zhang. / Ph.D.