published_or_final_version / Medical Sciences / Master / Master of Medical Sciences

published_or_final_version / Community Medicine / Master / Master of Philosophy

Physical inactivity is recognised as a major risk factor for non-communicable diseases such as hypertension, cardiovascular disease, diabetes and cancer. Current recommendations for participation in physical activity are 30 minutes or more of moderate-intensity physical activity on most, but preferably all days of the week. The aim of the study was to determine the effect of a physical activity programme on weight, blood pressure, body mass index and body fat classification among high school learners through a short-term physical activity intervention programme.

Radon is a naturally occurring radioactive element in the 238U decay series that is found in high concentrations in certain geological formations such as Caves. Exposure to high concentrations of radon has been positively linked to the incidence<br /> of lung cancer. This study used Electret ion chambers and the RAD7 continuous radon monitor to measure radon concentrations in the Cango Caves in the Western Cape Province, South Africa. Measurements were taken during summer i.e. February 2004 and March 2005. The results for the radon activity concentrations range from the minimum of<br /> about 800 Bq.m-3 to a maximum of 2600 Bq.m-3. The two techniques give very similar results, though the Electret ion chamber results appear to be consistently higher by a few percent where measurements were taken at the same locations. A<br /> mathematical model has been developed to investigate the radon concentrations in the Cave. Diffusion and ventilation have been considered as mechanisms for explaining the distribution of radon concentrations. The ventilation rate in the Cave has been estimated under certain assumptions, and it is found to be about 7 &times / 10&minus / 6 s&minus / 1 for the Van Zyl hall which is the first large chamber in the Cave. The radon concentration increases as one goes deeper into the Cave, but then becomes fairly constant for the deeper parts. The annual effective dose that the guides are exposed to in the Cave as a result of the radon concentrations, depends strongly on the time that they spend in the Cave and in which, halls they spend most of their time in the Cave. The initial results indicate an annual effective dose of 4-10 mSv, but this needs to be further investigated.

Each year approximately 600 000 infants, most of them in Sub-Saharan Africa are born with HIV infection as a result of mother to child transmission of HIV. Whereas significant progress has been made in reduction of mother to child transmission of HIV in developed countries, the situation remains desperate in developing countries. Progress has been hampered by shortage of staff, facilities, limited access to voluntary counselling and testing and lack of support for women by their partners and communities. The challenge is to increase voluntary counselling and testing uptake during antenatal care. Onandjokwe district in Northern Namibia is currently introducing the Prevention of Mother to Child Transmission Program (PMTCT). It has been found the previous PMTCT programs have failed because they adopted a top down approach where there was no community consultation. This study was conducted to explore the community perceptions, knowledge and attitudes regarding mother to child transmission of HIV through focus group discussions and in-depth interviews of key community members.

Patent protection grants the patent holder with a market monopoly, free from market competition allowing the patentee to charge any price; therefore medicines are sold at prices much higher than the marginal cost of production and distribution. The connection between international trade and intellectual property has aggravated human rights and public health concerns surrounding the inaccessibility of essential medicines. The World Trade Organisation‘s Trade Related Aspects of Intellectual Property Rights (TRIPS) Agreement is an international instrument which has greatly impacted intellectual property rights protection and access to medicine. It has globalized intellectual property law by obliging all Members to subscribe to the minimum international standards of protection for intellectual property. South Africa is an example of the issues faced whilst attempting to bring their domestic laws into compliance with the Agreement. The government had to attempt to strike a balance between creating an effective intellectual property infrastructure whilst realizing the therapeutic needs of those affected by HIV/AIDS. The South African Patents Act 57 of 1978 did not comply with the Agreement and was subsequently amended in order to bring its patent legislation in full compliance with the Agreement. Currently, South Africa grants patents for new uses or formulations of existing medicines consequently lengthening the period of patent monopoly by allowing pharmaceutical companies to obtain new patents for slight modifications to existing medicines. It is submitted that South Africa‘s patent legislation is more extensive than is necessary under international law, examples of this being disclosure standards and the process for compulsory licensing. In addition, it has not made use of provisions in its existing law to take measures to improve access to essential medicines, nor has it implemented legislative amendments consequent to the flexibilities established in the Doha Declaration. This dissertation seeks to review the steps South Africa has taken in its compliance with the TRIPS Agreement with respect to the relevant intellectual property legislation that has been enacted, including its implications for access to essential medicines. The intention behind this dissertation is to assess the efficacy of the intellectual property legislation in South Africa and its impact on access to medicines. / Thesis (LL.M.)-Univeristy of KwaZulu-Natal, Durban, 2012.

Submitted in fulfillment of the requirements for the degree of Doctor of Technology: Quality Management, Durban University of Technology, 2014. / Hearing conservation in the industrial setting has mainly focussed on the harmful effects of noise exposure on the auditory system. This study investigated the co-exposure to noise and ototoxic chemicals on the auditory system of workers engaged by labour brokers. It examined the adequacy of current occupational health and safety legislation to address chemically induced hearing loss and makes recommendations at a policy level to protect workers’ hearing at the workplace. This study is an exploratory cross-sectional field case study in an industrial setting. A sample of 300 workers was drawn from a rubber factory involved in the manufacture of components for the motor, shoe and plumbing industries in the metropolitan area of Durban. Purposive sampling was undertaken amongst a cohort of day shift workers which constituted the research subjects. The research tools used in the study included the completion of the NoiseChem questionnaire, conducting pure tone audiometric testing on research subjects, monitoring noise exposure levels and performing chemical air monitoring of the ambient environment. This study confirms that a segment of the research subjects were exposed to both ototoxic chemicals and noise. Chemical exposure of research subjects was within legal permissible limits in most instances. Noise exposure exceeded the noise rating limit of 85 dBA in certain work areas. Multiple regression analysis revealed that there was a slight trend towards co-exposure to chemicals and noise being risk factors for hearing loss with an odds ratio of 1.7 (95% CI = 0.34 – 8.57) but the p value was not significant. No significant association with hearing loss was evident for workers exposed to chemical only with odds ratio of 0.41 (95% CI = 0.11 – 1.53, p = 0.19) and noise only with odds ratio of 0.87 (95% CI = 0.32 – 2.31, p = 0.78). The study indicated that workers exposed to both ototoxic chemicals and noise may be more susceptible to hearing loss in their current jobs. The study draws attention to policy gaps in the Occupational Health and Safety Act and proposes changes to address the shortcomings. / D

Substantial evidence demonstrates that marriage is associated with better health outcomes and lower mortality risk. Some evidence suggests that there are gender and race/ethnicity differences between the marriage-health benefits association. However, previous studies on marriage and health have mainly focused on non-Hispanic White-Black differences. Limited information is available regarding the roles of Hispanics. The present study examined marital status, gender, and the differences between non-Hispanic Whites, non-Hispanic Blacks, and Hispanics, in health outcomes. A retrospective cohort analysis of 24,119 Hispanic, NH White, and NH Black adults admitted to a large hospital was conducted. A total of 16,661 patients identified as either married or single was included in the final analyses. Consistent with the broader literature, marriage was associated with beneficial hospital utilization outcomes. With respect to differences in these benefits, results suggest that married patients, Hispanic patients, and women, were less likely to experience in-hospital mortality. Similar effects were observed in aggregated length of stay with married Hispanic women hospitalized nearly 2 days less than their single counterparts (6.83 days and 8.66 days, respectively). These findings support existing literature that marriage is associated with health benefits, add to the emerging research of a Hispanic survival advantage, and broaden the understanding of marriage and health in terms of differences by racial/ethnicity.

Thesis is submitted in partial fulfilment of the requirements for the degree of M.Sc. Building (Project Management in Construction) to the Faculty of Engineering and the Built Environment, University of the Witwatersrand, 2017 / The construction industry plays an important role in our lives, more specifically the residential sector, which serves to help people access their basic human right to housing. Housing is a basic human right which most South Africans are yet to realise. The high demand for housing and other forms of infrastructure by both the private and public sectors have attracted entrepreneurs who fall under the small and medium contractor categories, to venture into the residential construction mostly as sub-contractors. The construction industry is predominantly constituted of small, micro and medium enterprises. The construction industry is also unfortunately widely known to be a hazardous and accident prone sector; whereby workers are exposed to health and safety hazards on a daily basis, some which lead to loss of life. Literature has found that small and micro enterprises (SMEs) experience more occupational health and safety problems in comparison to their medium and larger counterparts. A positive safety culture is considered as an essential contributor to improved occupational safety performance in construction. Due to the highly reported health and safety challenges faced by construction SMEs, the study seeks to determine the existing safety culture of small and micro enterprises operating in private residential construction sector. The researcher explores the safety perceptions, attitudes, and behaviour of construction workers and management safety practices on small residential construction sites and therefore determine the existing safety culture. An existing safety climate assessment questionnaire was administered to workers employed at the Waterfall Country Estate, Midrand and the findings indicated that there generally exists a good safety culture on the affluent residential construction site. Unsafe worker behaviours have been blamed as the lead cause of accidents on construction work sites, but the current health and safety status of industry calls for more accountability instead of blame shifting amongst stakeholders. Interventions and strategies that seek to address the occupational health and safety of the construction industry should not be reactive, but should rather be a proactive and anticipatory process. It is therefore crucial to begin exploring proactive approaches towards the establishment of a positive health and safety culture, whereby more commitment and accountability is shown from all key stakeholders who collectively have the means to influence and contribute towards the creation of a positive safety culture in residential construction. / XL2018

The objective of this research was to determine if mature landfill leachate could be treated to a level so that it was safe to discharge to the environment. The treatment method was an Advanced Oxidation Process. The process utilized Titanium Dioxide and UV. Three different reactor types were used, falling film, flow through and falling film + Electron Magnetic Oxygen Hydrogen (EMOH). To improve removal pre-treatment with titanium dioxide settling were conducted in conjunction with treatment in a reactor. The best removal was obtained with pre-treatment with titanium dioxide settling, followed by the falling film + EMOH reactor. In 8 hours, removal was 63% for COD, 53% for ammonia, 73% for alkalinity and 98% for calcium hardness. The kinetics found in this experiment show that full treatment times for safe discharge vary between contaminates. For complete removal of all tested contaminates to safe discharge regulations requires 185 hour of treatment. / Includes bibliography. / Thesis (M.S.)--Florida Atlantic University, 2015. / FAU Electronic Theses and Dissertations Collection