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Problem-solving deficits and poor health–related quality of life are associated with suicide risk; yet, little is known about the interrelations between these variables. In 220 primary care patients, we examined the potential mediating role of physical and mental health–related quality of life on the relation between social problem–solving ability and suicidal behavior. Participants completed the Suicidal Behaviors Questionnaire-Revised, Social Problem Solving Inventory-Revised, and Short-Form 36 Health Survey. Utilizing bootstrapped mediation, our hypotheses were partially supported; mediating effects were found for mental health–related quality of life on the relation between social problem-solving and suicidal behavior. Physical health–related quality of life was not a significant mediator. Greater social problem–solving ability is associated with better mental health–related quality of life and, in turn, to less suicidal behavior. Interventions promoting social problem–solving ability may increase quality of life and reduce suicide risk in primary care patients.

Background: Progressive respiratory muscle weakness and ineffective cough contributes to pulmonary morbidity and mortality in children with neuromuscular disease. Inspiratory muscle training aims to preserve or improve respiratory muscle strength, reduce respiratory complications and improve health-related quality of life. Objectives: To describe South African physiotherapists' knowledge and respiratory management strategies and determine the safety, viability, acceptability and efficacy of inspiratory muscle training for children 5-18 years with neuromuscular disease. Methods: Four studies were conducted: i) a quantitative descriptive survey; ii) a systematic review using Cochrane methodology; iii) a prospective, pre-experimental observational study and iv) a prospective, cross-over randomised controlled trial using a standardised 12-week inspiratory muscle training intervention. Results: i) South African physiotherapists (n=64) reported being aware of international clinical practice recommendations, however they favoured manual airway clearance techniques. The use of inspiratory muscle training in chronic management was well supported by South African physiotherapists. ii) Results of the systematic review (seven included studies; n=168) suggested that inspiratory muscle training may be effective in improving inspiratory muscle strength. There was insufficient evidence for an effect on patient morbidity or health-related quality of life. iii) The pre-experimental, pilot study (n=8) suggested that a six-week inspiratory muscle training programme was safe, viable, acceptable and associated with a significant increase in inspiratory muscle strength. iv) The cross-over randomised controlled trial (n=23) did not show evidence of a difference in the primary outcome measures (number of hospitalisations and respiratory tract infections) between intervention and control periods. There were no adverse events related to inspiratory muscle training. Inspiratory muscle strength (Pimax) and peak expiratory cough flow increased by 14.57 (±15.67)cmH2O and 32.27 (±36.60)L/min respectively during the intervention period compared to a change of 3.04 (±11.93)cmH2O (p=0.01) and -16.59 (±48.29)L/min (p=0.0005) during the control period. There was no evidence of change in spirometry, functional ability or total health-related quality of life scores following the intervention. Overall participant satisfaction with inspiratory muscle training was high and adherence was good. Conclusions: Inspiratory muscle training in children with neuromuscular disease is well tolerated, appears to be safe and is associated with significant improvements in inspiratory muscle strength and cough efficacy.

Bakgrund: Hypotyreos är en av världens vanligaste sjukdomar som drabbar cirka tio procent av befolkningen. Sjukdomen har i Sverige fördubblats från 2006 till 2017 framförallt bland kvinnor mellan 20−40 år. Hypotyreos är en endokrin, kronisk sjukdom som innebär minskad produktion av tyreoideahormoner vilket påverkar kroppens normala funktioner och utan behandling kan det leda till andra kroniska sjukdomstillstånd. Personer med hypotyreos kan dock oberoende av behandling känna ihållande symtom som påverkar deras hälsa. Syfte: Studiens syfte var att beskriva vad som påverkar livskvaliteten hos personer med hypotyreos. Metod: En allmän litteraturstudie utfördes genom att granska och analysera tio artiklar som relaterade till syftet. Resultatet från artiklarna sammanställdes till fyra kategorier vilka belyste faktorer som påverkade livskvaliteten hos personer med hypotyreos. Resultat: Att leva med hypotyreos innebär en påverkan på livskvaliteten för många personer då de har kvarstående symtom trots behandling. Resultatet visade att trötthet, övervikt och viktuppgång, psykisk ohälsa och behandlingen var faktorer som bidrog till en försämrad livskvalitet. Konklusion/Implikation: Forskning kring livskvalitet hos personer med hypotyreos bör vidareutvecklas för att öka sjuksköterskans kunskap om sjukdomen och bidra till en utveckling av omvårdnaden. / Background: Hypothyroidism is one of the most common diseases in the world, affecting about ten percent of the population. The disease has doubled in Sweden from 2006 to 2017, especially among women between the ages of 20−40 years. Hypothyroidism is an endocrine, chronic disease which means reduced production of thyroid hormones which affects the body's normal functions and without treatment it can lead to other chronic disease states. However, people with hypothyroidism, regardless of treatment, can feel persistent symptoms that affect their health. Aim: The aim of the study was to describe what affects the quality of life of people with hypothyroidism. Method: A general literature study was conducted by reviewing and analyzing ten articles related to the purpose. The results from the articles were compiled into four categories which highlighted factors that affected the quality of life of people with hypothyroidism. Results: Living with hypothyroidism has an impact on the quality of life for many people as they have persistent symptoms despite treatment. The results showed that fatigue, overweight and weight gain, mental illness and treatment were factors that contributed to a reduced quality of life. Conclusion/Implication: Research on quality of life in people with hypothyroidism should be further developed to increase the nurse's knowledge of the disease and contribute to the development of nursing.

Background and Aims: There is an increasing awareness that, in order to monitor health outcomes both mortality and morbidity need to be assessed. A common metric used to measure morbidity and functional limitation is the quality adjusted life year or QALY, which incorporates time spent in a health condition and Health-Related Quality of Life (HRQoL) into the measure. This is of increasing importance in Low Income Countries (LIC) where programmes have been adopted and implemented to address the high burden of child mortality. The ‘first 1000 days’ is one such initiative which has been adopted by the WHO to improve nutritional support, health care and social support for both the mother and child. One of the aims is to improve quality of life during this vulnerable period. As there is currently no appropriate measure of HRQoL in this age group, we set out to develop a valid and reliable, HRQoL instrument for children from 1 month to 3 years old, amenable to the elicitation of preference weights. Methods: The new HRQoL instrument, HRQoL-6D-IT, was based firstly on a mapping review of HRQoL measures for children. The next stage involved eliciting options through cognitive review from caregivers of very young children regarding HRQoL dimensions included in the EQ-5D-Y an existing validated HRQoL measure for older children. The care-givers were requested to identify items to be considered for inclusion, the wording and layout of the new measure. The item pool generated from the literature reviews and cognitive interviews were then assessed through a Delphi study with experts in the field. These items were further reduced through subsequent testing of items and retesting of a preliminary measure. The final items on the HRQoL-6D-IT included: movement, play, pain, relationships, communication and eating and, apart from pain, the descriptors referenced the behaviour of the child to age appropriate behaviour. The HRQoL-6D-IT was then tested for validity and reliability in a group of acutely-ill (AI), chronically-ill (CI) and typically developing (TD) children in two provinces in South Africa: Western and Eastern Cape. Results: The methodology used to identify candidate items was rigorous and yielded items which were developed to be observable with dimension descriptors referring to ‘age appropriate behaviour’. Caregivers were able to reliably report on HRQoL of their very young children from age 1-36 months. The content validity had been established during the development of the instrument. Concurrent validity of the different items (dimensions) was tested between the HRQoL-6D-IT and relevant items from the ASQ, FLACC and NIPS pain scale and Diet History.

Many patients are affected by chronic obstructive pulmonary disease (COPD), a progressive lung disease that obstructs air flow, resulting in dyspnea and inability to carry out daily activities. Despite optimal pharmacological management, COPD patients make frequent emergency room visits and are hospitalized due to exacerbations of COPD. Literature has suggested that pulmonary rehabilitation (PR), a nonpharmacological treatment, could help to decrease the symptoms that lead to illness exacerbation, hospital readmissions, and decreased quality of life in patients with COPD. The purpose of the project was to increase the quality of life and reduce admission rates for patients diagnosed with COPD through the development and implementation of patient education material that would increase PR awareness, increase patient motivation, and promote participation. The ACE star model was used to guide the project development, and the theoretical framework of the health belief model was used to enhance patients' perceptions and desires to participate in a PR program. Evaluation of the pretests and posttests revealed significant improvement in various variables, reduction of dyspnea, improved exercise tolerance, and increased knowledge. The evaluation of health-related quality of life using the short form 36 showed significant improvement in some subscales namely: general health, role emotional, with slight significance in bodily pain. There were no readmissions among the participants. The implementation of comprehensive PR has implications for positive social change because it helps patients with COPD to be more knowledgeable about their disease and allows for more independence and a higher quality of life.

Previous literature has shown that childhood trauma and adverse experiences are related to a wide range of negative outcomes that can span into adulthood (e.g., low self-worth, poor physical health, and increased likelihood of co-morbid psychological symptoms). However, a gap remains in the existing literature regarding early interventions that may target complicated outcomes (i.e., self-esteem and self-worth) while the survivor is still in childhood. This paper attempts to elucidate the impact that traumatic childhood experiences may have on self-worth, and the importance of implementing targeted intervention before the child reaches adulthood. Therefore, an extensive review was first conducted to gain further insight in regards to how specific variables, namely locus of control and health-related quality of life, may predict childhood development of self-worth. The present study then explored the influence of each factor on a child and adolescent community sample that experienced various types of trauma 61 children and adolescents who were survivors of varying types of trauma were recruited from a local mental health clinic (M=11.89; SD=2.49; 31 males, 30 females). Measures pertaining to locus of control, health-related quality of life, and self- worth were administered at their therapeutic baseline by a randomly assigned therapist. A measure of resiliency was also administered as a secondary exploratory analysis. Results highlighted pediatric quality of life and trauma type as meaningful predictors of self-worth outcomes. Additionally, resiliency as a construct with a significant correlational relationship with self-worth. All findings were interpreted for purposes of intervention, and treatment proposals were delineated.

Indiana University-Purdue University Indianapolis (IUPUI) / Taxane-induced musculoskeletal pain (TIMP) is musculoskeletal pain that includes myalgia (i.e., diffuse muscle pain, usually accompanied by malaise) and/or arthralgia (i.e., joint pain) that occurs following treatment with taxane-based chemotherapy. TIMP is a symptom that is clinically reported as negatively affecting most cancer survivors receiving taxane-based chemotherapy; however, TIMP is not comprehensively understood. The purpose of this dissertation was to conduct a cross sectional, descriptive, correlational pilot study to describe TIMP in women with ovarian cancer who were being or had been treated with paclitaxel-containing regimens. Specific aims were to: (1) describe the TIMP symptom experience (intensity, distress, duration, location, quality, temporal pattern, aggravating and alleviating factors, and pain management); (2) describe the associations between TIMP (intensity, distress) and co occurring symptoms (pain [general], peripheral neuropathy, impaired sleep, fatigue, emotional distress, and/or hot flashes); and (3) identify associations between TIMP (intensity, distress) and patient-reported outcomes (interference with daily activities, physical functioning, and health-related quality of life). Primary data collection was performed on a convenience sample of 15 women with ovarian cancer. Participants were recruited from an outpatient cancer clinic, local cancer support communities, and a national cancer survivors’ research registry. Descriptive statistics and Spearman’s correlations were used. Findings showed TIMP is moderate to severe in intensity on average, constant, affecting a large area of the body, and aggravated by everyday walking. Greater TIMP intensity or distress was associated with greater intensity and interference of most co-occurring symptoms and was associated with greater interference with daily activities, worse physical functioning, and worse health-related quality of life. Nurses are encouraged to comprehensively assess TIMP using structured, validated tools for pain to better intervene on aggravating and alleviating factors and pain management regimens. Prospective, longitudinal studies with larger sample sizes are needed to further understand TIMP and its impact on cancer survivors.

Indiana University-Purdue University Indianapolis (IUPUI) / Schizophrenia is a serious mental illness that significantly lessens health-related quality of life (HRQoL). A better understanding of HRQoL is needed to inform holistic and patient-centered treatments for schizophrenia. The purpose of this dissertation is to conduct an in-depth exploration of HRQoL in people with schizophrenia. The dissertation includes three components. The first component is an integrative literature review aimed at identifying factors associated with physical quality of life (QoL) in people with schizophrenia. The review reveals that symptoms of schizophrenia, depression, obesity or body mass index, and physical activity are associated with physical QoL in this population. The second and third components are based on illness narratives of 20 people with schizophrenia who had participated in a larger study of individuals diagnosed with serious mental illness. The second component of the dissertation is a qualitative descriptive study conducted to describe common HRQoL concerns in people with schizophrenia. The results indicate that these concerns were related to social relationships, psychiatric symptoms, psychiatric care, and employment. The third component of the dissertation is a parallel convergent mixed-methods study conducted to explore whether computerized lexical analysis (CLA) of illness narratives of people with schizophrenia can reveal their HRQoL concerns. CLA is an automatized process that counts words in text data and sorts them into pre-defined word categories. The results provide preliminary support for the potential use of CLA to efficiently assess HRQoL in people with schizophrenia as the CLA identified some of the HRQoL concerns that had been identified in the prior qualitative descriptive study. The results of the three studies reveal the complexity of the phenomenon of HRQoL in people with schizophrenia and can inform the development of strategies to identify and promote HRQoL in this population.

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