Bush, Elizabeth LeSueur.
No description available.
The use of comparative morphology of the infective larvae in identification and determining the incidence of some common nematode parasites in a herd of beef cattleShivnani, Gurdasmal Alimchand January 2011 (has links)
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Fairchild, Gordon Elkanah.
Call number: LD2668 .T4 1949 E32 / Master of Science
Ostlind, Daniel Albert.
LD2668 .T4 1962 O88
Nickel, Phillip Arnold.
Call number: LD2668 .T4 1966 N632 / Master of Science
McDougald, Larry R.
Call number: LD2668 .T4 1966 M137 / Master of Science
Studies on Ascaridia columbae : experimental life cycle in parenterally infected pigeons, and factors affecting the oviposition in vitroMelendez, Roy Daniel January 2011 (has links)
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18 May 2019
MSc (Applied Mathematics) / Department of Mathematics and Applied Mathematics / In this study, we develop a multiscale model of soil transmitted helminths in humans with a special reference to hookworm infection. Firstly, we develop a single scale model that comprises of five between host scale populations namely; susceptible humans, infected humans, eggs in the physical environment, noninfective worms in the physical environment and infective worms in the physical environment. Secondly, we extend the single scale model to incorporate within-host scales namely; infective larvae within-host, immature worms in small intestine, mature worm population and within-host egg population which resulted to a multiscale model. The models are analysed both numerically and analytically. The models are epidemiologically and mathematically well posed. Numerical simulation results show that there is a bidirectional relationship between the between-host and within-host scales. This is in agreement with the sensitivity analysis results, we noted that the same parameters that reduce reproductive number R0 are the same parameters that reduce the infective worms endemic equilibrium point. From the comparative effectiveness of hookworm interventions analysis results, we notice that any intervention combination that include wearing shoes controls and reduces the spread of the infection. The modelling framework developed in this study is vigorous to be applicable to other soil transmitted helminths infections / NRF
A survey of the helminths from Blarina brevicauda Say and Sorex cinereus Kerr of Delaware County, IndianaSergeant, Elaine January 1976 (has links)
Forty-two Blarina brevicauda and 50 Sorex cinereus from various locations in Delaware County, Indiana, were examined for helminth parasites. From zero to eight parasites were found in 98 percent of the B. brevicauda. From zero to five parasites were found in 92 percent of the S. cinereus. Longistriata depressa, Porrocaecum americanum, P. encapsulatum, Capillaria blarinae, Protogynella sp., Hymenolepis anthocephalus, Panopistus pricei, Entosiphonus thompsoni, Brachylaima rhomboideus, Trichuris sp., Parastrongyloides winchesi, and a larval spirurid nematode, probably Physaloptera limbata, parasitized B. brevicauda. Larval nematodes, which may be Angiostrongylus michiganensis were abundant in the digestive and respiratory tracts. B. brevicauda also contained a minute, unidentifiable nematode from the small intestine. Tapeworms from four different B. brevicauda were in such poor condition as to make positive identification difficult. These were probably H. blarinae. H. parva; H. serrula; H. faculata; H, longi; two different unidentifiable hymenolepids; P. americanum; P. encapsulatum; A. michiganensis; Pseudophysaloptera formosana soricina; L. depressa; P, pricei; C. rauschi; P. winchesi; larval capillarid nematodes from the liver, probably C. hepatica; and three small unidentifiable nematodes parasitized S. cinereus.First reports include: P. winchesi in an American Sorex sp., Trichuris sp. from the intestine of B. brevicauda, P, pricei in S. cinereus, and larval capillarids, possibly C. hepatica, from the liver of S. cinereus.Possible relationships between the parasites' life cycles and the hosts' habitats were discussed.
Grainger, John Robert
Almost 2 billion people world-wide are infected with parasitic helminths. These complex multicellular eukaryotic organisms are capable of establishing long-term infections even in the face of an intact immune response. Typically, in these settings regulatory components of the immune response, such as Foxp3+ T regulatory cells (Tregs), become dominant, limiting protective effector responses towards the parasite. Helminths are thought to have evolved mechanisms, including release of immunomodulatory molecules termed excretory-secretory products (ES), to sway the balance between the regulatory and effector arms of the immune response to favour their persistence. In this thesis both the development of a protective immune response toward, and the potential manipulation of the immune response by, the rodent gastrointestinal nematode Heligmosomoides polygyrus have been studied. Firstly, the effects of H. polygyrus ES (HES) on bone-marrow derived dendritic cells (DCs) were analysed. Although HES did not alter the phenotype of the DC it was found to be able to suppress the ability of the DC to respond to inflammatory stimuli. This activity was lost when HES was heat-inactivated (hiHES). After adoptive transfer, HES-pulsed DCs were able to induce a HESspecific T helper (Th)2-type response even if co-treated with an inflammatory stimulus. Th2-type responses are protective against H. polygyrus infection. Surprisingly, the ability of HES to generate a Th2-response in a co-treatment situation was not related to its anti-inflammatory properties; DCs co-treated with hiHES and an inflammatory stimulus were able to drive an equivalent Th2-response to HES in this situation. Next, making use of mouse strains with different susceptibility phenotypes to primary H. polygyrus infection, potential mechanisms of resistance were characterised. Development of granulomas in the gut wall were found to be associated with reduced worm burdens. Furthermore, in highly susceptible C57BL/6 mice, production of IL-23 was shown to be counter-regulatory to this process, as mice on the same background but deficient in this cytokine have increased numbers of granulomas and dramatically enhanced resistance. Susceptibility to H. polygyrus was also considered at the level of epigenetic regulation. A protein that binds specifically to methylated DNA, methyl-CpG binding domain protein (MBD)2, was found to affect the proportion of Foxp3+ Tregs within the CD4+ T cell population in vivo. Additionally, in vitro induction of Foxp3 in response to TGF-β was enhanced in MBD2-/- CD4+ T cells. MBD2-/- mice had a trend towards increased worm burdens when infected with H. polygyrus, suggesting that the difference in proportion of Tregs may limit generation of an effector response. Finally, the ability of HES to directly affect the regulatory arm of the immune response was focussed upon. It was found that HES was able to induce Foxp3 expression in naïve peripheral T cells, and that this was mediated by stimulation of the TGF-β pathway. The TGF-β mimic was of parasite origin as a pan-vertebrate TGF-β antibody was unable to block its effects but sera from H. polygyrus infected animals was competent to do this. Activity of this type was not limited to HES as ES from the ovine helminth Haemonchus contortus was found to have the same property. These data imply that some helminth parasites have evolved mechanisms to support generation of Foxp3+ Tregs, thus favouring the regulatory arm of the immune response and hence their own persistence.
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