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Caracterização In Vitro e In Vivo do pericárdio bovino reticulado com acetais do glutaraldeído para manufatura de biopróteses valvulares cardíacas. / Characterization in vitro and in vivo of bovine pericardium cross-linked with glutaraldehyde acetals for the manufacture of cardiac valve bioprostheses.Yoshioka, Sergio Akinobu 02 June 2000 (has links)
Este trabalho descreve a reação de reticulação alternativa do pericárdio bovino com os acetais do glutaraldeído, preparados a partir da solução de glutaraldeído na presença do etanol em meio ácido. Os acetais difundem para dentro da matriz colagênica, e a reticulação ocorre após a desproteção dos grupos aldeídicos com uma amina terciária. O material obtido sob estas condições mostrou as propriedades biológicas e mecânicas similares ou superiores àqueles descritos para o pericárdio bovino reticulado pelo procedimento convencional com glutaraldeído, e provavelmente, com resultados de uma distribuição e natureza química mais homogênea das reticulações formadas, devido à ausência das reticulações polímeros de glutaraldeído. As biopróteses manufaturadas com pericárdio reticulado com acetais do glutaraldeído, também mostraram durabilidade superior e foi menos suscetível ao processo de calcificação, como determinado em implantes subcutâneos em ratos. Resultados preliminares de teste à fadiga e performance hidrodinâmica foram caracterizados por um comportamento similar àqueles materiais tratados convencionalmente sugerindo que, o pericárdio reticulado com acetais do glutaraldeído pode ser um procedimento alternativo e mais eficiente na manufatura das biopróteses, particularmente com respeito à calcificação, um dos maiores problemas encontrados pós-implante. / This work describes the cross-linking of bovine pericardium with glutaraldehyde acetals, which are its protected forms. The acetals, prepared from a glutaraldehyde solution in the presence of ethanol in acidic media was al/owed to diffuse within the collagen matrix, and cross-linking achieved by deprotection with a tertiary amine. The material obtained under this conditions showed biological and mechanical properties similar or superior to those described for bovine pericardium crosslinked by conventional procedure with glutaraldehyde, and probably, as a results of a more homogeneous distribution and chemical nature of the formed crosslinks, that is the absence of polymeric cross-links. Bioprostheses manufactured with glutaraldehyde acetals cross-linked bovine pericardium, also showed higher durability and was less susceptible to calcification process, as determined in subcutaneous implant in rats. Preliminary results on fatigue test and hydrodynamic performance were characterized by a behavior similar to those observed for conventional/y treated materials suggesting that, glutaraldehyde acetals crosslinked bovine pericardium may be an alternate and more efficient procedure in the manufacture of bioprostheses, particularly in respect to calcification, one of the major problems found post-implantation.
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Caracterização In Vitro e In Vivo do pericárdio bovino reticulado com acetais do glutaraldeído para manufatura de biopróteses valvulares cardíacas. / Characterization in vitro and in vivo of bovine pericardium cross-linked with glutaraldehyde acetals for the manufacture of cardiac valve bioprostheses.Sergio Akinobu Yoshioka 02 June 2000 (has links)
Este trabalho descreve a reação de reticulação alternativa do pericárdio bovino com os acetais do glutaraldeído, preparados a partir da solução de glutaraldeído na presença do etanol em meio ácido. Os acetais difundem para dentro da matriz colagênica, e a reticulação ocorre após a desproteção dos grupos aldeídicos com uma amina terciária. O material obtido sob estas condições mostrou as propriedades biológicas e mecânicas similares ou superiores àqueles descritos para o pericárdio bovino reticulado pelo procedimento convencional com glutaraldeído, e provavelmente, com resultados de uma distribuição e natureza química mais homogênea das reticulações formadas, devido à ausência das reticulações polímeros de glutaraldeído. As biopróteses manufaturadas com pericárdio reticulado com acetais do glutaraldeído, também mostraram durabilidade superior e foi menos suscetível ao processo de calcificação, como determinado em implantes subcutâneos em ratos. Resultados preliminares de teste à fadiga e performance hidrodinâmica foram caracterizados por um comportamento similar àqueles materiais tratados convencionalmente sugerindo que, o pericárdio reticulado com acetais do glutaraldeído pode ser um procedimento alternativo e mais eficiente na manufatura das biopróteses, particularmente com respeito à calcificação, um dos maiores problemas encontrados pós-implante. / This work describes the cross-linking of bovine pericardium with glutaraldehyde acetals, which are its protected forms. The acetals, prepared from a glutaraldehyde solution in the presence of ethanol in acidic media was al/owed to diffuse within the collagen matrix, and cross-linking achieved by deprotection with a tertiary amine. The material obtained under this conditions showed biological and mechanical properties similar or superior to those described for bovine pericardium crosslinked by conventional procedure with glutaraldehyde, and probably, as a results of a more homogeneous distribution and chemical nature of the formed crosslinks, that is the absence of polymeric cross-links. Bioprostheses manufactured with glutaraldehyde acetals cross-linked bovine pericardium, also showed higher durability and was less susceptible to calcification process, as determined in subcutaneous implant in rats. Preliminary results on fatigue test and hydrodynamic performance were characterized by a behavior similar to those observed for conventional/y treated materials suggesting that, glutaraldehyde acetals crosslinked bovine pericardium may be an alternate and more efficient procedure in the manufacture of bioprostheses, particularly in respect to calcification, one of the major problems found post-implantation.
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Etude des tuyères composites pour une conception optimale d'une hydrolienne à axe horizontal / Study of composites ducts for optimal design of an horizontal axis tidal turbineAit Mohammed, Mahrez 13 January 2017 (has links)
La raréfaction des ressources fossiles non renouvelables et le dérèglement climatique font de la question énergétique un enjeu d’envergure mondiale. L’exploitation de nouvelles sources d’énergie renouvelable devient alors un objectif de première importance. L’énergie produite à partir des courants marins suscite depuis quelques années un intérêt particulier. Le concept de turbine sous-marine, appelée hydrolienne, désigne le dispositif permettant de convertir l’énergie cinétique des courants marins en énergie électrique. Ce travail de recherche traite les problématiques que pose la conception des hydroliennes à axe horizontal. Il sera mis en évidence que le monde des hélices marines présente une piste intéressante pour l’étude du comportement hydrodynamique des hydroliennes. Certains concepteurs d’hydroliennes avancent que l’ajout d’un système de carénage est favorable pour améliorer le rendement hydrodynamique. L’étude du gain hydrodynamique à encombrement constant que pourrait procurer l’ajout d’un carénage a donc été choisie comme point de départ de ce travail de recherche. Pour répondre au besoin des industriels lié à une problématique de gain de masse, les matériaux composites présentent un atout considérable en raison de leurs excellents rapports «masse/résistance» et «masse/rigidité». Une réalisation d’un carénage en matériaux composites présentant le meilleur ratio «puissance/masse» a été obtenue. Un carénage d’hydrolienne est de par sa position particulièrement confronté à des chocs. Ceci peut s’avérer très délicat car la structure composite en question est soumise à des sollicitations sévères liées à l’environnement marin. L’impact sur un carénage d’hydrolienne a été traité en détail dans ce travail de recherche. / Against the backdrop of the increasing scarcity of non-renewable fossil resources and climate change, the energy problem has become a worldwide issue. Hence, the exploitation of new renewable energy sources becomes a worldwide goal of primary importance. The concept of the underwater turbine, called tidal current turbine, designates the device which allows the conversion of the kinetic energy produced by marine currents in electric energy. This research study examines the problems related to the design of horizontal axis tidal current turbines. The present study shows that the world of marine propellers, sometimes entirely left out by the designers of tidal current turbines, presents an interesting avenue of research with regard to the hydrodynamic behaviour of tidal current turbines. Certain designers of tidal current turbines use a duct and hold that the addition of the duct contributes to the improvement of the hydrodynamic performance. Therefore, the study of the hydrodynamic benefits of ducted turbine using a constant overall cross-section than the bare turbine was the starting point of the present research work. In order to meet the needs of the manufacturers of tidal current turbines, which is generally linked to a problem of mass gain, composite materials present a considerable asset on account of their excellent «mass/resistance» and «mass/rigidity» relations. A structural design of ducted tidal current turbines using composite materials has therefore been examined. Hence, the design of a composite duct which yields the best «power/mass» ratio has been proposed. The duct of the tidal current turbine is especially confronted by the impacts due to its particular position. The impact damage aspect has also been examined in detail in the present research study.
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