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Introdução: A hipotermia inadvertida perioperatória é um evento frequente e atinge cerca de 70% dos pacientes cirúrgicos, levando a complicações importantes, como alterações cardiovasculares, infecção do sitio cirúrgico, desconforto ao paciente, aumento do tempo de hospitalização, entre outros. Por oferecer inúmeros riscos ao paciente cirúrgico, a ocorrência da hipotermia não intencional perioperatória tem ganhado espaço na literatura atual. A manutenção da temperatura perioperatória vem sendo sugerida pela literatura com a implementação de métodos passivos e ativos de aquecimento como o aumento da temperatura da sala cirúrgica, uso de cobertor de algodão, uso de cobertor térmico, uso de dispositivos de ar forçado, infusão de fluidos aquecidos, entre outros. No entanto, não há no Brasil nenhum estudo publicado onde se investigue a atuação das equipes que atuam no bloco cirúrgico realizam a prevenção da hipotermia perioperatória nos hospitais. Objetivos: Verificar como se dá o monitoramento da temperatura e a prevenção de hipotermia inadvertida perioperatória em pacientes cirúrgicos internados em hospitais brasileiros. Material e método: Estudo transversal, realizado na cidade de São Paulo através de questionário preenchido pelos enfermeiros participantes do 12° Congresso Brasileiro de Enfermagem em Centro Cirúrgico, Recuperação Anestésica e Centro de Material e Esterilização. Os dados foram analisados descritivamente e demonstrados em foram de tabelas. Resultados: O monitoramento da temperatura no período perioperatório ainda não é realizado sistematicamente por todos os profissionais de centro cirúrgico, porem a realização dessa pratica foi relatada por 92,4% no período pré-operatório, 83,8% no período intraoperatório e 94,9% no período pós-operatório. A prevenção da hipotermia inadvertida no perioperatório é uma pratica exercida pela grande maioria dos participantes (96%), com predomínio nos métodos passivos de manutenção da normotermia nos períodos pré-operatório (51%) e associação de métodos passivos e ativos nos períodos pós (64,6%) e intraoperatório (45,5%) de manutenção da normotermia ao paciente cirúrgico. Os principais profissionais envolvidos para a monitorização da temperatura e a prevenção da hipotermia perioperatória inadvertida são a equipe de enfermagem e os anestesiologistas. Apesar de um número grande de profissionais não informarem a taxa de ocorrência de hipotermia inadvertida perioperatória, nota-se que para a maioria dos respondentes a ocorrência desse evento é baixa. Conclusão: a realização de praticas para a manutenção da normotermia operatória é realidade para a equipe de enfermagem. A monitorização da temperatura ainda não é realizada de maneira constante em todo período perioperatório. A prevenção da hipotermia inadvertida no período perioperatório é pratica bastante frequente entre os procedimentos cirúrgicos. / Introduction: Perioperative inadvertent hypothermia is a frequent event and affects about 70% of surgical patients, leading to important complications, such as cardiovascular alterations, surgical site infection, patient discomfort, hospitalization time, and others. Because it offers innumerable risks to the surgical patient, the occurrence of perioperative unintentional hypothermia has gained space in the current literature. Perioperative temperature maintenance has been suggested in the literature with the implementation of passive and active heating methods such as increased operating room temperature, use of cotton blanket, use of thermal blanket, use of forced air devices, infusion of fluids heated, among others. However, there is no published study in Brazil to investigate the performance of the teams that work in the surgical block, and to prevent perioperative hypothermia in hospitals. Objectives: To verify how temperature monitoring and the prevention of perioperative inadvertent hypothermia occur in surgical patients hospitalized in Brazilian hospitals. Material and method: A cross-sectional study was carried out in the city of São Paulo through a questionnaire filled out by nurses participating in the 12th Brazilian Congress of Nursing in Surgical Center, Anesthetic Recovery and Material and Sterilization Center. The data were analyzed descriptively and demonstrated in the tables. Results: Temperature monitoring in the perioperative period has not been systematically performed by all surgical center professionals, but the practice of this practice was reported by 92.4% in the preoperative period, 83.8% in the intraoperative period and 94, 9% in the postoperative period. The prevention of inadvertent perioperative hypothermia is a practice practiced by the vast majority of participants (96%), with predominance in passive methods of maintaining normothermia in the preoperative periods (51%) and association of passive and active methods in the post- 64.6%) and intraoperative (45.5%) maintenance of normothermia in the surgical patient. The main professionals involved in temperature monitoring and the prevention of inadvertent perioperative hypothermia are the nursing team and anesthesiologists. Although a large number of professionals do not report the occurrence rate of inadvertent perioperative hypothermia, it is noted that for most of the respondents the occurrence of this event is low. Conclusion: the practice of practices for the maintenance of operative normothermia is reality for the nursing team. Temperature monitoring is not yet performed consistently throughout the perioperative period. The prevention of inadvertent hypothermia in the perioperative period is a very frequent practice among surgical procedures.

Introdução: A hipotermia inadvertida perioperatória é um evento frequente e atinge cerca de 70% dos pacientes cirúrgicos, levando a complicações importantes, como alterações cardiovasculares, infecção do sitio cirúrgico, desconforto ao paciente, aumento do tempo de hospitalização, entre outros. Por oferecer inúmeros riscos ao paciente cirúrgico, a ocorrência da hipotermia não intencional perioperatória tem ganhado espaço na literatura atual. A manutenção da temperatura perioperatória vem sendo sugerida pela literatura com a implementação de métodos passivos e ativos de aquecimento como o aumento da temperatura da sala cirúrgica, uso de cobertor de algodão, uso de cobertor térmico, uso de dispositivos de ar forçado, infusão de fluidos aquecidos, entre outros. No entanto, não há no Brasil nenhum estudo publicado onde se investigue a atuação das equipes que atuam no bloco cirúrgico realizam a prevenção da hipotermia perioperatória nos hospitais. Objetivos: Verificar como se dá o monitoramento da temperatura e a prevenção de hipotermia inadvertida perioperatória em pacientes cirúrgicos internados em hospitais brasileiros. Material e método: Estudo transversal, realizado na cidade de São Paulo através de questionário preenchido pelos enfermeiros participantes do 12° Congresso Brasileiro de Enfermagem em Centro Cirúrgico, Recuperação Anestésica e Centro de Material e Esterilização. Os dados foram analisados descritivamente e demonstrados em foram de tabelas. Resultados: O monitoramento da temperatura no período perioperatório ainda não é realizado sistematicamente por todos os profissionais de centro cirúrgico, porem a realização dessa pratica foi relatada por 92,4% no período pré-operatório, 83,8% no período intraoperatório e 94,9% no período pós-operatório. A prevenção da hipotermia inadvertida no perioperatório é uma pratica exercida pela grande maioria dos participantes (96%), com predomínio nos métodos passivos de manutenção da normotermia nos períodos pré-operatório (51%) e associação de métodos passivos e ativos nos períodos pós (64,6%) e intraoperatório (45,5%) de manutenção da normotermia ao paciente cirúrgico. Os principais profissionais envolvidos para a monitorização da temperatura e a prevenção da hipotermia perioperatória inadvertida são a equipe de enfermagem e os anestesiologistas. Apesar de um número grande de profissionais não informarem a taxa de ocorrência de hipotermia inadvertida perioperatória, nota-se que para a maioria dos respondentes a ocorrência desse evento é baixa. Conclusão: a realização de praticas para a manutenção da normotermia operatória é realidade para a equipe de enfermagem. A monitorização da temperatura ainda não é realizada de maneira constante em todo período perioperatório. A prevenção da hipotermia inadvertida no período perioperatório é pratica bastante frequente entre os procedimentos cirúrgicos. / Introduction: Perioperative inadvertent hypothermia is a frequent event and affects about 70% of surgical patients, leading to important complications, such as cardiovascular alterations, surgical site infection, patient discomfort, hospitalization time, and others. Because it offers innumerable risks to the surgical patient, the occurrence of perioperative unintentional hypothermia has gained space in the current literature. Perioperative temperature maintenance has been suggested in the literature with the implementation of passive and active heating methods such as increased operating room temperature, use of cotton blanket, use of thermal blanket, use of forced air devices, infusion of fluids heated, among others. However, there is no published study in Brazil to investigate the performance of the teams that work in the surgical block, and to prevent perioperative hypothermia in hospitals. Objectives: To verify how temperature monitoring and the prevention of perioperative inadvertent hypothermia occur in surgical patients hospitalized in Brazilian hospitals. Material and method: A cross-sectional study was carried out in the city of São Paulo through a questionnaire filled out by nurses participating in the 12th Brazilian Congress of Nursing in Surgical Center, Anesthetic Recovery and Material and Sterilization Center. The data were analyzed descriptively and demonstrated in the tables. Results: Temperature monitoring in the perioperative period has not been systematically performed by all surgical center professionals, but the practice of this practice was reported by 92.4% in the preoperative period, 83.8% in the intraoperative period and 94, 9% in the postoperative period. The prevention of inadvertent perioperative hypothermia is a practice practiced by the vast majority of participants (96%), with predominance in passive methods of maintaining normothermia in the preoperative periods (51%) and association of passive and active methods in the post- 64.6%) and intraoperative (45.5%) maintenance of normothermia in the surgical patient. The main professionals involved in temperature monitoring and the prevention of inadvertent perioperative hypothermia are the nursing team and anesthesiologists. Although a large number of professionals do not report the occurrence rate of inadvertent perioperative hypothermia, it is noted that for most of the respondents the occurrence of this event is low. Conclusion: the practice of practices for the maintenance of operative normothermia is reality for the nursing team. Temperature monitoring is not yet performed consistently throughout the perioperative period. The prevention of inadvertent hypothermia in the perioperative period is a very frequent practice among surgical procedures.

The thermogenic effects in hypothermia of four substrates--alanine, glycine, ethano, and pyruvate - were studied in seventeen experiments. Albino rats were decapitated, and their livers were removed. The livers were homogenized with phosphate buffer at -5° C. After equilibration in a refrigerated Warburg apparatus at 20° C, the substrates were added and tissue respiration was recorded over three hours. Heat production was calculated from O2 uptake and CO2 production. Results showed that alanine, glycine, and pyrvate yielded 93.19, 89.86, and 89.89 x 10^6 kg-cal compared to a control value of 86.11 x 10^-6 kg-cal. Ethanol provided 110.31 x 10^-6 kg-cal, a value significantly greater than for the other substrates. The substrates studied, especially ethanol, did, therefore increase heat production in an artificially hypothermic environment in homogenized rat livers.

The purpose of this integrated review of the literature was to determine the relationship between therapeutic hypothermia and cardiac arrhythmias. The reviewed literatures were English based articles from year 2003-2013. Relevant information from the American Heart Association and the International Liaison Committee on Resuscitation was used to further enhance research results. The results of this literature review showed hypothermia treatment propensity to prolong QT interval without precipitating life-threatening arrhythmias. Although arrhythmias can be potentially increased under induced hypothermia, it has been shown that treatment is easier while under hypothermic conditions. The reviewed research also shows that hypothermia treatment should be expanded to include more circumstance besides ventricular cardiac arrest. It was suggested that the reason for lack of use of hypothermia treatment under the suggested conditions was due to the restricted circumstances in which it is suggested to be used. Other recommendations include increased monitoring for cardiac rhythms during cardiac arrhythmias and protocols for arrhythmia treatment.

Le sepsis, état pathologique lié à une réaction inflammatoire systémique suite à une infection, est lapremière cause de mortalité dans les unités de réanimation médicale et de soins intensifs hospitaliers.Parmi les pistes thérapeutiques envisagées, l’hypothermie est un bon candidat. En effet, l’hypothermiemodérée induite augmente la durée de survie de rats septiques. Ce travail avait pour objectifd’apporter des éléments permettant de comprendre et d’identifier les mécanismes responsables decet effet bénéfique. Pour cela, différentes fonctions couramment affectées lors du sepsis(inflammation, stress oxydant, défaillance rénale, capacités de transport de l’oxygène par le sang etéquilibre acide-base) ont été étudiées sur des rats septiques en hypothermie modérée (34°C). Lesrésultats obtenus révèlent que l’hypothermie modérée ralentit de manière significative la production decytokines pro-inflammatoires et tend à exercer une diminution de la production radicalaire systémiquechez les rats septiques. L’apparition de l’acidose métabolique et la défaillance rénale sont égalementretardées. Enfin, alors que le sepsis en normothermie conduit à une diminution de la coopérativité etde l’affinité de l’hémoglobine pour l’oxygène, synonymes d’une adaptation face à des modificationspotentiellement délétères, en hypothermie modérée, ces paramètres ne sont pas modifiés. Cesrésultats concourent à penser que l’hypothermie modérée en ralentissant l’évolution du sepsis permetd’augmenter la durée de survie des rats septiques. Ainsi, l’hypothermie pourrait constituer une pistepour traiter les patients atteints de sepsis sévère dans le but de temporiser l’inflammation et decontrôler l’agression retardant ainsi les défaillances d’organes. / Despite numerous studies over the past twenty years, sepsis, a pathologic state related to a systemicinflammatory response following infection, remains the main cause of death in intensive care units.Among the therapeutic approaches proposed, hypothermia is a good candidate. Indeed, mild inducedhypothermia increased the survival duration of septic rats. This work aimed to provide elements tounderstand and identify the mechanisms responsible for this beneficial effect. Consequently, variousfunctions commonly affected during sepsis (inflammation, oxidative stress, renal failure, oxygen bloodcapacity and acid-base balance) were studied on septic rats maintained in mild induced hypothermia(34°C). The results showed that mild hypothermia significantly slows the cytokine proinflammatoryproduction and tends to exert a decrease in the radical systemic production of septic rats. Theappearance of metabolic acidosis and renal failure are also delayed. Finally, while in normothermiasepsis led to a decrease in the cooperativity and oxygen haemoglobin affinity, synonymous of anadaptation when faced with potential deleterious changes, in mild hypothermia, these parameters arenot modified. These results suggest that by reducing the development of sepsis, mild inducedhypothermia increases the survival duration of septic rats. Thus, hypothermia may be an option fortreating patients with severe sepsis by stalling inflammation and controlling aggression, therebydelaying organ failure.

published_or_final_version / Nursing Studies / Master / Master of Nursing

Hypothermia at birth is strongly associated with mortality and morbidity in preterm infants. Unfortunately, infants are prone to hypothermia immediately after birth. A large proportion of preterm infants, especially those of gestational age at less than 30 weeks, experience different levels of hypothermia. A frequently used possible preventive measure is the application of an occlusive wrap immediately after birth. However, no systematic review on this preventive measure supports its translation into practice. This dissertation aimed to evaluate the current evidence on the application of occlusive warp for preterm infants. Four electronic databases, Cochrane Library, PubMed, CINAHL, and Medline, were searched. Eight studies met the inclusion criteria of this dissertation. Data were extracted and the quality of the included studies was evaluated by the Scottish Intercollegiate Guidelines Network (SIGN). Six studies were graded as high quality studies and showed that occlusive wrapping significantly prevented the incidence of hypothermia among the preterm infants smaller than 30 weeks. An evidence-based Superwarm guideline was developed, which was deemed to be transferable to the local setting of neonatal intensive care unit with similar target clients and philosophy of care as with those in the identified studies. Also, the proposed innovation was considered to be feasible after examination of staff competency, resources, and approval methods. The potential benefits to preterm infants, nurses, and also the hospital were high, and risks to the patient were minimal. The estimated set-up cost including manpower and consumable cost was $1,720, and the running cost was also $1,720 per year. A 12 -month implementation program scheduled including communication with stakeholders, training to the frontline nurses, and a pilot of the guideline. Patient outcomes will be measured by admission temperature, temperature one hour after admission, and mortality rate. Healthcare provider outcomes include compliance rate, workload, acceptance of the proposed guideline, job satisfaction, knowledge, and skill enhancement in thermoregulation of the preterm infants. The quality of patient care was also considered in the system outcomes. Guideline effectiveness will be evaluated by the increase in admission temperature, nurse and physician satisfaction, and controlled program expenditure. / published_or_final_version / Nursing Studies / Master / Master of Nursing

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Thesis (M.Sc. (Physiology)) -- Mahidol University, 1976.