SOUZA, Kamille Leão de. A expansão das commodities e a suposta desindustrialização na região Nordeste do Brasil no período 1991-2012. 2013. 127 f.: Dissertação (mestrado) - Universidade Federal do Ceará. Mestrado Acadêmico em Economia Rural (MAER). Centro de Ciências Agrárias. Fortaleza-CE. 2013 / Submitted by Francisco Helder Macêdo Rangel (fhelder@ufc.br) on 2014-10-10T17:07:16Z No. of bitstreams: 1 2013_dis_klsouza.pdf: 1329267 bytes, checksum: 189bb2778404c732a679703c10dc924a (MD5) / Approved for entry into archive by Margareth Mesquita(margaret@ufc.br) on 2014-12-03T15:54:37Z (GMT) No. of bitstreams: 1 2013_dis_klsouza.pdf: 1329267 bytes, checksum: 189bb2778404c732a679703c10dc924a (MD5) / Made available in DSpace on 2014-12-03T15:54:37Z (GMT). No. of bitstreams: 1 2013_dis_klsouza.pdf: 1329267 bytes, checksum: 189bb2778404c732a679703c10dc924a (MD5) Previous issue date: 2013 / Nowadays deindustrialization underway in economies that have not yet reached a high per capita income is the main theme in debates. Several studies were conducted to Brazil on this subject, but the Northeast still lacks analysis in this area. The central hypothesis of this study is to verify ig the Northeast economy was deindustrialized in the period 1991-2012, from the continued growth of commodities in totalexports couopled with the highest share of products with higher technological content in the imports. The analysis was carried out by using data on the trade balance, exports and imports, registering the share of commodities and industrial products, according to the classification adopted by OECD and MDI C (high, medium-high, medium-low, low-tech and unprocessed products), the value added by industry, the share of manufacturing employment and total income (GDP). To this end, we calculated indicators foreign trade (Export Concentration Index-ICX, Concentration Index of Import-ICM, Revealed Comparative Advantage Index over the trade balance-VCR, simple rate of coverage of imports and TC-Index of intra-industrytrade-CII and an econometric model was regressed to verify traces of deindustrialization in relation to industrial production. The results indicate that the northeast export tariff undergoes a reprimarization that, when associated with the increased presence of industrial products with higher technological content of imports, show signs of deindustrialization. However, it is not possible to come to the conclusion that the northeast economy suffers the dutch disease because signs of loss of importance on the industrial sector in total did not appear on the analysis of industrial employment and of the value added by industry in the totaleconomy. There, such results corroborated with the econometric model regressed. However, some industries (textile, clothing and accessories and machinery, equipment and material) showed a decreasing trend in the evolution of the physical industry production index, which may indicate a kind of loss. / Nos dias atuais, é tema dos principais debates a desindustrialização em curso nas economias que ainda não atingiram alta renda per capita. Vários estudos foram realizados no Brasil sobre o assunto, mas a região Nordeste ainda carece de análises nessa área. A hipótese central deste estudo é verificar se a economia nordestina se desindustrializou no per5íodo 1991-2012, com o crescimento contínuo de commodities na pauta de exportações, aliado à maior participação de produtos de conteúdo tecnológico mais relevante na pauta de importações. A análise foi realizada fazendo uso de dados da balança comercial, exportação e importação, registrando a participação das commodities e dos produtos industriais segundo a classificação adotada pelo MDIC e OCDE (Ala, méida-alta, média-baixa, baixa intensidade tecnológica e produtos não industrializados), do valor agregado pela indústria, pela participação do emprego industrial no total e a renda (PIB). Para tal fim, foram calculados indicadores do comércio exterior (Índice de Concentração das Exportações-ICX, Índice de Concentração das Importações-ICM, Índice de Vantagem comparativa Revelada em relação ao saldo comerciakl-VCR, Taxa simples de Cobertura das importações-TC e o Índice de Comércio Intraindústria-CII) e regredido um modelo econométrico para verificar vestígios de desindustrialização concernente à produção industrial. Os resultados indicam que a pauta de exportação nordestina passa por uma reprimarização, que associada à maior presença de produtos industriais com maior conteúdo tecnológico nas importações apresenta sinais de desindustrialização. Não é possível concluir, no entanto, que a economia nordestina padeça da doença holandesa, pois, na análise do emprego industrial e do valor adicionado pela indústria no total da economia, não apareceram sinais de perda de importância do setor industrial no total, resultados esses corroborados pelo modelo econométrico regredido. Alguns segmentos industriais (têxtil, vestuário e acessórios, máquinas, aparelhos e materiais elétricos) expressam, contudo, uma tendência decrescente na evolução do índice de produção física industrial, o que pode indicar perda relativa desses ramos especificamente.

The preimplantation stages of mammalian development are dedicated to the differentiation of two extraembryonic epithelia, the trophectoderm (TE) and the primitive endoderm (PrE), and their segregation from the pluripotent embryonic lineage, the epiblast. The TE and PrE are responsible for implantation into the uterus and for producing the tissues that will support and pattern the epiblast as it develops into the foetus. PrE and epiblast are formed in a two step process that involves random cell fate specification, mediated by fibroblast growth factor (FGF) signalling, and cell sorting through several mechanisms. In the present work I have addressed aspects of both steps of this process. Chimaera assays showed that epiblast precursors transplanted onto a recipient embryo rarely differentiate into PrE, while PrE precursors are able to switch their identity and become epiblast. Transient stimulation or inhibition of the FGF4-ERK pathway in the chimaeras can modify the behaviour of these cells and restore the plasticity of epiblast precursors. This work shows that epiblast precursors are refractory to differentiation signals, thus ensuring the preservation of the embryonic lineage. I have also found that atypical Protein Kinase C (aPKC) is a marker of PrE cells and that pharmacological inhibition of aPKC impairs the segregation of PrE and epiblast precursors. Furthermore, it affects the survival of PrE cells and can alter the subcellular localisation of the PrE transcription factor GATA4. These data indicate aPKC plays a central role for the sorting of the PrE and epiblast populations and links cell position within the embryo to PrE maturation and survival. Lastly, I have found that aPKC can directly phosphorylate GATA4 in vitro. Knockdown of GATA4 affects cell position within the embryo, whereas aPKC knockdown reduces the number of GATA4-positive cells. These results indicate GATA4 plays an important role in cell sorting during preimplantation development and suggest phosphorylation by aPKC could determine its presence in the nuclei of PrE cells. My work, in the light of the current knowledge, supports a model where the earliest cell fate decisions during mammalian development depend on cellular interactions and not on inherited cell fate determinants. This robust mode of development underlies the plasticity of the preimplantation embryo and ensures the formation of the first mammalian cell lineages, critical for any further progression in mammalian development.

Diplomová práce se zabývá situací v oblasti Informačních center mládeže. Definuje aspekty současného systému fungování ICM a jejich financování. Zaměřuje se na ICM v kraji Vysočina. Rozebírá jejich vznik, počet pracovníků, provozovatele, provozní dobu, technické vybavení, materiální zajištění, ohlasy veřejnosti, návštěvnost, okruh poskytovaných služeb. Zjišťuje možnosti financování ICM. Vyjadřuje doporučení k ideálnímu stavu sítě ICM v kraji Vysočina.

Diplomová práce se zabývá situací v oblasti Informačních center mládeže. Definuje aspekty současného systému fungování ICM a jejich financování. Zaměřuje se na ICM v kraji Vysočina. Rozebírá jejich vznik, počet pracovníků, provozovatele, provozní dobu, technické vybavení, materiální zajištění, ohlasy veřejnosti, návštěvnost, okruh poskytovaných služeb. Zjišťuje možnosti financování ICM. Vyjadřuje doporučení k ideálnímu stavu sítě ICM v kraji Vysočina.

Diplomová práce se zabývá situací v oblasti Informačních center mládeže. Definuje aspekty současného systému fungování ICM a jejich financování. Zaměřuje se na ICM v kraji Vysočina. Rozebírá jejich vznik, počet pracovníků, provozovatele, provozní dobu, technické vybavení, materiální zajištění, ohlasy veřejnosti, návštěvnost, okruh poskytovaných služeb. Zjišťuje možnosti financování ICM. Vyjadřuje doporučení k ideálnímu stavu sítě ICM v kraji Vysočina.

Diplomová práce se zabývá situací v oblasti Informačních center mládeže. Definuje aspekty současného systému fungování ICM a jejich financování. Zaměřuje se na ICM v kraji Vysočina. Rozebírá jejich vznik, počet pracovníků, provozovatele, provozní dobu, technické vybavení, materiální zajištění, ohlasy veřejnosti, návštěvnost, okruh poskytovaných služeb. Zjišťuje možnosti financování ICM. Vyjadřuje doporučení k ideálnímu stavu sítě ICM v kraji Vysočina.

The human cerebral cortex, the outermost layer of the brain, is typically considered in imaging studies to consist of grey matter (GM), with white matter (WM) lying below it. With better imaging techniques, a third tissue type, found between GM and WM, can be identified. This layer contains myelinated axons and is found in the cortex, thus we call it intracortical myelin (ICM), or myelinated grey matter (GMm). We examined the cortical thickness measurements in female patients with bipolar I or II disorders (BD) versus healthy controls. Previous studies have only examined the thickness of the entire cortex, the GM. We developed a processing pipeline and a statistical tool for examining the ICM thickness between two groups. Results show that there are potential differences in GMm between BD and control groups. Further regional and statistical analysis is required to identify the regions of greatest difference, and to confirm significant differences between BD and control groups. / Thesis / Master of Science (MSc)

<p>The actin cytoskeleton is involved in many essential cellular events such as mitosis, cell migration, control of epithelial barrier function, and adherence of immune cells. Given the essential roles of the actin cytoskeleton, it is not surprising that it is a common target for bacterial virulence factors. <em>Legionella pneumophila</em>, the causative agent of Legionnaire’s pneumonia, establishes a replicative compartment using effectors secreted by its Dot/Icm secretion system. At least four Dot/Icm effectors, VipA, Ceg14, LegK2 and RavK have been shown to modulate the host actin cytoskeleton. Here, we identified RavJ (lpg0944) as an additional effector that interferes with the actin cytoskeleton in mammalian cells. We demonstrated that RavJ is a transglutaminase that functions to induce crosslink between actin and members of the Motin protein family, leading to inhibition of the binding between actin and ADF/cofilin. We also found that LegL1 (lpg0945) is a metaeffector of RavJ, which suppresses the transglutaminase activity of RavJ by blocking its enzymatic domain. </p>

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Greenhouse and laboratory experiments in 2011 determined that Clonostachys rosea can effectively prevent Botrytis cinerea infection in Vaccinium angustifolium blossoms. In vitro testing demonstrated that C. rosea germination was not significantly affected by the presence of Switch®, but was by either Pristine® or Maestro®. Field experiments completed during the summer of 2010 and 2011 indicated that the dispenser designs tested had no significant effects on Bombus impatiens foraging behaviours, aside from hive-activity. There was also no difference in the quantity of C. rosea applied by each to bees, the distribution of product in the field, or for blossoms exposed to bees from each dispenser to resist infection by B. cinerea. However, B. cinerea prevalence in blossoms from both treatments was significantly different from the control, with infection reduced by 10-20%. Technical issues with dispensers currently appear to be the limiting factor for application within commercial wild blueberry production.