The present study was undertaken to explore the relationship of cellular immunity to total serum ICE in an unselected sample of 278 healthy infants. Statistical analyses of infant history profiles and cellular immune and serum IgE determinations from cord blood and 10 month samples were performed using SPSSx. During the first year of life, the percent CD3, CD4, CD8, ERFC, and B-cell counts significantly increased and the CD4/CD8 ratio and responses to ConA and PW mitogens significantly decreased. Boys had lower percent CD8 cell counts and decreased responses to ConA and PW mitogens in cord blood. Cellular immune variable values were not associated with total serum ICE in any analysis. Early feeding method had no effect on 10 month serum IgE levels or cellular immune variables. Cord blood percent CD3 and CD4 cell counts were significantly decreased in infants with parental histories of asthma. In summary, (1) boys had a lower percent of suppressor T-cells and lower mitogen responses in cord blood (2) boys and girls reached similar levels for all variables by 10 months of age (3) infants with familial histories of asthma had fewer total and helper T-cells in cord blood.

A research thesis submitted for the degree of Doctor of Philosophy in Audiology in the Faculty of Humanities the University of the Witwatersrand March 2016. / Purpose: The main objective of the current study was to explore risk-based new-born hearing screening within a developing country by conducting early hearing detection in high-risk neonates within an academic hospital complex in Gauteng, South Africa. Specific objectives describing the case history factors and audio logical function in a group of high-risk determining the relationship between the case history factors and audio logical establishing the true-positive (TP) and true-negative (TN) results with different combinations of screening measures; establishing the percentage of TP and NT screening results in the total sample; and exploring the factors associated with follow-up return rate for hearing screening and diagnostic audio logical assessment. / GR2017

Intellectual stimulation of young children is crucial, because it helps to break the cycle of poverty by giving each child the skills needed to reach his or her maximum potential. There is a growing need for more extensive early childhood development programmes in South Africa. Several studies in early childhood development have been shown to directly draw a parallel with enhanced student achievement at school and in life (Ackerman, 2005; Bueno, Darling-Hammond, & Gonzales 2010; Frede, Jung, Barnett, & Figueras, 2009). This study therefore explored the effects of an intervention programme introducing numbers, shapes and colours to infants between the ages of three months and 12 months. The sample consisted of 63 infants, with a control group of 34 and an experimental group of 29. The participants were selected from the middle-income group and consisted of infants from three different ethnic groups (black, white and coloured). Nine participants from the experimental group formed part of the focus group, which met every two weeks to give feedback and discuss the development of the infants and experiences of the parents involved in the intervention programme. In this study quantitative and qualitative data was collected. This data was assessed and analysed in order to achieve the four aims of the research study. The Bayley Scales of Infant Development (III) was used to assess three areas of development, namely cognitive ability, language skills and motor skills for the quantitative part of the study. The adaptive behaviour and social-emotional functioning of the infants was also assessed using the BSID (III), and this data was used in conjunction with the focus group feedback and problem-solving scenarios for the qualitative part of the study. Gender and the two age categories (3–7 and 8–12 months) for both the experimental and the control groups were examined and excluded from possible explanations for any significant findings. It was also determined that the control and experimental groups were well matched at the start of the intervention programme. The findings for aim A, the pre-test and post- test results showed that an average of 60 days involved in intervention programme had a statistically significant effect (z = -4.32, p < 0.001) on the cognitive ability of the infants. The findings for aim B, for the comparison between the control and experimental groups after the intervention programme, indicated significant results for the cognitive subscale (U = 732, p < 0.01, r = 0.42). Although the language and motor scores showed an increase in the descriptive statistics for the experimental group after the intervention, the Mann-Whitney U test did not show a significant difference. The findings for the qualitative study for aim C revealed that there was no effect on the adaptive behaviour of the infants. The findings for the social-emotional scales descriptive statistics for the qualitative study in aim D showed that there was a fairly large increase in the composite score means of the experimental group in comparison with the control group. The large increase in results complements the social-emotional functioning theme that emerged from the focus group. Three main themes emerged from the focus group, namely the cognitive ability, communication skills and social-emotional functioning of the infants.The increase in the social-emotional scale for the intervention group and the increase in the cognitive scale as mentioned in aim B were interrelated. These early social-emotional experiences are linked to long-term positive outcomes in both the social and cognitive areas of development (Landry, Smith, Swank, & Miller-Loncar, 2000). The parents all reported the ability to interpret the communication from their infants when participating in the flashcard sessions. This communication forms a foundation for establishing language development. Relationships between an infant’s nonverbal communication skills and subsequent language development have been reported (Brooks & Meltzoff, 2005). The problem-solving scenarios that were assessed during the second assessment showed that the infants who participated in the intervention programme were able to correctly identify a flashcard 73% of the time in comparison with the control group who were only able to identify a flashcard 1.4% correctly. The results of the study show that an early intervention programme has the potential to increase an infant’s cognitive ability and enhance his or her social-emotional functioning. However, the long-term impact of these findings would have to be explored in a longitudinal study. / Psychology / M.A. (Psychology)

Studies have shown that human infants can integrate the multisensory attributes of their world and, thus, have coherent perceptual experiences. Multisensory attributes can either specify non-arbitrary (e.g., amodal stimulus/event properties and typical relations) or arbitrary properties (e.g., visuospatial height and pitch). The goal of the current study was to expand on Walker et al.'s (2010) finding that 4-month-old infants looked longer at rising/falling objects when accompanied by rising/falling pitch than when accompanied by falling/rising pitch. We did so by conducting two experiments. In Experiment 1, our procedure matched Walker et al.'s (2010) single screen presentation while in Experiment 2 we used a multisensory paired-preference procedure. Additionally, we examined infants' responsiveness to these synesthetic-like events at multiple ages throughout development (four, six, and 12 months of age). ... In sum, our findings indicate that the ability to match changing visuospatial height with rising/falling pitch does not emerge until the end of the first year of life and throw into doubt Walker et al.'s (2010) claim that 4-month-old infants perceive audiovisual synesthetic relations in a manner similar to adults. / by Nicholas Minar. / Thesis (M.A.)--Florida Atlantic University, 2013. / Includes bibliography. / Mode of access: World Wide Web. / System requirements: Adobe Reader.

Our everyday world consists of people and objects that are usually specified by dynamic and concurrent auditory and visual attributes, which is known to increase perceptual salience and, therefore, facilitate learning and discrimination in infancy. Interestingly, early experience with faces and vocalizations has two seemingly opposite effects during the first year of life, 1) it enables infants to gradually acquire perceptual expertise for the faces and vocalizations of their own race and, 2) it narrows their ability to discriminate the faces of other-race faces (Kelly et al., 2007). It is not known whether multisensory redundancy might help older infants overcome the other-race effect reported in previous studies. The current project investigated infant discrimination of dynamic and vocalizing other-race faces in younger and older infants using habituation and eye-tracking methodologies. Experiment 1 examined 4-6 and 10-12-month-old infants' ability to discriminate either a native or non-native face articulating the syllable /a/. Results showed that both the 4-6- and the 10-12-month-olds successfully discriminated the faces,regardless of whether they were same- or other-race faces. Experiment 2 investigated the contribution of auditory speech cues by repeating Experiment 1 but in silence. Results showed that only the 10-12-month-olds tested with native-race faces successfully discriminated them. Experiment 3 investigated whether it was speech per se or sound in general that facilitated discrimination of the other-race faces in Experiment 1 by presenting a synchronous, computer-generated "boing" sound instead of audible speech cues. Results indicated that the 4-6-month olds discriminated both types of faces but that 10-12-month-olds only discriminated own-race faces. These results indicate that auditory cues, along with dynamic visual cues, can help infants overcome the effects of previously reported narrowing and facilitate discrimination of other-race static, silent faces. Critically, our results show that older infants can overcome the other race-effect when dynamic faces are accompanied by speech but not when they are accompanied by non- speech cues. Overall, a generalized auditory facilitation effect was found as a result of multisensory speech. Moreover, our findings suggest that infants' ability to process other- race faces following perceptual narrowing is more plastic than previously thought. / Includes bibliography. / Dissertation (Ph.D.)--Florida Atlantic University, 2015. / FAU Electronic Theses and Dissertations Collection

Zhu, Yin. / Thesis (Ph.D.)--Chinese University of Hong Kong, 2013. / Includes bibliographical references (leaves 162-203). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstract also in Chinese; appendixes includes Chinese.

Estudos iniciais sobre a aquisição da locomoção aquática por bebês identificaram uma seqüência ordenada de padrões de movimento ao longo do primeiro ano de vida. A explicação dada a respeito dessa constatação sustenta que isso se deva a alterações no controle motor causado pela maturação do sistema nervoso. Estudos posteriores têm contestado a existência dessa seqüência predeterminada de padrões, sugerindo uma menor predisposição do organismo e uma maior influência ambiental na aquisição desses comportamentos. O presente projeto visou investigar o efeito da estimulação sistemática do reflexo de nadar no comportamento de bebês na locomoção aquática no primeiro ano de vida. Participaram do experimento dezeseis bebês, com idade media de quatorze semanas, divididos em dois: grupo experimental e controle. O registro dos dados foi feito com uma câmera (Panasonic Camerascope S-VHS Movie modelo AG 456) e a identificação e quantificação dos movimentos foram feitas mediante a análise quadro a quadro utilizando-se do software APAS 2000 (Ariel System). Consideraram-se os movimentos do corpo todo ou de partes e que durassem pelo menos dois segundos. Os resultados obtidos permitiram identificar diferenças significativas na duração do comportamento predominante do mergulho ventral autônomo entre os grupos nos componentes, cabeça, braços, pernas e tronco em nível de 5%. Nas outras demais posições experimentais os resultados obtidos não foram totalmente conclusivos. O que nos leva a afirmar que houve efeito de prática entre os grupos principalmente para a posição experimental do mergulho ventral autônomo / Early studies about acquisition of swimming behavior in infants identified an ordered sequence of movement patterns span the first year of life. The explanation attributed to this fact defends that it happens due to changes in motor control caused by the maturation of nervous system. Nevertheless, it has been questioned, suggesting a smaller predisposition of the organism in the skills acquisition process, suggesting a bigger environmental influence in the acquisition of this behavior. In this way, the present study aimed testing the effects of practice on elementary swim patterns. For this, sixteen full-terms, fourteen weeks ear old infants, were recruited from the Londrina State University community in Londrina. The infants were randomly assigned to one of two groups. The experimental group was taken to the aquatic environment twice a week for a period of seven consecutive months and received thirty minutes of stimulation of swimming patterns each day. The control group received no systematic stimulation. Both groups were taken to aquatic environment twice a month and filmed for a period of fifteen minutes in each experimental position. The movements made by all the body or the segments, during more than two consecutive seconds, were considered to this analysis. From the data gathered it was possible to identify some behavioural patterns regarding to the action of the head, the limbs and the trunk. A planned comparison confirmed that the duration of the most frequent movement of the experimental group was longer than that of the control group. Those results suggest that the effects of practice can provide variations on some swimming behavior

Background: Maternal sensitivity, or high quality maternal caregiving, in which the mother leads and structures the infant’s early experiences in a responsive way, is associated with improved child development outcomes and health, both in the immediate and long term, and thus an important area of public health research. Although previous research has established that exposure to high maternal sensitivity advances the outcome of infant cognitive development, factors such as breastfeeding, which is hypothesized to confound the association, or depression, which is negatively associated with sensitivity, have not yet been examined together in a single study. Maternal alcohol use, associated with both breastfeeding and depression, has not been examined in any study investigating the sensitivity-cognitive development association. The majority of infant studies examining the maternal sensitivity-infant cognition association include either normal birth weight infants or LBW infant samples. Using the LBW category may result in potential misclassification since this group combines at least two different phenomena and includes infants who have had either compromised gestational time as in the case of small for gestational age (SGA), or insufficient gestational time, as in the case of premature birth, or both. In studies using comparison groups, normal birth weight infants are sometimes compared to LBW infants or infants born prematurely. However, none of these studies examine the association between sensitivity and cognitive outcome in infants exclusively premature or SGA. Aim: This study investigates the association of several factors: (1) maternal depressive symptomology, (2) breastfeeding, (3) concurrent maternal alcohol intake and (4) infant biological vulnerability upon outcomes of (1) Maternal Sensitivity and (2) Infant Cognitive Development, as well as their effect on the association between senstivity and cognitive development. Methods: Using data from the Early Childhood Longitudinal Study-Birth (ECLS-B) Cohort, a nationally representative sample of U.S. born children, depressive symptomology was evaluated as an effect-modifier, and breastfeeding was evaluated as a confounder of the sensitivity-cognitive development association. Maternal alcohol use and biological vulnerability were also hypothesized to be confounders of the sensitivity-cognitive association. Univariate and multi-variable regression analyses were used to examine whether the four maternal factors were associated with Maternal Sensitivity, measured by the Nursing Child Assessment Teaching Scale (NCATS), and with Cognitive Development, measured by the Bayley Scale of Infant Development, Research Edition (BSF-R). Results: In univariate analyses, breastfeeding, depressive symptomology and alcohol use were associated with maternal sensitivity but only breastfeeding and depressive symptomology were associated with Cognitive Development In a final model examining the effect of sensitivity, depressive symptomology and breastfeeding upon the outcome of Cognitive Development, sensitivity (β =.375, p<.001) remained significantly associated with cognitive development after adjusting for breastfeeding (β =1.592, p<.001), depressive symptomology (β =-.061), p<.05), demographic factors and birthweight (R2=.053, p<.001). Depressive symptomology was not an effect modifier of the sensitivity-cognitive developmental association. Univariate regression analyses showed that of the measures of biological vulnerability, premature birth had the greatest association with both sensitivity and cognitive development in comparison to the LBW or SGA. In a multivariate regression model in which maternal sensitivity as an outcome, premature birth (β= -.524***) was associated with maternal sensitivity (R2=.100, p<.001), after adjusting for maternal depression and breastfeeding. In a multivariate regression model analysing the effect premature birth and maternal factors, including sensitivity in which cognitive development was the outcome, maternal sensitivity (β=.369, p<.001) and breastfeeding (β=1.567, p<.001) were positively associated with infant cognitive development, while premature birth (β= -2.949, p<.001) was negatively associated (R2=.049, p<.001). Conclusion: This research demonstrates that an independent association between maternal sensitivity and infant cognitive development remains even after adjusting for breastfeeding, and that breastfeeding is a separate means to advancing infant cognitive development. Premature birth, rather than SGA drove the negative association between low birth weight and cognitive development. Future research should look at the effects of premature birth separately from SGA when examining developmental outcomes. Keywords: Maternal Sensitivity, Parenting, Cognitive Development, Breastfeeding, Maternal Depression, Premature Birth, Small for Gestational Age, Low Birth Weight

The purpose of this case study was to explore and understand the function of music in an infant community. By observing the musical behaviors of seven children under the age of two in both childcare and home settings, I sought to gain new insights that can inform parents, caregivers, and educators about the engagement with and possible functions of music for infants. The theories of Communicative Musicality and psychobiological needs informed this study and provided the lenses through which I observed infant musicality. Data collection comprised semi-structured interviews with parents at home, interviews with teachers, weekly infant room observation fieldnotes, weekly infant music class video observations, parent and teacher diary entries, and artifacts such as memos, videos, and photos from the childcare and home settings. Data analysis involved identifying infant musical behaviors and their possible functions with respect to the child’s musical experience, framed as episodes. Through the use of portraiture, the individual music making of each infant was described within the contexts of the home, school, field observation, and music class settings, and relationships that developed through musical interactions were highlighted within the infant community. Results indicate that vocal and movement behaviors were the most prominent behaviors identified overall, and communication had the highest frequency of all functions. In contrast to the school-based teacher and researcher field observation settings where vocal behaviors were high, movement behaviors were identified as most prevalent during music class. The child-centered emergent curriculum provided space for the infants to demonstrate choice and leadership by setting up musical toys, pointing to an instrument, moving to indicate direction in a song, bringing song books to adults, singing fragments of songs, participating on the periphery, and gesturing for more. Infants listened and engaged in music class by moving and playing instruments and displayed their attentiveness by later recalling and initiating these activities in other settings. Increased infant room vocalizations outside music time included those resulting from delayed imitation and extensions from music class. Music is a social endeavor wherein infants build community, motivating leadership, friendship, and kinship.

In speech, vowels and consonants are two the basic sounds that combined result in lexically meaningful items in all languages. In tone languages, changes in pitch, tone differences also make meaningful lexical distinctions in spoken words. Young infants appear to have no trouble perceiving speech sounds and their production of sounds peculiar to their particular language environment proceeds relatively smoothly and rapidly compared with adults’ acquisition of foreign languages. One way of looking at how infants come to acquire speech sounds of their first language is by examining the speech input they receive. The term infant-directed speech (IDS) has been coined to describe the special way adults and even older children speak to infants. IDS is different to adult-directed speech in various acoustic/phonetic modifications, such as exaggerated prosody, increased pitch and vowel hyperarticulation (Burnham, Kitamura, and Vollmer-Conna, 2002; Kuhl et al., 1997). The exaggerated prosody and increased pitch appear to be related to the expression of affect and gaining infants’ attention (Burnham, Kitamura, and Vollmer-Conna, 2002), whereas vowel hyperarticulation appears to be related to infants’ speech development for a number of reasons. Firstly, investigating how adults speak to foreigners, Uther, Knoll, and Burnham (2007) found that vowels are also hyperarticulated in foreigner-directed speech as in IDS, while other acoustic modifications such as exaggerated prosody and increased pitch, related to affective and attentional factors, are not present in foreigner directed speech. Secondly, Liu, Kuhl, and Tsao (2003) found a positive correlation between vowel hyperarticulation and infants’ native speech perception; mothers who hyperarticulated their vowels more had infants who were better able to discriminate native consonant contrasts.\ While vowel hyperarticulation in IDS to 6-month-olds has been investigated in both tone languages such as Mandarin (Liu et al., 2003), and non-tone languages such as Russian, Swedish, American English (Kuhl et al., 1997) and Australian English (Burnham et al, 2002), no parallel studies have been conducted on the possibility of tone hyperarticulation in tone language IDS. If vowel hyperarticulation is related to infants’ language development then tones in tone hyperarticulated. The possibility of tone as well as vowel hyperarticulation in IDS of the tone language Cantonese, and the development of hyperarticulation across the first 12 months of infancy were investigated here using a longitudinal sequential cohort design. Two groups of native Cantonese mothers were recorded speaking to their infants, the first group at 3, 6, and 9 months, and the second at 6, 9, and 12 months. The study had four main aims (1) to investigate whether tone hyperarticulation occurs in IDS in a tone language Cantonese (2) to investigate whether vowel hyperarticulation occurs in IDS in Cantonese (IDS in this languages had not yet been investigated) and if 1 and 2 are the cases (3) to compare tone and vowel hyperarticulation, and (4) to chart the development of tone and vowel hyperarticulation across the infant’s first 12 months. Contrary to previous findings of vowel hyperarticulation in English Russian, Swedish, and Mandarin IDS to 6-month-olds (Burnham et al., 2002; Kuhl et al., 1997); vowel hyperarticulation was not found for Cantonese IDS. More detailed acoustic analysis examining different dimensions of the vowel space suggest that after the infant is 3 months old, mothers’ vowels begin to be hypoarticulated in IDS compared to ADS on dimensions of back versus front, and high versus low. This pattern of results is consistent with vowel perception studies which suggest that infants have already tuned into the native vowel categories by 4 to 6 months (Polka and Werker, 1994). Tone hyperarticulation, on the other hand, was indeed present at 3 months and increased to peak at 6 to 9 months before declining at 12 months. This pattern of tone hyperarticulation across the first year of infancy is consistent with infant language development – in which attenuation of perception of non-native tones had been found between 6 to 9 months (Mattock and Burnham, 2006). Moreover, detailed phonetic analysis revealed that while the level tones are more hyperarticulated than the contour tones, tones with similar onsets and offsets (i.e., the two rising tones) are actually hypoarticulated in IDS at 9 and 12 months, a time when infants have already tuned into native tones. Finally, results from a preliminary native speech discrimination study using the same infants provide some initial indication that mothers who hyperarticulate tones more also had infants who are better able to discriminate native Cantonese consonants. Together these results suggest that in Cantonese IDS vowels are underspecified whereas tones are consistently over-specified particularly at 6 months when infants are tuning into native tones. Moreover, during this initial period of tone acquisition, only level tones are over specified while tones with similar onsets and offsets are underspecified. It seems likely that for Cantonese language environment infants, during the early stages of language acquisition, pitch information specified by level tones is sufficient for initial acquisition of information about the Cantonese tone space and that information about vowels is not so essential at this time. These studies show that there is indeed tone hyperarticulation in IDS in tone languages, and that in order to make sense of the vowel hyperarticulation data in tone languages, it is important to investigate both vowels and tones in tone languages with complex tone systems such as Cantonese, instead of simply applying Anglocentric notions of vowel hypoarticulation. / Doctor of Philosophy (PhD)