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A study of the intestinal microbiota in health and disease : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Molecular Microbiology at Massey University, Palmerston North, New ZealandStewart, Jessica Anne January 2005 (has links)
The intestinal microbiota is a massive and complex community, essential to the human host for good health and well-being. However, this population has been associated with gastrointestinal disease, and remains poorly understood. The aim of this study was to develop and validate DNA-based assays for the intestinal microbiota and to apply these methodologies to faecal samples collected from healthy volunteers and patients with gastrointestinal disease. Over 250 faecal samples were analysed using temporal temperature gradient gel electrophoresis (TTGE) and real time PCR. Validated assays had high sensitivity and reproducibility. Healthy individuals displayed a high level of temporal stability during short term studies (≤ 6 weeks) and long term studies (1-4years). Analysis of faecal samples provided by identical and fraternal twins demonstrated an influence of host genetics over the composition of the predominant bacteria in children. Two intervention studies, bowel lavage and the Atkins' diet, were carried out to monitor the impact of environmental change on the population's stability in healthy volunteers. Following bowel lavage, microbial populations rapidly recovered to control densities, however the stability of the population was disturbed. Introduction of the Atkins' diet, led to a significant change in the composition of the microbial population. A preliminary study of the intestinal microbiota in disease groups was undertaken. Significant differences were detected between inflammatory bowel disease groups and controls. Cluster analysis in these patients indicated a potential association between the composition of the predominant bacterial population and disease localisation. The studies reported here demonstrate that the faecal microbiota in healthy individuals is a highly stable population under the influence of both host genetics and environmental variables, however the population present in patients with inflammatory bowel disease exhibits differences compared to healthy controls.
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Probiotics and prebiotics as a therapeutic strategy for inflammatory bowel disease.Geier, Mark Steven January 2007 (has links)
Title page, table of contents and abstract only. The complete thesis in print form is available from the University of Adelaide Library. / The primary aim of this thesis was to identify probiotics and/or prebiotics with the potential to reduce the severity of experimental colitis. The specific aims were to i) screen a range of candidate pro biotic strains for capacity to reduce symptoms of DSS-colitis, ii) characterize the effects of DSS within the small intestine, iii) assess, in vitro, the effect of probiotics on intestinal epithelial cell integrity, iv) assess the potential for the prebiotic, fructooligosaccharide, to reduce the severity of DSS-colitis alone, and in synbiotic combination with a probiotic strain. / http://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1280844 / Thesis (Ph.D.) -- University of Adelaide, School of Molecular and Biomedical Sciences, 2007
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Probiotics and prebiotics as a therapeutic strategy for inflammatory bowel disease.Geier, Mark Steven January 2007 (has links)
Title page, table of contents and abstract only. The complete thesis in print form is available from the University of Adelaide Library. / The primary aim of this thesis was to identify probiotics and/or prebiotics with the potential to reduce the severity of experimental colitis. The specific aims were to i) screen a range of candidate pro biotic strains for capacity to reduce symptoms of DSS-colitis, ii) characterize the effects of DSS within the small intestine, iii) assess, in vitro, the effect of probiotics on intestinal epithelial cell integrity, iv) assess the potential for the prebiotic, fructooligosaccharide, to reduce the severity of DSS-colitis alone, and in synbiotic combination with a probiotic strain. / http://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1280844 / Thesis (Ph.D.) -- University of Adelaide, School of Molecular and Biomedical Sciences, 2007
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Burdur il merkezi ilköğretim okullarındaki çocuklarda bağırsak parazitlerinin görülme sıklığı/Kılınç, Ahmet Selçuk. Kişioğlu, Ahmet Nesimi. January 2006 (has links) (PDF)
Tez (Yüksek Lisans) - Süleyman Demirel Üniversitesi, Sağlık Bilimleri Enstitüsü, Halk Sağlığı Anabilim Dalı, 2006. / Bibliyografya var.
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Use of microbiomics to study human impacts on complex microbial communities /Jernberg, Cecilia, January 2006 (has links)
Diss. (sammanfattning) Stockholm : Karolinska institutet, 2006. / Härtill 6 uppsatser.
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Isolation and characterization of regulatory peptides and bioactive compounds /Norberg, Åke, January 2004 (has links)
Diss. (sammanfattning) Stockholm : Karol inst., 2004. / Härtill 6 uppsatser.
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Adaptive responses during Giardia-host interactions /Palm, Daniel, January 2005 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2005. / Härtill 5 uppsatser.
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Isolation and characterization of novel intestinal polypeptides of the enteroinsular and brain-gut axes and of macrophages /Chen, Zheng-wang. January 1900 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst. / Härtill 5 uppsatser.
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Drugs in horses : pharmacokinetics and pharmacodynamics /Olsén, Lena. January 2007 (has links) (PDF)
Diss. (sammanfattning) Uppsala : Sveriges lantbruksuniv., 2007. / Härtill 5 uppsatser.
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Cytochrome P450 3A and ABC-transport proteins in horse /Tydén, Eva, January 2008 (has links) (PDF)
Diss. (sammanfattning) Uppsala : Sveriges lantbruksuniversitet, 2008. / Härtill 5 uppsatser.
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