Diabetes is a group of metabolic diseases characterized by hyperglycaemia resulting from defects in insulin secretion, insulin action, or both. Several models have been developed for describing the glucose-insulin system. Silber and Jauslin developed a semi-mechanistic integrated glucose insulin (IGI) model which simultaneously describe glucose and insulin profiles in either healthy subjects or type 2 diabetis mellitus (T2DM) patients. The model was developed for describing the basal system, i.e. when no drugs are present in the body. In this thesis the IGI model was extended to also include the effects of anti-diabetic drugs on glucose homeostasis. The model was extended to describe postprandial glucose and insulin excursions in T2DM patients treated with either biphasic insulin aspart or the GLP-1 receptor agonist liraglutide. These extensions make the model a useful tool in drug development as it can be used for elucidating the effects of new products as well as for clinical trial simulation. In this thesis several modelling tasks were also performed to get a more mechanistic description of the glucose-insulin system. A model was developed which describes the release of the incretin hormones glucosedependent insulinotropic polypeptide and glucagon-like peptide-1 following the ingestion of various glucose doses. The effects of these hormones on the beta cell function were incorporated in a model describing both the C-peptide and insulin concentrations in healthy subjects and T2DM patients during either an oral glucose tolerance test or an isoglycaemic intravenous glucose infusion. By including measurements of both C-peptide and insulin concentrations in the model it could also be used to characterize the hepatic extraction of insulin.

Available bandwidth is a time-dependant variable that defines the spare bandwidth in an end-to-end network path. Currently, there is significant focus in the research community on the design and development of Available Bandwidth Estimation Tools (ABETs), and a few tools have resulted from this research. However, there is no comprehensive evaluation of these tools and the research work in this thesis attempts to fill that gap. A performance evaluation of important ABETs like Pathload, IGI and pathChirp in terms of their accuracy, convergence time and intrusiveness is conducted in several scenarios. A 2k factorial design is carried out to analyze the importance of the size of probe packets, number of probe packets per train, number of trains, and frequency of runs in these performance metrics. ABETs are very important because of their potential in solving many network research problems. For example, ABETs can be used in congestion control in transport layer protocols, network management tools, route selection and configuration in overlay networks, SLA verification, topology building in peer to peer networks, call admission control, dynamic encoding rate modification in streaming applications, traffic engineering, capacity planning, intelligent routing systems, etc. This thesis looks at applying ABETs in the congestion control of transmission control protocol (TCP).Current implementations of TCP in the Internet perform reasonably well in terms of containing congestion, but their sending rate adjustment algorithm is unaware of the accurate network conditions and available resources. TCP's Additive Increase Multiplicative Decrease (AIMD) congestion control algorithm cannot efficiently utilize the available bandwidth to the full potential and this is especially true in high bandwidth networks.

Advances of magnetic resonance imaging (MRI) techniques enable visualguidance to identify the anatomical target of interest during the image guidedintervention(IGI). Non-rigid image registration is one of the crucial techniques,aligning the target tissue with the MRI preoperative image volumes. As thegrowing demand for the real-time interaction in IGI, time used for intraoperativeregistration is increasingly important. This work implements 3D diffeomorphicdemons algorithm on Nvidia GeForce GTX 1070 GPU in C++ based on CUDA8.0.61 programming environment, using which the average registration time hasaccelerated to 5s. We have also extensively evaluated GPU accelerated 3D diffeomorphicregistration against both CPU implementation and Matlab codes, and theresults show that GPU implementation performs a much better algorithm efficiency.

Submitted by Irene Nascimento (irene.kessia@ufpe.br) on 2016-10-17T17:39:21Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Dissertação SANTOS, Fernando Batista dos. PPGA-UFPE.2016..pdf: 13103348 bytes, checksum: 6979439dc4122edf4be162f1c93a976b (MD5) / Made available in DSpace on 2016-10-17T17:39:21Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Dissertação SANTOS, Fernando Batista dos. PPGA-UFPE.2016..pdf: 13103348 bytes, checksum: 6979439dc4122edf4be162f1c93a976b (MD5) Previous issue date: 2016-08-24 / Esta dissertação tem por objetivo etnografar a presença de Igi Oṣè, conhecida entre nós como baobá (Adansonia digitata), no Ilê Axé Opô Aganju, Lauro de Freitas, BA. Liderado por Balbino Daniel de Paula, Obaràyí, o Aganju foi um dos contemplados pelo Projeto (Im)Plantando Morada dos Ancestrais em Salvador, CEAO-UFBA/SEMUR (2006), que objetivou a disseminação dessa árvore prioritariamente nos jardins sagrados baianos, a partir de mudas transportadas do Recife, desde 2005, para a capital baiana. Até então, os únicos registros dessa espécie da flora africana no arboreto urbano de Salvador se encontravam restritos ao Largo 2 de julho (Praça do Campo Grande) e ao Largo de Nazaré (Praça Almeida Couto) e, no Candomblé, apenas ao Ilê Axé Alabaxé, em Maragogipe, onde a árvore foi plantada em 24 de junho de 1993. O trabalho de campo foi realizado de setembro de 2015 a fevereiro de 2016. No Aganju, Igi Oṣè passa a ser associado ao vodun ao qual se atribui a primazia do culto às árvores na nação Jeje (PARÉS, 2006), a evidenciar absorções que ocorrem entre as diversas nações do Candomblé na Bahia. Ainda desconhecido pela maioria da comunidade religiosa, o acesso aos loci botânico e – mesmo que incipiente - litúrgico do Candomblé propiciado por esses sujeitos ao baobá ratifica a criativa tradição de (re)invenção religiosa visando à manutenção da África soteropolitana por essas comunidades que demonstram prestígio político ao atuarem de modo a serem contempladas por ações acadêmicas e políticas. / Èròngbà àpilèko yìí ni láti se ìwádìí ní òrínkínniwín lórí Igi Osè ti ó gbajúgbajàs láàrín wa tí òpòlopò si mo orúkò rè gégé bíi baobá (Adansonia digitata) èyi tí ó wà ní gbàgede Ilé Àse Òpó Aganjú ni Lauro de Freitas, Bahia lábé àkóso alàgbà Balbino Daniel de Paula, Obaràyí, fún àkànse isé ìwádìi lábé ètò tí a pe àkolé rè ni Gbígbín Ibùgbé fún awon Òrìsà ni ilú Salvador labe àkóso ètò àjosepò laarin CEAO-UFBA ati SEMUR (2006). Kókó èròngba ètò náà ni lati se ìfilólè igi-osè yí nipa gbigbin awon pòpórò igi-osè náa ti a mú lati ilú Recife wa si ilè Bahia ni odun 2005. Saájú àkókò yìí, àkosílè tí a ríkà ni wípé eyo méjì péré ni irúfé èyà igi-osè àbáláyé ti ilè Áfíríkà tí a lè ri ní agbègbé ìlú Salvador: òkan ni gbágede ogbà ti a mò sí dois de Julho (Largo Campo Grande) nígbàtí èkejì si wà ni gbàgede ojúde tí a mò sí Praça Almeida Couto ni adúgbò Nazaré. Bákannáà, ákosílè fi yéwa pé ni àwùjo awon olírìsà (Candomblé), awon olùsìn vodum ní ìfokànsìn púpò si igi-osè nítorípé láarin awon olóòsà vodúm, igiosè jé igi pàtàkì fun awon ìran aláwòdúdú ti a mò si jeje ni ilè Basíì (PARÉS, 2006). Lilo tí awon olórísà candomblé yókù náà nlo igi-osè yìí bayìí fihan wipe àjosepò tó gúnmó ni o wà láàrín gbogbo awon elésìn àbálayé orìsà, vodum ati nkisi ti o parapò di Candomblé ni ilè Bahia ti o si tan kálè de gbogbo ilè Bàsíì. Biótilèjépé òpolópò awon olórìsà elésìn àbáláyé ìran ènìyàn dúdú ni Ilè Bàsíì ni kò dá ojúlówó igi-osè mò dúnjú, wíwà tí irúfé igi ti won npe ni baobâ wà ni àwùjo Bahia báyìí gegebi igi ìsòyè ni awon ibi tuntun ti a sèsè fi wón lólè si yìí gégébíi loci botanico fihan ipa tí ifokànsìn tí o múnámúnà tí o sí so ilè Bahia di gbajúgbajà láàrín awujo awon oloosa lágbàáyé se jé elérìí sí ifé tí awon babanla awon ènìyàn dúdú tí won ko jékì èsìn ati ìse ìsèmbáyé ilè Áfíríkà parun ní ilè Améríkà èyí tí o sì fá gbígbajúmò tí èsìn Candomblè ti ilè Bahia se gbajúmo tobéègéé ti ó fi di ohun tí òpòlopò onímò ìjìnlè ati ìjoba yàn án láàyò fún isé akadá ati ètò ìfowósowópò pelú ètò ìsèlú.