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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
61

A study on the biological activities of glycodelins on lymphocytes and natural killer cells /

Lee, Cheuk-lun. January 2009 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2009. / Includes bibliographical references (leaves 232-263). Also available online.
62

Real-time RT-PCR analysis of two epitope regions encoded by the VP2 gene of infectious bursal disease viruses

Mickael, Claudia Silva, January 2005 (has links)
Thesis (Ph. D.)--Ohio State University, 2005. / Title from first page of PDF file. Document formatted into pages; contains xiii, 136 p.; also includes graphics (some col.) Includes bibliographical references (p. 120-136). Available online via OhioLINK's ETD Center
63

Expression of C/EBPβ in Myeloid Progenitors During Sepsis Promotes Immunosuppression

Dai, Jun, Kumbhare, Ajinkya, Youssef, Dima, Yao, Zhi Q., McCall, Charles E., El Gazzar, Mohamed 01 November 2017 (has links)
Sepsis-induced myeloid-derived suppressor cells (MDSCs) contribute to immunosuppression associated with sepsis. We reported that the CCAAT enhancer-binding protein C/EBPβ activates microRNA (miR)-21 and miR-181b expressions, which induce transcription factor NFI-A to support the generation and expansion of MDSCs in the bone marrow and spleens of septic mice. Here, using a conditional knockout mouse model lacking C/EBPβ in the myeloid lineage, we find that without C/EBPβ, myeloid progenitor cells could not express miR-21 or miR-181b, and ectopic expression of C/EBPβ in the C/EBPβ-deficient myeloid progenitors activated the expression of the two miRNAs. Moreover, C/EBPβ-reconstituted myeloid cells expressed IL-10 and reduced T cell proliferation and function, similar to control MDSCs that express C/EBPβ. Exogenous expression of miR-21 and miR-181b in the C/EBPβ-deficient myeloid progenitors from septic mice produced similar results. Notably, NFI-A-dependent transactivation of NF-kB MDSC generating pathway was reversed in the C/EBPβ-deficient myeloid progenitors from septic mice. Together, these results support that decreasing C/EBPβ expression prevents MDSC generation and decreases immunosuppression in septic mice, providing a target for sepsis treatment.
64

Identifying Molecular Mechanisms of Immunomodulation by Staphylococcal Superantigens in Humans

Lee, Juyeun 04 May 2018 (has links)
Superantigens are exotoxins produced by Staphylococcus aureus and induce extensive T cell proliferation and proinflammatory cytokines, leading to toxic shock syndrome at high concentrations. However, the role of superantigens produced at relatively low concentrations during asymptomatic colonization or chronic infection has not been well established. In this dissertation, we demonstrated that stimulation of human PBMCs with staphylococcal enterotoxin C1 (SEC1) at the dose inducing a half maximal T cell proliferation (suboptimal stimulation) induced immunosuppressive CD4+CD25+FOXP3+ and CD8+CD25+FOXP3+ T cells. The suppression of these cells was mainly mediated by the galectin-1. We found that suboptimal stimulation with SEC1 induced differential activation of PI3K-mTOR-Akt pathway, leading to expression of FOXP3 isoforms preferably localized to the nucleus and induction of PTEN that contributes to maintain stability and suppressive activity of regulatory T cells. Taken together, these results demonstrate the important role of superantigen produced at low concentration during asymptomatic colonization that induce immunosuppressive CD4+ and CD8+ regulatory T cells to promote survival, propagation, and colonization for S. aureus in the host.
65

Studies on a soluble immunosuppressive factor produced by Leishmania donovani infected macrophages

Fielding, Mark January 1994 (has links)
No description available.
66

The mechanisms of immunosuppression in rats infected by Trypanosoma lewisi /

Proulx, Chantal January 1988 (has links)
No description available.
67

Effet des agents immunosuppresseurs et du rejet aigu sur la fonction endothéliale des artères coronaires

Jeanmart, Hugues January 2001 (has links)
Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.
68

Proteasome Inhibitor Treatment of Antibody Mediated Rejection and Mixed Acute Rejection: Defining Factors that Predict Long-Term Outcomes

Lichvar, Alicia B. 29 September 2017 (has links)
No description available.
69

Identification of nonspecific immunosuppressive factor associated with cancer patients /

Svedersky, Lloyd Paul January 1980 (has links)
No description available.
70

PGE?-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment / PGE?-EP2 / EP4 シグナルは炎症性の腫瘍微小環境下で mregDC-Treg 軸経路を亢進させることにより免疫応答を抑制する

Punyawatthananukool, Siwakorn 25 March 2024 (has links)
京都大学 / 新制・課程博士 / 博士(医学) / 甲第25167号 / 医博第5053号 / 京都大学大学院医学研究科医学専攻 / (主査)教授 生田 宏一, 教授 椛島 健治, 教授 濵﨑 洋子 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

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