The main aim of this thesis was to study the role of the indirect actions of γ-rays and α-particles on the complexity of primary DNA damages and the repair fidelity of major DNA repair pathways: non-homologous end joining (NHEJ), homologous recombination repair (HRR) and base excision repair (BER). The complexity of radiation-induced damages increases and the proximity between damages decreases with increasing LET due to formation of ionization clusters along the particle track. The complexity of damages formed can be modified by the free radical scavenger dimethyl sulfoxide (DMSO). In addition, the effects of low doses of low dose rate γ-radiation on cellular response in terms of differentiation were investigated. Paper I investigates the role of the indirect effect of radiation on repair fidelity of HRR, NHEJ and BER when damages of different complexity were induced by radiation or by potassium bromate. We found that potassium bromate induces complex DNA damages through processing of base modifications and that the indirect effect of radiation has a high impact on the NHEJ pathway. Results in paper II confirmed our conclusions in paper I that the indirect effect from both γ-rays and α-particles has an impact on all three repair pathways studied and NHEJ benefits the most when the indirect effect of radiation is removed. In paper III we investigated the effects of low dose/dose rate γ-radiation on the developmental process of neural cells by using cell models for neurons and astrocytes. Our results suggest that low dose/dose rate γ-radiation attenuates differentiation and down-regulates proteins involved in the differentiation process of neural cells by an epigenetic rather than cytotoxic mechanism. / <p>At the time of doctoral defense, the following paper was unpublished and had a status as follows: Paper 2: Manuscript.</p>

The world-wide globalisation that has taken place during the past decades has led to more Multinational Enterprises (MNEs) choosing to relocate some parts of their organisation to other countries. China, which is in command of the world’s lowest-cost manufacturing plants, is the first destination for MNEs. Although China presents a great opportunity for MNEs, this investment does not come without its difficulties, MNEs wishing to invest in China are confronted with certain challenges. MNEs are faced with dealing with the notable differences in Western and Chinese business culture. One particular difference is related to intercultural communication between western managers and Chinese managers. The theory of low context and high context cultures states that the Chinese communicate indirectly and Western countries directly. The main purpose of this research is to find out if the Chinese manager, after obtaining experience negotiating with foreign managers from low context cultures, adopts a more direct communication style. The purpose of this research is to answer the following question: Does the Chinese manager have a preference for direct or indirect communication when negotiating with foreign managers? The following hypotheses were stated: Ho: Chinese managers prefer direct communication during business negotiations with foreign managers. Ha: Chinese managers prefer indirect communication during business negotiations with foreign managers A quantitative method with a positivistic epistemology was used for the research. Quantitative research is an exploratory study with a deductive approach and therefore the most appropriate method for this research was a survey. A survey was chosen for data collection and a questionnaire based on the research model was developed and used as the survey instrument to collect data from the target group. The target group was stated as Chinese managers with at least three years work experience, fluent in English and with experience in negotiations with managers from cultures considered as low-context cultures such as Germany, Sweden and the United States of America. The target group was selected from the MBA programs at Fudan University. The SPSS program was utilised to analyse the responses and to test the hypothesis. Numeric values were assigned to each of the responses, with 5 being the most direct and 1 being the most indirect. The scale was appropriately reversed for negative questions. Descriptive statistics were obtained about distribution, variability and central tendency of the variables. t tests were applied to compare group means. Furthermore, a regression analysis was conducted to estimate a linear relationship between direct communication and the lack of miscommunication showed by the descriptive test. All tests were conducted at a 95% confidence level. The result of the hypothesis test indicated that Chinese managers have preference towards direct communication when conducting business negotiations with foreign managers.

This study concentrates on two questions – “Should banks take environmental concerns?”and “What is the attitude of Swedish banks towards sustainability?” The theory related to environmental concerns in the financial sector is presented and further on the empirical data describing the situation within the Swedish banking sector is discussed. The empirical data was collected with the aid of a semi-structured interview and offers a real-life example of actions and attitudes of two case banks in Sweden – SEB and Handelsbanken. The aim of this paper is not restricted to presenting and discussing the collected theoretical and empirical data but also to involve the reader in the environmental way of thinking. This text is based on the idea that banks are liable for the indirect impact on the environment and need to acknowledge that some borrowers involve in environmentally harmful businesses. The research method used for this study is of a qualitative nature, more precisely it is an exploratory research which aims to explain. The semi-structured interview used to study the attitudes of the chosen Swedish case banks, was composed of two types of questions – closed- and open-ended. Special characteristics of a semi-structured interview are the prompts and probes in its structure. These are the approaches to guide the respondent to reach broader coverage and greater depth in his/her answers. Through the interview results, it became evident that the environmental issues have gained certain visibility within the Swedish banking sector. The given answers pointed towards the impression that maintaining a sound corporate image is the prior concern of a bank and indicated that banking sector in Sweden undergoes external pressure to pursue environmentally friendly activities. It is clear that banks play a major role by financing the continuous damage to our planet, and it is comforting to know the banking sector is undergoing the pressure of becoming more involved in sustainable development. The conclusions and the empirical evidence presented in this study are hoped to give a simplified view on environmental concerns within banking sector.

Companies need different information about their operations, so that they can make better decisions and be more effective in the business world. One way to obtain that information is through looking at how costs are assigned to different cost objects, such as products or services. Of special interest is the allocation of indirect costs, because if these costs make up an important part of an organisation, then grasping them will help the firm be more competitive and respond better to customers and their needs. One method of allocating indirect costs is called activity based costing, or ABC, and it looks upon what activities that are being performed by a company, how much they cost based on resource usage, what drives the costs, and most importantly, it assigns these ex-penses to products/services. The aim of this thesis has been to investigate whether the ABC method can be applied in an event organising company. In order to reach the purpose we have used the example of Elmia AB, an event and trade show organiser situated in Jönköping, Sweden. The focus of our investigation was exhibition stands used in trade shows. We have come to the conclusion that activity based costing is applicable when it comes to event organisers in the sense that it is possible to identify major activities and depict re-sources. However, problems emerge when trying to estimate costs of resources because it is hard to know in advance what customers want, and therefore one cannot clearly distin-guish or set fixed and variable costs, nor can one easily cope with problems of unused ca-pacity, that is resources that are supplied but not used. This is especially the case with cus-tomised exhibition stands. The process is somewhat easier when it comes to standardised offerings, because they are less complicated since they are already set and cannot be much altered by the customers. Furthermore, cost drivers can be applied in this setting, at least theoretically because they provide help in determining what processes the customers might find important. On the other hand, they might be rather difficult to measure. Finally, the actual assigning of costs to cost objects is hard, because for the complex solutions, one cannot easily find common activities across different stands, but this can be easier to do when exhibition stand pack-ages are standardised and demand is better traceable. We have based our results on one company as a generalisation of event organisers as a whole, and we can argue that the example that we have chosen can be a good representa-tive of this particular branch of the service industry, because it shows how important indi-rect costs are to this dynamic business and also it reveals the importance of customers and their role when applying activity based costing to the environment. However, in order to have a complete conclusion with respect to our aim, more research is needed in other event and trade show organising firms because there are company specific situations in terms of size, structure, culture, etc, of a company that makes ABC a special case that changes ac-cording to different objectives of different users.

Antiplatelet therapy with clopidogrel is widely used in patients with coronary artery disease, but the recent development of the new P2Y12 receptor antagonists prasugrel and ticagrelor will increase treatment options. An overview of systematic reviews was performed to summarize available evidence on clopidogrel. Current data on prasugrel and ticagrelor were identified by a systematic review and used for an indirect treatment comparison (ITC) of the drugs against each other and versus placebo in the absence of head-to-head clinical trials. Adjusted indirect comparison according to Bucher, Bayesian methods for mixed treatment comparisons using Winbugs, and generalized linear mixed models using SAS were employed for ITC, yielding almost identical results: prasugrel was favored regarding stent thrombosis and ticagrelor regarding major bleeding. However, substantial differences in trial design were identified, demanding caution when interpreting these results. On the basis of the obtained results, a randomized controlled trial was designed within the gap of current evidence.

Plant growth-promoting rhizobacteria (PGPR) are free-living, soil-borne bacteria that colonize the rhizosphere and, when applied to crops, enhance the growth of plants. Plant growth-promoting rhizobacteria may enhance plant growth either by direct or indirect mechanisms. The direct mechanisms of action include nitrogen fixation,production of phytohormones and lowering of ethylene concentrations. The objective of this study was to determine whether Pseudomonas putida strain 6-8 isolated from the rhizosphere of legume crops grown in Saskatchewan fields was able to promote the growth of canola cv. Smart and lentil cv. Milestone plants by direct mechanisms. Initial studies determined the effect of strain 6-8 and other known phytohormoneproducing PGPR strains on the growth of canola and lentil plants both in gnotobiotic and growth chamber conditions. Variations in the results were observed, as there were significant differences among trials. Strain 6-8 enhanced the growth of canola cv. Smart in growth pouches but not in pots in growth chamber studies. In the case of lentil cv.Milestone, strain 6-8 had no significant effect in growth pouches, but it significantly increased root dry weight, shoot dry weight and root surface area in pots in growth chamber studies. A similar effect was observed with wild-type strains GR12-2 and G20- 18. Strain GR12-2 was consistent in promoting the growth of lentil cv. Milestone both in growth pouches and in pots in growth chambers when compared to other strains and the control. The ability of the PGPR strains to produce auxin and cytokinin phytohomones in pure culture and in the canola rhizosphere was tested using the enzyme linked immunosorbent assay (ELISA). All the PGPR strains produced indole compounds and the concentration of the indoles produced increased with increasing concentrations of the precursor tryptophan. There were no significant differences among PGPR strains in production of indole-3-acetic acid (IAA) when assayed using ELISA. The concentrations of IAA secreted by PGPR strains were extremely low (0.19 µg/ml 9.80 µg/ml). Strain 6-8 produced the cytokinins, isopentenyl adenosine (IPA), zeatin riboside (ZR) and dihydroxyzeatin riboside (DHZR) in pure culture. Indole-3-acetic acid was detected in supernatants obtained from canola growth pouches inoculated with PGPR strains, but there were no significant differences in the concentrations of IAA secreted among PGPR strains. Significantly higher concentrations of IPA and ZR were observed in the rhizosphere of canola inoculated with strain 6-8 than in the non-inoculated control. Strain 6-8 produced siderophores, solubilized inorganic phosphate and used 1-aminocyclopropane-1-carboxylic acid (ACC), the precursor of ethylene, as sole nitrogen source. These traits are considered to be alternative mechanisms for direct plant growth promotion. A qualitative and quantitative study of root colonization by strain 6-8 was conducted by tagging the strain with green fluorescent protein in conjunction with confocal laser scanning microscopy and by conventional plating. The populations of strain 6-8 were higher on canola roots than on lentil roots by conventional plating. Similar results were also observed in confocal laser scanning microscopy (CLSM) studies after 5, 7 and 9 days for canola and 3, 6 and 9 days for lentil. Pseudomonas putida strain 6-8 produced cytokinins and also possessed other direct growth promoting characteristics. The ability of strain 6-8 to promote the growth of canola cv. Smart in growth pouches and lentil cv. Milestone in growth chamber studies may be related to these direct growth promoting characteristics. Strain 6-8 may have potential for development as a plant growth-promoting rhizobacterial inoculant.

Antiplatelet therapy with clopidogrel is widely used in patients with coronary artery disease, but the recent development of the new P2Y12 receptor antagonists prasugrel and ticagrelor will increase treatment options. An overview of systematic reviews was performed to summarize available evidence on clopidogrel. Current data on prasugrel and ticagrelor were identified by a systematic review and used for an indirect treatment comparison (ITC) of the drugs against each other and versus placebo in the absence of head-to-head clinical trials. Adjusted indirect comparison according to Bucher, Bayesian methods for mixed treatment comparisons using Winbugs, and generalized linear mixed models using SAS were employed for ITC, yielding almost identical results: prasugrel was favored regarding stent thrombosis and ticagrelor regarding major bleeding. However, substantial differences in trial design were identified, demanding caution when interpreting these results. On the basis of the obtained results, a randomized controlled trial was designed within the gap of current evidence.

Plant growth-promoting rhizobacteria (PGPR) are free-living, soil-borne bacteria that colonize the rhizosphere and, when applied to crops, enhance the growth of plants. Plant growth-promoting rhizobacteria may enhance plant growth either by direct or indirect mechanisms. The direct mechanisms of action include nitrogen fixation,production of phytohormones and lowering of ethylene concentrations. The objective of this study was to determine whether Pseudomonas putida strain 6-8 isolated from the rhizosphere of legume crops grown in Saskatchewan fields was able to promote the growth of canola cv. Smart and lentil cv. Milestone plants by direct mechanisms. Initial studies determined the effect of strain 6-8 and other known phytohormoneproducing PGPR strains on the growth of canola and lentil plants both in gnotobiotic and growth chamber conditions. Variations in the results were observed, as there were significant differences among trials. Strain 6-8 enhanced the growth of canola cv. Smart in growth pouches but not in pots in growth chamber studies. In the case of lentil cv.Milestone, strain 6-8 had no significant effect in growth pouches, but it significantly increased root dry weight, shoot dry weight and root surface area in pots in growth chamber studies. A similar effect was observed with wild-type strains GR12-2 and G20- 18. Strain GR12-2 was consistent in promoting the growth of lentil cv. Milestone both in growth pouches and in pots in growth chambers when compared to other strains and the control. The ability of the PGPR strains to produce auxin and cytokinin phytohomones in pure culture and in the canola rhizosphere was tested using the enzyme linked immunosorbent assay (ELISA). All the PGPR strains produced indole compounds and the concentration of the indoles produced increased with increasing concentrations of the precursor tryptophan. There were no significant differences among PGPR strains in production of indole-3-acetic acid (IAA) when assayed using ELISA. The concentrations of IAA secreted by PGPR strains were extremely low (0.19 µg/ml 9.80 µg/ml). Strain 6-8 produced the cytokinins, isopentenyl adenosine (IPA), zeatin riboside (ZR) and dihydroxyzeatin riboside (DHZR) in pure culture. Indole-3-acetic acid was detected in supernatants obtained from canola growth pouches inoculated with PGPR strains, but there were no significant differences in the concentrations of IAA secreted among PGPR strains. Significantly higher concentrations of IPA and ZR were observed in the rhizosphere of canola inoculated with strain 6-8 than in the non-inoculated control. Strain 6-8 produced siderophores, solubilized inorganic phosphate and used 1-aminocyclopropane-1-carboxylic acid (ACC), the precursor of ethylene, as sole nitrogen source. These traits are considered to be alternative mechanisms for direct plant growth promotion. A qualitative and quantitative study of root colonization by strain 6-8 was conducted by tagging the strain with green fluorescent protein in conjunction with confocal laser scanning microscopy and by conventional plating. The populations of strain 6-8 were higher on canola roots than on lentil roots by conventional plating. Similar results were also observed in confocal laser scanning microscopy (CLSM) studies after 5, 7 and 9 days for canola and 3, 6 and 9 days for lentil. Pseudomonas putida strain 6-8 produced cytokinins and also possessed other direct growth promoting characteristics. The ability of strain 6-8 to promote the growth of canola cv. Smart in growth pouches and lentil cv. Milestone in growth chamber studies may be related to these direct growth promoting characteristics. Strain 6-8 may have potential for development as a plant growth-promoting rhizobacterial inoculant.

In this dissertation I investigate whether or not a series of social, demographic, and cultural factors affect fertility differently, in either direction or magnitude, for men and women. This work situates the study of male fertility within the existing demographic literature, models and compares male and female fertility through the use of a variety of dependent and independent variables, discovers which of those variables reveal a difference between the determinants of male and female fertility, and extends understanding of how male fertility should be studied in addition to and alongside female fertility. Although there is a significant literature on the biological and anatomic components of male fertility, there is little work published on the social and cultural factors that affect male fertility. Comparisons of male and female fertility are also lacking within the discipline of demography. The National Survey of Family Growth (Cycle 7) provides survey data on both men and women on a number of social, cultural, and demographic variables used either on their own, or as components in the construction of indicator variables. I present the results of models utilizing both direct and indirect measures of fertility. Three models are direct measures of fertility, and three other indirect models examine behaviors as a measure of exposure to the risk of fertility. Only four of these models were significant under the initial analysis. Within each of the models, the respondent’s age, poverty level, age at first intercourse, and whether the respondent ever married or cohabited presented the most frequent differences, in either direction, magnitude, or both, between males and females. I discuss the implications of the findings presented in the dissertation, as well as the potential for future research using other data or methods.

Abstract Due to the dramatically sociotechnical change plus the Asia finance crisis influence, the non-employment rate and the number of jobless labor are getting higher in Taiwan currently. This case study is an employment research of the semiconductor company M after one year of factory closing to realize the re-employment status of employees who left company M one year ago. It investigated the job finding problems of employees who left company M after factory closing. While the average age of company M's employees are 43 years old, the re-employment problems of workers would be very much similar to the placement problems of middle senior workers (defined by government as those workers with age between 45 and 65). By using questionnaire collection, this study checked the re-employment status of those who left company M one year ago. And tested the job satisfaction to those who are having jobs as well as investigated the job finding problems to those who are jobless. Also tested the awareness of public resources of job placement assistance provided by government on questionnaires. This study also discussed about the employee competence training for job change need. And examined the effectiveness of the outplacement assistance done by Human Resources department of company M one year ago in order to make a better outplacement assistance program example for any company who needs. This research also interviewed the Human Resources department heads to exchange the empirical practice viewpoint of captured subject from the industrial companies. This case study found that the non-employment rate of a senior company (employees with average age over 40) might be high above 40% after one year of factory closing. The age discrimination of recruitment is the key factor for senior worker to find a new job after factory closing. Current Labor Law and Labor Insurance regulations may have some unfavorable items, which are out of dates, to impact the job finding of senior workers. People didn't fully utilize the public resources which government put on for senior workers' job placement assistance. This study also found that the individual competence training for job change of indirect labor workers is different from direct labor workers. Indirect labor workers prefer the Business Management application training while the direct labor workers prefer the soft service business items such as Cooking or Salon Beauty skill. The tested population expect to receive the individual competence training (for job change) sponsored by both firms and government while the Human Resources department heads of firms recognize it as government's responsibility. In order to make a better mass labor transfer practice for the need of factory closing, this study made suggestions to firms, workers and government respectively: ¡E How to proceed a better outplacement assistance program for a factory which is going to discharge mass employees due to business close. ¡E How to deal with the job termination for those who work for a company going to close the business. ¡E How to support the job placement assistance for senior workers,