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Background: Individuals with binge eating disorder (BED) experience a loss of control (i.e., poor inhibitory control) during binge eating, where stress is a common antecedent for binge episodes. However, few studies examine acute stress in BED and, to date, psychosocial stress relationships with inhibitory control are unexamined. Purpose: The current study investigated acute psychosocial stress effects on inhibitory control in BED. Additionally, inhibitory control relationships with BED treatment outcome were explored. Methods: Thirty-three individuals with BED were randomized to a stress (n = 17) or no stress condition (n = 16). All completed self-report measures including the Profile of Mood States and the Binge Urge Scale. Following the stressor, individuals completed the Stop-Signal Task (SST), a well-validated measure of inhibitory control. Relationships between post-stress anxiety with inhibitory control and eating pathology were explored. Furthermore, treatment outcome relationships with levels of inhibitory control, and negative urgency (an impulsive personality trait) were explored. Results: In the stress condition, individuals reported increased state anxiety immediately following stress, but experienced a decrease back to baseline levels of anxiety by the end of the SST. Stress resulted in impaired inhibitory control performance on the SST. Binge urges increased across both conditions over time. Measures of inhibitory control and negative urgency did not relate to treatment outcome. Conclusion: This study is novel in directly examining psychosocial stress effects on inhibitory control, which has not been studied in BED. These results show subjective stress effects in BED are short-lived; however, behaviourally, stress has a lingering effect on inhibitory control. Increasing binge urges across the experimental session in the no stress condition suggests a role for generalized anxiety on this impulse. These findings have clinical implications for binge urges as a therapeutic target, and for informing individuals with BED about the implications of stress on their binge eating. / Thesis / Master of Science (MSc)

Background: Lower inhibitory control has been shown to associate with greater risk for obesity in adolescence. On average, females have moderately higher rates of behavioral inhibitory control than males. These difference in inhibitory control across sex may influence overeating and development of obesity. This study examined whether sleep duration and sleep quality are associated with food-related inhibitory control and whether this association is moderated by biological sex. Methods: A total of 59 emerging adults ages 18 to 25 (37 males, 22 females) who had a BMI within the overweight or obese categories (BMI ≥25) completed self-report measures of eating and sleep behavior. Participants completed a Go/NoGo behavioral task to evaluate their inhibitory control when presented with images of high- and low-calorie foods. Results: In general, our hypotheses regarding sex differences were not supported by this study. We did not find a significant association between sleep duration and food-related inhibitory control, nor did we find a significant association between sleep quality and inhibitory control. We did find that poorer sleep quality was associated with greater loss of control eating (p = 0.001). Conclusion: Our findings suggest that sleep quality has notable impacts on food-related inhibitory control. The findings from our study could be utilized in future research towards understanding the complex relationship between sleep duration and quality, inhibitory control, and eating behaviors.

Fearful temperament represents one of the robust predictors of the development of child and adolescent anxiety. Not all children with fearful temperament unvaryingly develop anxiety, however. Diverse processes resulting from the interplay among attention, cognitive control, and motivational system drive the trajectories toward more adaptive or maladaptive directions. In this study, I examined various factors that underlie the association between fearful temperament at age 9 and adolescent anxiety symptoms including attention biases, different components of effortful control, and frontal EEG asymmetry. 78 children participated in this study. Results indicate that fearful temperament at age 9 significantly predicted adolescent anxiety symptoms. This association, however, was moderated by children's effortful control and frontal EEG asymmetry at age 9. Specifically, fear at 9 years predicted adolescent anxiety only when children had low attentional control, low inhibitory control, low activation control, and exhibited greater right activation from baseline to task. The associations between AB and fearful temperament as well as anxiety were not significant. The association between fear at 9 years and sustained AB during adolescence, however, was moderated by children's attentional control, inhibitory control, and frontal EEG asymmetry at age 9. Specifically, fear predicted attention biases away from threat when children had high attentional control, high inhibitory control, and showed greater left activation. The findings will be discussed in terms of the roles of attention biases in the development of anxiety and how different components of effortful control and frontal EEG asymmetry contribute to the resilience process. / Doctor of Philosophy / Anxiety disorders represent one of the most commonly occurring mental health problems in childhood and adolescence. Children who tend to show wariness and distress to negative stimuli are more likely to have anxiety. Not all children with fearful temperament develop anxiety, however. Certain individual characteristics can protect fearful children from having anxiety symptoms. In this study, I examined the roles of attentional biases toward threat (AB), different components of self-regulation (EC), and the asymmetrical frontal brain activation (FA) in changing the relation between fearful temperament and anxiety. 78 children participated in this study. Results indicated that adolescents were at higher risk for anxiety if they showed high fearful temperament at age 9. However, the risk could be attenuated if children were better able to control their attention and behaviors, and exhibited greater left activation from resting to a mildly stressful situation at age 9. In addition, fearful children were better able to direct attention away from threat during adolescence if they were better able to control their attention and behaviors, and exhibited greater left activation from resting to a mildly stressful situation at age 9. The findings provide suggestions for early identification and intervention of children who are more vulnerable to anxiety during adolescence.

As virtual experiences are rapidly substituting a significant proportion of in-person interactions during the COVID pandemic, it is critical to monitor the effect of screen exposure time on developing children’s behavior and nervous system. Screen use boosts information accessibility and, therefore, may delay the development of the inhibitory control networks in children, who are vulnerable to immediate reward-orientated tendencies and not yet capable of controlling their impulsivity. Therefore, it was hypothesized that as children become more exposed to screens, the development of the inhibitory control network would be delayed and their reward sensitivity will be augmented. Using the ABCD Study Data Repository, 8,334 children’s behavioral and neural data (aged 9-11) were included. Robust mediation analysis and correlation analysis were used to investigate how Screen Time interacts with children’s reward-orientated tendency (e.g. Behavioral approach system, BAS) and the brain's inhibitory network. Intrinsic Frontoparietal Network-Striatum (FPN-Striatum) connectivity strength was used as neural indices of the inhibitory control quality in children. Results showed that Screen Time significantly mediated the relationship between BAS and both waves of the intrinsic inhibitory process. A higher BAS was linked to a longer Screen Time and weaker inhibitory network connectivity. This complete/full mediation model indicates that Screen Time negatively influenced the strength of FPN-Striatum connectivity. In conclusion, the study revealed specific behavioral and neural correlates of screen exposure using a large database, and suggested that increasing screen exposure time may impair the inhibitory capability and increase impulsivity in children. / M.S. / The current study explored the effect of daily screen exposure in pre-adolescent children to provide an important springboard for future work in protecting developing children against the negative impacts of screen use, which has increased significantly during the COVID-19 pandemic. Over 8,000 children’s data from the Adolescent Brain Cognitive Development (ABCD) project was included and found that an increased daily screen exposure time is linked to an inefficient inhibitory control system in the brain. As children’s inhibitory control systems are still developing, this negative effect further hinder the maturation of inhibitory-control systems two years later. Given that the virtual movement is irreversible, the results provide scientific evidence that a balance between screen time and non-screen activities is required for developing children.

Shyness is highly related to internalizing problems. However, not all shy children develop serious internalizing problems (IP). The aim of the current study was to identify the endogenous factors that might contribute to the resilience process from a self-regulation perspective. Participants included 73 children (33 boys; 40girls) who visited the lab at 6 and 9 years of age. Shyness, attentional control (AC), inhibitory control (IC), frontal electroencephalogram (EEG) asymmetry were measured at both 6 and 9 years using age appropriate questionnaires and tasks. Results indicated that age 6 shyness did not directly predict age 9 IP; instead it indirectly predicted IP through age 9 shyness. Neither AC, IC, frontal EEG asymmetry, nor the stability of frontal EEG asymmetry moderated the association between age 6 shyness and age 9 IP. However, there was a positive concurrent association between shyness and IP at 9 years. In addition, AC and IC moderated the shyness-IP association at age 9. Shyness was significantly associated with IP only when children had low AC or IC, but not when children had high AC or IC. / Master of Science / Shyness is highly related to internalizing problems. However, not all shy children develop serious internalizing problems (IP). The aim of the current study was to identify the within-individual factors that might protect children away from having IP from a self-regulation perspective. Participants included 73 children (33 boys; 40girls) who visited the lab at 6 and 9 years of age. Shyness, attentional control (AC), inhibitory control (IC), frontal electroencephalogram (EEG) asymmetry were measured at both 6 and 9 years using age appropriate questionnaires and tasks. Results indicated that children who are shy at 6 years old may not have IP at 9 years old. Instead children who are shy at 6 years old tend to be shy at 9 years old. And those who are shy at 9 years old are more likely to have IP at the same period of time. Neither AC, IC, frontal EEG asymmetry, nor the stability of frontal EEG asymmetry affect the direction or degree of the association between age 6 shyness and age 9 IP. In addition, AC and IC affect the concurrent shyness-IP association at age 9. Shyness was significantly associated with IP only when children had low AC or IC, but not when children had high AC or IC.

Agtarap, Wright, Mlynski, Hammad, and Blackledge took an initial step in providing support for the predictive validity of a new conceptual analysis concerned with behavioral restraint, defined as active resistance against a behavioral impulse or urge. The current study was designed to partially replicate and extend findings from their study, employing a common film protocol and a procedure for inducing low- and high levels of fatigue. Analyses on key data indicated that the fatigue manipulation was ineffective. On the other hand, they supported the suggestion that behavioral restraint should be proportional to the strength of an urge being resisted so long as success is perceived as possible and worthwhile. Analyses also provided evidence of gender differences for this behavioral restraint task. Women showed relatively enhanced CV responses to my manipulation of urge magnitude, performed less well, rated the behavioral restraint challenge as harder, and rated success on the more difficult behavioral restraint task as more important. A broad indication is that men and women can differ in the strength of impulses they experience in response to stimulus presentations as well as in the importance they place on resisting the impulses.

Alcohol intoxication represents one situation an individual might increase their amount of risk taking when driving. This dissertation is comprised of three studies that investigate the mechanisms by which alcohol increases driver risk-taking. Study 1 examined the effect of alcohol on driver risk-taking using a proxemics approach. The study also tested whether alcohol-induced increases in risky driving co-occurred with pronounced impairment in the driver’s skill. The study also examined whether the most disinhibited drivers were also the riskiest. Indeed, alcohol increased driver risk-taking and impaired driving skill. The study also revealed risky driving can be dissociable from impairing effects on driver skill and that poor inhibitory control is selectively related to elevated risky driving. Studies 2 and 3 built on this work by addressing whether the apparent dissociation between behavioral measures of driver risk and skill was mediated by perceptions the drivers held. While maintaining the distinction between driver risk and skill, Study 2 tested the relationship between drivers’ BAC estimations and their tendency to take risks on the roadway. Drivers who estimated their BAC to be lower were the riskiest drivers following both alcohol and placebo. Study 3 addressed whether risky driving could be increased by environmental factors that shape perceptions the driver holds. There is evidence post-licensure training programs might inadvertently generate overconfidence in drivers’ perceived ability to operate a motor vehicle and thus fail to perceive dangers normally associated with risky driving behavior. To test this hypothesis, twenty-four drivers received either advanced skill training or no training in a driving simulator. Drivers who received skill training showed increased risky driving under alcohol whereas those who received no training tended to decrease their risk taking. Trained drivers also self-reported more confidence in their driving ability. Taken together, these studies represent a large step towards the betterment of laboratory-based models of driving behavior. The work highlights the importance of distinguishing between driver risk-taking and driving skill. The studies also identified that drivers’ personal beliefs influence alcohol-induced risky driving; this suggests training programs focused on correcting drivers’ misconceptions might be most efficacious in reducing their risk taking on the roadway.