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Distinct roles of interferon regulatory factor (IRF)-3 and IRF-7 in the activation of antitumor properties of human macrophagesGoubau, Delphine. January 1900 (has links)
Thesis (M.Sc.). / Written for the Dept. of Microbiology and Immunology. Title from title page of PDF (viewed 2008/05/14). Includes bibliographical references.
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A Protein Coding Variant in IRF7 is associated with SLE Risk and Affects Production of Type IIinterferonFjellman, Ellen V. F. 05 October 2021 (has links)
No description available.
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Interferon Regulatory Factor 7 (IRF7) in Systemic Lupus ErythematosusVerba, Mark J. 09 November 2020 (has links)
No description available.
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The Linear Ubiquitin Assembly Complex Modulates Latent Membrane Protein 1 Activation of NF-κB and Interferon Regulatory Factor 7Wang, Ling, Wang, Yujia, Zhao, Juan, Ren, Junping, Hall, Kenton H., Moorman, Jonathon P., Yao, Zhi Q., Ning, Shunbin 01 January 2017 (has links)
Recently, linear ubiquitin assembly complex (LUBAC)-mediated linear ubiquitination has come into focus due to its emerging role in activation of NF-κB in different biological contexts. However, the role of LUBAC in LMP1 signaling leading to NF-κB and interferon regulatory factor 7 (IRF7) activation has not been investigated. We show here that RNF31, the key component of LUBAC, interacts with LMP1 and IRF7 in Epstein-Barr virus (EBV)-transformed cells and that LUBAC stimulates linear ubiquitination of NEMO and IRF7. Consequently, LUBAC is required for LMP1 signaling to full activation of NF-κB but inhibits LMP1-stimulated IRF7 transcriptional activity. The protein levels of RNF31 and LMP1 are correlated in EBV-transformed cells. Knockdown of RNF31 in EBV-transformed IB4 cells by RNA interference negatively regulates the expression of the genes downstream of LMP1 signaling and results in a decrease of cell proliferation. These lines of evidence indicate that LUBAC-mediated linear ubiquitination plays crucial roles in regulating LMP1 signaling and functions.
IMPORTANCE We show here that LUBAC-mediated linear ubiquitination is required for LMP1 activation of NF-κB but inhibits LMP1-mediated IRF7 activation. Our findings provide novel mechanisms underlying EBV-mediated oncogenesis and may have a broad impact on IRF7-mediated immune responses.
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