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Thèse d'exercice : Médecine : Nancy 1 : 2009. / Titre provenant de l'écran-titre.

Thesis (M.S.)--University of Wisconsin. School of Nursing, 1976. / eContent provider-neutral record in process. Description based on print version record.

The crime of habitual drunkenness under s. 360 of the Criminal Code The purpose of this thesis could be summarized as a complex analysis of a crime of habitual drunkenness under s. 360 of the Czech Criminal Code. The described crime (sometimes named 'rauschdelikt᾿) represents one of possible approaches to a problematic question: How to hold a perpetrator who has committed a crime in mental state of insanity (irresponsibility), in which he had induced himself by use of alcohol, narcotics or similar substances, liable? As far as conformity with elementary principles of criminal law (such as 'nullum crimen sine culpa᾿) is concerned, the crime of habitual drunkenness seems to be the most suitable answer to the previous question. The crime of 'rauschdelikt᾿ is an old legal institute that is specific in many aspects. I have chosen the topic within the context of recent recodification of substantive criminal law. A previous regulation of this crime was often criticised for many reasons (e.g. improper title, too stringent penal sanction etc.). Thus we can now review if those criticised deficiencies have been set right. The thesis is divided into ten chapters. Chapter One is introductory and defines basic terminology used in the thesis, such as 'insanity᾿, 'culpability᾿ and so on. The third subchapter...

Uma das classes químicas de herbicidas que merece particular atenção é a dos bipiridílicos, representada pelo paraquat e diquat. Atualmente, muitos países têm banido ou restringido o uso destes herbicidas devido à grande quantidade de casos de intoxicação acidental, suicídio e envenenamento (tentativa de homicídio) ocorridos no passado. Em contrapartida, o paraquat ainda é bastante utilizado em cerca de 130 nações, com prevalência em países subdesenvolvidos ou em vias de desenvolvimento. O presente trabalho tem por objetivo o estudo e o desenvolvimento de métodos analíticos semi-quantitativo e quantitativo em amostras biológicas (plasma e urina) e aplicação no diagnóstico e investigação da intoxicação aguda por paraquat e diquat. Análises semi-quantitativas de triagem foram realizadas pela técnica enzimática-colorimétrica. Análises confirmatórias foram realizadas pela técnica de cromatografia em fase gasosa acoplada à espectrometria de massa (GC-MS). Após o desenvolvimento e validação dos métodos, as análises foram aplicadas em amostras de pacientes suspeitos de intoxicação aguda por paraquat/diquat atendidos no Hospital Regional do Vale do Ribeira (Pariquera-Açu) e no Hospital de Clínicas da Universidade Estadual de Campinas (SP). Foram avaliadas a efetividade do teste rápido semi-quantitativo e a correlação das concentrações plasmáticas e urinárias do paraquat/diquat obtidas com o método por GC-MS com o grau de intoxicação e o prognóstico de sobrevida dos pacientes após o diagnóstico e tratamento. / One of the chemical classes of herbicides that deserve particular attention is that of bipyridyl, represented by paraquat and diquat. Currently, many countries have banned or restricted these herbicides since large number of accidental intoxication, poisoning and suicide attempt cases occurred in the past. In spite of this, paraquat is still used in more than 130 countries, with prevalence in developing countries. The aim of this work was the study and the development of a screening test and a quantitative analytical method in biological samples (plasma and urine) and their application in diagnosis and prognosis of acute paraquat and diquat intoxication. Semi-quantitative analyses were performed by an enzymatic-colorimetric technique. Confirmatory analyses were performed by a gas chromatographic-mass spectrometric (GC-MS) method. After the development and the validation of both methods, analyses were applied to samples from patients suspected of acute paraquat/diquat poisoning attended in Hospital Regional do Vale do Ribeira (Pariquera-Açu) and Hospital de Clínicas da Universidade Estadual de Campinas (SP). In this present paper, we also evaluated the effectiveness of the rapid test and the correlation of paraquat/diquat plasma and urinary concentrations obtained with the GC-MS method with the degree of intoxication and prognosis of survival of patients after diagnosis and treatment.

Orientador: Michiko Sakate / Banca: Noeme de Sousa Rocha / Banca: Maria do Carmo Fernandez Vailati / Banca: Mário Roberto Hatayde / Banca: Márcia Ferreira da Rosa Sobreira / Resumo: O uso de antiinflamatórios não esteroidais (AINEs) aumentou significativamente na clínica médica de pequenos animais após a descoberta de AINEs seletivos, e isso resultou em uma elevação da incidência de intoxicações por estes medicamentos. O presente estudo teve como objetivo avaliar a histologia e o índice apoptótico hepático, níveis de citocinas séricas e fibrinogênio plasmático nos ratos tratados com diclofenaco, meloxicam e firocoxibe. Utilizaram-se 90 animais que foram divididos em seis grupos de 15 animais cada: G1 - controle: 0,3mL/100g de solução fisiológica; G2 - diclofenaco de sódio: 15mg/kg; G3 - meloxicam: 2mg/kg; G4 - meloxicam: 10mg/kg; G5 - firocoxibe: 5mg/kg; G6 - firocoxibe: 25mg/kg. A medicação foi realizada por meio de gavage, a cada 24 horas, por cinco dias. Após a eutanásia dos ratos, foram colhidos materiais para dosagens de fibrinogênio e citocinas, análise histopatológica e de apoptose hepática. Os ratos tratados com diclofenaco, meloxicam e firocoxibe não apresentaram diferença estatística em relação aos índices apoptóticos hepáticos. A concentração sérica de TNF- foi semelhante em todos os grupos avaliados, e a IL-10 foi maior nos grupos tratados com os AINEs quando comparada ao grupo de solução fisiológica. O fibrinogênio plasmático elevou-se nos ratos tratados com diclofenaco e com meloxicam. As alterações histopatológicas foram mais frequentemente observadas nos animais que receberam diclofenaco e alterações leves, com o uso de meloxicam e firocoxibe. O meloxicam e o firocoxibe foram considerados AINEs seguros, pois não causaram alterações significativas nos ratos tratados com a dose recomendada e discreto grau de toxicidade no grupo tratado com cinco vezes a dosagem / Abstract: The employ of non-steroidal anti-inflammatory drugs increased significantly in medical clinic of small animals after the discovery of NSAID selected and this effected in an increase of times of intoxications by these medicines. The present study aims to evaluate the histology and the hepatic apoptotic index, quantify serum dosage of cytokines and plasmatic fibrinogen in rats deal with diclofenac, meloxicam and firocoxibe. It were used 90 animals which they're divided in six groups with 15 animals each one. G1- control: 0.3mL/100g physiologic solution; G2- diclofenac: 15mg/kg (positive control); G3- meloxicam: 2mg/kg; G4- meloxicam: 10mg/kg; G5- firocoxib: 05mg/kg; G6- firocoxib: 25mg/kg. Medication was administered though gavage every 24 hours by five days. After euthanasia of these rats, were cropped materials to dosing of fibrinogen, cytokines, hipathology and hepatic apoptosis. The rats which were under care with diclofenac, meloxicam and firocoxibe didn't show difference statistics in report to the hepatic apoptotic index. TNF- serum concentration was similar to all groups and IL-10 concentration was higher on the groups which were under care with the AINEs when were compared with the group of physiological solution. The plasma fibrinogen is elevated in rats treated with diclofenac and meloxicam. The most frequency histopathological changes were observed in animals that received diclofenac and mild changes, with the use of meloxicam and firocoxib. Meloxicam and firocoxib cam be considered NSAIDs safe, because they didn't cause significatives alterations in the rats treated with the recommended dose and a slight degree of toxicity in the group treated with five times the dosage / Doutor

Thèse d'exercice : Médecine. Médecine générale : Nantes : 2007. / Bibliogr.

Reproduction de : Thèse d'exercice : Médecine. Médecine générale : Nantes : 2008. / Bibliogr.

Reproduction de : Thèse d'exercice : Médecine vétérinaire : Toulouse 3 : 2007. / Titre provenant de l'écran titre. Bibliogr. p. 129-139.

College-aged individuals experience verbal and physical dating aggression at high rates, which is troubling given the associated deleterious consequences. Verbal and physical aggression are highly correlated, with verbal aggression often serving as a precursor to physical aggression. The current studies examined factors that may influence the likelihood and escalation of dating aggression in response to a dating conflict scenario, including alcohol intoxication, self-regulation, and trait aggressivity. Study 1 assessed the construct validity of a newly developed audio-taped scenario of mutual aggression as well as a hot sauce task. Men and women with (n=31) and without (n=30) a history of past-year dating aggression provided responses to the conflict scenario using the Articulated Thoughts in Simulated Situations (ATSS) procedure. Under the guise of an assessment of sensitivity, participants allocated hot sauce for a fictitious participant to consume. Results supported the construct validity of the conflict scenario but not the hot sauce task, which was therefore not included in Study 2. Study 2 examined the influence of alcohol's pharmacological and expectancy effects as well as one’s ability to self-regulate thoughts, feelings, and behavior on aggression intentions in response to the mutual aggression conflict scenario. Participants were randomized to either receive alcohol (n=48; blood alcohol content M = .082%), placebo (n=48), or no alcohol (n=48). Using ATSS procedures identical to Study 1, intoxicated individuals articulated more verbal aggression intentions overall and exhibited a greater increase across the conflict scenario than those who did not receive alcohol, but did not differ from those who received placebo. There were no effects of alcohol on physical aggression intentions. Individuals who received placebo and who were poorer at suppressing emotions articulated more verbal aggression intentions than intoxicated individuals. Additionally, individuals higher in trait aggressivity articulated more physical aggression intentions and intoxicated individuals with lower relationship satisfaction articulated more verbal aggression intentions. Results suggest that both the pharmacological and expectancy effects of alcohol were important to the occurrence of aggression. Whereas higher trait aggressivity and lower relationship satisfaction may be risk  factors  for  aggression,  regulating  one’s  emotions  may  reduce  the frequency of aggression. / text